The Xavante Longitudinal Health Study in Brazil: Objectives, design, and key results.

OBJECTIVE: The Xavante Longitudinal Health Study was developed to permit granular tracking of contemporary health challenges faced by indigenous communities in Brazil, taking into consideration ongoing historical processes that may be associated with increases in child undernutrition, adult obesity, and cardiovascular disease risks. METHODS: This was an open-cohort study with six semiannual data collection waves from 2009 to 2012. The study was undertaken in two Xavante villages, Pimentel Barbosa and Etênhiritipá, State of Mato Grosso, Central Brazil. No sampling technique was used. Data collection placed emphasis on growth and nutrition of children under five and nutrition status, blood pressure, and blood glucose levels of adolescents and adults. RESULTS: Baseline data collection began in July/August 2009 with a population census (656 individuals). Between the first and final waves, the study population increased by 17%. At baseline, stunting and wasting was elevated for most age groups <10 years. Overweight, obesity, and increased risk of metabolic complications were expressive among individuals >17 years, disproportionately affecting females. Anemia was elevated in most age groups, especially among females. Mean systolic and diastolic blood pressure was moderate. The overall prevalence of high blood pressure was relatively low. CONCLUSIONS: Our findings reveal marked health disparities relative to the Brazilian national population and a complex dietary health epidemiology involving the double burden of malnutrition, rapidly changing nutritional indicators, and elevated metabolic disease risk. The topically broad multidisciplinary focus permitted construction of the richest longitudinal data set of socio-epidemiological information for an indigenous population in Brazil.

Context-dependence of race self-classification: Results from a highly mixed and unequal middle-income country.

Ethnic-racial classification criteria are widely recognized to vary according to historical, cultural and political contexts. In Brazil, the strong influence of individual socio-economic factors on race/colour self-classification is well known. With the expansion of genomic technologies, the use of genomic ancestry has been suggested as a substitute for classification procedures such as self-declaring race, as if they represented the same concept. We investigated the association between genomic ancestry, the racial composition of census tracts and individual socioeconomic factors and self-declared race/colour in a cohort of 15,105 Brazilians. Results show that the probability of self-declaring as black or brown increases according to the proportion of African ancestry and varies widely among cities. In Porto Alegre, where most of the population is white, with every 10% increase in the proportion of African ancestry, the odds of self-declaring as black increased 14 times (95%CI 6.08-32.81). In Salvador, where most of the population is black or brown, that increase was of 3.98 times (95%CI 2.96-5.35). The racial composition of the area of residence was also associated with the probability of self-declaring as black or brown. Every 10% increase in the proportion of black and brown inhabitants in the residential census tract increased the odds of self-declaring as black by 1.33 times (95%CI 1.24-1.42). Ancestry alone does not explain self-declared race/colour. An emphasis on multiple situational contexts (both individual and collective) provides a more comprehensive framework for the study of the predictors of self-declared race/colour, a highly relevant construct in many different scenarios, such as public policy, sociology and medicine.

Indigenous and tribal peoples' health (The Lancet-Lowitja Institute Global Collaboration): a population study.

BACKGROUND: International studies of the health of Indigenous and tribal peoples provide important public health insights. Reliable data are required for the development of policy and health services. Previous studies document poorer outcomes for Indigenous peoples compared with benchmark populations, but have been restricted in their coverage of countries or the range of health indicators. Our objective is to describe the health and social status of Indigenous and tribal peoples relative to benchmark populations from a sample of countries. METHODS: Collaborators with expertise in Indigenous health data systems were identified for each country. Data were obtained for population, life expectancy at birth, infant mortality, low and high birthweight, maternal mortality, nutritional status, educational attainment, and economic status. Data sources consisted of governmental data, data from non-governmental organisations such as UNICEF, and other research. Absolute and relative differences were calculated. FINDINGS: Our data (23 countries, 28 populations) provide evidence of poorer health and social outcomes for Indigenous peoples than for non-Indigenous populations. However, this is not uniformly the case, and the size of the rate difference varies. We document poorer outcomes for Indigenous populations for: life expectancy at birth for 16 of 18 populations with a difference greater than 1 year in 15 populations; infant mortality rate for 18 of 19 populations with a rate difference greater than one per 1000 livebirths in 16 populations; maternal mortality in ten populations; low birthweight with the rate difference greater than 2% in three populations; high birthweight with the rate difference greater than 2% in one population; child malnutrition for ten of 16 populations with a difference greater than 10% in five populations; child obesity for eight of 12 populations with a difference greater than 5% in four populations; adult obesity for seven of 13 populations with a difference greater than 10% in four populations; educational attainment for 26 of 27 populations with a difference greater than 1% in 24 populations; and economic status for 15 of 18 populations with a difference greater than 1% in 14 populations. INTERPRETATION: We systematically collated data across a broader sample of countries and indicators than done in previous studies. Taking into account the UN Sustainable Development Goals, we recommend that national governments develop targeted policy responses to Indigenous health, improving access to health services, and Indigenous data within national surveillance systems. FUNDING: The Lowitja Institute.

