Serial Changes of Fatty Degeneration and Clinical Outcomes after Repair of Medium-Sized Rotator Cuff Tears.

Background: This study was designed to longitudinally analyze quantitative intramuscular and perimuscular fat and evaluate clinical outcomes according to healing degree after rotator cuff repair. Methods: From June 2013 through October 2018, patients who had undergone repair due to medium-sized rotator cuff tears and serial chest computed tomography (CT) preoperatively and at early (6-12 months) and late (at least 3 years) postoperative follow-ups were included. Supraspinatus (SST) intramuscular fat fraction ratio (IFFR) and perimuscular fat fraction ratio (PFFR) were calculated using chest CT. The rotator cuff integrity was categorized as healed, smaller retear (SRT), and larger retear (LRT) by comparing the preoperative tear size and retear size in shoulder CT arthrography at postoperative follow-ups. Clinical outcomes were evaluated using the American Shoulder and Elbow Surgeons (ASES) score, the University of California at Los Angeles (UCLA) shoulder rating scale, and the Constant score preoperatively and at early and late postoperative follow-ups. Results: In the LRT group, compared with the preoperative values, there were increases in the SST IFFR and PFFR at the early (p = 0.002 and p = 0.006, respectively) and late (p < 0.001 and p < 0.001, respectively) postoperative time points. Late postoperative clinical scores (UCLA and Constant scores) were not improved compared to preoperative scores (p = 0.156 and p = 0.094, respectively). In the SRT group, there was no difference in the mean SST IFFR and PFFR between preoperative and early postoperative time points (p = 0.766 and p = 0.180, respectively), but the late postoperative values were higher than preoperative values (p = 0.009 and p = 0.049, respectively). Late postoperative clinical scores (ASES, UCLA, and Constant scores) in the SRT group improved compared to preoperative time (p < 0.001, p < 0.001, and p = 0.016, respectively). In the healed group, compared with the preoperative values, there was no difference in the mean SST IFFR and PFFR at postoperative time points; however, the late postoperative clinical scores (ASES, UCLA, and Constant scores) were improved (all p < 0.001). Conclusions: In the SRT group, IFFR and PFFR progressed in the late postoperative period and clinical scores improved over time. However, in the LRT group, IFFR and PFFR progressed in the early and late postoperative periods and clinical scores did not improve at the late postoperative follow-up.

Patterns of Anterior Inferior Tibiofibular Ligament Avulsion Fracture Accompanied by Ankle Fracture.

The anterior inferior tibiofibular ligament (AITFL) avulsion fracture accompanying an ankle fracture can compromise ankle stability, necessitating accurate evaluation and a clear understanding of its pathophysiology.. The aim of this study was to investigate the association between AITFL avulsion fracture and Lauge-Hansen, Wagstaffe classification. A retro-prospective study was conducted at a university-affiliated tertiary care medical center. We selected 128 patients who underwent surgery at our institution between January 2013 and July 2017 and analyzed the association between AITFL avulsion fracture and the foot position. According to the modified Wagstaffe classification system, there were 39 cases of type II, followed by 9 cases of type III and 8 cases of type IV. Of the7 pronation-abduction fractures, 3 were AITFL avulsion fracture (43%), while of the 21 pronation-external rotation fractures, 9 were AITFL avulsion fracture (43%). Of the 95 supination-external rotation fractures, there were 56 cases (59%) of AITFL avulsion fractures. Of the pronation fractures, 0% were fibular avulsion fractures and 43% were tibial avulsion fractures. Of the supination fractures, 44% were fibular avulsion fractures and 16% were tibial avulsion fracture. The difference in the ratio of fibular to tibial avulsion fractures between pronation and supination fractures was significant (p < .001). These results suggest that tibial avulsion fractures of type IV in the modified Wagstaffe classification and pronation fractures occur due to collision with the anterolateral corners of the distal bone when the talus externally rotates. Moreover, in cases of pronation fractures, a new type of AITFL avulsion fracture has been observed.

