RESUMO
BACKGROUND: The aim of this study was to evaluate the effects on adipocyte morphology of 2 techniques of fat harvesting and of fat purification in lipofilling, considering that the number of viable healthy adipocytes is important in fat survival in recipient areas of lipofilling. METHODS: Fat harvesting was performed in 10 female patients from flanks, on one side with a 2-mm Coleman cannula and on the other side with a 3-mm Mercedes cannula. Thirty milliliter of fat tissue from each side was collected and divided into three 10 mL syringes: A, B, and C. The fat inside syringe A was left untreated, the fat in syringe B underwent simple sedimentation, and the fat inside syringe C underwent centrifugation at 3000 rpm for 3 minutes. Each fat graft specimen was processed for examination under low-vacuum scanning electron microscope. Diameter (µ) and number of adipocytes per square millimeter and number of altered adipocytes per square millimeter were evaluated. Untreated specimens harvested with the 2 different techniques were first compared, then sedimented versus centrifuged specimens harvested with the same technique were compared. Statistical analysis was performed using Wilcoxon signed rank test. RESULTS: The number of adipocytes per square millimeter was statistically higher in specimens harvested with the 3-mm Mercedes cannula (P = 0.0310). The number of altered cells was statistically higher in centrifuged specimens than in sedimented ones using both methods of fat harvesting (P = 0.0080) with a 2-mm Coleman cannula and (P = 0.0050) with a 3-mm Mercedes cannula. Alterations in adipocyte morphology consisted in wrinkling of the membrane, opening of pore with leakage of oily material, reduction of cellular diameter, and total collapse of the cellular membrane. CONCLUSIONS: Fat harvesting by a 3-mm cannula results in a higher number of adipocytes and centrifugation of the harvested fat results in a higher number of morphologic altered cells than sedimentation.
Assuntos
Adipócitos/patologia , Lipectomia/métodos , Gordura Subcutânea/transplante , Adipócitos/transplante , Catéteres , Centrifugação/efeitos adversos , Feminino , Humanos , Lipectomia/efeitos adversos , Lipectomia/instrumentação , Microscopia Eletrônica de Varredura , Gordura Subcutânea/patologiaRESUMO
Although success rate of deep inferior epigastric perforator (DIEP) flap breast reconstruction has greatly improved, complications still occasionally occur. Perfusion-related complications (PRCs) (ie, fat necrosis and partial flap necrosis) are the most frequent concern, affecting aesthetic final result of the reconstructed breast. The aim of our study was to retrospectively investigate 287 consecutive DIEP flap breast reconstructions to investigate predictive and protective factors for PRCs.From May 2004 to February 2012, 287 DIEP flap breast reconstructions were performed on 270 patients; 247 unilateral flaps, including Holm vascular zones I to III, were retrospectively selected and analyzed. Tobacco use, mean blood pressure over the first postoperative 48 hours, superficial epigastric vein drainage, medial/lateral row perforator, nulliparity, crystalloid versus combined crystalloid/colloid intravenous fluid infusion therapy, and learning curve were evaluated by univariate and multivariate logistic regression analyses.Perfusion-related complications occurred 32 (12.9%) times, 79 (31.9%) patients were smokers, 48 (19.4%) showed postoperative mean blood pressure less than 75 mm Hg, 29 (11.7%) were nulliparous, and 173 (70%) had superficial epigastric vein drainage. Selected perforators were 110 (44.5%) from lateral row, 137 (55.5%) from medial row; 91 (36.8%) received crystalloid fluid infusion, whereas 156 (63.2%) combined crystalloid/colloid fluid infusion. From univariate analysis emerged significance of nulliparity, perforator row and intravenous fluid infusion for PRC. Nevertheless, multivariate model confirmed only nulliparity as a significant risk factor (P = 0.029), although variable correlations to other predictors were found: both medial row perforator and combined crystalloid/colloid fluid infusion potentially decrease the PRC risk of 11.6% and 27.6%, respectively. Learning curve did not show significant decrease of PRC risk over time.Our study first proved nulliparity as a statistically significant predictor for PRCs in DIEP flap breast reconstruction, possibly due to different superficial abdominal perfusion between pluriparous and nulliparous women, with potential weaker pattern of perforators and smaller angiosomes in the latter. The choice of medial row perforators and combined crystalloid/colloid fluid infusion might reduce PRC risk.
