[Combination of arterial hypertension and type 2 diabetes mellitus with obesity].

The aim of the study was to elucidate dynamics of the incidence of arterial hypertension (AH), 2 type diabetes mellitus (DM), and obesity as the main risk factor of these conditions, combinations between them and certain circulation disorders in the patients admitted to our clinic from 2003 to 2011. We analysed 25,451 case histories. Patients were regarded as having AH, DM, obesity, coronary heart disease, cardiac rhythm disturbances and cerebovascular disorders if they had verified diagnosis of nosological forms corresponding to the respective ICD-10 codes. Their occurrence was calculatedfor 3 three-year periods with reference to the mean age of the patients in different groups. It was shown that increased incidence of AH in the above time periods was associated with the enhanced occurrence of combination of AH and obesity or AH, obesity and DM. Similarly, the increased incidence of DM was associated with the enhanced occurrence of combination DM, AH, and obesity. A significant increase of the mean age was documented only in women with AH and obesity and in men with AH or AH plus obesity. The presence of DM in AH patients had no appreciable effect on the frequency of cerebrovascular pathology that increased in the presence ofAH with obesity.

[Andrological status of adolescents and its connection to anthropometric and hormonal descriptions in the students of technical college group].

The purpose of this investigation was to study the interrelation of andrological status with anthropometric and hormonal descriptions for age-specific features discovery of male sexual system pathological states at technical college students. 147 adolescents aged 15-17 years old were examined. Only 41 of them were found to have no abnormalities in their genital system development; in 35 adolescents sexual development was delayed; and 97 adolescents were found to have various andrological diseases (varicocele, phimosis, gynecomastia, testicular asymmetry, etc.) or clinical signs for development of these diseases. In 26 adolescences delayed sexual development was combined with the andrological pathology. The normal andrological status was usually accompanied with the highest frequency of low values of anthropometric indicators and indices that reflect the influence of various hormonal systems on the bodily constitution, as well as expressed anthropometricheterogeneity. In adolescents with andrological pathology or clinical signs for its development, in all anthropometric parameters the higher values were seen more frequently than low values against the background of highest group anthropometric homogeneity. Summative anthropometric characteristics of the adolescents group with delayed sexual development were between those of the adolescents groups with normal andrological status and andrological pathology The number of correlational relationships of anthropometric and hormonal indicators with the levels of cortisol and dehydroepiandrosteronesulphate was the lowest in the group of adolescents with normal andrological status as compared to their peers with delayed sexual development and andrological pathology. Only in the group of adolescents with normal andrological status the correlation analysis of data showed physiological influence of sexual hormones on anthropometric indicators. Thus, lower influence of sexual system hormones during this ontogenesis stage contributes to slowing down the process of sexual maturation both with the development of andrological pathology in adolescents.

[Adrenocortical and renin-angiotensin systems in dynamics of experimental diabetes].

Components of the adrenocortical system (adrenal and blood corticosteroid hormones and hepatic and renal 11beta-hydroxysteroid dehydrogenase activity) and also activity of the most important enzyme of the renin-angiotensin system, tissue and blood angiotensin converting enzyme (ACE) have been investigated in dynamics of alloxan diabetes. The study has shown that the initial period of diabetes is characterized by activation of synthesis and secretion of adrenocortical hormones into blood. High blood glucose and glucocorticoid honnones increase activity of the renin-angiotensin system in lungs and decrease ACE secretion into blood. This is accompanied by a decrease of activity of the renin-angiotensin system in kidneys. Subsequent progression of diabetes resulted in impairments of physiologically determined correlations between the components of these systems. Development of experimental diabetes for 30 days was accompanied by sign of a decrease of the adrenal glucocorticoid function regardless of stable impairments of carbohydrate metabolism. Under these conditions increased adrenal and hepatic 11beta-hydroxysteroid dehydrogenase activity may be responsible for maintenance of elevated levels of the main glucocorticoid in blood and tissues. Factor analysis revealed impairments in intersystem relationships between the adrenocortical and renin-angiotensin systems in experimental diabetes thus suggesting disintegration of regulatory systems.

[Age dependence of metabolic syndrome association with obesity types among women].

