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1.
Acta Otorrinolaringol Esp ; 54(2): 157-60, 2003 Feb.
Artigo em Espanhol | MEDLINE | ID: mdl-12802993

RESUMO

We present the consequences corresponding to a bilateral section of the main trunk of vagus nerve at cervical level in a patient with an oropharyngeal carcinoma with bilateral neck nodes. As a consequence of the bilateral resection of both vagus nerves during neck dissections, as well as motor and sensitive damage of the larynx and pharynx, we could observe affection of the normal tone of the oesophagus, stomach and duodenum which forced to enteral nutrition by direct jejunal access, and a disorder of the cardiac rhythm due to loss of the parasympathetic innervation appeared.


Assuntos
Bradicardia/etiologia , Carcinoma de Células Escamosas/cirurgia , Transtornos de Deglutição/etiologia , Complicações Intraoperatórias , Neoplasias Orofaríngeas/cirurgia , Nervo Vago/cirurgia , Carcinoma de Células Escamosas/diagnóstico por imagem , Humanos , Masculino , Pessoa de Meia-Idade , Neoplasias Orofaríngeas/diagnóstico por imagem , Tomografia Computadorizada por Raios X
3.
N Engl J Med ; 345(9): 647-55, 2001 Aug 30.
Artigo em Inglês | MEDLINE | ID: mdl-11547718

RESUMO

BACKGROUND: After an episode of acute bleeding from esophageal varices, patients are at high risk for recurrent bleeding and death. We compared two treatments to prevent recurrent bleeding--endoscopic ligation and combined medical therapy with nadolol and isosorbide mononitrate. METHODS: We randomly assigned 144 patients with cirrhosis who were hospitalized with esophageal variceal bleeding to receive treatment with endoscopic ligation (72 patients) or the combined medical therapy (72 patients). Sessions of ligation were repeated every two to three weeks until the varices were eradicated. The initial dose of nadolol was 80 mg orally once daily, with adjustment according to the resting heart rate; isosorbide mononitrate was given in increasing doses, beginning at 20 mg once a day at bed time and rising over the course of one week to 40 mg orally twice a day, unless side effects occurred. The primary end points were recurrent bleeding, complications, and death. RESULTS: The median follow-up period was 21 months. A total of 35 patients in the ligation group and 24 in the medication group had recurrent bleeding. The probability of recurrence was lower in the medication group, both for all episodes related to portal hypertension (P=0.04) and for recurrent variceal bleeding (P=0.04). There were major complications in nine patients treated with ligation (seven had bleeding esophageal ulcers and two had aspiration pneumonia) and two treated with medication (both had bradycardia and dyspnea) (P=0.05). Thirty patients in the ligation group died, as did 23 patients in the medication group (P=0.52). The probability of recurrent bleeding was lower for patients with a hemodynamic response to therapy, defined as a decrease in the hepatic venous pressure gradient of more than 20 percent from the base-line value or to less than 12 mm Hg (18 percent, vs. 54 percent in patients with no hemodynamic response at one year; P<0.001), and the probability of survival was higher (94 percent vs. 78 percent at one year, P=0.02). CONCLUSIONS: Combined therapy with nadolol and isosorbide mononitrate is more effective than endoscopic ligation for the prevention of recurrent bleeding and is associated with a lower rate of major complications. A hemodynamic response to treatment is associated with a better long-term prognosis.


Assuntos
Antagonistas Adrenérgicos beta/uso terapêutico , Endoscopia , Varizes Esofágicas e Gástricas/tratamento farmacológico , Varizes Esofágicas e Gástricas/cirurgia , Hemorragia Gastrointestinal/tratamento farmacológico , Hemorragia Gastrointestinal/cirurgia , Dinitrato de Isossorbida/uso terapêutico , Nadolol/uso terapêutico , Vasodilatadores/uso terapêutico , Análise Atuarial , Antagonistas Adrenérgicos beta/administração & dosagem , Antagonistas Adrenérgicos beta/efeitos adversos , Quimioterapia Combinada , Feminino , Hemorragia Gastrointestinal/prevenção & controle , Hemodinâmica , Humanos , Dinitrato de Isossorbida/administração & dosagem , Dinitrato de Isossorbida/efeitos adversos , Dinitrato de Isossorbida/análogos & derivados , Ligadura , Masculino , Pessoa de Meia-Idade , Nadolol/administração & dosagem , Nadolol/efeitos adversos , Complicações Pós-Operatórias , Análise de Regressão , Prevenção Secundária , Análise de Sobrevida , Vasodilatadores/administração & dosagem , Vasodilatadores/efeitos adversos
4.
Gastroenterol Hepatol ; 23(1): 14-5, 2000 Jan.
Artigo em Espanhol | MEDLINE | ID: mdl-10726378

