Implementation opportunities and challenges to piloting a community-based drug-checking intervention for sexual and gender minority men in Vancouver, Canada: a qualitative study.

BACKGROUND: In response to the overdose crisis, a collaborative group of two community-based organizations, a health authority and a research institute in Vancouver, Canada, implemented a pilot community-based drug checking (CBDC) intervention for sexual and gender minority (SGM) men. This study identified key factors that influenced the implementation of the CBDC intervention, including opportunities and challenges. METHODS: We conducted semi-structured interviews with seven pertinent parties involved in the CBDC, including policymakers, researchers and representatives from community-based organizations. These interviews were coded and analyzed using domains and constructs of the Consolidated Framework for Implementation Research. RESULTS: While drug-related stigma was identified as a challenge to deliver drug checking services, participants described the context of the overdose crisis as a key facilitator to engage collaboration between relevant organizations (e.g., health authorities, medical health officers, community organizations) to design, resource and implement the CBDC intervention. The implementation of the CBDC intervention was also influenced by SGM-specific needs and resources (e.g., lack of information about the drug supply). The high level of interest of SGM organizations in providing harm reduction services combined with the need to expand drug checking into community spaces represented two key opportunities for the CBDC intervention. Here, SGM organizations were recognized as valued partners that fostered a broader culture of harm reduction. Participants' emphasis that knowing the composition of one's drugs is a "right to know", particularly in the context of a highly contaminated illicit drug market, emerged as a key implementation factor. Lastly, participants emphasized the importance of involving SGM community groups at all stages of the implementation process to ensure that the CBDC intervention is appropriately tailored to SGM men. CONCLUSIONS: The context of the overdose crisis and the involvement of SGM organizations were key facilitators to the implementation of a drug checking intervention in SGM community spaces. This study offers contextualized understandings about how SGM knowledge and experiences can contribute to implement tailored drug checking interventions.

Assessing options for poppers policy in Canada: A call to action for evidence-based policy reform.

When inhaled, poppers products (alkyl nitrites) relax smooth muscle tissue and produce a pleasant "rush." As such, they are used by some gay, bisexual, and other men who have sex with men (sexual minority men), including during anal intercourse. In 2013, Health Canada cracked down on poppers sales by introducing threats of fines and imprisonment and seizing poppers in stores and at the border. While no new legislation was introduced, Health Canada takes the position that poppers fall within the definition of a "drug" under the Food and Drugs Act because they "modify organic function" in humans. This crackdown has not prevented poppers use and has added harms related to an illicit and unregulated drug supply. In an effort to reduce harms and advance more equitable and public health-centred approaches to poppers drug policy, we discuss how a series of anticipated outcomes (accessibility, equity, consumer safety, commercial feasibility, and stigma) relate to the following alternative approaches to regulation: (1) poppers as a prescription medicine; (2) poppers as a non-prescription drug (likely accessible 'over-the-counter'); (3) poppers as a consumer product rather than just a medicine; and (4) ending the crackdown without legislative changes. To improve health equity and reduce harms among sexual minority men in a way that is politically and commercially feasible, we recommend the last approach-ending the crackdown without legislative changes-including ceasing the confiscation of poppers products in stores and at the border.

Queering poppers literature: A critical interpretive synthesis of health sciences research on alkyl nitrite use and Canadian policy.

BACKGROUND: Poppers (alkyl nitrites) are vasodilators used by many gay, bisexual, and other men who have sex with men (GBMSM) to relieve pain, enhance pleasure, and facilitate penetration during sex. In 2013, the Canadian government cracked down on the sale of poppers products, however prevalence of poppers use among GBMSM in Canada remains high. Poppers have been studied by medical researchers since the 1980s, yet qualitative and community-based research to inform federal policy, remains somewhat less common. METHODS: We conducted a critical interpretive synthesis (CIS) to better understand poppers health literature using the medical model of health as a point of reference. Analysis was performed using inductive and deductive methods including reflexive note-taking, mind-mapping, and close coding. 153 publications were identified to inform this review of which 5 were chosen for coding based on a purposive sampling framework. RESULTS: Our findings are unified within a theoretical construct we term responsibility. Responsibility is a construct we use to describe the bias we identified in health sciences literature regarding poppers use that tends to exaggerate the necessity for poppers cessation, and devalue both the benefits of poppers use and the perspectives and experiences of people who use poppers. The emphasis on individual behavior change within the literature appears to be motivated less by objective measures or assessments of health risks and outcomes, and more by harmful stereotypes that position gay men and people who use drugs as inherently irresponsible. CONCLUSION: We conclude by discussing how these findings have important implications for the review of current policy on poppers sales in Canada which remains influenced by a literature base prejudiced by factors such as homophobia, heteronormativity, and drug stigma, and recommend areas for future work.

