RESUMO
The EMF and Breast Cancer on Long Island Study (EBCLIS) was a case-control study designed to evaluate the possible association between exposure to electromagnetic fields (EMFs) and breast cancer. Eligible women were participants in the population-based Long Island Breast Cancer Study Project, were under 75 years of age at enrollment, were residentially stable, and were identified between August 1, 1996, and June 20, 1997. Of those eligible, 576 cases and 585 controls participated in EBCLIS (87% and 83%, respectively). In-home data collection included various spot and 24-hour EMF measurements, ground-current magnetic field measurements, wire mapping of overhead power lines servicing the home, and an interview. Odds ratios and 95% confidence intervals were based on multivariate logistic regression analyses. All odds ratios were close to 1 and nonsignificant. For the highest quartile of 24-hour EMF measurements, the odds ratio was 0.97 (95% confidence interval (CI): 0.69, 1.37) in the bedroom and 1.09 (95% CI: 0.78, 1.51) in the most lived-in room. For the highest exposure category of ground-current measurements, the odds ratio was 1.13 (95% CI: 0.88, 1.44) in the bedroom and 1.08 (95% CI: 0.85, 1.38) in the most lived-in room. These and other EBCLIS results agree with other recent reports of no association between breast cancer and residential EMF exposures.
Assuntos
Neoplasias da Mama/epidemiologia , Campos Eletromagnéticos/efeitos adversos , Exposição Ambiental/estatística & dados numéricos , Adulto , Distribuição por Idade , Idoso , Neoplasias da Mama/etiologia , Estudos de Casos e Controles , Feminino , Humanos , Modelos Logísticos , Pessoa de Meia-Idade , New York/epidemiologia , Razão de Chances , Vigilância da População , Características de ResidênciaRESUMO
OBJECTIVES: (1) To describe baseline patterns of adherence to American Diabetes Association and American Academy of Ophthalmology vision care guidelines for diabetes in the Diabetic Retinopathy Awareness Program, and (2) to evaluate factors associated with nonadherence. This paper describes the baseline characteristics of a population enrolled in a prospective, randomized clinical trial. DESIGN: Cross-sectional study. PARTICIPANTS: Between October 1993 and May 1994, the study identified 2308 persons with diabetes, 18 years of age or older, who were residents of Suffolk County, New York, via a multimedia community-wide recruitment campaign. INTERVENTION AND METHODS: Eligibility for the trial was determined during a 20-minute phone interview, which included questions about vision care practices; diabetes management; and knowledge, attitudes, and beliefs about diabetes, vision, and diabetic retinopathy. This paper describes these patient characteristics at baseline. Eligible patients would be randomized subsequently to a 2-year diabetes educational intervention arm, which included mailed packets and newsletters focused on vision care, or to a control nonintervention arm. MAIN OUTCOME MEASURE: Nonadherence to guidelines at baseline was defined as the absence of a dilated eye examination during the year before recruitment into the study. RESULTS: Of the 2308 persons interviewed, 813 (35%) did not follow the vision care guidelines; two thirds of this group reported no eye examination in the year before the interview, and one third had an undilated examination. Ophthalmologists performed 49% of the examinations in the nonadherent group, versus 86% in the adherent group. In logistic regression analyses, factors related to nonadherence were: younger age (odds ratio [OR] = 0.97), type 2 diabetes with or without insulin use (OR = 1.62 and 1.99, respectively), shorter diabetes duration (OR = 0.97), last eye examination performed by an optometrist (OR = 5.32) or other nonophthalmologist (OR = 4.29), less practical knowledge about diabetes (OR = 1.57), and no prior formal diabetes education (OR = 1.30). CONCLUSIONS: Within this population, more than one third of participants had not been following vision care guidelines. Nonadherence was linked to several potentially modifiable factors; changes in these factors could enhance the early detection of diabetic retinopathy.