RESUMO

The diagnosis of achalasia is based on the patient's symptoms and on manometric studies although other diseases present similar symptomatology. To present an elderly woman clinically and manometrically diagnosed with achalasia of the cardia who was treated by dilatation. When the patient relapsed and was surgically treated she was found to have and esophageal adenocarcinoma. When considering a diagnosis of achalasia, alternative diagnoses (especially neoplasias) should be borne in mind, especially in unusual situations, such as rapid onset or in the elderly.


Assuntos
Transtornos de Deglutição/diagnóstico , Acalasia Esofágica/diagnóstico , Adenocarcinoma/complicações , Adenocarcinoma/diagnóstico , Idoso , Idoso de 80 Anos ou mais , Biópsia , Cárdia/patologia , Transtornos de Deglutição/etiologia , Diagnóstico Diferencial , Acalasia Esofágica/etiologia , Feminino , Humanos , Neoplasias Gástricas/complicações , Neoplasias Gástricas/diagnóstico
5.
Hepatology ; 30(2): 384-9, 1999 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-10421644

RESUMO

Recent trials have shown that somatostatin (SMT) is as effective as sclerotherapy in the treatment of acute variceal bleeding and that the combination of both treatments is more effective than sclerotherapy alone. To assess whether the addition of sclerotherapy improves the efficacy of SMT alone, all patients admitted to our unit with gastrointestinal bleeding and with suspected cirrhosis received a continuous infusion of SMT (250 micrograms/h). Endoscopy was performed between 1 and 5 hours later, and patients with esophageal variceal bleeding were randomized to receive or not to receive sclerotherapy. In both groups, SMT infusion was continued for 5 days. Fifty patient admissions were allocated to each group. Therapeutic failure occurred in 21 cases of the SMT group and in 7 cases of the combined-therapy group (P =.002). Failure to control the acute episode occurred in 24% vs. 8% (P =.03) and early rebleeding in 24% vs. 7% (P =.03), respectively. Transfusional requirements were significantly higher in the SMT group, while the incidence of complications was lower (8% vs. 24%; P =.029). In the multivariate analysis, the presence of shock at admission and active bleeding during endoscopy were the variables that better predicted the failure of therapy with SMT alone. Mortality at 6 weeks was similar. These data demonstrate that the addition of sclerotherapy significantly improves the efficacy of SMT alone for the treatment of acute variceal bleeding, although it also increases the rate of complications. Patients with shock and those with active bleeding are more likely to benefit from this combined therapy.


Assuntos
Varizes Esofágicas e Gástricas/terapia , Hemorragia Gastrointestinal/terapia , Escleroterapia , Somatostatina/uso terapêutico , Doença Aguda , Adulto , Idoso , Emergências , Varizes Esofágicas e Gástricas/mortalidade , Feminino , Hemorragia Gastrointestinal/mortalidade , Humanos , Masculino , Pessoa de Meia-Idade , Análise Multivariada , Estudos Prospectivos , Escleroterapia/efeitos adversos , Somatostatina/efeitos adversos , Taxa de Sobrevida , Falha de Tratamento
6.
Eur J Gastroenterol Hepatol ; 11(3): 239-42, 1999 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-10333194

RESUMO

OBJECTIVE: The epidemiology of Helicobacter pylori infection is still under investigation, and the exact source of infection and its mode of transmission are still unknown. The purpose of this prospective study was to determine whether medical professionals in Spain, especially gastroenterologists and gastrointestinal endoscopists, have a higher prevalence of H. pylori infection. METHODS: Two hundred and twenty four medical professionals attending the annual gastroenterology meeting in Spain (176 men, 48 women; mean age, 41.8 +/- 11.4 years; range, 25-73 years) and a control group of 189 persons of similar age were investigated for the prevalence of H. pylori infection by using the 13C-urea breath test. All medical professionals completed a questionnaire regarding medical specialty and regular performing of gastrointestinal endoscopy procedures. RESULTS: The overall prevalence of H. pylori infection in total medical professionals was 52.7%, compared with 51.9% in the control group (P > 0.05). When specialty was considered, the prevalence of H. pylori infection among gastroenterologists was 53.3%, also not significantly higher than 50.0% among non-gastroenterologists (P > 0.05). There were no statistical differences of H. pylori prevalence among endoscopists and non-endoscopists. CONCLUSIONS: Medical practice and, more specifically, gastroenterology and the regular performance of gastrointestinal endoscopy pose no additional risk for H. pylori infection in Spain.