Anemia among indigenous women in Brazil: findings from the First National Survey of Indigenous People's Health and Nutrition.

BACKGROUND: Anemia is recognized as a major public health problem that disproportionately affects vulnerable populations. Indigenous women of reproductive age in Brazil are thought to be at high risk, but lack of nationwide data limits knowledge about the burden of disease and its main determinants. This study aimed to assess the prevalence of anemia and associated factors in this population using data from The First National Survey of Indigenous People's Health and Nutrition in Brazil. METHODS: Data were collected from Indigenous women between 15 and 49 years old based on a nationwide sample of villages. The outcomes of interest were hemoglobin levels (g/dL) and anemia (< 12 g/dL for nonpregnant and < 11 g/dL for pregnant women). Multilevel models were used to explore associations with contextual (village) and individual (household/woman) level variables. RESULTS: Based on data for 6692 Indigenous women, the nationwide mean hemoglobin level was 12.39 g/dL (95% CI: 12.29-12.50). Anemia prevalence was high (33.0%; 95% CI: 30.40-35.61%) and showed pronounced regional disparities. No village-level characteristics were associated with anemia or hemoglobin levels in the multilevel model. Even after controlling for upper level variables, socioeconomic status, parity, body mass index, and having been treated for malaria were associated with anemia and hemoglobin levels. CONCLUSION: The prevalence of anemia in Brazilian Indigenous women was 12% greater than the national estimates for women of reproductive age. Anemia prevalence and mean hemoglobin levels among Indigenous women appear to be partly explained by some previously recognized risk factors, such as socioeconomic status, body mass index, and malaria; however, part of the variability in these outcomes remains unexplained. Knowledge of health status and its potential determinants is essential to guide public policies aimed at controlling anemia burden in Indigenous communities.

Prevalence of pneumonia and associated factors among indigenous children in Brazil: results from the First National Survey of Indigenous People's Health and Nutrition.

BACKGROUND: Based on data from a nationally representative sample of indigenous villages in Brazilian indigenous reserves, the study sought to estimate the prevalence of pneumonia and evaluate associated factors among indigenous children under 5 years of age. METHODS: Sociodemographic, clinical and reported data on child respiratory health from the First National Survey of Indigenous People's Health and Nutrition in Brazil were collected for 6128 children. Prevalence of pneumonia was calculated for independent variables and hierarchical multivariate analyses were performed to assess associations. RESULTS: The overall prevalence proportions of cough, nasal congestion, pneumonia, and pneumonia with fever were 44.4%, 31.0%, 2.63%, and 1.28%, respectively. In the multivariate model, pneumonia was more frequent among children living in the South/Southeast and North regions of Brazil. Children living in larger households or houses with wood or thatch roofing, as well those with low birthweight or stunting, presented higher risk of pneumonia. Pneumonia was less prevalent among children living in houses with wood flooring and those presenting low weight-for-age. CONCLUSIONS: The study results demonstrate that pneumonia is an important cause of illness among indigenous children throughout Brazil. The association between pneumonia and household characteristics suggests that indoor home environment is closely related to the respiratory health of indigenous children.

Nutritional status and growth of indigenous Xavante children, Central Brazil.

BACKGROUND: The aim of this study was to characterize the nutritional status of Xavante Indian children less than 10 years of age in Central Brazil and to evaluate the hypothesis of an association between child nutrition and socioeconomic differentiation in this population. METHODS: A cross-sectional study was conducted in July 2006 that included all children under the age of 10 from the Xavante village Pimentel Barbosa in Mato Grosso, Brazil. The data collected included weight, height, and sociodemographic information. Sociodemographic data were used to generate two indices ("income" and "wealth") and to determine the proportion of adults in each household. Descriptive analyses were performed for weight-for-age (W/A), height-for-age (H/A), and weight-for-height (W/H) using the NCHS and the WHO growth references. Univariate and multivariate analyses were conducted using H/A and W/A as a response variables. RESULTS: Of a total of 246 children under the age of ten residing in the village, 232 (94.3%) were evaluated. Following the NCHS reference, 5.6% of children under the age of ten presented low W/A and 14.7% presented low H/A. Among children under the age of five, deficit percentages for weight and height were 4.5% and 29.9%, respectively, following the WHO curves. Among children < 2 years of age, H/A index variability was found to be directly related to child's age and inversely related to the proportion of adults in the household. Maternal BMI was positively associated with growth for children from 2 to 4 years of age, explaining 11.5% of the z-score variability for the H/A index. For children 5 years of age and older, the wealth index and maternal height were positively associated with H/A. No significant associations were found using W/A as the dependent variable. CONCLUSION: This study demonstrated that undernutrition, in particular linear growth deficit, is a notable health issue for Xavante children. These findings contrast with the nutritional profile observed among Brazilian children nationally, which is characterized by a sharp decline in child undernutrition in recent decades, even in the poorest regions of the country. This discrepancy calls attention to the persistent health disparities that exist between indigenous and non-indigenous people in Brazil.