Assuntos
Diabetes Mellitus Tipo 1/complicações , Retinopatia Diabética/diagnóstico , Conhecimentos, Atitudes e Prática em Saúde , Cooperação do Paciente/estatística & dados numéricos , Seleção Visual/normas , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Cegueira/prevenção & controle , Estudos Transversais , Retinopatia Diabética/etiologia , Feminino , Guias como Assunto , Humanos , Masculino , Pessoa de Meia-Idade , Nefrologia , Oftalmologia , Estudos Prospectivos , Sociedades MédicasRESUMO
PURPOSE: Recruiting participants is a major challenge for population studies. We present the recruitment methods followed by the Diabetic Retinopathy Awareness Program (DRAP), a community-based, randomized, masked, controlled trial to meet and exceed its sample size goals. METHODS: A county-wide multi-media promotional campaign to recruit and enroll participants in the trial was planned and executed from October 1993 through April 1994, with the assistance of the local news media and community and professional groups. A toll-free 800 number recruitment line was established, and postage-paid recruitment postcards distributed. The trial was designed to examine whether a mailed educational intervention could increase compliance with vision care guidelines among persons with diabetes in the community. RESULTS: A total of 2308 persons with diabetes were interviewed for eligibility and 813 enrolled in the intervention trial, exceeding the original recruitment goals of 1800 and 600, respectively. Those who completed the enrollment interview reflected county demographics. During recruitment, newspaper, television and radio stories featured the study; pharmacies and physician offices displayed study materials; public service announcements appeared in local print and broadcast media. The largest single recruitment response was a local television news report, followed by a newspaper story. CONCLUSIONS: These experiences substantiate the need for a comprehensive coordinated approach, using planned multiple sources, to achieve recruitment success. By engaging the lay and professional communities along with the media, recruitment costs can be kept to a minimum. Participant costs can be minimized by employing a toll-free number and eliminating study participant travel, thus allowing for inclusion of traditionally underserved populations. This approach is applicable to other studies, where community-based participation is desired.
Assuntos
Retinopatia Diabética/prevenção & controle , Seleção de Pacientes , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Retinopatia Diabética/epidemiologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , New YorkRESUMO
PURPOSE: Several statements have been issued to the effect that no consistent, significant link has been demonstrated between cancer and electromagnetic fields (EMF). However, there continues to be much interest in a possible association with breast cancer, in part because breast cancer risk is substantially higher in industrialized countries than in other areas, and electric power generation and consumption is one of the hallmarks of industrialized societies. In 1987, Stevens proposed a biological mechanism whereby two products of electric power generation, EMF and light at night, might contribute to mammary carcinogenesis through inhibition of melatonin. METHODS: We conducted a comprehensive review of the epidemiologic literature and hypothesized mechanisms pertaining to EMF exposure and the risk of breast cancer, in order to assess whether or not there was evidence to suggest a link between EMF and breast cancer. RESULTS: Some occupational epidemiological studies have demonstrated an increased incidence of breast cancer among mainly male electrical workers. It has been difficult to study women, as few are employed in these types of occupations. In all, there have been eleven occupational studies related to breast cancer in women, and statistically significant risk ratios have been observed: 1.98 for pre-menopausal women in occupations with high EMF exposure in one study, 2.17 in all women who worked as telephone installers, repairers, and line workers in another study, and 1.65 for system analysts/ programmers, 1.40 for telegraph and radio operators, and 1.27 for telephone operators in a third study. However, six of the studies did not find any significant effects and two found effects only in subgroups. The results of the eight studies of residential exposure and four electric blanket studies have been inconsistent, with most not demonstrating any significant association. However, this might be attributed, at least to some extent, to difficulties in assessing residential exposure in these studies, as well as other methodological considerations. CONCLUSIONS: The biologic plausibility of an association between EMF and breast cancer, coupled with suggestive data from occupational studies and unexplained high incidence rates of breast cancer, suggests that further investigation of this possible association is warranted.