Assuntos
Pessoal de Saúde/estatística & dados numéricos , Infecções por Helicobacter/epidemiologia , Helicobacter pylori , Adulto , Idoso , Testes Respiratórios , Isótopos de Carbono , Distribuição de Qui-Quadrado , Intervalos de Confiança , Endoscopia Gastrointestinal/estatística & dados numéricos , Feminino , Gastroenterologia/estatística & dados numéricos , Humanos , Masculino , Pessoa de Meia-Idade , Razão de Chances , Prevalência , Estudos Prospectivos , Fatores de Risco , Espanha/epidemiologia , Inquéritos e Questionários , Ureia
7.
Am J Gastroenterol ; 93(12): 2457-62, 1998 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-9860409

RESUMO

OBJECTIVE: Selective intestinal decontamination with norfloxacin is useful in the prevention of bacterial infections in cirrhotic patients with gastrointestinal bleeding. However, bleeding cirrhotic patients with ascites, encephalopathy, or shock are at high risk to develop bacterial infections in spite of prophylactic norfloxacin. The aim of this study was to assess whether the addition of intravenous ceftriaxone could improve the efficacy of prophylaxis with norfloxacin in these patients. METHODS: Fifty-six cirrhotic patients with gastrointestinal hemorrhage and ascites, encephalopathy, or shock were randomized into two groups: Group 1 (n = 28) received oral norfloxacin 400 mg/12 h for 7 days, and group 2 (n = 28) received norfloxacin plus intravenous ceftriaxone 2 g daily during the first 3 days of admission. RESULTS: Ten patients were excluded because of community-acquired infection, surgery, or death within the first 24 h. The incidence of bacterial infections during hospitalization was 18.1% in group 1 and 12.5% in group 2 (p = NS). The incidence of severe infections (spontaneous bacterial peritonitis, bacteremia, or pneumonia) was also similar in both groups: 9% in group 1 versus 8.3% in group 2 (p = NS). There were no statistical differences between the two groups with respect to duration of hospitalization or mortality. The cost of antibiotic therapy (including prophylaxis and treatment of infections) was significantly higher in group 2. CONCLUSION: These results suggest that the addition of intravenous ceftriaxone during the first 3 days of hospitalization does not improve the cost-efficacy of oral norfloxacin in the prevention of bacterial infections in cirrhotic patients with gastrointestinal bleeding and high risk of infection.


Assuntos
Anti-Infecciosos/administração & dosagem , Infecções Bacterianas/prevenção & controle , Ceftriaxona/administração & dosagem , Cefalosporinas/administração & dosagem , Hemorragia Gastrointestinal/etiologia , Cirrose Hepática/complicações , Cirrose Hepática/tratamento farmacológico , Norfloxacino/administração & dosagem , Administração Oral , Idoso , Anti-Infecciosos/economia , Anti-Infecciosos/uso terapêutico , Infecções Bacterianas/epidemiologia , Ceftriaxona/uso terapêutico , Cefalosporinas/uso terapêutico , Análise Custo-Benefício , Feminino , Humanos , Incidência , Injeções Intravenosas , Masculino , Pessoa de Meia-Idade , Norfloxacino/economia , Norfloxacino/uso terapêutico
8.
Rev Esp Enferm Dig ; 89(8): 647-9, 1997 Aug.
Artigo em Espanhol | MEDLINE | ID: mdl-9471208

RESUMO

Although distal dissemination from breast cancer is commonly found in bones, lungs, liver and brain, others less common sites have been occasionally reported. A 60 year-old woman with long standing disseminated breast cancer disease was admitted to our hospital with upper gastrointestinal bleeding. At endoscopy, an abnormal area was seen in the lesser curvature of the stomach. Invasion of the gastric wall by metastases from carcinoma of the breast was diagnosed in the biopsy. No further treatment was warranted and the patient died soon thereafter. Gastric metastases are primarily located in the submucosa and muscular layers of the stomach. Lack of mucosal involvement suggests a blood-borne spread. Although our patient had no progesterone receptors in the primary breast tumor, previous studies have suggested that the presence of receptors may facilitate gastrointestinal spread. Gastric metastases from extraintestinal cancers may be asymptomatic, and are usually late events in the progression of the disease.


