RESUMO
CIRM has created a unique funding process and structure aimed to make a meaningful impact on translating science into the clinic. By sharing some of the lessons learned by CIRM, we hope to provide insights into concrete improvements that have made a difference in our efforts.
RESUMO
Cardiac myocytes have a complex network of signals that regulates their essential role in the rhythmic pumping of the heart. This network is an appealing model system in which to study the basic principles underlying cellular signalling mechanisms. Progress in this effort has come through the establishment of standardized myocyte isolation and culture procedures and characterization of important signalling responses.
Assuntos
Miócitos Cardíacos/fisiologia , Pesquisa , Transdução de Sinais , Envelhecimento , Animais , Técnicas de Cultura de Células/métodos , Separação Celular , Camundongos , Modelos Biológicos , Miócitos Cardíacos/citologia , Miócitos Cardíacos/metabolismo , Projetos de PesquisaRESUMO
The Alliance for Cellular Signaling has chosen the mouse B lymphocyte as a model system to understand basic principles that govern cellular signalling. Progress to that end has focused initially on establishing a reproducible experimental cell system and characterizing essential signalling responses. Although unravelling this complex network will take years, findings revealed in the interim will prove immensely useful to the scientific community at large.