Surface distortion of FeRu nanoparticles improves the hydrogen evolution reaction performance in alkaline media.

Rational design of electrocatalysts, including an increased catalytic surface area, a unique surface structure, and improved conductivity, for facilitating the hydrogen evolution reaction (HER) is emerging as an important issue. In this work, we consider the engineering of catalyst surfaces as an effective and feasible way to accelerate the HER kinetics. By etching the surface Fe of FeRu alloy nanoparticles (NPs) using hydrofluoric acid (HF), a distorted catalytic surface of FeRu NPs was formed. The distorted surface of the HF-treated FeRu NPs was successfully analyzed by X-ray absorption spectroscopy, high-resolution photoemission spectroscopy, and electrochemical absorption/desorption experiments. The electrocatalytic HER activity of the HF-treated FeRu NPs demonstrated that surface distortion enhances the water dissociation reaction and the electron transfer rate. As a result, the surface-distorted FeRu NPs improved HER performances in alkaline media compared to the pristine FeRu alloy NP/C, commercial Ru/C, and the state-of-the-art Pt/C catalysts.

Influence of joint volume on range of motion after arthroscopic rotator cuff repair.

BACKGROUND: Capsular contracture is a well-known etiology in the primary stiff shoulder; thus capsular contracture and resultant decreased joint volume could lead to postoperative stiffness, which is a commonly reported morbidity after arthroscopic rotator cuff repair (ARCR). The purpose of this study was (1) to quantify the joint volume (total joint volume and each quadrant compartmental volume) using computed tomography arthrography (CTA) and (2) to demonstrate the relationship between joint volume and postoperative range of motion (ROM) after ARCR. MATERIALS AND METHODS: Eighty-three patients (60 ± 5.11 years, men = 26, women = 57) who had undergone ARCR between January 2015 to December 2020 due to small to medium full-thickness tear and followed by CTA 6 months postoperatively were retrospectively reviewed. An image reconstruction program (3D Slicer, version 4.11.2 software) was used to calculate the joint volume (total joint volume and quadrant compartment joint volumes; anteroinferior, anterosuperior, posterosuperior and posteroinferior). For shoulder ROM, data including scaption (Sc), external rotation on side (ERs), external rotation at 90° (ER90), and internal rotation on back (IRb) were collected 6 months postoperatively. An evaluation of the correlation between joint volume and each shoulder motion was performed. RESULTS: There were moderate correlations between the total joint volume and each motion (Sc: Pearson coefficient, 0.32, p = 0.0047; ERs: Pearson coefficient, 0.24, p = 0.0296; ER90: Pearson coefficient, 0.33, p = 0.0023; IRb: Pearson coefficient, 0.23, p = 0.0336). Among the quadrant compartments, the anteroinferior (Sc: Pearson coefficient, 0.26, p = 0.0199; ERs: Pearson coefficient, 0.23, p = 0.0336; ER90: Pearson coefficient, 0.25, p = 0.0246; IRb: Pearson coefficient, 0.26, p = 0.0168) and posterosuperior (Sc: Pearson coefficient, 0.24, p = 0.029; ER90: Pearson coefficient, 0.29, p = 0.008; IRb: Pearson coefficient, 0.22, p = 0.0491) and posteroinferior (Sc: Pearson coefficient, 0.30, p = 0.0064; ER90: Pearson coefficient, 0.29, p = 0.0072) showed moderate correlations with each shoulder motion. CONCLUSION: Total joint volume, anteroinferior compartment joint volume, posterosuperior compartment joint volume and posteroinferior compartment joint volume were related to postoperative ROM after ARCR. Perioperative methods to increase the joint volume, especially the anteroinferior, posterosuperior and posteroinferior parts of the capsule may prevent postoperative stiffness after ARCR. LEVEL OF EVIDENCE: Level III; Retrospective Case-Control Study.

Safety and Efficacy of the Baska Mask Versus Endotracheal Intubation in 64 Women Undergoing Elective Laparoscopic Gynecological Surgery Under General Anesthesia: A Prospective Single-Center Study.