The study included 335 women aged 21 to 74 years. Results showed that age appears to be associated with progressive accumulation of fat tissue and magnitude of the waist-to-hip circumference ratio, which are mostly expressed in the second period of middle age. Ratio of gynoid and android species frequency among women with overweight and obesity in the first and second period of middle age groups and elderly age was 2.7:1; 1.3:1 and 0.2:1, respectively. Occurrence of metabolic syndrome in this age groups of women with gynoid species was 16.3; 18.9 and 30.0%; but with android species 62.5; 47.9 and 83.0%, respectively. Our results allow to state that women with gynoid species have the lowest risk of metabolic syndrome even in elderly age.

[Association of erectile dysfunction with hypogonadism and metabolic syndrome among men of various age groups].

The integrated study included 184 men aged from 22 to 60 years who were formed into two groups, of the first and second period of middle age. The direct relation of both erectile dysfunction frequency and expressiveness from age was developed. The same dependence was found for hypogonadism clinical features, metabolic syndrome and its components, but inverse relation was detected between age and testosterone content in blood. The presence of erectile dysfunction was associated with testosterone level reduction, hypogonadism clinical features frequency, metabolic syndrome and most its components increase without the age. It was shown that first and second period of middle age men with erectile dysfunction did not display the difference in blood testosterone content, metabolic syndrome and its components frequency. Hence, the main risk factors of erectile dysfunction development form qualitatively already in young men; they accumulate quantitatively with age producing the androgenous disorders evolution.

[The prevalence of metabolic syndrome in an organized population].

Triple screening of industrial employees (city of Mirny, West Yakutia) was carried out in 1991-2007 in conformity with the WHO/CINDI protocol designed to elucidate risk factors of chronic non-infectious diseases. The study included 2221 subjects. Metabolic syndrome (MS) was diagnosed based on criteria of NCEP-ATP III Program modified in 2005. The prevalence of MS increased during 17 years more than three-fold in both men and women (from 6 3 to 23.0% and from 9.2 to 32.4% respectively). In other words, it grows continuously. The commonest components in the structure of MS in men and women were arterial hypertension, abdominal obesity, hyperglycemia in 1991 and arterial hypertension, low HDLP cholesterol level, abdominal obesity in 2000 and 2007 (additionally, hypertriglyceridemia in men).

[Serum hormonal levels in diamond-extracting industry workers of Yakutia, with surface and underground type of work].

The authors studied influence of work type (surface or underground) on serum hormonal levels in male workers of "International" mine within diamond-extracting complex of Yakutia-Sakha Republic. The results obtained show compensation and adaptation changes of endocrine system in males engaged into underground work vs. those of surface work.

[Nature of obesity and the rate of aging in women with reproductive function disturbances].

Anthropometrics and metabolic features of obesity were determined, the rate of aging was evaluated in young women (mean age of 25,5 years) with infertility (as a result of polycystic ovary syndrome, chronic anovulation and other reproductive non-inflammatory disturbances) compared to these in different age groups of women with obesity, who have already realized their reproductive potential up to the moment of the survey. The metabolic disturbances ordinarily peculiar to mature age women, were found in women with infertility due to increased visceral fat content, which has begun to accumulate already in pre- and pubertal periods of their ontogenesis. These women showed the highest aging rate coefficient and that results in biological age growth compared with chronological one. Thus, visceral obesity early development combined with reproductive function disturbances is associated with the rate of aging increase in young women.

[Association of age-dependent magnetosensitivity dynamics with arterial hypertension].

The purpose of the research was to define magneto sensitivity degree in males depending on age and presence or absence of arterial hypertension. It has been shown, that at aging in the examined groups the number of males possessing high magneto sensitivity degree according to hypotensive type of cardiovascular reaction to magnetic test is decreasing (30,2% in children and up to 0% in males of senile age) and increasing (2,2 up to 36,0%, correspondingly) - according to hypertensive type. In the group of middle aged males with arterial hypertension the number of high magneto sensitive persons on hypertensive type was 5 times higher as compared to the group of practically healthy males of similar age. The results obtained demonstrate that at aging reactions of cardiovascular system on external physical impacts essentially change, dependence of an organism on changes of the geomagnetic field amplifies and probability of risk of hypertonic crisis development during the fluctuations of the Earth magnetic field increases.

[Complex evaluation of the impact of emerging mining industries in Northern regions on public health]. / Kompleksnaia otsenka vozdeistviia stroiashchikhsia gorno-obogatitel'nykh predpriiatii Severa na zdorov'e naseleniia.

The studies covered public health state in vicinity of concentration enterprise being built in Far North, with selecting a cohort of workers extracting diamonds in Yakutia, conducting a primary standardized health screening in accordance with WHO program. The public health state is characterized in connection with ecologic, social and economic circumstances. The authors necessitate complex evaluation of influence caused by industrial enterprises on health of workers and general population.

