1.
Chem Commun (Camb)
; 48(6): 901-3, 2012 Jan 21.
Artigo
em Inglês
| MEDLINE
| ID: mdl-22138854
RESUMO
Total synthesis of antimalarial diterpenoid (+)-kalihinol A, isolated from marine sponge Acanthella sp., is achieved. This total synthesis involves regioselective alkylation of an epoxide, construction of a tetrahydropyran ring by iodo-etherification, construction of a cis-decalin ring by intramolecular Diels-Alder reaction, isomerization of cis-decalin to trans-decalin, and subsequent functionalization of the trans-decalin ring.