Human mobility on the Brazilian coast: an analysis of strontium isotopes in archaeological human remains from Forte Marechal Luz Sambaqui.

This study investigated strontium isotopes in the dental enamel of 32 human skeletons from Forte Marechal Luz sambaqui (shellmound), Santa Catarina, Brazil, aiming at identifying local and non-local individuals. The archeological site presents pot sherds in the uppermost archeological layers. Dental enamel was also examined from specimens of terrestrial fauna ((87)Sr/(86)Sr = 0.71046 to 0.71273) and marine fauna ((87)Sr/(86)Sr = 0.70917). The (87)Sr/(86)Sr isotope ratio for individuals classified as locals ranged from 0. 70905 to 0. 71064 and was closer to the isotope ratio of the seawater than to the ratio of the terrestrial fauna, indicating a strong influence of marine strontium on the inhabitants of this sambaqui. The results indicate the existence of three non-local individuals ((87)Sr/(86)Sr = 0.70761 to 0.70835), buried in both the level without pottery and the layer with pottery, possibly originated from the Santa Catarina Plateau, close to the municipality of Lages, or from the Curitiba Plateau. The occurrence of a slight difference between the isotope ratios of local individuals buried in the archeological layer without pottery, when compared to those in the layer with pottery, suggests a possible change in dietary patterns between these two moments in the site's occupation.

Human mobility on the Brazilian coast: an analysis of strontium isotopes in archaeological human remains from Forte Marechal Luz Sambaqui

This study investigated strontium isotopes in the dental enamel of 32 human skeletons from Forte Marechal Luz sambaqui (shellmound), Santa Catarina, Brazil, aiming at identifying local and non-local individuals. The archeological site presents pot sherds in the uppermost archeological layers. Dental enamel was also examined from specimens of terrestrial fauna (87Sr/86Sr = 0. 71046 to 0. 71273) and marine fauna (87Sr/86Sr = 0. 70917). The 87Sr/86Sr isotope ratio for individuals classified as locals ranged from 0. 70905 to 0. 71064 and was closer to the isotope ratio of the seawater than to the ratio of the terrestrial fauna, indicating a strong influence of marine strontium on the inhabitants of this sambaqui. The results indicate the existence of three non-local individuals (87Sr/86Sr = 0. 70761 to 0. 70835), buried in both the level without pottery and the layer with pottery, possibly originated from the Santa Catarina Plateau, close to the municipality of Lages, or from the Curitiba Plateau. The occurrence of a slight difference between the isotope ratios of local individuals buried in the archeological layer without pottery, when compared to those in the layer with pottery, suggests a possible change in dietary patterns between these two moments in the site's occupation.

O presente estudo investigou isótopos de estrôncio em esmalte dentário de 32 remanescentes humanos do sambaqui do Forte Marechal Luz, Santa Catarina, Brasil, com o objetivo de identificar indivíduos locais e não-locais. O sítio arqueológico apresenta fragmentos de cerâmica em suas camadas arqueológicas mais recentes. Além das amostras humanas, foram analisadas amostras de esmalte dentário de espécimes de fauna terrestre (87Sr/86Sr = 0,71046 a 0,71273) e fauna marinha (87Sr/86Sr = 0,70917). A razão 87Sr/86Sr dos indivíduos classificados como locais variou de 0,70905 a 0,71064, sendo próxima a razão de estrôncio existente nos oceanos e distante da razão obtida para a fauna terrestre do mesmo sítio, indicando uma influência marinha na origem do estrôncio dos habitantes desse sambaqui. Foram identificados de três indivíduos não locais (87Sr/86Sr = 0,70761 a 0,70835), sepultados em ambas camadas arqueológicas sem evidência e com evidência de cerâmica. Estes indivíduos podem ter origem no planalto catarinense, no entorno do município de Lages, ou do planalto curitibano. A ocorrência de uma pequena diferença entre as razões isotópicas dos indivíduos locais sepultados nas camadas sem evidência de cerâmica, daqueles sepultados nas camadas ceramistas, sugere a possibilidade de uma mudança nos padrões de alimentação entre esses dois momentos de ocupação do sítio.