Assuntos
Mamoplastia/métodos , Paridade , Retalho Perfurante/patologia , Adulto , Idoso , Artérias Epigástricas , Feminino , Seguimentos , Humanos , Modelos Logísticos , Pessoa de Meia-Idade , Análise Multivariada , Necrose , Avaliação de Resultados em Cuidados de Saúde , Fatores de Proteção , Estudos Retrospectivos , Fatores de RiscoAssuntos
Biomarcadores Tumorais/análise , Carcinoma de Célula de Merkel/diagnóstico , Cicatriz , Linfonodos/patologia , Neoplasias Cutâneas/diagnóstico , Esternotomia , Idoso de 80 Anos ou mais , Axila , Carcinoma de Célula de Merkel/química , Carcinoma de Célula de Merkel/patologia , Carcinoma de Célula de Merkel/radioterapia , Cromogranina A/análise , Humanos , Imuno-Histoquímica , Queratina-20/análise , Metástase Linfática/radioterapia , Masculino , Neoplasias Cutâneas/química , Neoplasias Cutâneas/patologia , Neoplasias Cutâneas/radioterapiaRESUMO
The risk of surgical site infection is always present in surgery; the use of prosthetic materials is linked to an increased possibility of infection. Breast augmentation and breast reconstruction with implants are gaining popularity in developing countries. Implant infection is the main complication related to breast aesthetic and reconstructive surgery. In the present paper, we reviewed the current microbiological knowledge about implant infections, with particular attention to risk factors, diagnosis, clinical management, and antibiotic prophylaxis, focusing on reports from developing countries. After breast aesthetic surgery, up to 2.9% of patients develop a surgical site infection, with an incidence of 1.7% for acute infections and 0.8% for late infections. The rate of surgical site infection after post-mastectomy breast reconstruction is usually higher, ranging from 1% to 53%. The clinical features are not constant, and bacterial culture with antibiogram is the gold standard for diagnosis and for identification of antibiotic resistance. While waiting for culture results, empiric therapy with vancomycin and extended-spectrum penicillins or cephalosporins is recommended. Some patients require removal of the infected prosthesis. The main methods to bring down the risk of infection are strict asepsis protocol, preoperative antibiotic prophylaxis, and irrigation of the surgical pocket and implant with an antibiotic solution.
Assuntos
Implantes de Mama/efeitos adversos , Infecções Relacionadas à Prótese/epidemiologia , Antibacterianos/farmacologia , Antibioticoprofilaxia/métodos , Técnicas Bacteriológicas , Países em Desenvolvimento , Humanos , Incidência , Infecções Relacionadas à Prótese/diagnóstico , Infecções Relacionadas à Prótese/microbiologia , Infecções Relacionadas à Prótese/prevenção & controle , Fatores de RiscoRESUMO
BACKGROUND: The thoracodorsal artery perforator flap was described mainly for partial breast reconstruction by Hamdi. The purpose of this article is to describe the use of the pedicled thoracodorsal artery perforator flap for total autologous breast reconstruction without using an implant. METHODS: Between January of 2009 and December of 2011, seven patients underwent total breast reconstruction with a pedicled thoracodorsal artery perforator flap. The mean age of the patients was 53 years (range, 43 to 62 years), and the mean body mass index was 27 kg/m (range, 24 to 32 kg/m). RESULTS: The mean size of the harvested skin paddle was 23.7 × 8.8 cm (range, 15 × 7 cm to 39 × 14 cm). The flaps were based on one to three perforators and successfully transferred with an average operative time of 3 hours. No seroma occurred at the donor site. Average hospital stay was 4 days (range, 3 to 6 days). At an average follow-up of 21.5 months, two patients underwent additional revisions using autologous fat grafting, with overall fat injection volumes of 240 and 280 cc, respectively. CONCLUSION: The pedicled thoracodorsal artery perforator flap offers an alternative for total autologous breast reconstruction in small to medium breasted patients when abdominal tissues are not available. CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, IV.
