Efeitos de um programa de reabilitação sobre capacidade física de pacientes pós-infecção por SARS-CoV-2: um estudo retrospectivo / Effects of a rehabilitation program on the physical capacity of patients after SARS-Cov-2 infection: a retrospective study

Objetivo: avaliar o efeito de um programa de reabilitação sobre a capacidade física de pacientes integrantes de um programa de reabilitação pós-infecção por SARS-CoV-2. Métodos: estudo observacional de incidência retrospectiva, com amostra de prontuários de pacientes >18 anos, participantes do programa de reabilitação pós-COVID-19 no Centro de Reabilitação da PUCRS. Foram extraídos dados demográficos, antropométricos e de testes funcionais, incluindo o teste da caminhada dos seis minutos (TC6) e o teste de sentar e levantar (TSL), antes e depois do programa. O programa foi composto por treinamento aeróbico e re-sistido, duas vezes por semana, totalizando 16 sessões. O treinamento aeróbico foi conduzido na esteira com duração de 30 minutos, sendo avaliada frequência cardíaca, saturação, pressão arterial e escala de Borg (dispneia e cansaço em membros inferiores). O treino resistido foi realizado após o teste de repetição máxima (1RM) com a carga variando entre 50-80% de 1RM, durante 30 minutos. Resultados: foram incluídos 13 pacientes, com média de idade de 51,0±16,4 anos. Ao comparar os resultados pré e pós-reabilitação, encontramos diferenças significativas na distância percorrida no TC6, sendo de 480,5±91,3 metros pré e 722,1±235,9 metros após a intervenção (p<0,001), bem como no percentual do previsto, sendo 87,5±18,8 pré e 130,7±43,5 após (p=0,001). Além disso, ao analisar o TSL, verificou-se uma redução significativa no tempo, de 12,3±4,7 segundos pré-programa para 8,8±2,2 após (p=0,005). Conclusão: o programa de reabilitação apresentou impacto positivo na capaci-dade física de pacientes que integraram o programa de reabilitação pós-infecção por SARS-CoV-2

Objective: to evaluate the effect of a rehabilitation program on the physical capacity of patients participating in a rehabilitation program after SARS-CoV-2 infection. Methods: retrospective incidence observational study, with a sample of medical records of patients >18 years old, participants in the post-covid-19 rehabilitation program at the PUCRS Rehabilitation Center. Demographic, anthropometric and functional test data: six-minute walk test (TC6) and sit-to-stand teste (TSL) were extracted pre and post program. The program consisted of aerobic and resistance training, twice a week, totaling 16 sessions. Aerobic training was performed on a treadmill lasting 30 minutes, with heart rate, saturation, blood pressure and Borg (dyspnea and fatigue in the lower limbs) being evaluated. Resistance training was performed after the maximum repetition test (1RM) with a load ranging from 50-80% of 1RM, for 30 minutes. Results: 13 patients were included, with a mean age of 51.0±16.4 years. When comparing the pre and post rehabilitation results, we found significant differences in the distance covered in the TC6, being 480.5±91.3 meters before and 722.1±235.9 meters after the inter-vention (p<0.001) and in the percentage of predicted, being 87.5±18.8 pre and 130.7±43.5 post (p=0.001). Fur-themore, when analyzing the TSL, we found a significant reduction in time of 12.3±4.7 seconds pre-program and 8.8±2.2 post (p=0.005). Conclusion: the rehabilitation program had a positive impact on the physical capacity of patients who parti-cipated in the rehabilitation program after SARS-CoV-2 infection

Impact of maternal physical exercise on inflammatory and hypothalamic-pituitary-adrenal axis markers in the brain and lungs of prenatally stressed neonatal mice.

This study aimed to evaluate the effects of maternal exercise on alterations induced by prenatal stress in markers of the inflammatory process and the hypothalamic-pituitary-adrenal axis in the brain and lungs of neonatal mice. Female Balb/c mice were divided into three groups: control, prenatal restraint stress, prenatal restraint stress and physical exercise before and during the gestational period. On day 0 (PND0) and 10 (PND10), mice were euthanized for brain and lung analyses. The gene expression of GR, MR, IL-6, IL-10, and TNF in the brain and lungs and the protein expression of MMP-2 in the lungs were analyzed. Maternal exercise reduced IL-6 and IL-10 gene expression in the brain of PND0 mice. Prenatal stress and maternal exercise decreased GR, MR, IL-6, and TNF gene expression in the lungs of PND0 mice. In the hippocampus of PND10 females, exercise inhibited the effects of prenatal stress on the expression of MR, IL-6, and IL-10. In the lungs of PND10 females, exercise prevented the decrease in GR expression caused by prenatal stress. In the hippocampus and lungs of PND10 males, prenatal stress decreased GR gene expression. Our findings confirm the effects induced by prenatal stress and demonstrate that physical exercise before and during the gestational period may have a protective role on inflammatory changes.