BACKGROUND The Baska mask is a supraglottic airway device that has a continuous non-inflatable flexible cuff that mimics an airway, reducing the risk of overinflation and aspiration of gastric contents. This prospective study from a single center aimed to compare the safety and efficacy of the Baska mask vs endotracheal intubation (ET) in 64 women undergoing elective laparoscopic gynecological surgery in Trendelenburg position under general anesthesia. MATERIAL AND METHODS This was a prospective randomized study conducted on 64 adult female patients, 32 in each group, undergoing gynecologic surgery under general anesthesia. The study population was divided into 2 groups: the Baska group and the ET group. The respiratory and haemodynamic variables, the degree of gastric distension, and postoperative pharyngolaryngeal symptoms were compared between groups. RESULTS After 2 patients dropped out of the study, data from 62 patients were analyzed. The Baska group showed significantly shorter device insertion time (28.4±10.7 vs 46.6±19.8, P=0.001), a significantly lower oropharyngeal leak pressure at all studied time points, and a higher leak fraction at 1 min after the completion of pneumoperitoneum (5.6% vs 2.1%, P=0.031) compared to the ET group. Respiratory and haemodynamic variables, the gastric antrum size, and postoperative pharyngolaryngeal symptoms showed no significant difference. CONCLUSIONS This study supports the findings from previous studies in patients undergoing general surgery. The Baska mask was as effective as ET in ventilation during general anesthesia in women undergoing elective laparoscopic gynecological surgery. Respiratory and hemodynamic responses were similar to ET, and no complications were associated with the Baska mask in this study.

Magnesium Sulfate and Cerebral Oxygen Saturation in Mild Traumatic Brain Injury: A Randomized, Double-Blind, Controlled Trial.

Perioperative cerebral hypoperfusion/ischemia is considered to play a pivotal role in the development of secondary traumatic brain injury (TBI). This prospective randomized, double-blind, controlled study investigated whether magnesium sulfate (MgSO4) infusion was associated with neuroprotection in maintaining regional cerebral oxygen saturation (rSO2) values in patients with mild TBI undergoing general anesthesia. Immediately after intubation, we randomly assigned patients with TBI to receive either intravenous MgSO4 (30 mg/kg for 10 min, followed by a continuous infusion of 15 mg/kg/h) or a placebo (saline) during surgery. We also implemented an intervention protocol for a sudden desaturation exceeding 20% of the initial baseline rSO2. The intraoperative rSO2 values were similar with respect to the median (left. 67% vs. 66%, respectively; p = 0.654), lowest, and highest rSO2 in both groups. The incidence (left 31.2% vs. 24.3%; p = 0.521) and duration (left 2.6% vs. 3.5%; p = 0.638) of cerebral desaturations (the relative decline in rSO2 < 80% of the baseline value) were also similar for both groups. Although the patients suffered serious traumatic injuries, all critical desaturation events were restored (100%) following stringent adherence to the intervention protocol. Intraoperative remifentanil consumption, postoperative pain intensity, and fentanyl consumption at 6 h were lower in the MgSO4 group (p = 0.024, 0.017, and 0.041, respectively) compared to the control group, whereas the satisfaction score was higher in the MgSO4 group (p = 0.007). The rSO2 did not respond to intraoperative MgSO4 in mild TBI. Nevertheless, MgSO4 helped the postoperative pain intensity, reduce the amount of intraoperative and postoperative analgesics administered, and heighten the satisfaction score.

COVID-19 and hospitality 5.0: Redefining hospitality operations.

The sudden outbreak of COVID-19 has severely affected the global hospitality industry. The hygiene and cleanliness of hotels has become the focal point in the recovery plan during COVID-19. This study investigates the effects of past disasters on the global hospitality industry, and how the industry responded to them. Since past pandemics and epidemics identified hygiene and cleanliness as an important factor, this study further explores the role of technology in ensuring hygiene and cleanliness. Hence, this study further examines the scalability of Industry 5.0 design principles into the hospitality context, leading to Hospitality 5.0 to improve operational efficiency. The study further delineates how Hospitality 5.0 technologies can ensure hygiene and cleanliness in various touchpoints in customer's journey. This study serves as a foundation to understand how synergy between humans and machines can be achieved through Hospitality 5.0. The theoretical and practical implications are discussed.