Cytokine genes are associated with tuberculin skin test response in a native Brazilian population.

Tuberculosis was a major cause of population decline among Brazilian indigenous peoples and remains a leading cause of morbidity and mortality among them. Despite high BCG coverage, results of Tuberculin Skin Test (TST) reactivity have shown high rates of anergy in Amazonian Indians. Given the high prevalence of anergy in these populations and the fact that genetic host factors play an important role in susceptibility to Mycobacterium tuberculosis (MTB), the aim of this study was to evaluate the association of nineteen polymorphisms in fifteen genes related to immune response and anergy in the Xavante, an indigenous group from Brazil. A total of 481 individuals were investigated. TST anergy was observed in 69% of them. Polymorphisms in four genes showed absence or very low variability: SP110, PTPN22, IL12RB1 and IL6. IFNG +874 A/T heterozygotes and IL4-590 C/C homozygotes were more frequent in those individuals who presented a positive TST (prevalence ratios of 1.9 and 2.0 respectively). The risk of anergy was 1.5 in IL10-1082 G/G homozygotes when compared to carriers for the A allele. In indigenous groups such as the Xavante exposure to a variety of infections, associated with specific genetic factors, may disturb the T-helper 1 and T-helper 2 balance leading to increased immunological susceptibility.

Intestinal Parasitic Infection in the Suruí Indians, Brazilian Amazon / Parasitosis intestinal en los Indios Suruí, Amazonia Brasilera / Infecção por parasitoses intestinais entre os Indios Suruí, Amazônia Brasileira

This study reports the results of a cross-sectional survey carried out in 2005 to investigate the epidemiology of intestinal parasitism among the Suruí Indians, Brazilian Amazon. A total of 519 stool samples were examined by zinc-sulphate-flotation and formol-ether-sedimentation. Entamoeba histolytica/E. dispar-positive samples were further tested by ELISA. Thirty-six percent of the subjects were positive for one more helminth species; 70.7% harbored at least one protozoan species. The most frequent helminth was Hymenolepis nana (29.5%). Nematodes were rare (hookworm= 3.3%; Strongyloides stercoralis= 0.2%). Capillaria sp. was identified in 5.2% of the samples and one case of parasitism by Dipylidium caninum was detected. Prevalence of Giardia duodenalis and E. histolytica/E. dispar was 16.2% and 12.3%, respectively. Based on ELISA, the prevalence of E. histolytica infection was 3.2%. The overall prevalence of intestinal nematode infections depicted in this study was surprisingly low compared to what is often reported for other indigenous populations in the Brazilian Amazon. It is argued that the prevalence of helminths in the Suruí are associated with anthelminthic mass treatment schemes undertaken by the Indian health service, in the absence of other measures. The authors propose that a special program aimed at controlling intestinal parasitism in indigenous communities should step beyond the top-down distribution of medication, but rather be designed in collaboration with the target population, encompassing education, better housing, alternative sewage disposal systems and safe water supply to all villagers.

Se reportan los resultados de un estudio transversal llevado a cabo en 2005 sobre la epidemiología del parasitismo intestinal en indios Suruí de la amazonia brasilera. Un total de 519 muestras de heces fueron examinadas por flotación en sulfato de zinc y sedimentación en etil-éter. Muestras positivas para Entamoeba histolytica/E. dispar fueron testeadas por ELISA. Una o más especies de helmintos estuvieron presentes en 36% de los sujetos y 70,7% presentaron al menos una especie de protozoario. El helminto más frecuente fue Hymenolepis nana (29,5%). Los nematodos fueron escasos (anquilostomo= 3,3%; Strongyloides stercoralis= 0.2%). Se identificó Capillaria sp. en 5,2% de las muestras y se detectó un caso de parasitismo por Dipylidium caninum. Las prevalencias de Giardia duodenalis y E. histolytica/E. dispar fueron 16,2% y 12,3%, respectivamente. Según ELISA la prevalencia de infección por E. histolytica fue 3,2%. La prevalencia de infección por nematodos fue sorpresivamente baja en comparación con reportes frecuentes en otras poblaciones indígenas de la amazonia brasilera. Se argumenta que los cambios en la prevalencia de helmintiasis en los Suruí se asocian a tratamientos masivos con antihelmínticos llevados a cabo por el servicio de salud de indígenas, en ausencia de otras medidas. Se propone que un programa especial orientado a controlar el parasitismo intestinal en poblaciones indígenas debe desligarse de la distribución de medicación, sino ser diseñado en colaboración con los habitantes locales, abarcando educación, mejores viviendas y sistemas de drenaje y disposición de residuos, y suministro de agua segura a todos los pobladores.