[The role of prevention in decreasing endocrine pathology]. / K voprosu o roli profilaktiki v snizhenii éndokrinnoi patologii.

Time course of changes in the incidence of thyroid diseases and their association with other noncontagious chronic diseases (NCCD) have been evaluated among therapeutic patients hospitalized at Research Center for Clinical and Experimental Medicine of Siberian Division of Russian Academy of Medical Sciences in 1983-1995. The incidence of thyroid diseases was low in 1983, when prevention of iodine-deficiency diseases was a state program. In 1989, when iodine deficiency prevention was reduced, the incidence of cases with enlarged gland and its dysfunction has drastically increased. In 1995, when the system of population protection from endemic goiter virtually ceased to function, the incidence of thyroid diseases increased, including such serious diseases as diffuse toxic goiter, nodular goiter, primary hypothyrosis, and autoimmune thyroiditis; the number of patients in whom thyroid diseases were concomitant with other NCCD increased. These results demonstrate the principal significance of the preventive trend in public health.

[Functional state of the thyroid gland in rats receiving an increased quantity of iodine with drinking water]. / Funktsional'noe sostoianie shchitovidnoi zhelezy u krys, poluchavshikh povyshennye kolichestva ioda s pit'evoi vodoi.

Thyroid and adrenocortical function was examined in rats fed increasing quantities of iodine with drinking water. No noticeable deviations in thyroid hormone levels were found in the blood of experimental animals. Thyroid hormone levels in thyroid tissue were changing in the same direction in the animals kept on various iodine diets, these changes depending on experiment duration: an increase of thyroxine and more so, of triiodothyronine was observed in 50 days, and reduction thereof in 90 days. In rats fed the maximal iodine dose, 8000 micrograms daily, the level of thyroglobulin in thyroid tissue decreased. Increased iodine consumption reduced the glucocorticoid function of the adrenals in experimental animals, as manifested by reduction of corticosterone levels in the adrenals, blood plasma, and reduction of nonmetabolized hormone excretion with the urine.

[The thermoregulatory response to noradrenaline in rats tested for stress or pharmacological exposures in the early postnatal period]. / Termoreguliatornyi otvet na noradrenalin u krys, ispytavshikh stressovye ili farmakologicheskie vozdeistviia v rannem postnatal'nom periode.

Norepinephrine-induced increase of the thermoconductivity of the body surface was depressed in rats exposed to cold, handling or treatment with thyroid hormone or alpha-adrenomimetic (mezatone) during the first week after birth. This effect was enhanced by prolonged cold exposure of adult animals. On the contrary, the norepinephrine-induced increase of heat losses from the tail surface was higher in new-born rats, exposed to cold or treated with beta-adrenomimetic (novodrine) than in control or mezatone-treated groups. The effects of neonatal stress or pharmacological treatment on oxygen consumption and rectal temperature responses to norepinephrine were unsignificant.

[Hormonal regulation of sodium excretion by the kidneys during hunger therapy of obese patients]. / Gormonal'naia reguliatsiia ékskretsii natriia pochkami pri lechenii golodaniem bol'nykh ozhireniem.

Sodium excretion and the blood levels of aldosterone, renin, atrial natriuretic peptide (ANP), and insulin were investigated in 9 women with obesity of alimentary-constitutional type during hunger therapy and resumed nutrition. It has been assumed that restricted sodium excretion with the kidneys during fasting is mainly caused by activation of the renin-angiotensin-aldosterone system, with ANP contributing to it, insulin not playing the major role in this process.

[Endocrine-metabolic relations in rats with genetic arterial hypertension]. / Endokrinno-metabolicheskie otnosheniia u kryss geneticheski obuslovlennoi arterial'noi gipertenziei.

Levels of triiodothyronine, thyroxine, insulin, glucose and free fatty acids in the blood; contents of adrenaline, noradrenaline in adrenals and glycogen in the liver; activity of phenylethanolamine-N-methyltransferase in adrenals, hexokinase and glucose-6-phosphatase in the liver were studied in male Wistar rats and rats with inherited stress-induced arterial hypertension /ISIAH/. It was found that genetically caused rise of hypophyseal-thyroid systems activity in ISIAH-rats leads to a decrease of insulin blood level, activation of lipolysis and breach of glucose tolerance.