Four-year Epidemiological Surveillance of the Spanish Registry of Research in Contact Dermatitis and Cutaneous Allergy: Current Situation and Trends. / Vigilancia epidemiológica en los últimos 4 años del Registro Español de Investigación en Dermatitis de Contacto y Alergia Cutánea: situación actual y tendencias.

BACKGROUND: The epidemiological surveillance of contact dermatitis is one of the objectives of the Spanish Registry of Research in Contact Dermatitis and Cutaneous Allergy. Knowing whether the prevalence of positive tests to the different allergens changes over time is important for this monitoring process. OBJECTIVES: To describe the various temporary trends in allergen positivity in the GEIDAC standard series from 2018 through December 31, 2022. METHODS: This was a multicenter, observational trial of consecutive patients analyzed via patch tests as part of the study of possible allergic contact dermatitises collected prospectively within the Spanish Registry of Research in Contact Dermatitis and Cutaneous Allergy. The data was analyzed using 2 statistical tests: one homogeneity test (to describe the changes seen over time) and one trend test (to see whether the changes described followed a linear trend). RESULTS: A total of 11327 patients were included in the study. Overall, the allergens associated with a highest sensitization were nickel sulfate, methylisothiazolinone, cobalt chloride, methylchloroisothiazolinone/methylisothiazolinone, and fragrance mix i. A statistically significant decrease was found in the percentage of methylisothiazolinone positive tests across the study years with an orderly trend. CONCLUSIONS: Although various changes were seen in the sensitizations trends to several allergens of the standard testing, it became obvious that a high sensitization to nickel, methylchloroisothiazolinone/methylisothiazolinone and fragrances mix i remained. Only a significant downward trend was seen for methylisothiazolinone.

Papulopustular Rosacea: Response to Treatment with Oral Azithromycin. / Rosácea papulopustulosa: respuesta al tratamiento con azitromicina oral.

INTRODUCTION: Oral tetracyclines and topical antibiotics have been used to treat papulopustular rosacea (PPR) for years, but it is not uncommon to find patients who do not respond to this standard treatment. In such refractory cases, oral azithromycin has proven to be an effective option. MATERIAL AND METHOD: We conducted a prospective pilot study of 16 patients with PPR who were treated with oral azithromycin after a lack of response to oral doxycycline and metronidazole gel. At the first visit, the patients were assessed for baseline severity of PPR on a 4-point clinical scale and started on oral azithromycin. At the second visit, response to treatment in terms of improvement from baseline was evaluated on a 3-point scale. Patients were then scheduled for follow-up visits every 12 weeks to assess long-term effectiveness. RESULTS: All 16 patients experienced an improvement in their PPR following treatment with oral azithromycin. Eight weeks after completion of treatment, 14 patients (87.5%) showed complete or almost complete recovery (slight or no residual redness and complete clearance of papules and pustules). Only 2 patients experienced a new episode of inflammatory PPR lesions during follow-up. CONCLUSIONS: The findings of this pilot study suggest that oral azithromycin could be a very effective short-term and long-term treatment for RPP resistant to conventional treatment.

[Congenital solitary fibromatosis]. / Fibromatosis congénita solitaria.

Infantile myofibromatosis is included in fibrous proliferations of infancy, processes with specific clinic, histology, and evolution, that are characterized by nodules in the skin, bones, and viscera. It's prognosis is varied, depending on whether it is manifested in the solitary or multicentric form. We describe a patient with congenital solitary myofibromatosis.

[Mucopurulent cervicitis at a clinic for sexually transmitted diseases]. / Cervicitis mucopurulenta en una clínica de ETS.

In a series of 1,011 women seen in the Diagnosis Center of Sexually Transmitted Diseases of the Faculty of Medicine of Seville, we study the prevalence of cervical infections caused by Neisseria gonorrhoeae and/or Chlamydia trachomatis and also mucopurulent cervicitis (CMP), these last diagnosed by the presence of more than 10 polymorphonuclear leukocytes x 1,000 magnification in Gram stain of secretion or endocervical mucopus. We calculate the predictive value that the diagnosis of the CMP had in detecting cervical infection by chlamydia and gonococcus. N. gonorrhoeae was isolated in 56 patients (5.5%), C. trachomatis in 83 (8.2%) and both in 15 (1.5%). In all, 154 women presented cervical infections, which correlates to a prevalence of 15.2%. CMP was diagnosed in 267 patients and, of these, 43.4% had cervical infection accused by N. gonorrhoeae and/or C. trachomatis. The diagnosis criteria of CMP used as predictors of cervical infection, had a sensibility of 0.75 and a specificity of 0.82, with a positive predictive value of 0.42.

[De Sanctis-Cacchione syndrome. Apropos of 2 cases]. / Síndrome de De Sanctis-Cacchione. A propósito de dos observaciones.

We report two cases of xeroderma pigmentosum (XP), with neurologic alterations, representing a partial, although not complete form of the syndrome of De Sanctis-Cacchione. The clinical and aetiological features of the condition are discussed.

Aplasia cutis congenita.

We report a family with aplasia cutis congenita, an extremely rare condition. Particular attention is paid to the clinical, etiologic, and genetic characteristics. The only possible treatment, as in the first case in this family, is excision and reconstruction by dermatologic surgery procedures.

Congenital fistulas of the lower lip. Radiographic evaluation.

Congenital fistula of the lower lip was observed in 3 members of a family. There was no evidence of associated congenital malformations. In the father, we performed fistulography with radiopaque substance, showing that the fistular tract extended beyond the orbicularis oris muscle, a feature with no previous report in the literature.

[Zinsser-Cole-Engman syndrome. Congenital dyskeratosis]. / Síndrome de Zinsser-Cole-Engman. Disqueratosis congénita.

The fortieth observation in the world literature and the four in Spain of Zinsser-Cole-Engman. Syndrome is presented, and for this reason we have reviewed the clinical, hematological, genetical and diagnostic features of this disease.

[Pseudoxanthoma elasticum. Apropos of 7 cases]. / Pseudoxantoma elástico. A propósito de siete observaciones.

Seven cases of P X E, four of them seen in the last six months in our clinic, are revised in the Department of Dermatology Medical-Surgical and Venereology of Sevilla (Faculty of Medicine), realising clinical, histological and ultrastructural studies.

[Bullous pemphigoid in a 5-month-old infant]. / Penfigoide ampolloso en un lactante de cinco meses.

After observing a case of pemphigoid in a 5-month-old infant, verified inmunologically, we comment on the clinical, histological, biochemical and immunological tests and review the benign chronic bullous dermatosis of the childhood.

[Behçet's syndrome. Apropos of 12 cases]. / Síndrome de Behçet. A propósito de doce observaciones.

Twelve observations of Behcet's syndrome are described, which comply with the diagnostic criteria of O'DUFFY. The clinic symptomatology is reviewed and compared with those found by other authors.