Este trabalho apresenta os resultados de um estudo seccional conduzido em 2005 que visou investigar o perfil epidemiológico das parasitoses intestinais entre os índios Suruí, localizados em Rondôna, Amazônia brasileira. Um total de 519 amostras fecais foi examinado pelas técnicas de flutuação com sulfato de zinco e sedimentação com formol-éter. Amostras positivas para Entamoeba histolytica/E. díspar foram posteriormente testadas pelo método ELISA. Trinta e seis por cento dos indivíduos encontravam-se positivos para pelo menos uma espécie de helminto; 70,7% abrigavam pelo menos uma espécie de protozoário. O helminto mais freqüente foi Hymenolepis nana (29,5%). Nematódeos foram raros (ancilostomídeos= 3,3%; Strongyloides stercoralis= 0,2%). Capillaria sp. foi identificado em 5,2% das amostras e um caso de parasitismo por Dipylidium caninum foi observado. As prevalências de Giardia duodenalis e E. histolytica/E. dispar foram de 16,2% e 12,3%, respectivamente. Baseada no teste ELISA, a prevalência de infecção por E. histolytica foi de 3,2%. A prevalência total de infecção intestinal por nematódeos demonstrada neste estudo foi surpreendentemente baixa se comparada ao que tem sido geralmente reportado para outras populações indígenas da Amazônia brasileira. Argumenta-se que a baixa prevalência de helmintos entre os Suruí está em larga medida associada a esquemas de tratamento em massa com anti-helmínticos dispensados pelo serviço de saúde indígena. Os autores propõem que um programa especial destinado ao controle de parasitoses intestinais em comunidades indígenas deve ir além da distribuição de medicamentos. Preferencialmente, deve ser planejado em colaboração com a população alvo, considerando aspectos educacionais e visando a melhoria nas moradias e no sistema de esgoto e de fornecimento de água.

Anthropometric evaluation of indigenous Brazilian children under 60 months of age using NCHS/1977 and WHO/2005 growth curves / Avaliação antropométrica de crianças indígenas menores de 60 meses, a partir do uso comparativo das curvas de crescimento NCHS/1977 e OMS/2005

OBJETIVOS: Descrever e analisar comparativamente os dados antropométricos de crianças indígenas Suruí, Xavánte e Wari' menores de 60 meses, a partir dos conjuntos de curvas de crescimento NCHS/1977 e WHO/2005. MÉTODOS: A antropometria seguiu técnica padronizada e os dados foram convertidos em escores z utilizando-se os programas Epi-Info (Versão 3.4) e WHO-Anthro (Versão Beta). Os índices estatura/idade (E/I), peso/idade (P/I) e peso/estatura (P/E) foram os descritores do estado nutricional em todas as crianças menores que 60 meses e também o índice de massa corporal (IMC) nas de 24-59 meses. RESULTADOS: As prevalências de E/I < -2 escores z foram: crianças Suruí, 31,4 (NCHS/1977) e 38,6% (WHO/2005); Xavánte, 30,9 e 42,3%; Wari', 61,7 e 68,3%. As prevalências de P/I < -2 escores z foram: crianças Suruí, 12,4 (NCHS/1977) e 8,5% (WHO/2005); Xavánte, 16,5 e 11,6%; Wari', 51,7 e 45,0%. As prevalências de P/E < -2 escores z para as crianças Suruí foram nulas (NCHS/1977 e WHO/2005); para as Xavánte, 1,7 e 3,3%; e para as Wari', 1,7% e nula. As prevalências de P/E > 2 escores z para as crianças Suruí foram 3,9 (NCHS/1977) e 3,9% (WHO/2005); Xavánte, nula e 0,8%; Wari', nulas para ambas as curvas. Nas crianças Suruí de 24 a 59 meses o percentual com escore z > 2 para o IMC foi de 5,4% (WHO/2005); Xavánte, 9,5%; Wari', 0%. CONCLUSÕES: Há diferenças importantes nos resultados da avaliação nutricional, a depender do conjunto de curvas utilizadas, ainda que o emprego de ambas revele elevadas prevalências de desnutrição. Sugere-se que, inclusive para fins de comparabilidade, estudos com populações indígenas apresentem seus resultados utilizando os dois conjuntos de curvas de crescimento.