Assuntos
Neoplasias da Mama/epidemiologia , Neoplasias da Mama/etiologia , Campos Eletromagnéticos/efeitos adversos , Exposição Ambiental , Feminino , Humanos , Masculino , Doenças Profissionais/epidemiologia , Doenças Profissionais/etiologia , Fatores de RiscoRESUMO
The accurate and valid measurement of personal exposure to magnetic fields poses a major challenge for epidemiologic studies. When considering the various methods to assess exposure, it is unclear which measures are most relevant for studies of human disease, if any. Given these uncertainties, the Electromagnetic Fields and Breast Cancer on Long Island Study (EBCLIS) undertook a pilot study to develop the data collection protocol for a case-control study of breast cancer and magnetic fields. The pilot study used and compared various methods to assess residential exposures to magnetic fields, and related these measures to personal exposures. It included 31 women without breast cancer (mean age, 63+/-7 yr) who lived in their present homes for at least 15 yr. The pilot study consisted of an in-home interview, spot and 24-h magnetic field waveforms and broadband recordings, ground currents, wire coding, and personal 24-h broadband measurements. From the regression analyses, the model that best predicted personal magnetic field exposures included 24-h measurements in the bedroom and in the most lived-in room; as well as ground current test loads taken at the center of this most lived in room (r(2)=86%). The addition of other variables in this regression model yielded only small and nonsignificant increases in r(2). As a direct result of this pilot, EBCLIS will include ground current measurements in its protocol, which have not previously been collected as part of an epidemiologic study. Ground currents may be important because they may be richer in 180 Hz components than are the other currents in a power system. EBCLIS will have the opportunity to examine the ground-current hypothesis in the context of female breast cancer.
Assuntos
Neoplasias da Mama/epidemiologia , Campos Eletromagnéticos , Exposição Ambiental , Poluição do Ar em Ambientes Fechados , Neoplasias da Mama/etiologia , Feminino , Habitação , Humanos , Pessoa de Meia-Idade , New York/epidemiologia , Projetos Piloto , Reprodutibilidade dos TestesRESUMO
Three independent case-control studies with similar methodologies were conducted in India, the United States and Italy to investigate risk factors by cataract type. Their common objectives were to evaluate risk factors for each cataract type, giving priority to nutritional factors, and to determine whether risk factors differed among cataract types. Data included self-reporting of food frequencies and various biochemical determinations. A higher body mass index was the only nutritional factor found by more than one study to be associated with cataract, being less frequent in cases than in controls. Blood nutritional status from one study showed that a high antioxidant index decreased risk for at least one cataract type, high glucose-6-phosphate dehydrogenase values increased risk for at least one cataract type, a high albumin globulin ratio decreased risk for mixed cataract, and high iron levels decreased risk for cortical cataract. Only one of the three studies found that a high nutritional status, high dietary antioxidant index, and use of multiple vitamin supplements decreased risk for cataract. Findings from these studies suggest socioeconomic and nutritional components to cataract risk, although not consistently across studies or cataract types. Differences between studies may be due to differences in populations and/or data collection methods. Because reducing cataract risk would have major implications for a large segment of the population, clinical trials seem appropriate to confirm and evaluate the potentially modifiable risk factors suggested by these studies.
