Status of Dyslipidemia in Vitamin D Supplemented Argentinean Indigenous Children Versus A Non-supplemented Mixed Population Group.

BACKGROUND: Epidemiological studies have suggested an inverse association between circulating levels of vitamin D and cardiovascular disease risk biomarkers, including an atherogenic lipid profile. OBJECTIVE: To compare the prevalence and the distribution of lipid levels among vitamin D supplemented Argentinean indigenous San Antonio de los Cobres (SAC) children with a nonsupplemented Buenos Aires (BA) mixed population group. METHODS: A group of indigenous children from SAC with hypovitaminosis D supplemented with vitamin D; and a nonsupplemented group from a BA mixed population were compared via a cross sectional study. Anthropometric measures, glucose, lipids, vitamin D, and insulin were measured. RESULTS: The mean ages were 10.3 + 2.3 in SAC and 8.7 ± 1.8 years in BA children. There was a lower prevalence of overweight 7.9%(15/192) vs 17.8% (23/129); and of obesity 1.6% (3/192) vs 30.2% (39/129) in SAC vs. BA respectively. Approximately half of the SAC children versus 30% from BA had optimal vitamin D levels (≥30ng/mL). There was a significantly higher prevalence of high triglycerides (TG) (27.6%vs 4.6%) and low HDL-C (21.3% vs 5.4%) in SAC vs BA children, respectively. In separate linear regression models, we found that despite effective vitamin D repletion, SAC children had higher TG and TG/HDL-C values, whereas HDL-C levels were lower than those of BA children adjusted for age, gender, BMI, and insulin levels. CONCLUSION: Indigenous Argentinean children have a higher risk for dyslipidemia in comparison with BA children, even after vitamin D treatment, suggesting that dyslipidemia could be related to diet or ethnic backgrounds.

Improvement of Apolipoprotein B in Argentine Indigenous School Children after Vitamin D Supplementation.

OBJECTIVE: To determine whether vitamin D supplementation improves non-traditional cardiovascular risk factors such as Apo B levels among indigenous children. METHODS: A prospective two-year study evaluated a treated cohort of 190 children (104 males) aged 9.4+ 2.2 years. Children were divided into group A (n=104; 54.7%) and group B (n=86; 45.3%). Both groups received vitamin D supplementation with 100,000 u/year; group B was treated in 2013 and group A in 2014. All subjects were evaluated at the end of each treatment and anthropometric measures, lipids and vitamin D levels between the two groups were compared. RESULTS: Changes in vitamin D levels were significantly higher in Group A, which was supplied in 2014, than in group B, which was not supplied in 2014 (6.8 vs 0.96 ng/dL; respectively). Levels of LDL-C and Apo B were improved in group A versus B: LDL-C (-5.7 vs 6.9 mg/dL respectively) and Apo B (-0.9 vs 11. mg/dL respectively). Several multiple regression linear analyses showed that changes in vitamin D were significantly associated with lower LDL-C levels (Beta- 0.41, p<0.01; R2 0.07); and with lower Apo B levels (Beta-0.37, p<0.01; R2 0.17). CONCLUSION: Vitamin D supplementation among indigenous children could improve Apo B levels.

Improvement in lipid profile after vitamin D supplementation in indigenous argentine school children.