OBJECTIVES: To perform a comparative analysis of anthropometric data from Suruí, Xavánte and Wari' indigenous children under 60 months of age using the NCHS/1977 and the WHO/2005 growth curves. METHODS: Anthropometric measurements followed standard procedures and the data obtained were converted into z scores using the Epi-Info (Version 3.4) and WHO-Anthro (Version Beta) softwares. The indices height/age (H/A), weight/age (W/A) and weight/height (W/H) were descriptors of nutritional status for all children under 60 months of age, as well as the body mass index (BMI) for children 24-59 months old. RESULTS: The frequencies of Suruí children < -2 z scores for H/A were 31.4 (NCHS/1977) and 38.6% (WHO/2005); Xavánte 30.9 and 42.3%; Wari' 61.7 and 68.3%. The frequencies of Suruí children < -2 z scores for W/A were 12.4 (NCHS/1977) and 8.5% (WHO/2005); Xavánte 16.5 and 11.6%; Wari' 51.7 and 45.0%. None of the Suruí children were < -2 z scores for W/H (NCHS/1977 and WHO/2005); the frequencies of Xavánte children were 1.7 and 3.3% and Wari' 1.7 and 0.0%. The frequencies of Suruí children > 2 z scores for W/H were 3.9 (NCHS/1977) and 3.9% (WHO/2005); Xavánte 0.0 and 0.8%; Wari' 0.0 and 0.0%. The frequency of Suruí children aged 24-59 months > 2 z scores for BMI was 5.4% (WHO/2005); Xavánte 9.5%; and Wari' 0.0%. CONCLUSIONS: Our findings revealed important differences in the results from nutritional assessment, according to the set of growth curves used; however, the use of both growth curves revealed a high prevalence of malnutrition. Therefore, future studies with indigenous populations should present their results using two sets of growth curves to allow consistent comparison.

Anthropometric evaluation of indigenous Brazilian children under 60 months of age using NCHS/1977 and WHO/2005 growth curves.

OBJECTIVES: To perform a comparative analysis of anthropometric data from Suruí, Xavánte and Wari' indigenous children under 60 months of age using the NCHS/1977 and the WHO/2005 growth curves. METHODS: Anthropometric measurements followed standard procedures and the data obtained were converted into z scores using the Epi-Info (Version 3.4) and WHO-Anthro (Version Beta) softwares. The indices height/age (H/A), weight/age (W/A) and weight/height (W/H) were descriptors of nutritional status for all children under 60 months of age, as well as the body mass index (BMI) for children 24-59 months old. RESULTS: The frequencies of Suruí children < -2 z scores for H/A were 31.4 (NCHS/1977) and 38.6% (WHO/2005); Xavánte 30.9 and 42.3%; Wari' 61.7 and 68.3%. The frequencies of Suruí children < -2 z scores for W/A were 12.4 (NCHS/1977) and 8.5% (WHO/2005); Xavánte 16.5 and 11.6%; Wari' 51.7 and 45.0%. None of the Suruí children were < -2 z scores for W/H (NCHS/1977 and WHO/2005); the frequencies of Xavánte children were 1.7 and 3.3% and Wari' 1.7 and 0.0%. The frequencies of Suruí children > 2 z scores for W/H were 3.9 (NCHS/1977) and 3.9% (WHO/2005); Xavánte 0.0 and 0.8%; Wari' 0.0 and 0.0%. The frequency of Suruí children aged 24-59 months > 2 z scores for BMI was 5.4% (WHO/2005); Xavánte 9.5%; and Wari' 0.0%. CONCLUSIONS: Our findings revealed important differences in the results from nutritional assessment, according to the set of growth curves used; however, the use of both growth curves revealed a high prevalence of malnutrition. Therefore, future studies with indigenous populations should present their results using two sets of growth curves to allow consistent comparison.

Crescimento físico de crianças indígenas xavantes de 5 a 10 anos de idade em Mato Grosso / Physical growth of five to ten year old Xavante indian children in Mato Grosso

Objetivo:Investigar o perfil de crescimento físico de crianças xavantes de 5 a 10 anos de idade, que vivem nas Terras Indígenas Sangradouro-Volta Grande e São Marcos (Mato Grosso). Métodos: O inquérito foi realizado em fevereiro de 1997 em duas escolas indígenas administradas por missionários salesianos. A amostra incluiu 233 crianças entre 5 e 10 anos incompletos. Foram coletados dados referentes a data de nascimento, peso, estatura, perímetro paquial e dopa cutânea tricipital. Para estatura e peso, as informações xavantes foram comparadas com as curvas do National Center for Health Statistics (NCHS), preconizadas pela Organização Mundial da Saúde. Resultados: Os resultados demonstram que 9 por ciento das crianças xavantes apresentam valores de estatura/idade inferiores a -2 escores z. No caso dos meninos, há diferenças estatisticamente significantes (p < 0,05) nas médias de escores z para os índices estatura/idade e peso/idade entre as duas comunidades investigadas, o que não foi observado para as meninas. As crianças xavantes apresentam valores médios de estatura inferiores aos observados em crianças norteamericanas, contudo por vezes próximos às medianas das crianças pasileiras investigadas pela Pesquisa Nacional sope Saúde e Nutrição (PNSN). Conclusões: O perfil de crescimento físico das crianças xavantes distancia-se, em certos aspectos, daquele comumente descrito para crianças de outras populações indígenas da América do Sul. Com base nas evidências encontradas, parece-nos adequado sugerir que as curvas de referência norte-americanas podem ser aplicadas para avaliar o estado nutricional das crianças xavantes,