Assuntos
Mamoplastia/métodos , Retalho Perfurante , Adulto , Feminino , Humanos , Pessoa de Meia-Idade , Estudos Retrospectivos , Artérias TorácicasRESUMO
The intra-operative latissimus dorsi (LD) pedicle damage during axillary lymph-node dissection by the general surgeon is a rare complication leading to flap failure and poor outcomes. The authors present their experience on this topic and develop a classification of the thoracodorsal (TD) pedicle injuries and reconstruction algorithm. Pedicle damage of LD occurred in five cases, three of which were experienced during immediate breast reconstruction and two observed in patients who underwent prior surgery. In two cases the thoracodorsal vein (TDV) was damaged in its proximal segment, thus end-to-end anastomosis was performed between distal stump of TDV and circumflex scapular vein (CSV). In one case the TDV required simple microsurgical repair while in other two cases the severe damage of vein and artery required more complex surgical strategies in attempt to salvage the flap. Four cases completely survived with one case of rippling phenomenon. One case had partial flap necrosis that required subtotal muscle resection. Based on these cases, the authors have developed a reconstruction algorithm in attempt to repair LD pedicle damage while preserving breast reconstruction. Taking into account its anatomical conformation, TD pedicle injuries are classified in four different types and available options are suggested for all of them according to the anatomical site and to the mechanism and timing of injury.
Assuntos
Algoritmos , Complicações Intraoperatórias/classificação , Complicações Intraoperatórias/cirurgia , Mamoplastia/métodos , Músculos Superficiais do Dorso/lesões , Retalhos Cirúrgicos , Adulto , Idoso , Axila/cirurgia , Dissecação , Feminino , Humanos , Pessoa de Meia-Idade , Músculos Superficiais do Dorso/transplanteRESUMO
Arm morbidity following unilateral Latissimus Dorsi (LD) flap harvest is controversial and bilateral harvest is considered potentially disabling. Arm and shoulder disability was investigated in patients undergoing bilateral mastectomy and immediate LD flap reconstruction. Thirty consecutive bilateral immediate reconstructions with denervated LD flaps, performed between 2005-2009, were retrospectively analyzed. Patients were assessed for arm function by conducting the Disability of Arm, Shoulder and Hand (DASH) test, between 12-51 months after surgery (mean 23 months). Disability scores ranged from 1-100%, with 1-25% being regarded as mild dysfunction, 26-50% as moderate dysfunction, 51-75% as severe dysfunction, and 76-100% as total dysfunction. A statistical analysis was performed using the Fisher exact test and the multivariate linear regression model for variables. The Global Mean Dash score was 14.8%. Twenty-four patients presented a mild functional deficit (< 25%), while six presented a moderate one (< 50%). Five of them presented a score < 40%, while only one patient presented a score of 49.1%. Higher scores were significantly associated (p < 0.001) with major postoperative complications and lower ones with re-innervated LD flaps (p < 0.01). An insignificant functional impairment was noted in most patients, while a moderate-to-severe one was noted only in the group with complications. Greater impairment is observed in the heavy activities. The DASH test is a useful tool in terms of informing patients and helping the surgeon to choose the best surgical option.