Protein-induced conformational change in glycans decreases the resolution of glycoproteins in hydrophilic interaction liquid chromatography.

An understanding of why hydrophilic interaction liquid chromatography gives a higher resolution for glycans than for glycoproteins would facilitate column improvements. Separations of the glycoforms of ribonuclease B compared to its released glycans were studied using a commercial hydrophilic interaction liquid chromatography column. The findings were used to devise a new hydrophilic interaction liquid chromatography column. For the commercial column, chromatograms and van Deemter plots showed that selectivity and efficiency are comparable factors in the higher resolution of the released glycans. The higher selectivity for the released glycans was associated with more water molecules displaced per added mannose. To investigate why, three-dimensional structures of the glycoprotein and the glycan were computed under chromatographic conditions. These showed that hydrogen bonding within the free glycan makes its topology more planar, which would increase contact with the bonded phase. The protein sterically blocks the hydrogen bonding. The more globular-shaped glycan of the glycoprotein suggests that a thicker bonded phase might improve selectivity. This was tested by making a column with a copolymer bonded phase. The results confirmed that selectivity is increased. The findings are possibly broadly relevant to glycoprotein analysis since the structural motif involved in internal hydrogen bonding is common to N-linked glycans of human glycoproteins.

Community-Based Participatory Approaches to Knowledge Translation: HIV Prevention Case Study of the Investigaytors Program.

Approaches to knowledge translation (KT) that engage community stakeholders in the research cycle have been identified as particularly promising for addressing the "know-do" gap. Using the case study of a long-standing community-based participatory research (CBPR) project known as the "Investigaytors," this article describes the development and implementation of a KT intervention aimed at facilitating access to HIV pre-exposure prophylaxis for gay, bisexual, and other sexual minority men in British Columbia, Canada, through a publicly funded program. In doing so, we offer a model of CBPR for KT that is highly participatory, driven by community members, and centered around capacity building. We also present findings from a focus group with eight volunteer co-researchers to capture the perspectives of community members involved in the CBPR process and to evaluate the strengths and challenges associated with the use of a CBPR framework for KT. Findings from the focus group reveal how the inclusion of multiple perspectives from community, academic, and healthcare partners contributes to the perceived strength and credibility of the KT intervention opportunities for improving the CBPR process and how the CBPR process itself can be a form of integrated KT. This work has implications for future KT that deploys a CBPR framework, including an expanded understanding of reciprocity that can include benefits such as training and professional development, as well as introducing a novel approach to KT that is driven by community and integrates multiple perspectives. We conclude with reflections on implementing CBPR practices for KT in different settings.

Poppers, queer sex and a Canadian crackdown: Examining the experiences of alkyl nitrite use among young sexual minority men.

BACKGROUND: Poppers (i.e., alkyl nitrites) are commonly used during sex by gay, bisexual, and other men who have sex with men (sexual minority men). Poppers act as vasodilators when inhaled, resulting in a sensation some users refer to as a 'head rush', while also relaxing smooth muscles and facilitating penetration during anal sex. In 2013, Health Canada initiated a crackdown on poppers products. The current study aims to examine the experiences and perspectives of young sexual minority men who use poppers in the context of the federal crackdown. METHODS: We draw on 50 semi-structured, in-depth interviews collected from 2018 to 2019 in Vancouver with sexual minority men ages 15-30. We used a combination of both inductive and deductive techniques during data analysis to identify several key themes. RESULTS: Participants' discussions reflected positive effects of poppers use relating to sexual pleasure and bodily control. Participants used poppers to enhance pleasure, reduce pain and injury (e.g., from tears in anal tissue), and improve their capacity to "let go" and enjoy sex. Conversely, some participants described a loss of control resulting from poppers use, including experiences of dependency on poppers for sexual pleasure. Poppers were also discussed as linked to participants' personal identities as sexual minority men. In the context of the federal crackdown, uncertainty about the health effects of poppers use was high, while knowledge to safely and comfortably procure poppers in Canada was, at times, low. CONCLUSION: Poppers play an important role in the experience of sexual pleasure and the ability to reduce harms during anal sex. Unfortunately, the current crackdown restricts access to a safe and regulated supply while creating uncertainty and confusion about poppers use. We call on the federal government to bring the voices of sexual minority men to the forefront in the revisiting of the federal crackdown on poppers in Canada.