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1.
Curr Pharm Des ; 28(31): 2519-2537, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35909288

RESUMO

Molecular hydrogen proved itself as a novel therapeutic candidate and has been thriving from the beginning with its potential clinical significance, higher affinity, and cellular integrity and permeability. Hydrogen Therapy (HT) has gained scientists' attention with the proven clinical ability to attenuate chronic inflammation, diminish oxidative stress, restrict apoptosis, minimize cellular injury, and refine tissue functioning. Therapeutic Implementation of H2 for disease prevention and treatment is a newly emerging field with limited knowledge available on formulations, tissue-specific effects, efficacy, and safety. This article will discuss HT's therapeutic potential for its efficacy and safety in cardiovascular, respiratory, hematological, metabolic, infectious, and neurodegenerative disorders. In addition to this, the molecular mechanisms and nanotechnological implications of hydrogen therapy will be discussed in detail. Finally, the article will provide insight into advancements and automation, future perspectives, and recommendations. There is a need to study and conduct higher-scale trials targeting personalized treatments under molecular and genetic vitals.


Assuntos
Hidrogênio , Doenças Neurodegenerativas , Humanos , Hidrogênio/uso terapêutico , Estresse Oxidativo , Apoptose , Inflamação/tratamento farmacológico , Doenças Neurodegenerativas/tratamento farmacológico
2.
Sci Total Environ ; 818: 151754, 2022 Apr 20.
Artigo em Inglês | MEDLINE | ID: mdl-34800451

RESUMO

The demand for innovative waste treatment techniques has arisen because of the establishment and operation of rigorous waste discharge guidelines into the environment. Due to the rapid increase in the human population, wastewater treatment is a procedure of increasing significance. As a result, wastewater treatment systems are intended to sustain high activities and densities of such microorganisms which meet the different purification requirements. The waste produced by the pharmaceutical industry, if not adequately treated, has harmful repercussions for the environment as well as public health. Bioremediation is an innovative and optimistic technology that can be used to remove and reduce heavy metals from polluted water and contaminated soil. Because of cost-effectiveness and environmental compatibility, bioremediation using microorganisms has an excellent potential for future development. A diverse range of microorganisms, including algae, fungi, yeasts, and bacteria, can function as biologically active methylators, capable of modifying toxic species. Microorganisms play a crucial role in heavy metal bioremediation. Nanotechnology may minimize industry expenses by producing environmentally friendly nanomaterials to alleviate these contaminants. The use of microorganisms in nanoparticle synthesis gives green biotechnology a positive impetus to cost reduction and sustainable production as a developing nanotechnology sector.


Assuntos
Metais Pesados , Purificação da Água , Bactérias , Biodegradação Ambiental , Fungos , Humanos , Metais Pesados/análise , Purificação da Água/métodos
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