Crescimento físico de crianças indígenas xavantes de 5 a 10 anos de idade em Mato Grosso / Physical growth of five to ten year old Xavante indian children in Mato Grosso

Objetivo: Investigar o perfil de crescimento físico de crianças xavantes de 5 a 10 anos de idade, que vivem nas Terras Indígenas Sangradouro-Volta Grande e São Marcos (Mato Grosso). Métodos: O inquérito foi realizado em fevereiro de 1997 em duas escolas indígenas administradas por missionários salesianos. A amostra incluiu 233 crianças entre 5 e 10 anos incompletos. Foram coletados dados referentes a data de nascimento, peso, estatura, perímetro braquial e dobra cutânea tricipital. Para estatura e peso, as informações xavantes foram comparadas com as curvas do National Center for Health Statistics (NCHS), preconizadas pela Organização Mundial da Saúde. Resultados: Os resultados demonstram que 9% das crianças xavantes apresentam valores de estatura/idade inferiores a -2 escores z. No caso dos meninos, há diferenças estatisticamente significantes (p

Objective: This study investigated the physical growth of Xavante indian children 5-10 years of age living at the Sangradouro and São Marcos reservations, Mato Grosso, Central Brazil. Methods: A cross-sectional survey was carried out in February 1997 at two Indian schools. The following data were collected: birth date, sex, weight, stature, upper arm circumference and triceps skinfold thickness. Data on stature and weight were compared to the National Center for Health Statistics (NCHS) growth curves, following recommendations put forward by the World Health Organization. Results: The results show that 9% of the sample were below -2 S.D. for height for age. For boys, statistically significant differences (p<0.05) in height for age and weight for age z-score values were observed between the two communities. Similar differences were not observed for girls. Xavante children are shorter in stature than D.S. childrenoHowever, for some age groups, their average values of stature overlap with those ofBrazilian children investigated by the PesquisaNacional sobre Saúde e Nutrição (PNSN). Conclusions: The physical growth of Xavante children present important differences when compared to the growth profile of a number of other SouthAmerican indigenous populations. It is argued that NorthAmerican curves might be appropriate to evaluate the nutritional status of the Xavante children.

Crescimento físico de crianças indígenas xavantes de 5 a 10 de idade em Mato Grosso / Physical growth of five o ten year old Xavante indian children Mato Grosso

Objetivo: Investigar o perfil de crescimento físico de crianças xavantes de 5 a 10 anos de idade, que vivem nas Terras Indígenas Sangradouro - Volta Grande e São Marcos (Mato Grosso). Métodos: O inquérito foi realizado em fevereiro de 1997 em duas escolas indígenas administradas por missionários salesianos. A amostra incluiu 233 crianças entre 5 e 10 anos incompletos. Foram coletados dados referentes a data de nascimento, peso, estatura, perímetro braquial e dobra cutânea tricipital. Para estatura e peso, as informações xavantes foram comparadas com as curvas do National Center for Healtth Statistics (NCHS), preconizadas pela Organização Mundial de Saúde. Resultados demonstram que 9 por cento das crianças xavantes apresentam valores de estatura/idade inferiores a 2 escores z. No caso dos meninos, há diferenças estatisticamente significantes (p<0,05) nas médias de escores z para os índices estatura/idade e peso/idade entre as duas comunidades investigadas, o que não foi observado para as meninas. As crianças xavantes valores médios de estaturas inferiores aos observados em crianças norte americanas, contudo por vezes próximos às medianas das crianças brasileiras investigadores pela Pesquisa Nacional sobre Saúde e Nutrição (PNSN). Conclusões: O perfil de crescimento físico das crianças xavantes distancia-se em certos aspectos, daquele comumente descrito para crianças de outras populações indígenas da América do Sul. Com base nas evidências encontradas, parece-nos adequado sugerir que as curvas de referência norte-americanas podem ser aplicadas para avaliar o estado nutricional das crianças xavantes

Haplotype and allele frequencies for three genes of the dopaminergic system in South American Indians.