Assuntos
Adenocarcinoma/secundário , Neoplasias da Mama/patologia , Neoplasias Gástricas/secundário , Feminino , Humanos , Pessoa de Meia-Idade
9.
N Engl J Med ; 334(25): 1624-9, 1996 Jun 20.
Artigo em Inglês | MEDLINE | ID: mdl-8628357

RESUMO

BACKGROUND: Patients who have bleeding from esophageal varices are at high risk for rebleeding and death. We compared the efficacy and safety of endoscopic sclerotherapy with the efficacy and safety of nadolol plus isosorbide mononitrate for the prevention of variceal rebleeding. METHODS: Eighty-six hospitalized patients with cirrhosis and bleeding from esophageal varices diagnosed by endoscopy were randomly assigned to treatment with repeated sclerotherapy (43 patients) or nadolol plus isosorbide-5-mononitrate (43 patients). The primary outcomes were rebleeding, death, and complications. The hepatic venous pressure gradient was measured at base line and after three months. RESULTS: Base-line data were similar in the two groups, and the median follow-up was 18 months in both. Eleven patients in the medication group and 23 in the sclerotherapy group had rebleeding. The actuarial probability of remaining free of rebleeding was higher in the medication group for all episodes related to portal hypertension (P = 0.001) and variceal rebleeding (P = 0.002). Four patients in the medication group and nine in the sclerotherapy group died (P = 0.07 for the difference in the actuarial probability of survival). Seven patients in the medication group and 16 in the sclerotherapy group had treatment-related complications (P = 0.03). Thirty-one patients in the medication group underwent two hemodynamic studies; 1 of the 13 patients with more than a 20 percent decrease in the hepatic venous pressure gradient had rebleeding, as compared with 8 of the 18 with smaller decreases in the pressure gradient (P = 0.04) for the actuarial probability of rebleeding at two years). CONCLUSIONS: As compared with sclerotherapy, nadolol plus isosorbide mononitrate significantly decreased the risk of rebleeding from esophageal varices.


Assuntos
Antagonistas Adrenérgicos beta/uso terapêutico , Varizes Esofágicas e Gástricas/terapia , Hemorragia Gastrointestinal/prevenção & controle , Dinitrato de Isossorbida/análogos & derivados , Nadolol/uso terapêutico , Escleroterapia , Vasodilatadores/uso terapêutico , Análise Atuarial , Antagonistas Adrenérgicos beta/efeitos adversos , Quimioterapia Combinada , Varizes Esofágicas e Gástricas/tratamento farmacológico , Varizes Esofágicas e Gástricas/mortalidade , Feminino , Humanos , Dinitrato de Isossorbida/uso terapêutico , Masculino , Pessoa de Meia-Idade , Nadolol/efeitos adversos , Recidiva , Escleroterapia/efeitos adversos , Análise de Sobrevida , Resultado do Tratamento
10.
Rev Esp Enferm Dig ; 88(2): 99-106, 1996 Feb.
Artigo em Espanhol | MEDLINE | ID: mdl-8664080

RESUMO

AIM: To evaluate the efficiency of omeprazole (20 mg/12 h) plus amoxycillin (1 gr/12 h) in eradicating Helicobacter pylori in duodenal ulcer patients studied in four hospitals in our country. METHODS: One-hundred and four patients (mean age: 49 +/- 16 years, 67% males) attended at four general hospitals in Spain, who had a duodenal ulcer demonstrated by endoscopy. These patients were infected with H. pylori demonstrated by urease test and histologic methods, and in 32 by a breath test and 18 by culture. Omeprazole 20 mg b.i.d. plus amoxycillin 1 gr b.i.d. was administered for 2 weeks. Endoscopy was repeated 1 month after completing therapy, and the aforementioned diagnostic methods were performed again. RESULTS: Eradication was achieved in 29% of cases (n = 30). In multiple logistic regression analysis, duration of ulcer disease was the only variable which correlated with success in H. pylori eradication (chi(2) = 7.2; p = 0.02). Additional variables (age, sex, smoking, pre-treatment with omeprazole, AINEs or H2 antagonist, ulcer size, and antral histologic gastritis) were not correlated with H. pylori eradication. Ulcer healing was demonstrated in 80% of patients (n = 83), and the healing rate was higher when eradication was achieved (97%) than in H. pylori-positive patients (73%) (p < 0.01). Compliance was good in all cases. No adverse effects were observed. CONCLUSION: [corrected] Disappointing results were obtained with omeprazole (20 mg b.i.d.) plus amoxycillin (1 gr b.i.d.) on H. pylori eradication. This combination cannot be recommended in our country at the doses employed in this study.