Assuntos
Avaliação da Deficiência , Mastectomia/métodos , Músculos Superficiais do Dorso/transplante , Retalhos Cirúrgicos , Atividades Cotidianas , Adulto , Idoso , Feminino , Seguimentos , Humanos , Pessoa de Meia-Idade , Análise Multivariada , Complicações Pós-Operatórias , Estudos Retrospectivos , Retalhos Cirúrgicos/inervaçãoRESUMO
Dermatofibrosarcoma protuberans is a rare cutaneous malignant tumor associated with a high cure rate but with a high incidence of local recurrence. Because of its tentacle-like subcutaneous infiltrating pattern that extends far beyond the clinically visible skin lesion, a wide resection margin is recommended. Hence, its localization to the head-and-neck regions, although rare, represents a real challenge for both the oncologic surgeon and the reconstructive surgeon, who aim to achieve a radical resection of the tumor with the best possible aesthetic outcome.A case of a 21-year-old Mediterranean man who presented with a 7-month history of a slowly growing subcutaneous lesion of the left preauricular region is reported. A diagnosis of dermatofibrosarcoma protuberans CD34+ was confirmed through surgical biopsy, and the patient subsequently underwent a wide en bloc local surgical resection, followed by anterolateral thigh perforator free flap reconstruction. Healing was uneventful. Initially, there was some facial nerve neurapraxia; however, this completely subsided within 3 months after the surgery. At the 13-month follow-up, the patient was completely well and free from the disease.
Assuntos
Dermatofibrossarcoma/cirurgia , Neoplasias Faciais/cirurgia , Retalhos de Tecido Biológico/transplante , Retalho Perfurante/transplante , Procedimentos de Cirurgia Plástica/métodos , Neoplasias Cutâneas/cirurgia , Anastomose Cirúrgica/métodos , Nervo Facial/fisiopatologia , Seguimentos , Humanos , Masculino , Coxa da Perna/cirurgia , Sítio Doador de Transplante/cirurgia , Cicatrização/fisiologia , Adulto JovemRESUMO
BACKGROUND: The aim of this study was to investigate nipple-areola complex sensation at 48-month follow-up following superolateral pedicled reduction mammaplasty using the pressure-specified sensory device. METHODS: Data regarding nipple-areola complex sensation for static and moving one- and two-point discrimination were collected from 30 active group hypertrophic-breasted patients undergoing superolateral pedicled reduction mammaplasty preoperatively, at 6 months, and at 48 months, and from a control group of 30 unoperated women with normal-sized breasts. Breast volume was assessed using the BREAST-V instrument. RESULTS: For the nipple, static one-point discrimination showed that mean pressure thresholds for the active group at 48 months were 4.10 and 4.19 times higher than preoperatively and in the control group (p<0.001), respectively; moving one-point discrimination showed that mean pressure thresholds for the active group at 48 months were 4.08 and 3.23 times higher than preoperatively and in the control group (p<0.001), respectively. For the areola, static one-point discrimination showed that mean pressure thresholds in the active group at 48 months were 4.12 and 4.83 times higher than preoperatively and in the control group (p<0.001), respectively; moving one-point discrimination showed that mean pressure thresholds from the active group at 48 months were 4.56 and 4.46 times higher than preoperatively and in the control group (p<0.001), respectively. CONCLUSIONS: Despite a slight worsening at 6 months after surgery, patients who had undergone superolateral pedicled reduction mammaplasty showed significant nipple-areola complex sensibility reduction at 48-month follow-up. Although the nipple-areola complex of hypertrophic-breasted patients was seen to be nonsignificantly less sensitive than normal-sized breasts, a significant decrease of sensation was observed following reduction mammaplasty. CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, II.