OBJECTIVE: To determine whether vitamin D supplementation of indigenous school children living at high altitude who are vitamin D insufficient improves lipid profile. METHODS: A prospective two-year study evaluated 60 children (29 males) from Hogar School who received 100,000 units of vitamin D and 36 children (16 males) from Sosa School who received 50,000 units. Anthropometric measures, Triglycerides (TG), HDL-C, TG/HDL-C, and vitamin D levels were measured in November 2011 and in November 2013. RESULTS: Children aged 8.8 ± 2 years with mean z-BMI (-0.43) were evaluated. After vitamin D supplementation, mean vitamin D levels increased from 14.7 to 32.1 ng/mL (p < 0.01) in Hogar and from 14.6 to 25.1 ng/mL (p < 0.01) in Sosa School. Furthermore, mean HDL-C increased significantly in Hogar (39.8 to 43.9 mg/dL); while no significant changes were found in Sosa School (44.4 to 45.1 mg/dL). Though no significant changes were found in median TG (117 to 111 mg/dL) and TG/HDL (3.0 to 2.7 mg/dL) in Hogar; TG (95 to 111 mg/dL) and TG/HDL-C (2.2 to 2.4 mg/dL) increased significantly in Sosa School. Several multiple linear regression analyses showed that children from Hogar School decreased TG/HDL-C by 1.3 mg/dL (R(2): 0.14), HDL-c by 3.6 mg/dL (R(2): 0.13), and TG by 31 mg/dL (R(2): 0.11), adjusted for confounding factors. CONCLUSIONS: Indigenous children who received 100,000 U of vitamin D significantly improved vitamin D and lipid levels compared to children who received 50,000 U, suggesting that optimal vitamin D levels are associated with a healthier lipid profile.

Association between vitamin D and Apo B concentrations in Argentinean Indian children.

OBJECTIVE: The objective of the study was to determine the prevalence of vitamin D insufficiency and its association with non-traditional cardiovascular disease (CVD) risk factors such as Apo B in South American Indian school children. METHODS: A cross-sectional study of 355 children (166 Males) aged 9.6±2.3 y was performed. Anthropometric measures, glucose, lipids, insulin, Apo B, Apo A, and vitamin D concentrations were measured. RESULTS: The prevalence of overweight and obesity was 10.7% (38) per CDC. One child (0.3%) had optimal vitamin D concentrations [25(OH)D[>30 ng/ml. Univariate analysis showed significant associations between vitamin D and HDL-C (r=0.12 p<0.05), age (r=-0.11 p<0.05) BMI (r=-0.22 p<0.05), LDL-C (r=-0.22 p<0.01), triglycerides (r=-0.16 p<0.01), non HDL-C (r=-0.21 p<0.01), Apo B (r=-0.23 p<0.01), Apo B/Apo A (r=-0.21 p<0.01), insulin (r=-0.17 p<0.05), and HOMA-IR (r=-0.16 p<0.05). Multiple linear regression analysis showed that female gender and Apo B were significantly associated with vitamin D adjusted for confounding factors (R(2) 0.12). CONCLUSION: Vitamin D deficiency was associated with increased Apo B among Indian children, suggesting that it could be used as a risk marker of CVD.

Improvement in high-density lipoprotein cholesterol levels in argentine Indian school children after vitamin D supplementation.

BACKGROUND/AIMS: Low vitamin D levels correlate with dyslipidemia, but limited data exist on indigenous children. The objective was to determine whether vitamin D supplementation improves high-density lipoprotein cholesterol (HDL-C) levels among Koya children. METHODS: A prospective 1-year study evaluated a treated cohort of 70 (38 males) children aged 10.3 ± 2.1 years who received 5,000 U of vitamin D weekly during 8 weeks, and a control group of 20 (8 males) children aged 9.2 ± 1.1 years who did not receive vitamin D. RESULTS/CONCLUSIONS: At baseline, 18 (20%) had severe vitamin D deficiency (<10 ng/ml), 66 (73.3%) had deficiency (10 to <20 ng/ml), and 6 (6.6%) had insufficiency (20 to <30 ng/ml). At baseline, there was no significant difference in the prevalence of hypovitaminosis D between groups. After 1 year, the prevalence of severe vitamin D deficiency decreased from 20 to 0%, and that of insufficiency increased from 6 to 19% (p < 0.001) only in the treated group. The prevalence of low HDL-C also decreased in the treated group only (35.7-5.7%; p < 0.01). Multiple linear regression analysis showed that treated children improved HDL-C levels by 4 mg/dl (R(2): 0.13) adjusted for confounding factors, suggesting that vitamin D supplementation among Indian children improved HDL-C levels.