Assuntos
Catarata/epidemiologia , Dieta/efeitos adversos , Adulto , Idoso , Estudos de Casos e Controles , Catarata/etiologia , Escolaridade , Feminino , Humanos , Índia/epidemiologia , Itália/epidemiologia , Masculino , Pessoa de Meia-Idade , Estado Nutricional , Razão de Chances , Análise de Regressão , Fatores de Risco , Luz Solar/efeitos adversos , Estados Unidos/epidemiologiaRESUMO
Age as an independent risk factor for survival of Hodgkin's disease (HD) was investigated using data for the 6345 patients in the American College of Surgeons, Patterns of Care Study. Patients were divided into those 15 to 34 years of age, and those older than 50 years. Older patients had higher rates of advanced stage and B symptoms (e.g., Stage IVB, 19.7% compared with 7.7%) and significantly higher rates of poor prognosis histologic types, odds ratio (OR) = 3.7. The older population with clinical stage (CS) I and II disease was also less likely to have received any of the selected staging procedures, bone marrow biopsy, lymphogram, or laparotomy (OR = 4.48). The two populations were equivalently understaged when CS was compared with pathologic stage (PS). In each category the older patients were more likely to have received no therapy; for PS I and II disease the OR for older patients compared with the younger patient was 2.14. When stratified by PS, B symptom status, histologic type, and treatment the older patients continued to show poorer 5-year survival by the life-table method. The authors' hypothesis--that older patients equivalently staged and treated would have no significant difference in long-term survival--was not substantiated by the data. However, in the analyses in which corrections for the known risk factors were made, the difference in survival was not as great as that in the crude, unstratified data. This study, as well as other recent studies utilizing smaller numbers of patients, finds age an independent predictor of poorer survival in HD patients.
Assuntos
Doença de Hodgkin/mortalidade , Adolescente , Adulto , Fatores Etários , Idoso , Feminino , Doença de Hodgkin/patologia , Doença de Hodgkin/terapia , Humanos , Masculino , Pessoa de Meia-Idade , Estadiamento de Neoplasias , Taxa de SobrevidaRESUMO
The reported milk consumption habits of 3,334 cancer patients and 1,300 comparable control subjects seen at Roswell Park Memorial Institute were studied. The cancer patient group included persons diagnosed with cancers of the oral cavity, stomach, colon, rectum, lung, breast, uterus, cervix, prostate, or bladder. Data were obtained by means of a standardized admissions questionnaire. As a group, control patients were more likely to report never drinking whole milk; cancer patients more often reported frequent consumption of whole milk. Relative risks of different patterns of milk consumption for specific cancer diagnoses, adjusted for sex, age, smoking history, education, and county of residence, were calculated with multiple logistic regression analysis. Elevated risks for frequent consumption of whole milk relative to not drinking milk were observed for cancers of the oral cavity, stomach, colon, rectum, lung, bladder, breast, and cervix. Reduced risks for frequent consumption of 2% milk relative to not drinking milk were observed for cancers of the oral cavity, stomach, rectum, lung, and cervix. Preference for exclusive consumption of reduced-fat milk was linked to significant risk reduction for oral and cervical cancers, and drinking only whole milk was linked to significant risk increases for cancers of the oral cavity, stomach, rectum, lung, and breast. Some associations were observed for a computed index of milk fat intake, but the overall pattern of effects was not fully explained by variations in fat content. The effects observed for some sites may be confounded by other dietary or nondietary correlates of risk.
Assuntos
Gorduras na Dieta/administração & dosagem , Leite , Neoplasias/etiologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Animais , Gorduras na Dieta/efeitos adversos , Comportamento Alimentar , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Leite/efeitos adversos , Análise Multivariada , Fatores de RiscoRESUMO
A Breast Cancer Detection Awareness Program (BCDAP) was conducted in Western New York during the spring of 1987 in conjunction with a national effort by the American Cancer Society. The importance of screening mammography was promoted by public education through the media combined with promotion of breast cancer screening services available from 26 health care providers. Women were instructed to call a hot line to receive a coupon for a low-cost mammogram, if eligible to participate. A provider directory was included to facilitate scheduling appointments. The program resulted in 6,355 women requesting a coupon. From this population 3,178 women utilized the coupon to receive a mammogram. Although the screening rate of 50% was encouraging, approximately half of the callers to the hot line did not receive a mammogram. To increase the screening rate in future programs, it would be useful to determine why some women did not take advantage of the discount coupon.