Magnesium Sulfate Enables Patient Immobilization during Moderate Block and Ameliorates the Pain and Analgesic Requirements in Spine Surgery, Which Can Not Be Achieved with Opioid-Only Protocol: A Randomized Double-Blind Placebo-Controlled Study.

Spine surgery is painful despite the balanced techniques including intraoperative and postoperative opioids use. We investigated the effect of intraoperative magnesium sulfate (MgSO4) on acute pain intensity, analgesic consumption and intraoperative neurophysiological monitoring (IOM) during spine surgery. Seventy-two patients were randomly allocated to two groups: the Mg group or the control group. The pain intensity was significantly alleviated in the Mg group at 24 h (3.2 ± 1.7 vs. 4.4 ± 1.8, p = 0.009) and 48 h (3.0 ± 1.2 vs. 3.8 ± 1.6, p = 0.018) after surgery compared to the control group. Total opioid consumption was reduced by 30% in the Mg group during the same period (p = 0.024 and 0.038, respectively). Patients in the Mg group required less additional doses of rocuronium (0 vs. 6 doses, p = 0.025). Adequate IOM recordings were successfully obtained for all patients, and abnormal IOM results denoting warning criteria (amplitude decrement >50%) were similar. Total intravenous anesthesia with MgSO4 combined with opioid-based conventional pain control enables intraoperative patient immobilization without the need for additional neuromuscular blocking drugs and reduces pain intensity and analgesic requirements for 48 h after spine surgery, which is not achieved with only opioid-based protocol.

Functionalization of Molybdenum Disulfide via Plasma Treatment and 3-Mercaptopropionic Acid for Gas Sensors.

Monolayer and multilayer molybdenum disulfide (MoS2) materials are semiconductors with direct/indirect bandgaps of 1.2-1.8 eV and are attractive due to their changes in response to electrical, physicochemical, biological, and mechanical factors. Since the desired electrical properties of MoS2 are known, research on its electrical properties has increased, with focus on the deposition and growth of large-area MoS2 and its functionalization. While research on the large-scale production of MoS2 is actively underway, there is a lack of studies on functionalization approaches, which are essential since functional groups can help to dissolve particles or provide adequate reactivity. Strategies for producing films of functionalized MoS2 are rare, and what methods do exist are either complex or inefficient. This work introduces an efficient way to functionalize MoS2. Functional groups are formed on the surface by exposing MoS2 with surface sulfur vacancies generated by plasma treatment to 3-mercaptopropionic acid. This technique can create 1.8 times as many carboxyl groups on the MoS2 surface compared with previously reported strategies. The MoS2-based gas sensor fabricated using the proposed method shows a 2.6 times higher sensitivity and much lower detection limit than the untreated device.

Au nanoparticle@hollow mesoporous carbon with FeCo/graphitic shell nanoparticls as a magnetically recyclable yolk-shell nanocatalyst for catalytic reduction of nitroaromatics.

We have developed a highly stable and magnetically recyclable yolk-shell nanocatalyst for catalytic reduction of nitroaromatics. This nanocatalyst is composed of a ~13 nm Au nanoparticle encapsulated in a hollow mesoporous carbon (hmC) shell with a diameter of ~120 nm and a thickness of ~15 nm. The hmC shell contains ~6 nm FeCo/graphitic carbon shell (FeCo/GC) nanoparticles. We have synthesized the Au@hmC-FeCo/GC nanocatalyst by thermal decomposition of Fe and Co precursors in silica of a solid core/mesoporous shell structure containing a Au nanoparticle within the core, subsequent ethylene chemical vapor deposition (CVD), and then removal of the silica by treatment with aqueous HF. The Au@hmC-FeCo/GC has superparamagnetism and high saturation magnetization (29.2 emu g-1) at room temperature. It also shows a type IV sorption isotherm, typical for mesoporous carbon (pore diameter = 3.5 nm), thereby ensuring ready accessibility to the Au core by substrates. We have shown that the Au@hmC-FeCo/GC catalyses the reduction of 4-nitrophenol and 4-nitrotoluene more efficiently than Au nanoparticles do, can be separated very quickly from the reaction mixture using an magnet, and can be reused for the same reduction reaction at least five times without loss of the initial level of catalytic activity.

