RESUMO
Morning report is an important clinical learning activity in many neurological institutions. A long experience of these meetings allows identification of several components to enhance its success. Meetings are best if brief (one or two cases) and held regularly, preferably daily and early in the working day, with full in-person team engagement. A senior clinician should lead the meeting and commit to a single interpretation, without fear of being wrong. Although the environment is relaxed (refreshments typically provided), it is a working meeting and with the essential focus on the patient rather than the learners. The rich learning experience is greatly enhanced by a subsequent confidential email summary and interpretation of the case(s) sent to all participants.
Assuntos
Visitas de Preceptoria , Humanos , Visitas de Preceptoria/organização & administração , AprendizagemRESUMO
We present two historic cases of severe encephalopathy associated with antithyroid antibodies. The first was published by Lord Brain of Eynsham, and the second was from our department's archives. Although both cases are from archival sources, they continue to inform current clinical care. We briefly review the poorly defined entity, Hashimoto's encephalopathy, and discuss diagnostic advances for autoimmune encephalopathy and for Creutzfeldt-Jakob disease. We advocate for giving a trial of corticosteroids to patients with 'encephalopathy, not otherwise specified' while awaiting antibody results or more definitive testing. Our case, initially diagnosed as having Creutzfeldt-Jakob disease, responded remarkably (with video evidence) to a trial of corticosteroids.
Assuntos
Autoanticorpos/sangue , Síndrome de Creutzfeldt-Jakob/sangue , Síndrome de Creutzfeldt-Jakob/diagnóstico , Encefalite/sangue , Encefalite/diagnóstico , Doença de Hashimoto/sangue , Doença de Hashimoto/diagnóstico , Encefalopatias/sangue , Encefalopatias/diagnóstico , Síndrome de Creutzfeldt-Jakob/tratamento farmacológico , Diagnóstico Diferencial , Encefalite/tratamento farmacológico , Feminino , Doença de Hashimoto/tratamento farmacológico , Humanos , Masculino , Metilprednisolona/administração & dosagem , Pessoa de Meia-IdadeRESUMO
Structural and functional elements of biological systems are highly conserved across vertebrates. Many neurological and psychiatric conditions affect both humans and animals. A cross-species approach to the study of brain and behaviour can advance our understanding of human disorders via the identification of unrecognized natural models of spontaneous disorders, thus revealing novel factors that increase vulnerability or resilience, and via the assessment of potential therapies. Moreover, diagnostic and therapeutic advances in human neurology and psychiatry can often be adapted for veterinary patients. However, clinical and research collaborations between physicians and veterinarians remain limited, leaving this wealth of comparative information largely untapped. Here, we review pain, cognitive decline syndromes, epilepsy, anxiety and compulsions, autoimmune and infectious encephalitides and mismatch disorders across a range of animal species, looking for novel insights with translational potential. This comparative perspective can help generate novel hypotheses, expand and improve clinical trials and identify natural animal models of disease resistance and vulnerability.
Assuntos
Transtornos de Ansiedade , Disfunção Cognitiva , Modelos Animais de Doenças , Encefalite , Epilepsia , Transtornos dos Movimentos , Dor , Pesquisa Translacional Biomédica , Animais , Encefalite/imunologia , Encefalite/virologia , HumanosAssuntos
Anemia Perniciosa/diagnóstico , Disfunção Cognitiva/etiologia , Idoso , Anemia Perniciosa/complicações , Anemia Perniciosa/tratamento farmacológico , Encéfalo/diagnóstico por imagem , Diagnóstico Diferencial , Humanos , Injeções Intramusculares , Angiografia por Ressonância Magnética , Imageamento por Ressonância Magnética , Masculino , Ácido Metilmalônico/sangue , Exame Neurológico , Equilíbrio Postural , Transtornos de Sensação/etiologia , Sorodiagnóstico da Sífilis , Treponema pallidum/imunologia , Vitamina B 12/administração & dosagem , Deficiência de Vitamina D/complicações , Deficiência de Vitamina D/diagnósticoRESUMO
Acute idiopathic hyperammonemia in an adult patient is a life-threatening condition often resulting in a rapid progression to irreversible cerebral edema and death. While ammonia-scavenging therapies lower blood ammonia levels, in comparison, clearance of waste nitrogen from the brain may be delayed. Therefore, we used magnetic resonance spectroscopy (MRS) to monitor cerebral glutamine levels, the major reservoir of ammonia, in a gastric bypass patient with hyperammonemic coma undergoing therapy with N-carbamoyl glutamate and the ammonia-scavenging agents, sodium phenylacetate and sodium benzoate. Improvement in mental status mirrored brain glutamine levels, as coma persisted for 48h after plasma ammonia normalized. We hypothesize that the slower clearance for brain glutamine levels accounts for the delay in improvement following initiation of treatment in cases of chronic hyperammonemia. We propose MRS to monitor brain glutamine as a noninvasive approach to be utilized for diagnostic and therapeutic monitoring purposes in adult patients presenting with idiopathic hyperammonemia.
