RESUMO
OBJECTIVE: This study assessed the potential of topical Calendula officinalis extract on the healing of oral mucositis induced by 5-fluorouracil (5-FU) in hamsters. STUDY DESIGN: Oral mucositis was induced in 60 male hamsters by 5-FU (60 mg/kg) on days 0, 5, and 10 of the study. The cheek pouch was scratched with a sterile needle on days 1 and 2. On days 12-17, 5% and 10% C. officinalis gel and gel base groups were treated and then compared with a control group. Macroscopic and microscopic scores and weights were evaluated. RESULTS: Microscopic and macroscopic scores of mucositis were lower in the 5% and 10% C. officinalis gel groups than in the gel base and control groups (P < .05). Weight gain was noted in the treatment groups compared with the gel base and control groups (P < .05). CONCLUSIONS: Calendula officinalis extract accelerated the healing of oral mucositis in hamsters.
Assuntos
Antimetabólitos Antineoplásicos/efeitos adversos , Calendula , Fluoruracila/efeitos adversos , Fitoterapia/métodos , Extratos Vegetais/uso terapêutico , Estomatite/tratamento farmacológico , Abscesso/induzido quimicamente , Abscesso/patologia , Animais , Antimetabólitos Antineoplásicos/administração & dosagem , Carboximetilcelulose Sódica , Cricetinae , Portadores de Fármacos , Eritema/induzido quimicamente , Eritema/patologia , Fluoruracila/administração & dosagem , Géis , Hiperemia/induzido quimicamente , Hiperemia/patologia , Injeções Intraperitoneais , Masculino , Mesocricetus , Doenças da Boca/induzido quimicamente , Doenças da Boca/patologia , Mucosa Bucal/efeitos dos fármacos , Mucosa Bucal/lesões , Mucosa Bucal/patologia , Hemorragia Bucal/induzido quimicamente , Hemorragia Bucal/patologia , Úlceras Orais/induzido quimicamente , Úlceras Orais/patologia , Reepitelização/efeitos dos fármacos , Método Simples-Cego , Estomatite/induzido quimicamente , Estomatite/patologia , Fatores de Tempo , Aumento de Peso , Cicatrização/efeitos dos fármacosRESUMO
OBJECTIVE: The purpose of this study is to evaluate the effect of intraurethral captopril gel as an antifibrotic agent on patients with urethral stricture. MATERIALS AND METHODS: In the first phase of clinical trial, 13 rabbits were included and local side-effects of captopril gel were evaluated. In the second phase, 56 patients were enrolled from April 2004 to January 2006. After internal urethrotomy the patients were classified into three patient groups: (i) received placebo gel (group I); (ii) received 0.1% captopril gel (group II); and (iii) instilled 0.5% captopril gel intraurethrally (group III). RESULTS: In phase I, no significant local side-effects were seen in the urethra of rabbits. In phase II, the mean age of the patients was 39.5 and the mean follow-up duration was 16 months. The most common etiology of the urethral stricture in the patients was iatrogenic (35.7%), most of their strictures had a depth of 0.5 cm or less (67.8%), and the length of most strictures was between 1 and 2 cm (41.1%). The patients' maximum urine flow increased more in groups II and III, than in group I (P < 0.04, P < 0.05, respectively). The recurrence rate was less in groups II and III than in group I (P < 0.05). In terms of the maximal urine flow and recurrence rate, no significant difference was seen between group II and group III (P = 0.13, P = 0.21, respectively). CONCLUSION: Captopril gel is a safe, effective and non-toxic agent for decreasing the recurrence rate of the urethral stricture after internal urethrotomy. However, more studies, including more cases and a longer follow up, are needed to prove the effect of captopril gel on patients' urethra.