Highly stable mesoporous silica nanospheres embedded with FeCo/graphitic shell nanocrystals as magnetically recyclable multifunctional adsorbents for wastewater treatment.

Highly stable and magnetically separable mesoporous silica nanospheres (MSNs) embedded with 4.6 ± 0.8 nm FeCo/graphitic carbon shell nanocrystals (FeCo/GC NCs@MSNs) were synthesized by thermal decomposition of metal precursors in MSNs and subsequent methane CVD. The FeCo/GC NCs@MSNs had a high specific surface area (442 m2 g-1), large pore volume (0.65 cm3 g-1), and tunable size (65 nm, 130 nm, and 270 nm). Despite the low magnetic metal content (8.35 wt%), the FeCo/GC NCs@MSNs had a sufficiently high saturation magnetization (17.1 emu g-1). This is due to the superior magnetic properties of the FeCo/GC NCs, which also enable fast magnetic separation of the nanospheres. The graphitic carbon shell on the FeCo NCs not only protects the alloy core against oxidation and acid etching in 35% HCl(aq), but also facilitates non-covalent, hydrophobic interactions with the hydrocarbon chains of organic dyes such as methyl orange and methylene blue. Surface functionalization of the FeCo/GC NCs@MSNs with thiol groups provides efficient capacity for binding with Hg2+ ions. We have shown that the thiol-functionalized FeCo/GC NCs@MSNs (FeCo/GC NCs@MSNs-SH) work as multifunctional adsorbents for organic dyes (target organic pollutants) and Hg2+ ions (target inorganic pollutant). We also demonstrated that the FeCo/GC NCs@MSNs-SH are excellent recyclable adsorbents for methyl orange.

Shape-controlled Pt nanocubes directly grown on carbon supports and their electrocatalytic activity toward methanol oxidation.

Synthesis of shape-controlled Pt nanocrystals is substantial and important for enhancing chemical and electrochemical reactions. However, the removal of capping agents, shape-controlling chemicals, on Pt surfaces is essential prior to conducting the catalytic reactions. Here we report a facile one-pot synthesis of Pt nanocubes directly grown on carbon supports (Pt nanocubes/C) with modulating the kinetic reaction factors for shaping the nanocrystals, but without adding any capping agents for preserving the clean Pt surfaces. Well-dispersed Pt nanocubes/C shows enhanced activity and long-term stability toward methanol oxidation reaction compared to the commercial Pt/C catalyst.

A Highly Stable and Magnetically Recyclable Nanocatalyst System: Mesoporous Silica Spheres Embedded with FeCo/Graphitic Shell Magnetic Nanoparticles and Pt Nanocatalysts.

We have developed a highly stable and magnetically recyclable nanocatalyst system for alkene hydrogenation. The materials are composed of mesoporous silica spheres (MSS) embedded with FeCo/graphitic shell (FeCo/GC) magnetic nanoparticles and Pt nanocatalysts (Pt-FeCo/GC@MSS). The Pt-FeCo/GC@MSS have superparamagnetism at room temperature and show type IV isotherm typical for mesoporous silica, thereby ensuring a large enough inner space (surface area of 235.3 m(2) g(-1), pore volume of 0.165 cm(3) g(-1), and pore diameter of 2.8 nm) to undergo catalytic reactions. We have shown that the Pt-FeCo/GC@MSS system readily converts cyclohexene into cyclohexane, which is the only product isolated and Pt-FeCo/GC@MSS can be seperated very quickly by an external magnetic field after the catalytic reaction is finished. We have demonstrated that the recycled Pt-FeCo/GC@MSS can be reused further for the same hydrogenation reaction at least four times without loss in the initial catalytic activity.