Assuntos
Encéfalo/diagnóstico por imagem , Coma/tratamento farmacológico , Glutamina/metabolismo , Hiperamonemia/tratamento farmacológico , Espectroscopia de Ressonância Magnética/métodos , Encéfalo/metabolismo , Coma/etiologia , Feminino , Derivação Gástrica/efeitos adversos , Glutamatos/uso terapêutico , Humanos , Hiperamonemia/complicações , Hiperamonemia/diagnóstico por imagem , Hiperamonemia/metabolismo , Pessoa de Meia-Idade , Fenilacetatos/uso terapêutico , Benzoato de Sódio/uso terapêutico , Resultado do TratamentoAssuntos
Amebíase/diagnóstico , Encéfalo/patologia , Meningoencefalite/diagnóstico , Acanthamoeba/isolamento & purificação , Amebíase/complicações , Análise Química do Sangue , Encéfalo/diagnóstico por imagem , Encéfalo/parasitologia , Encefalopatias/induzido quimicamente , Cardiomiopatias/complicações , Diagnóstico Diferencial , Diplopia/etiologia , Evolução Fatal , Humanos , Hospedeiro Imunocomprometido , Masculino , Meningoencefalite/complicações , Meningoencefalite/parasitologia , Pessoa de Meia-Idade , Debilidade Muscular/etiologia , Sarcoidose/complicações , Sarcoidose/diagnóstico , Tomografia Computadorizada por Raios XRESUMO
BACKGROUND: Multiple sclerosis (MS) can affect cardiovascular function in a variety of ways leading to abnormalities in blood pressure response, heart rate, heart rhythm, left ventricular systolic function, and may cause pulmonary edema or cardiomyopathy. Cardiovascular dysfunction in MS is incompletely understood and likely underrecognized. REVIEW SUMMARY: The clinical presentation and pathophysiology of cardiovascular dysfunction in MS are reviewed, as are the cardiovascular toxicities of MS therapies, fingolimod and mitoxantrone. Cardiovascular dysfunction in MS can be caused by brainstem lesions affecting autonomic pathways in the medulla, overall plaque burden, and clinical severity of the disease. CONCLUSIONS: Cardiovascular abnormalities may be clinical or subclinical, and can lead to sudden death in some cases. Neurologists should be aware of the clinical presentation and pathophysiology of cardiovascular dysfunction in MS so as to ameliorate cardiovascular symptoms, prevent cardiovascular complications, and choose therapeutic agents that do not worsen underlying cardiovascular disease.
Assuntos
Anormalidades Cardiovasculares/etiologia , Anormalidades Cardiovasculares/fisiopatologia , Esclerose Múltipla/complicações , Esclerose Múltipla/fisiopatologia , Animais , Sistema Nervoso Autônomo/fisiopatologia , Pressão Sanguínea , Cloridrato de Fingolimode/efeitos adversos , Frequência Cardíaca , Humanos , Mitoxantrona/efeitos adversos , Esclerose Múltipla/tratamento farmacológicoRESUMO
Neurologic complications of infective endocarditis (IE) are common and frequently life threatening. Neurologic events are not always obvious. The prediction and management of neurologic complications of IE are not easily approached algorithmically, and the impact they have on timing and ability to surgically repair or replace the affected valve often requires a painstaking evaluation and joint effort across multiple medical disciplines in order to achieve the best possible outcome. Although specific recommendations are always tailored to the individual patient, there are some guiding principles that can be used to help direct the decision-making process. Herein, we review the pathophysiology, epidemiology, manifestations, and diagnosis of neurological complications of IE and further consider the impact they have on clinical decision making.
RESUMO
Susac's syndrome is a rare autoimmune microangiopathy characterized by the clinical triad of encephalopathy, branch retinal artery occlusions, and sensorineural hearing loss. In many cases, the clinical triad is not fully present at the onset of symptoms. MRI studies often show characteristic punched out lesions of the central fibers of the corpus callosum, and leptomeningeal enhancement and deep gray matter lesions may also be seen. Here we present a case of Susac's syndrome in a middle aged man with the unique clinical finding of cauda equina syndrome and spinal MRI showing diffuse lumbosacral nerve root enhancement. Biopsy specimens of the brain, leptomeninges, and skin showed evidence of a pauci-immune endotheliopathy, consistent with pathology described in previous cases of Susac's syndrome. This case is important not only because it expands the clinical features of Susac's syndrome but also because it clarifies the mechanism of a disorder of the endothelium, an important target for many disorders of the nervous system.