Assuntos
Doenças Mamárias/cirurgia , Mama/inervação , Mamoplastia , Retalhos Cirúrgicos/inervação , Adulto , Mama/cirurgia , Doenças Mamárias/patologia , Feminino , Humanos , Hipertrofia , Pessoa de Meia-Idade , Recuperação de Função Fisiológica , SensaçãoRESUMO
BACKGROUND: Reconstruction of a functional tongue with proper motility and sensation after subtotal resection is a demanding procedure. The authors describe the reinnervated mushroom-shaped anterolateral thigh perforator flap for subtotal tongue reconstruction. METHODS: Thirteen patients (mean age, 54.8 years; range, 49 to 71 years) diagnosed with T3 and T4 squamous cell carcinomas were allocated prospectively to anterior total mobile (n = 7) or subtotal tongue resection (n = 6). All patients received the mushroom-shaped anterolateral thigh perforator flap. A Likert scale ranging from 1 to 4 was used to assess speech intelligibility, swallowing function, and cosmetic results. Epicritic and proprioceptive sensitivity testing was performed with the Pressure-Specified Sensory Device on the tip of the tongue preoperatively, on the neotongue at the donor site preoperatively, and at the recipient site 12 months postoperatively; protopathic thermoreceptor and nociceptors were clinically investigated. Outcomes were analyzed, and values of p < 0.05 were considered significant. RESULTS: All flaps healed uneventfully (mean follow-up, 18 months). Six patients (46.2 percent) recovered a nearly natural deglutition, whereas seven (53.8 percent) had mild impairment (p = 0.274). Normal intelligible speech was achieved in seven cases (53.8 percent), and acceptable intelligible speech was achieved in six (46.2 percent) (p = 0.286). Aesthetic results were excellent in eight patients (61.5 percent) and good in five (38.5 percent) (p = 0.592). All patients recovered epicritic, proprioceptive, and protopathic sensitivity; cortical upgrading phenomena of the recipient nerve were observed. CONCLUSION: The reinnervated mushroom-shaped anterolateral thigh perforator flap was found to be an innovative and effective option for subtotal tongue reconstruction.
Assuntos
Carcinoma de Células Escamosas/cirurgia , Glossectomia , Retalho Perfurante/transplante , Procedimentos de Cirurgia Plástica/métodos , Neoplasias da Língua/cirurgia , Língua/cirurgia , Idoso , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Retalho Perfurante/inervação , Estudos Prospectivos , Coxa da Perna , Língua/inervação , Resultado do TratamentoRESUMO
Although the fibula free flap (FFF) is a useful choice for mandible reconstruction, its application for large oromandibular defects is still debated upon. We report the use of FFF with a bilobed perforator-based skin paddle for combined hemiglossectomy, floor-of-the-mouth, tonsillar pillar, and mandibular body defect. A case of an 84-year-old woman with a 2.5 × 3.5-cm exophytic ulcerated mass on the right side of the tongue, extended to omolateral gengival fornix, tonsillar pillar, and mandibular body, is reported. An osteocutaneus FFF with a 7-cm bone strut and a 17 × 10-cm bilobed shaped skin paddle was performed. The longer lobe was used to restore tongue shape, whereas the smaller lobe was used to line the pelvic floor, gingival, and tonsillar pillar. The postoperative period was uneventful. The patient was capable to protrude her neotongue beyond the virtual incisors line and to touch the hard palate at different degrees of mouth opening. The bilobed perforator-based skin paddle FFF is felt to be a sound option for large compound oromandibular defects offering the possibility to safely base the skin component on a single peroneal perforator while achieving effective tongue mobility preservation.
Assuntos
Fíbula/transplante , Neoplasias Mandibulares/cirurgia , Retalhos Cirúrgicos , Neoplasias da Língua/cirurgia , Idoso de 80 Anos ou mais , Diagnóstico Diferencial , Feminino , Humanos , Imageamento por Ressonância Magnética , Neoplasias Mandibulares/diagnóstico , Tomografia Computadorizada por Raios X , Neoplasias da Língua/diagnóstico , Ultrassonografia DopplerRESUMO
Cavernous malformations (CMs) are vascular anomalies of the nervous system mostly located in the brain. Cerebral cavernous malformations can present sporadically or familial, as a consequence of an autosomal dominant condition, with incomplete penetrance and variable clinical expression. Occasionally, extraneural manifestations of CMs involving the skin have been described. We report the case of two siblings presenting in adulthood diffuse cutaneous vascular lesions associated with cerebral CMs that, after surgical excision and histopathologic analysis, resulted to cavernous haemangiomas. Genomic DNA was extracted from peripheral blood, and molecular evaluation of KRIT1 gene was performed. Although no signs of neurological impairment were reported, cerebral MRI revealed multiple images in both patients, suggestive of cavernous haemangiomas. The genetic study demonstrated a nonsense mutation (c.535C>T) in the KRIT1 (Krev-1/rap1 interaction trapped 1) gene. Few reports describe extraneural manifestations of Cavernous malformation syndrome (CMs) related to a KRIT1 mutation; these involve the skin and are associated with hyperkeratotic cutaneous capillary-venous malformation. CMs should be suspected in patients developing multiple nodular cutaneous venous lesions in adulthood.