Propargylic substitution reactions with various nucleophilic compounds using efficient and recyclable mesoporous silica spheres embedded with FeCo/graphitic shell nanocrystals.

Phosphomolybdic acid (PMA, H3PMo12O40) functioned as a catalyst for reactions of secondary propargylic alcohols and nucleophiles. Highly stable and magnetically recyclable mesoporous silica spheres (MMS) embedded with FeCo-graphitic carbon shell nanocrystals (FeCo/GC@MSS) were fabricated by a modified Stöber process and chemical vapor deposition (CVD) method. The FeCo/GC@MSS were loaded with phosphomolybdic acid (PMA@FeCo/GC@MSS), and their catalytic activity was investigated. Propargylic reactions of 1,3-diphenyl-2-propyn-1-ol with a wide range of nucleophiles bearing activating substituents were catalyzed under mild conditions. It was found that the MMS possess mesoporosities and have enough inner space to load FeCo and phosphomolybdic acid. The FeCo/GC@MSS were found to be chemically stable against acid etching and oxidation. This suggests that the nanocrystals can be used as a support for an acid catalyst. Moreover, the magnetic property of the nanocrystals enabled the facile separation of catalysts from the products.

Ultra-small, uniform, and single bcc-phased Fe(x)Co(1-x)/graphitic shell nanocrystals for T1 magnetic resonance imaging contrast agents.

We have synthesized ultra-small and uniform Fe(x)Co(1-x)/graphitic carbon shell (Fe(x)Co(1-x)/GC) nanocrystals (x=0.13, 0.36, 0.42, 0.50, 0.56, and 0.62, respectively) with average diameters of <4 nm by thermal decomposition of metal precursors in approximately 60 nm MCM-41 and methane CVD. The composition of the Fe(x)Co(1-x)/GC nanocrystals can be tuned by changing the Fe:Co ratios of the metal precursors. The Fe(x)Co(1-x)/GC nanocrystals show superparamagnetic properties at room temperature. The Fe(0.50)Co(0.50)/GC, Fe(0.56)Co(0.44)/GC, and Fe(0.62)Co(0.38)/GC nanocrystals have a single bcc FeCo structure, whereas the Fe(0.13)Co(0.87)/GC, Fe(0.36)Co(0.64)/GC, and Fe(0.42)Co(0.58)/GC nanocrystals have a mixed structure of bcc FeCo and fcc Co. The single bcc-phased Fe(x)Co(1-x)/GC nanocrystals functionalized with phospholipid-poly(ethylene glycol) (PL-PEG) in phosphate buffered saline (PBS) are demonstrated to be excellent T(1) MRI contrast agents.

Variations in process and outcome in inpatient palliative care services in Korea.

PURPOSES: Hospice programs in Korea have been largely based on volunteer activity, religious services, or social services. Recent government policy of designating medically based inpatient palliative care services and per diem payment system made it necessary to monitor the quality of these services. We examined the variation in the process and outcomes of palliative care services, using 2009 data obtained from the Korean Terminal Cancer Patient Information System. METHODS: Data were collected from 3,867 patients with terminal cancer who were registered in 34 inpatient palliative care centers designated by the Ministry of Health and Welfare. We used the mean length of stay and the subsequent place of care as process indicators, and change in average pain score as an outcome indicator. The data were analyzed using descriptive statistics, and analysis of covariance for the case-mix adjustment. RESULTS: There were considerable variations among services with regards to the mean length of stay (i.e., 10.5 to 32.6 days for each admission) and subsequent place of care (i.e., 39.8% to 92.6% ended in death at the first admission), even after stratification by service level. The mean change in average pain score varied from -1.48 to 2.16, and remained significant after case-mix adjustment. CONCLUSION: We found considerable variations among palliative care services with regard to the mean length of stay, subsequent place of care, and change in average pain score. Continued assessment of the variations in process and outcomes will assist in developing the national benchmarking system and the evaluation of the government policy.