Assuntos
Neoplasias da Mama/prevenção & controle , Educação em Saúde/organização & administração , Programas de Rastreamento/organização & administração , Adulto , Idoso , Neoplasias da Mama/diagnóstico por imagem , Feminino , Educação em Saúde/normas , Humanos , Mamografia , Programas de Rastreamento/normas , Pessoa de Meia-Idade , New York , Avaliação de Programas e Projetos de SaúdeRESUMO
This paper presents results from a survey of adult women that assessed knowledge, beliefs, and practices regarding the causes, symptoms, detection methods, and treatment of breast cancer. The study population was determined through random selection of household telephone numbers from the Buffalo, New York area telephone directory. Completed interviews were collected from 563 women over the age of 18. Telephone interviews were conducted by trained interviewers, between April and July of 1985. Survey results are compared to those found in the 1979 National Cancer Institute nationwide survey on breast cancer to evaluate if ther have been changes in public awareness about the disease. Differences in knowledge, beliefs, and practices regarding breast cancer were also studied in relation to age, race, and educational background. Overall, women's knowledge about breast cancer has significantly increased since the 1979 survey. However, while more women can name mammography as a diagnostic tool only 15% of women who have heard of mammography reported having had a mammogram. Generally, younger women, white women and those with some college education were more knowledgeable about breast cancer risk factors, symptoms, detection methods, and treatments. Results from this study suggest that although knowledge about breast cancer has improved, women have not adopted recommended early detection practices. Special efforts need to be directed toward health professionals, making mammography more accessible to women who are nonwhite, older and with no college education.
Assuntos
Neoplasias da Mama , Conhecimentos, Atitudes e Prática em Saúde , Adolescente , Adulto , Feminino , Humanos , Mamografia/estatística & dados numéricos , National Institutes of Health (U.S.) , New York , Estudos de Amostragem , Inquéritos e Questionários , Estados UnidosRESUMO
We examined variations in cancer survival rates among a large number of hospitals in the United States. Survival rates for breast cancer, prostate cancer, and Hodgkin's disease were calculated from patient care studies of the American College of Surgeons and were linked to data on hospital characteristics from the surveys of the American Hospital Association. When patient, disease, treatment, and institutional characteristics were examined in multivariate analyses, medical school affiliation, residency training, and community size were not related to hospitals' cancer survival experience. Patterns of care involving greater use of staging laparotomy with splenectomy for Hodgkin's diseases, lesser use of mastectomy without axillary dissection for breast cancer and, greater use of bone scanning and lesser use of hormone therapy for prostate cancer all were associated with better survival. The differences between hospitals' survival rates were large but we found that the differences were more a function of patient characteristics, disease stage, and tumor histology than of hospital affiliations, location, size, facilities, or treatment patterns. These findings provide some data upon which future public health interventions to affect cancer mortality may be planned and evaluated.
Assuntos
Hospitais , Neoplasias/mortalidade , Neoplasias da Mama/mortalidade , Feminino , Doença de Hodgkin/mortalidade , Número de Leitos em Hospital , Masculino , Neoplasias/terapia , Afiliação Institucional , População , Neoplasias da Próstata/mortalidadeRESUMO
A review of national resources presently available for linking cancer morbidity and mortality data with information on environmental factors is presented. Additional sources of data on exposure, obtained directly from the patient or from his/her hospital record, are discussed. At the patient level, an interview questionnaire records standardized data on residential and occupational experiences and on a variety of life-style factors such as smoking, alcohol, nutrition, medication, and exercise. At the hospital level, a simple model "exposure registry" is presented which, at minimal cost, would facilitate the collection of limited data on smoking and employment (occupation/business) from the in-patient hospital admission form and from the medical and nursing notes in the patient's record. Both of these instruments represent efforts toward the development of standardized data sets on environmental and personal exposures which would constitute valuable additions to data already collected by the worldwide network of cancer registries.