Assuntos
Amoxicilina/administração & dosagem , Antiulcerosos/administração & dosagem , Úlcera Duodenal/tratamento farmacológico , Infecções por Helicobacter/tratamento farmacológico , Helicobacter pylori , Omeprazol/administração & dosagem , Penicilinas/administração & dosagem , Adulto , Idoso , Quimioterapia Combinada , Feminino , Humanos , Modelos Logísticos , Masculino , Pessoa de Meia-Idade
11.
Eur J Nucl Med ; 22(10): 1123-8, 1995 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-8542895

RESUMO

The aim of this study was to assess the gastric emptying rate of two antacids using an scintigraphic technique and simultaneous monitoring of gastric pH in 16 healthy male volunteers. Ten ml of Talcid (hydrotalcite 1 g) and Maalox (Mg-Al-hydroxide), with a similar neutralization capacity, were labelled with technetium-99m using a pyrophosphate bridge. Labelled antacids were given on separate days (within 2 weeks), 1 h after a standard meal. Intragastric pH was measured for at least 4 h, using ambulatory pH-metry with a dual-crystant antimony catheter. Continuous monitoring was started 1 h prior to the meal (baseline) and lasted 3 h (post-prandial, post-antacid and final periods). The antacid capacity of labelled and unlabelled antacids was similar. The mean percentages of antacids retained in the stomach fitted a linear model. The mean half-emptying time of Talcid was 63.9 +/- 27.9 min, while that of Maalox was 57.3 +/- 23.9 min (P = NS). The recordings of gastric pH (mean values of pH for each period) showed a similar profile for both antacids. The mean pH (Maalox vs Talcid) was 1.69 vs 2.07 in the baseline period, 1.95 vs 1.93 in the post-prandial period, 1.79 vs 1.15 in the post-antacid period (P = NS) and 0.4 vs 0.52 in the final period (P < 0.05 vs prior periods). In conclusion, the gastric emptying of Talcid and Maalox was similar and pH profiles were parallel and remained unchanged for the two antacids within the first hour of intake. A significant decrease in pH was observed 1 h after intake of the antacids, suggesting a possible rebound effect.


Assuntos
Hidróxido de Alumínio , Antiácidos , Esvaziamento Gástrico , Hidróxido de Magnésio , Adulto , Hidróxido de Alumínio/farmacocinética , Hidróxido de Alumínio/farmacologia , Antiácidos/farmacocinética , Antiácidos/farmacologia , Estudos Cross-Over , Método Duplo-Cego , Combinação de Medicamentos , Determinação da Acidez Gástrica , Humanos , Concentração de Íons de Hidrogênio , Hidróxido de Magnésio/farmacocinética , Hidróxido de Magnésio/farmacologia , Masculino , Pirofosfato de Tecnécio Tc 99m
12.
Endoscopy ; 27(4): 308-12, 1995 May.
Artigo em Inglês | MEDLINE | ID: mdl-7555936

RESUMO

BACKGROUND AND STUDY AIMS: Although high rates of initial hemostasis can be achieved with endoscopic injection therapy in actively bleeding ulcers, the incidence of rebleeding is not negligible. Optimal conditions for clotting may require achieving deep and sustained acid inhibition to avoid the deleterious effect of acid and pepsin secretions on the hemostatic process. The aim of this study was to assess whether omeprazole could improve the efficacy of ranitidine as an adjunct treatment in endoscopic injection therapy to avoid rebleeding. PATIENTS AND METHODS: Eighty-six patients with active arterial bleeding from a peptic ulcer disclosed at emergency endoscopy were included in this prospective trial. All patients received injections of 1:10,000 adrenaline. Subsequently, they were randomized to receive either intravenous omeprazole (n = 45), with an initial dose of 80 mg followed by 40 mg every eight hours for four days and thereafter with oral administration; or ranitidine (n = 41), 50 mg every six hours for 12 to 24 hours and thereafter with oral administration. RESULTS: The two groups were well matched in terms of clinical and endoscopic data. There were no statistically significant differences between the groups with regard to: further bleeding (29% in both groups), need for emergency surgery (20% in the omeprazole group vs. 22% in the ranitidine group), transfusion requirements (2.4 +/- 2.2 vs. 2.2 +/- 2.1 units), length of hospital stay (14.1 +/- 13.9 vs. 15.3 +/- 15.4 days), or mortality (7% vs. 2%). CONCLUSIONS: Our results suggest that omeprazole does not improve the efficacy of ranitidine after endoscopic injection therapy in patients with an active arterial bleeding ulcer.