Assembly of individual TiO2-C60/porphyrin hybrid nanoparticles for enhancement of photoconversion efficiency.

Rational organization of porphyrin and C60 on the electrode surface in photovoltaic structures is essential to yield high quantum efficiency. In the present work, individual TiO2 nanoparticles were modified by introducing C60 and porphyrin units on the surface, and then electrophoretically deposited on an ITO/SnO2 electrode. The morphology of the photoactive layer on the electrode was significantly different from that of the layer produced as a result of separate deposition of C60 and porphyrin. The maximum incident photon to current efficiency of the resulting electrode approached 88% at 410 nm, which is the highest value among molecule-based photovoltaic cells reported to date. This indicates that molecular assembly of the C60 and porphyrin units on the individual nanoparticles through strong chemical attachment is a key factor in improving effective electron transfer between the photoactive units and the electrodes.

The role of water for the phase-selective preparation of hexagonal and cubic cobalt oxide nanoparticles.

A selective preparation and the formation mechanism of hexagonal and cubic CoO nanoparticles from the reaction of [Co(acac)(2)] (acac=acetylacetonate) and amine have been investigated. CoO nanoparticles with a hexagonal pyramidal shape were yielded under decomposition conditions with amine. Importantly, the addition of water altered the final phase to cubic and comprehensively changed the reaction mechanism. The average sizes of the hexagonal and cubic CoO nanoparticles could be controlled either by changing the amine concentration or by using different reaction temperatures. Detailed formation mechanisms are proposed on the basis of gas chromatography-mass spectrometry data and color changes of the reaction mixture. The hexagonal CoO phase is obtained through two distinct pathways: solvolysis with C-C bond cleavage and direct condensation by amine. On the other hand, the cubic CoO nanoparticles were synthesized by strong nucleophilic attack of hydroxide ions from water and subsequent C-C bond breaking. The resulting caboxylate ligand can stabilize a cobalt hydroxide intermediate, leading to the generation of a thermodynamically stable CoO phase.

Expression of endometrial protein markers in infertile women and the association with subsequent in vitro fertilization outcome.

Endometrial biopsies were performed during the luteal phase just before an IVF cycle in 104 infertile women, and immunohistochemical staining was performed to investigate expression patterns of hCG-LH receptor, leukemia-inhibitory factor, macrophage colony-stimulating factor, HOXA-10, vascular endothelial growth factor A, and their relation to subsequent IVF pregnancy. Only glandular expression of vascular endothelial growth factor A in early luteal endometrium was significantly higher in the pregnant group compared with the nonpregnant group (6.0 ± 3.9 vs. 2.9 ± 3.4) and thus could be a predicting marker for subsequent IVF pregnancy.

High-contrast in vivo visualization of microvessels using novel FeCo/GC magnetic nanocrystals.

FeCo-graphitic carbon shell nanocrystals are a novel MRI contrast agent with unprecedented high per-metal-atom-basis relaxivity (r(1) = 97 mM(-1) sec(-1), r(2) = 400 mM(-1) sec(-1)) and multifunctional capabilities. While the conventional gadolinium-based contrast-enhanced angiographic magnetic MRI has proven useful for diagnosis of vascular diseases, its short circulation time and relatively low sensitivity render high-resolution MRI of morphologically small vascular structures such as those involved in collateral, arteriogenic, and angiogenic vessel formation challenging. Here, by combining FeCo-graphitic carbon shell nanocrystals with high-resolution MRI technique, we demonstrate that such microvessels down to approximately 100 mum can be monitored in high contrast and noninvasively using a conventional 1.5-T clinical MRI system, achieving a diagnostic imaging standard approximating that of the more invasive X-ray angiography. Preliminary in vitro and in vivo toxicity study results also show no sign of toxicity.