Assuntos
Neoplasias do Sistema Nervoso Central/genética , Códon sem Sentido , Hemangioma Cavernoso do Sistema Nervoso Central/genética , Proteínas Associadas aos Microtúbulos/genética , Proteínas Proto-Oncogênicas/genética , Idoso , Malformações Arteriovenosas , Neoplasias do Sistema Nervoso Central/diagnóstico , Feminino , Hemangioma Cavernoso do Sistema Nervoso Central/diagnóstico , Humanos , Proteína KRIT1 , Masculino , Irmãos , Dermatopatias Vasculares/diagnóstico , Dermatopatias Vasculares/genéticaRESUMO
UNLABELLED: Although reports of late hematoma after placement of breast implants are rare, there has been a noticeable increase in these reports in recent years. Various etiologies have been proposed, usually relating to history of trauma, anticoagulant use, or physical strain. In this case report, we describe a 61-year-old patient who slowly developed a unilateral intracapsular hematoma 2 years after breast reconstruction with Biocell (Natrelle; Allergan, Inc, Irvine, California) textured implants. This case is unique because of the intraoperative finding of 2 capsules surrounding the implant, with the hematoma between the 2 layers. We also discuss the possible pathophysiological mechanisms of this phenomenon. LEVEL OF EVIDENCE: 5.
Assuntos
Implante Mamário/efeitos adversos , Implante Mamário/instrumentação , Implantes de Mama , Neoplasias da Mama/cirurgia , Hematoma/etiologia , Mastectomia , Feminino , Hematoma/patologia , Hematoma/fisiopatologia , Humanos , Pessoa de Meia-Idade , Desenho de Prótese , Resultado do TratamentoRESUMO
PURPOSE: The aim of this study was to evaluate treatment-related complications, outcomes, and patient satisfaction in women with locally advanced breast cancer who received post-mastectomy radiation therapy (PMRT) after breast reconstruction (BR). MATERIALS AND METHODS: Between October 2007 and November 2010, 46 patients with locally advanced breast cancer who underwent mastectomy followed by BR received PMRT at our Department. Radiotherapy was delivered to the chest wall with a dose of 50 Gy in 25 fractions over 5 weeks. RESULTS: The median follow-up was 19 months. Skin erythema grade 1 and 2 was seen in 44 (96%) and two (4%) patients, respectively. Major complications, requiring additional corrective surgical procedure, occurred in three (7%) patients (one patient with prosthesis, one patient with tissue expander and one patient with deep inferior epigastric perforator flap). At univariate analysis, smoking, chemotherapy, hormone therapy with tamoxifen and reconstruction with implant were associated with overall complications (capsular contracture and reconstruction failure). Forty (86%) patients were very satisfied or satisfied with the cosmetic outcome of reconstruction. CONCLUSIONS: Radiotherapy can be safely delivered after BR, with a low complication rate and good patient satisfaction. Further randomised studies are needed to better define the optimal timing of breast reconstruction and post-mastectomy radiation therapy.