Assuntos
Antiulcerosos/uso terapêutico , Úlcera Duodenal/complicações , Hemostase Endoscópica , Omeprazol/uso terapêutico , Úlcera Péptica Hemorrágica/terapia , Ranitidina/uso terapêutico , Úlcera Gástrica/complicações , Adulto , Idoso , Antiulcerosos/administração & dosagem , Intervalos de Confiança , Quimioterapia Combinada , Úlcera Duodenal/diagnóstico , Endoscopia , Feminino , Hemostase Endoscópica/métodos , Humanos , Injeções Intralesionais , Masculino , Pessoa de Meia-Idade , Omeprazol/administração & dosagem , Úlcera Péptica Hemorrágica/diagnóstico , Estudos Prospectivos , Ranitidina/administração & dosagem , Úlcera Gástrica/diagnóstico , Resultado do Tratamento
13.
Rev Esp Enferm Dig ; 86(1): 499-504, 1994 Jul.
Artigo em Espanhol | MEDLINE | ID: mdl-7917561

RESUMO

AIM: to assess whether nadolol could improve the results of sclerotherapy in the prevention of varices rebleeding. EXPERIMENTAL DESIGN: prospective study in which patients with cirrhosis and Child-Pugh's class A or B and with their first hemorrhage from esophageal varices, diagnosed by emergency endoscopy, were included. After initial control of bleeding with emergency sclerotherapy, the patients were randomized into two groups to receive long-term variceal sclerotherapy either alone (group 1) or plus nadolol (group 2). Sclerotherapy was performed by intravariceal injection of 5% ethanolamine at days 0, 4 10, 30 and then monthly until eradication of varices. Nadolol was administered during the whole follow-up in a dose to reduce resting pulse rate by 25% (mean final dose: 82 +/- 31 mg/d). PATIENTS: During a two year period (1989-1991), 40 patients with cirrhosis (from alcohol abuse in 48%), were included. 18 patients were allocated in group 1 and 22 in group 2. RESULTS: Both groups were well-matched for clinical, biological and endoscopic data. Follow-up was similar in both (24.3 +/- 10.6 months in group 1 vs 27.3 +/- 9.8 in group 2). Nine patients in group 1 (50%) and 13 in group 2 (59%) rebled during the follow-up, with a total number of 14 and 22 rebleeding episodes respectively (p = NS). There were no differences between the two groups when considering rebleeding index, transfusional requirements per rebleeding episode and the cumulative percentage of patients free from rebleeding. Severe complications attributable to treatment were observed in 22% of patients in group 1 and in 27% in group 2 (p = NS). Two patients died in each group. CONCLUSIONS: In patients undergoing long-term sclerotherapy for prevention of variceal rebleeding, nadolol confers no additional benefit.


Assuntos
Varizes Esofágicas e Gástricas/terapia , Hemorragia Gastrointestinal/prevenção & controle , Nadolol/uso terapêutico , Escleroterapia , Adulto , Idoso , Terapia Combinada , Varizes Esofágicas e Gástricas/complicações , Feminino , Hemorragia Gastrointestinal/etiologia , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Recidiva
14.
Gastrointest Endosc ; 40(1): 34-9, 1994.
Artigo em Inglês | MEDLINE | ID: mdl-8163132

RESUMO

A prospective and randomized trial involving 104 patients was performed to assess whether second-look endoscopy could improve the efficacy of injection therapy for bleeding ulcers. The inclusion criteria were the presence of active arterial bleeding or a non-bleeding visible vessel at emergency endoscopy. All the patients received emergency injection of 1:10,000 adrenaline and were subsequently randomized (52 patients in each group) according to whether or not they would receive a second elective endoscopy within the first 24 hours with repeated injection if a visible vessel was still identified. Both groups were well matched for clinical and endoscopic data. A tendency towards better results was noted in the group that received a second-look endoscopy; the two groups were compared in regard to further bleeding (21% versus 29%, 95% confidence interval of the difference = -24.3 to 8.5), need for emergency surgery (8% versus 15%, 95% confidence interval of the difference = -19.9 to 4.5), transfusion requirements (1.7 +/- 1.9 versus 2.5 +/- 2.5 units, 95% confidence interval of the difference = -1.6 to 0.07), length of hospital stay (9.3 +/- 8.6 versus 11.8 +/- 10.8 days, 95% confidence interval of the difference = -6.2 to 1.4), and mortality rate (2% versus 4%). Although these trends did not achieve statistical significance, a type II error cannot be ruled out. However, according to our results, several hundred patients would be required to demonstrate statistically these relatively small differences.(ABSTRACT TRUNCATED AT 250 WORDS)


