RESUMO
Invasive disseminated neonatal aspergillosis is an uncommon disease, with only scattered reports in literature in the last few years. Here we report on a 25-week gestational age, 730 g at birth preterm female infant who developed on day-of-life 10 multiple cutaneous exhulcerative lesions in her right arm, trunk and abdomen. Early recognition and diagnosis of these lesions as a due to cutaneous initial symptom of cutaneous disseminated aspergillosis, as well as prompt treatment with Liposomal amphotericin B + Itraconazole, secured successful recovery from the systemic infection. Skin lesions healed without any surgical treatment. The infant was discharged in good health. Long-term follow-up at three years of age revealed normality of all neurodevelopmental and cognitive parameters. To our knowledge, this is one of the very few cases of survival, free from sequelae, for a preterm infant affected by neonatal cutaneous disseminated aspergillosis.
Assuntos
Aspergilose/diagnóstico , Aspergilose/tratamento farmacológico , Dermatomicoses/diagnóstico , Dermatomicoses/tratamento farmacológico , Doenças do Prematuro/tratamento farmacológico , Anfotericina B/uso terapêutico , Antifúngicos/uso terapêutico , Feminino , Seguimentos , Humanos , Recém-Nascido de Peso Extremamente Baixo ao Nascer , Recém-Nascido , Doenças do Prematuro/diagnóstico , Itraconazol/uso terapêutico , Resultado do TratamentoRESUMO
The case of Poland syndrome reported incorporates a number of previously unrecorded features: hypoplasia of the left lung and agenesia of the epiglottis in addition to the standard symptoms. The case also presents certain features typical of the Moebius Syndrome.
Assuntos
Síndrome de Poland/patologia , Adulto , Epiglote/anormalidades , Epiglote/patologia , Evolução Fatal , Feminino , Humanos , Recém-Nascido , Pulmão/anormalidades , Pulmão/patologiaAssuntos
Gastrite/induzido quimicamente , Adolescente , Biópsia , Criança , Pré-Escolar , Cimetidina/uso terapêutico , Feminino , Tecnologia de Fibra Óptica , Determinação da Acidez Gástrica , Mucosa Gástrica/patologia , Gastrinas/sangue , Gastrite/diagnóstico , Gastrite/tratamento farmacológico , Gastroscopia , Humanos , MasculinoRESUMO
The authors investigated and compared lymphocyte subsets natural killer in 33 newborns and in 33 healthy adults. From 5 ml of heparinized venous blood were separated mononuclear cells on density-gradient Ficoll-Hypaque. The vitality was determined with immunofluorescent method (orange acridine and ethiobromide). It was positive if resulted at least 95%. Lymphocyte phenotype was also examined after incubation with monoclonal antiserum Becton-Dickinson conjugated with FITC and PE for 45' at 4 degrees C. Two hundred cells were counted on each slide with fluorescent microscopy. Total number of T-lymphocyte (Leu-4) was increased in newborns; total B-cells (Leu-12) were similar in newborns and healthy adults; T-helper/T-suppressor (Leu-3a/Leu-2a) ratio was above the normal range for increase T-helper. The percentage of subsets with double marker Leu-2a+/Leu-3a+ was always about 15-20%. NK cells with phenotype HNK-1 (Leu-7) were a little number in newborns while the percentage of NK-cells-Leu-11a was similar among adults and newborns.