Assuntos
Neoplasias da Mama/radioterapia , Neoplasias da Mama/cirurgia , Mamoplastia , Satisfação do Paciente , Neoplasias da Mama/patologia , Terapia Combinada , Feminino , Humanos , Mastectomia , Pessoa de Meia-Idade , Gradação de Tumores , Estadiamento de Neoplasias , Complicações Pós-Operatórias , Radioterapia/efeitos adversos , Radioterapia/métodos , Dosagem Radioterapêutica , Resultado do TratamentoRESUMO
BACKGROUND: Breast volume assessment enhances preoperative planning of both aesthetic and reconstructive procedures, helping the surgeon in the decision-making process of shaping the breast. Numerous methods of breast size determination are currently reported but are limited by methodologic flaws and variable estimations. The authors aimed to develop a unifying predictive formula for volume assessment in small to large breasts based on anthropomorphic values. METHODS: Ten anthropomorphic breast measurements and direct volumes of 108 mastectomy specimens from 88 women were collected prospectively. The authors performed a multivariate regression to build the optimal model for development of the predictive formula. The final model was then internally validated. A previously published formula was used as a reference. RESULTS: Mean (±SD) breast weight was 527.9 ± 227.6 g (range, 150 to 1250 g). After model selection, sternal notch-to-nipple, inframammary fold-to-nipple, and inframammary fold-to-fold projection distances emerged as the most important predictors. The resulting formula (the BREAST-V) showed an adjusted R of 0.73. The estimated expected absolute error on new breasts is 89.7 g (95 percent CI, 62.4 to 119.1 g) and the expected relative error is 18.4 percent (95 percent CI, 12.9 to 24.3 percent). Application of reference formula on the sample yielded worse predictions than those derived by the formula, showing an R of 0.55. CONCLUSIONS: The BREAST-V is a reliable tool for predicting small to large breast volumes accurately for use as a complementary device in surgeon evaluation. An app entitled BREAST-V for both iOS and Android devices is currently available for free download in the Apple App Store and Google Play Store. CLINICAL QUESTION/LEVEL OF EVIDENCE: Diagnostic, II.
Assuntos
Doenças Mamárias/diagnóstico , Mama/anatomia & histologia , Mamoplastia/métodos , Modelos Teóricos , Antropometria/métodos , Mama/cirurgia , Doenças Mamárias/cirurgia , Feminino , Humanos , Hipertrofia/cirurgia , Mamoplastia/ética , Mamilos/cirurgia , Tamanho do Órgão , Valor Preditivo dos Testes , Estudos Prospectivos , Reprodutibilidade dos TestesRESUMO
BACKGROUND: A retrospective analysis of our series of denervated latissimus dorsi (LD) breast reconstructions showed a high incidence of postoperative LD contraction. Anatomical studies with a prospective clinical trial are set up to outline a successful denervation procedure. METHODS: Fifteen fresh cadavers were dissected to study thoracodorsal nerve course. Subsequently, 40 consecutive LD breast reconstructions were divided randomly in equal groups and underwent either distal (group A) or proximal (group B) nerve resection and clipping. The presence of postoperative contraction was evaluated clinically and instrumentally at 2-year follow-up. Statistical analysis of data was performed by Fisher exact test. RESULTS: Cadaver dissections showed distal branching of thoracodorsal nerve in 20% of cases. Incidence of postoperative LD contraction was 35% (7/20) in group A and 0% in group B. A significantly lower rate of contraction in group B was demonstrated (P = 0.004). CONCLUSIONS: Type B proximal nerve resection allows for effective denervation reducing incidence of postoperative contraction (P = 0.004).
Assuntos
Neoplasias da Mama/cirurgia , Mamoplastia/métodos , Contração Muscular , Denervação Muscular/métodos , Complicações Pós-Operatórias/prevenção & controle , Músculos Superficiais do Dorso/cirurgia , Retalhos Cirúrgicos/inervação , Método Duplo-Cego , Eletromiografia , Feminino , Seguimentos , Humanos , Incidência , Mastectomia , Pessoa de Meia-Idade , Complicações Pós-Operatórias/diagnóstico , Complicações Pós-Operatórias/epidemiologia , Complicações Pós-Operatórias/etiologia , Estudos Prospectivos , Músculos Superficiais do Dorso/inervação , Resultado do TratamentoRESUMO
Fibula modeling techniques for mandible reconstruction carry a high risk of bone perfusion impairment and low predictability of osteotomy angles. To restore the parabolic shape of the mandible, the number of osteotomies should be as small as possible to preserve both periosteal and endosteal perfusion. We report our approach with sagittal split osteotomy (SSO) technique for mandibular angle reconstruction.Obwegeser-Dal Pont SSO of fibula flaps was performed on 10 patients who underwent mandibular angle reconstruction. Bone segments were tilted according to stereolithographic template and fixed with 3 bicortical screws in triangular fashion. Fibula-gonial angle at 15 days and 6 months from surgery was compared with the contralateral-mandibular-gonial angle using Kruskal-Wallis test with a P < 0.05 considered significant.Mean bone length and skin paddle size were 15.6 cm (range, 13-18 cm) and 22.5 cm (range, 3 × 4 cm to 11 × 5 cm). Bone unions occurred at 12 months (mean follow-up, 39 months). No differences (P > 0.05) between fibula-gonial angle at 15 days (mean, 122.88 ± 0.55 degrees; range, 122.49-123.27 degrees) and 6 months (mean, 123.36 ± 0.88 degrees; range, 122.73-123.99 degrees) and contralateral-mandibular-gonial angle (mean, 123.20 ± 0.80 degrees; range, 122.62-123.77 degrees) were observed.Fibula SSO allows for new-mandible angle shaping, reducing risk of pedicle and endosteal vascular impairment. Triangular bone fixation thereby emerges as a reliable technique, enhancing functional and aesthetic long-term outcomes.