Assuntos
Endoscopia Gastrointestinal , Hemostase Endoscópica , Úlcera Péptica Hemorrágica/diagnóstico , Úlcera Péptica Hemorrágica/tratamento farmacológico , Emergências , Epinefrina/administração & dosagem , Feminino , Humanos , Injeções , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Recidiva
15.
Dig Dis Sci ; 38(11): 2062-70, 1993 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-8223082

RESUMO

Endoscopic injection therapy was performed in a consecutive series of 233 patients admitted for a bleeding peptic ulcer with active arterial hemorrhage or a nonbleeding visible vessel disclosed at emergency endoscopy. Further bleeding occurred in 57 cases (24.5%). The present study was conducted to evaluate whether any clinical or endoscopic features could identify the patients at high risk of therapeutic failure. Multiple logistic regression analysis showed that failure was significantly related to: (1) the ulcer location on the posterior wall (P = 0.004) or superior wall (P = 0.003) of the duodenal bulb, (2) the ulcer size (P = 0.011), and (3) the existence of associated diseases (P = 0.012). The validity of the prediction rule based on these factors was evaluated by receiver-operating characteristic curves and was confirmed and prospectively validated in an independent sample of 81 patients with a bleeding peptic ulcer treated by endoscopic injection. We conclude that once the initial control of bleeding has been achieved by injection therapy, the present prediction rule can be used to identify candidates for alternative treatment.


Assuntos
Úlcera Duodenal/complicações , Hemostase Endoscópica , Úlcera Péptica Hemorrágica/terapia , Úlcera Gástrica/complicações , Epinefrina/uso terapêutico , Feminino , Humanos , Modelos Logísticos , Masculino , Pessoa de Meia-Idade , Úlcera Péptica Hemorrágica/epidemiologia , Polidocanol , Polietilenoglicóis/uso terapêutico , Curva ROC , Fatores de Risco , Soluções Esclerosantes/uso terapêutico , Trombina/uso terapêutico , Falha de Tratamento
16.
J Clin Gastroenterol ; 17(3): 195-200, 1993 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-8228078

RESUMO

In a prospective randomized trial involving 63 patients with bleeding peptic ulcer, we assessed whether the addition of 1% polidocanol improved the results achieved by 1/10(4) adrenaline alone for injection therapy. The inclusion criterion was the presence of active arterial bleeding or a nonbleeding visible vessel at emergency endoscopy. Thirty patients were treated with 1/10(4) adrenaline (group A) and 33 with adrenaline plus 1% polidocanol (group B). Initial hemostasis was achieved in 97% of cases in both groups and permanent hemostasis in 87% patients in group A and in 76% in group B (p = NS). Mortality was 6% in group A and 3% in group B. There were no differences between the two groups regarding requirements for emergency surgery, the number of transfusions, or the length of hospital stay. One patient in group B had a perforation. No other relevant complications were noted. In conclusion, combined therapy does not improve the results achieved with adrenaline alone.


Assuntos
Epinefrina/uso terapêutico , Hemostase Endoscópica , Úlcera Péptica Hemorrágica/terapia , Polietilenoglicóis/uso terapêutico , Soluções Esclerosantes/uso terapêutico , Epinefrina/administração & dosagem , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Úlcera Péptica Hemorrágica/epidemiologia , Polidocanol , Polietilenoglicóis/administração & dosagem , Estudos Prospectivos , Resultado do Tratamento
17.
Eur J Nucl Med ; 20(7): 600-2, 1993 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-8370380

RESUMO

The aim of this study was to assess the influence of the normal menstrual cycle and of menopause on the gastric emptying rate of solids. Gastric emptying was studied in 15 premenopausal and ten postmenopausal women with an isotopic technique after the ingestion of a radiolabelled test meal. Premenopausal women were studied twice: within 1 week prior to menses and again 1 week after onset of menses. Postmenopausal women were studied only once. The emptying curves of the solid component of the meal fitted a linear model. The half-emptying time was 78 +/- 5 min during the follicular phase, 75 +/- 7 min during the luteal phase and 76 +/- 6 min in postmenopausal women (differences not statistically significant). The mean percentages of the meal retained in the stomach at different time intervals were also similar in the three groups. These results suggest that the menstrual cycle does not influence the gastric emptying rate of solids, which remains unchanged in relation to the follicular phase or after menopause.


