1.
Medchemcomm
; 7(11): 2076-2082, 2016 Nov 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27840672
RESUMO
We report the synthesis of two novel pyrrole-imidazole polyamides with N-terminal guanidinium or tetramethylguanidinium groups and evaluate their antiviral activity against three cancer-causing human papillomavirus strains. Introduction of guanidinium improves antiviral activity when compared to an unsubstituted analog, especially in IC90 values. These substitutions change DNA-binding preferences, while binding affinity remains unchanged.