Assuntos
Fíbula/transplante , Neoplasias Mandibulares/cirurgia , Osteotomia Sagital do Ramo Mandibular/métodos , Procedimentos de Cirurgia Plástica/métodos , Retalhos Cirúrgicos , Parafusos Ósseos , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Resultado do TratamentoRESUMO
BACKGROUND: High incidence of epidermolysis and full thickness necrosis of Wise-pattern skin-sparing mastectomy (WPM) skin flaps to almost 30% represent the Achilles' heel of this procedure. Our purpose was to investigate potential predictors of skin flap ischemic complications (SFIC) in WPM. METHODS: A total of 75 immediate prosthetic reconstructions following Wise-pattern mastectomy on 63 patients were retrospectively analyzed to assess risk factors for SFIC and their impact on aesthetic outcomes and patient satisfaction. There were 2 clusters of hypothetic predictors investigated: patient-related (age, body mass index, smoking, neoadjuvant chemotherapy) and procedure-related (implant weight, breast weight, curative-prophylactic procedure, axillary lymph nodes dissection). Significant predictors from univariate and mixed-effects multivariate logistic regression analyses were considered to be important selection criteria that expose the patients to higher risk of SFIC. Moreover, patients were divided into 3 subgroups according to postoperative outcome: (A) group healed uneventfully, (B) with partial thickness, and (C) with full thickness necrosis. Aesthetic evaluations scores of subgroups were analyzed and compared using a Kruskal-Wallis analysis of variance, and Dunn's test for multiple comparisons between subgroups. RESULTS: Smoking and weight of prosthesis >468 g showed significant association with SFIC, additionally analysis of aesthetic evaluations confirmed differences between subgroups (p = 0.001), and multiple testing showed significance between subgroup A and C (p < 0.05). CONCLUSIONS: Patients with clinically significant predictors are at higher risk of postoperative SFIC and consequently less satisfied of their aesthetic outcomes. The surgeon should consider alternative procedures for such patients, and prostheses heavier than 468 g should be avoided.
Assuntos
Neoplasias da Mama/cirurgia , Carcinoma Intraductal não Infiltrante/cirurgia , Carcinoma Lobular/cirurgia , Mamoplastia , Mastectomia/reabilitação , Complicações Pós-Operatórias , Retalhos Cirúrgicos , Adulto , Idoso , Neoplasias da Mama/patologia , Carcinoma Intraductal não Infiltrante/patologia , Carcinoma Lobular/patologia , Feminino , Seguimentos , Humanos , Pessoa de Meia-Idade , Necrose , Estadiamento de Neoplasias , Prognóstico , Estudos RetrospectivosRESUMO
We describe a left-handed man who had a giant periosteal chondroma of the proximal phalanx of the left third finger with compression of the digital neurovascular structures, and the flexor and extensor tendons. Cutaneous pressure thresholds of the digital nerves were tested, showing complete sensory recovery 24 months postoperatively.