A Modified Electrochemical Sensor Based on N,S-Doped Carbon Dots/Carbon Nanotube-Poly(Amidoamine) Dendrimer Hybrids for Imatinib Mesylate Determination.

Imatinib mesylate, an anticancer drug, is prescribed to treat gastrointestinal stromal tumors and chronic myelogenous leukemia. A hybrid nanocomposite of N,S-doped carbon dots/carbon nanotube-poly(amidoamine) dendrimer (N,S-CDs/CNTD) was successfully synthesized and used as a significant modifier to design a new and highly selective electrochemical sensor for the determination of imatinib mesylate. A rigorous study with electrochemical techniques, such as cyclic voltammetry and differential pulse voltammetry, was performed to elucidate the electrocatalytic properties of the as-prepared nanocomposite and the preparation procedure of the modified glassy carbon electrode (GCE). A higher oxidation peak current was generated for the imatinib mesylate on a N,S-CDs/CNTD/GCE surface compared to the GCE and CNTD/GCE. The N,S-CDs/CNTD/GCE showed a linear relationship between the concentration and oxidation peak current of the imatinib mesylate in 0.01-100 µM, with a detection limit of 3 nM. Finally, the imatinib mesylate's quantification in blood-serum samples was successfully performed. The N,S-CDs/CNTD/GCE's reproducibility and stability were indeed excellent.

Fluorescent cellulosic composites based on carbon dots: Recent advances, developments, and applications.

Cellulose and its derivatives are highly applicable in advanced applications on the basis of fluorescence phenomena. Carbon dots (CDs) have also appealing properties, such as high photoluminescence, easy synthesis pathway, cheap source materials, chemical stability, and easy functionalization. In this regard, combination of luminescent CDs with natural cellulosic materials could adjust or expand its desirable properties and have advanced applications. This review summarizes chemical and physical incorporation of CDs and graphene quantum dots into different types of cellulosic materials to yield smart fluorescent materials with applications in films, catalysts, bioimaging, drug delivery, anticounterfeiting, and fluorescence chemosensors for sensing pH, temperature, cations, anions, glucose, and aromatic amines. The challenges and future directions in fluorescent materials based on CDs are also briefly discussed. We hope that these studies will provide more consideration and curiosity for chemists, biologists, and materials scientists working in the field of fluorescent and CDs-containing cellulosic materials.