Assuntos
Esvaziamento Gástrico/fisiologia , Menopausa/fisiologia , Ciclo Menstrual/fisiologia , Adulto , Idoso , Feminino , Alimentos , Humanos , Pessoa de Meia-Idade , Valores de Referência
18.
Gastroenterology ; 103(4): 1267-72, 1992 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-1397884

RESUMO

To assess the efficacy of selective intestinal decontamination with norfloxacin in the prevention of bacterial infections in cirrhotic patients with gastrointestinal hemorrhage, 119 patients were included in a prospective randomized study. Group 1 (n = 60) received norfloxacin orally or through a nasogastric tube, 400 mg twice daily for 7 days beginning immediately after emergency gastroscopy; group 2 (n = 59) was the control group. We found a significantly lower incidence of infections (10% vs. 37.2%; P = 0.001), bacteremia and/or spontaneous bacterial peritonitis (3.3% vs. 16.9%; P less than 0.05), and urinary infections (0% vs. 18.6%; P = 0.001) in patients receiving norfloxacin, as a consequence of decrease in the incidence of infections caused by aerobic gram-negative bacilli. The decrease in mortality observed in the treated group (6.6% vs. 11.8%) did not reach statistical significance. The cost for antibiotic treatment showed a 62% reduction in the treated group compared with the control group. The results show that selective intestinal decontamination with norfloxacin is useful in preventing bacterial infections in cirrhotics with gastrointestinal hemorrhage.


Assuntos
Infecções Bacterianas/prevenção & controle , Hemorragia Gastrointestinal/complicações , Cirrose Hepática/complicações , Norfloxacino/uso terapêutico , Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade
19.
Rev. boliv. ginecol. obstet ; 15(2): 57-61, ago. 1992. tab
Artigo em Espanhol | LILACS | ID: lil-127609

RESUMO

Fueron examinados los resultados de los semiogramas de 97 pacientes (ambulatorios/externos al Instituto de Genetica) que fueron sometidos a diferentes esquemas de tratamiento para la infertilidad masculina. 82 de los pacientes (84,54 //) continuaron presentando anormalidades en los indicadores seminologicos seleccionados, luego de un periodo variable de tratamiento. La motilidad y la aglutinacion espermatica parecen ser las alteraciones mas frecuentes en los seminogramas anormales en este grupo de pacientes


Assuntos
Humanos , Masculino , Adulto , Pessoa de Meia-Idade , Infertilidade Masculina/reabilitação , Bolívia , Capacitação Espermática/fisiologia , Espermatogênese/fisiologia , Motilidade dos Espermatozoides/fisiologia , Sêmen/fisiologia , Aglutinação Espermática
20.
Enferm Infecc Microbiol Clin ; 10(4): 190-4, 1992 Apr.
Artigo em Espanhol | MEDLINE | ID: mdl-1606220

RESUMO

BACKGROUND: We evaluate two different commercially available kits for detecting specific antibodies against Helicobacter pylori in a group of 48 patients with gastrointestinal symptoms that underwent an endoscopic procedure. We also study the seroprevalence of anti-H. pylori antibodies in asimptomatic individuals from our area. METHODS: Microbiologic and pathologic studies were performed in 48 gastric biopsies, in relation with antibodies detection using ELISA (Pylori stat test, Whittaker) and latex particles agglutination (Pyloriset, Orion). We also used ELISA tests for determining the seroprevalence of H. pylori antibodies in 139 asimptomatic individuals. RESULTS: Ninety-four percent of patients with peptic ulcer disease and 81% of patients without peptic ulcer disease but complaining of dyspepsia were infected by H. pylori. None of the patients with normal gastric mucosae was found to be infected. Sensitivity and specificity of ELISA test were 100% and 73%. Latex test sensitivity and specificity were 46% and 82%. The seroprevalence of antibodies among healthy individuals in our area increases with age (19% among children under 9 years of age) and reaches a peak at 40-49 years of age (84%), with a mean value of 60% in all ages' groups. CONCLUSIONS: There is a high correlation between Helicobacter pylori infection and gastric mucosa alterations. The ELISA test is best correlated with other laboratory data used for defining infection. The seroprevalence of H. pylori antibodies is also high, and therefore we recommend that the use of serologic diagnostic test must be highly selective.


Assuntos
Infecções por Helicobacter/diagnóstico , Helicobacter pylori , Testes Sorológicos/métodos , Adolescente , Adulto , Anticorpos Antibacterianos/sangue , Criança , Pré-Escolar , Ensaio de Imunoadsorção Enzimática , Gastroscopia , Infecções por Helicobacter/epidemiologia , Humanos , Lactente , Testes de Fixação do Látex , Pessoa de Meia-Idade , Espanha/epidemiologia
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