Haplotype and allele frequencies for the dopamine D2 receptor gene (DRD2), dopamine D4 receptor gene (DRD4), and dopamine transporter protein gene (SLC6A3) were determined in 135 individuals from five Brazilian Indian tribes, and the results integrated with those previously presented for this ethnic group. DRD2 and DRD4 were highly polymorphic. Haplotypes including TaqI A1 at DRD2, and the seven repeat allele at DRD4 were the most frequent variants, while the SLC6A3 locus was monomorphic for the 10 repeat allele in South American Indians. Genetic distances and the corresponding neighbor-joining tree indicated a geographic dichotomy between North + Central American and South American natives, with the exception of the Wai Wai, who live north of the Amazon river and are grouped in the northern cluster. G(ST) estimates from these genes vary between 0.05 and 0.11 for North and South America, respectively, indicating a higher degree of differentiation of the latter groups. These results are in accordance with previous genetic data on other systems, as well as with the history and biodemographical data of South American Indians. Am. J. Hum. Biol. 12:638-645, 2000. Copyright 2000 Wiley-Liss, Inc.

Perfusäo cerebral retrógrada é método eficaz de proteçäo cerebral?: resultados imediatos de estudo consecutivo e randomizado / Is retrograde cerebral perfusion an effective method for cerebral protection?: immediate results of a consecutive and randomized study

Foram estudados 30 pacientes com diagnóstico de aneurisma ou dissecçäo de aorta tratados cirurgicamente. O método utilizado consistiu: uso de hipotermia profunda, parada circulatória total, infusäo de 0,20 mg/Kg de peso de dexametasona intravenosa e 10 mg/Kg/peso de thiopental, colocaçäo dos pacientes em Trendelemburg a 45 graus durante o período de parada respiratória. Os 30 pacientes foram operados consecutivamente e randomizados em 2 grupos. Grupo I constituído de 15 pacientes, nos quais foi utilizada a perfusäo cerebral retrógrada (PCR) através da veia cava superior e Grupo II também com 15 pacientes nos quais näo foi utilizada PCR. Onze (36,7 por cento) pacientes tinham aneurisma da aorta ascendente e arco aórtico, 7 (23,3 por cento) tinham dissecçäo aguda da aorta do tipo I, 6 (20 por cento) com dissecçäo crônica da aorta ascendente e os 6 (20 por cento) restantes outros diagnósticos näo agrupáveis. Foi realizada análise das seguintes variáveis independentes para mortalidade: idade, sexo, tempo de circulaçäo extracorpórea, tempo de parada circulatória, diagnóstico, complicaçöes prévias, comparando os dois grupos. A mortalidade imediata do Grupo I foi de 4/15 (insuficiência respiratória) 26,6 por cento e no Grupo II 3/15 (coma) 20,0 por cento - p =1,00. A incidência de complicaçöes neurológicas no Grupo I foi 3/15 (20,0 por cento) e no Grupo II, 2/15 (13,3 por cento) p = 1,000. A análise estatística utilizando o teste exato de Fisher näo demonstrou diferença entre os dois grupos com relaçäo à mortalidade imediata e complicaçöes neurológicas. As causas de óbito foram: insuficiência respiratória em 4 pacientes, alteraçäo neurológica, hiperpotassemia e infarto do miocárdio, respectivamente nos 3 últimos. No presente trabalho, concluímos que a associaçäo de PCR näo oferece proteçäo cerebral mais eficaz que a parada circulatória total associada à hipotermia profunda, para o tempo de isquemia utilizado.

Crescimento físico em estatura de escolares de ascendência japonesa na cidade de Säo Paulo, Brasil / Physical growth in stature of school children of Japanese ancestry in the city of Säo Paulo, Brazil

Apresenta os resultados de um inquérito transversal que visou caracterizar o crescimento físico em estatura de uma amostra de escolares de ascendência japonesa (três ou quatro avós nascidos no Japäo) e de alto status sócio-econômico residentes na cidade de Säo Paulo. A amostra inclui 124 indivíduos entre 7 e 10 anos de idade e de ambos os sexos. Os resultados demonstram que as crianças de ascendência japonesa apresentam médias de estatura inferiores às medianas das curvas de referência NCHS ("National Center for Health Statistics", EUA). As médias säo similares às medianas de uma amostra de crianças japonesas e inferiores àquelas de maior renda da PNSN ("Pesquisa Nacional sobre Saúde e Nutriçäo", Brasil). Os achados näo apóiam a hipótese de uniformidade do potencial de crescimento físico em estatura em crianças, lançando dúvidas acerca da utilizaçäo de uma única referência de crescimento na avaliaçäo antropométrica do estado nutricional.

Intestinal parasitism in the Xavante indians central Brazil

Este trabalho reporta os resultados de um inquerito transversal qualitativo e quantitativo sobre parasitas intestinais entre os Xavantes do Brasil Central. A. lumbricoides (25 por cento) e ancilostomideos (33,6 por cento) foram os helmintos mais frequentes; complexo E.histolytica (7,8 por cento) e G. lamblia (8,6 por cento) os protozoarios mais comuns. A maioria dos individuos positivos albergava somente uma especie de helminto (58,5 por cento)...