Chronic exposure to PM10 induces anxiety-like behavior via exacerbating hippocampal oxidative stress.

As one of the most environmental concerns, inhaled particulate matter (PM10) causes numerous health problems. However, the associations between anxiety behavior and toxicity caused by PM10 have rarely been reported so far. To investigate the changes of behavior after PM10 exposure and to identify the potential mechanisms of toxicity, PM10 samples (with doses of 15 mg/kg and 30 mg/kg) were intratracheally instilled into rats to simulate inhalation of polluted air by the lungs. After instillation for eight weeks, anxiety-like behavior was evaluated, levels of oxidative stress and morphological changes of hippocampus were measured. The behavioral results indicated that PM10 exposure induced obvious anxiety-like behavior in the open field and elevated plus maze tests. Both PM10 concentrations tested could increase whole blood viscosity and trigger hippocampal neuronal damage and oxidative stress by increasing superoxide dismutase (SOD) activities and malondialdehyde levels, and decreasing the expressions of antioxidant-related proteins (e.g., nuclear factor erythroid 2-related factor 2 (Nrf2), SOD1 and heme oxygenase 1). Furthermore, through collecting and analyzing questionnaires, the data showed that the participants experienced obvious anxiety-related emotions and negative somatic responses under heavily polluted environments, especially PM10 being the main pollutant. These results show that PM10 exposure induces anxiety-like behavior, which may be related to suppressing the Nrf2/Keap1-SOD1 pathway.

Alternate-day fasting ameliorated anxiety-like behavior in high-fat diet-induced obese mice.

Alternate-day fasting (ADF) has been reported to reduce body weight, neuroinflammation, and oxidative stress damage. However, it is not known whether ADF affects obesity-induced anxiety-like behavior. Here, male C57BL/6 mice were given an alternate fasting and high-fat diet (HFD) or standard chow diet (SD) every other day for 16 or 5 weeks. After the intervention, the degree of anxiety of the mice was evaluated by the open field test (OFT) and the elevated plus maze (EPM) test. Pathological changes in the hippocampus, the expression of Sirt1 and its downstream protein monoamine oxidase A (MAO-A) in the hippocampus, and the expression of 5-hydroxytryptamine (5-HT) were detected. Compared with HFD-fed mice, HFD-fed mice subjected to ADF for 16 weeks had a lower body weight but more brown adipose tissue (BAT), less anxiety behavior, and less pathological damage in the hippocampus, and lower expression of Sirt1 and MAO-A protein and higher 5-HT levels in the hippocampus could be observed. In addition, we noted that long-term ADF intervention could cause anxiety-like behavior in SD mice. Next, we changed the intervention time to 5 weeks. The results showed that short-term ADF intervention could reduce the body weight and increase the BAT mass of SD mice, but it did not affect anxiety. These results indicated that long-term ADF ameliorated obesity-induced anxiety-like behavior and hippocampal damage, but caused anxiety in normal-weight mice. Short-term ADF did not produce adverse emotional reactions in normal-weight mice. Here, we might provide new ideas for the treatment of obesity-induced anxiety.

Wide-spectrum laser beam shaping for full-color volume holographic optical element recording.

For homogeneous diffraction efficiency of the recorded volume holographic optical element (vHOE), a recording beam of uniform intensity is required. A multicolor vHOE is recorded by an RGB laser source with Gaussian intensity distribution; during equal exposure time, recording beams of different intensities would result in different diffraction efficiencies in different recording areas. In this paper, we present a wide-spectrum laser beam shaping system design method, by which the incident RGB laser beam can be controlled into uniform intensity distribution with a spherical wavefront. This beam shaping system can be added to any recording system to obtain uniform intensity distribution without altering the beam shaping effect of the original recording system. The proposed beam shaping system is composed of two aspherical lens groups, and the design method with an initial point design and optimization design method is given. An example is built to demonstrate the feasibility of the proposed beam shaping system.

Tailoring high-performance illumination lenses for extended non-Lambertian sources.

A key challenge in tailoring compact and high-performance illumination lenses for extended non-Lambertian sources is to take both the étendue and the radiance distribution of an extended non-Lambertian source into account when redirecting the light rays from the source. We develop a direct method to tailor high-performance illumination lenses with prescribed irradiance properties for extended non-Lambertian sources. A relationship between the irradiance distribution on a given observation plane and the radiance distribution of the non-Lambertian source is established. Both edge rays and internal rays emanating from the extended light source are considered in the numerical calculation of lens profiles. Three examples are given to illustrate the effectiveness and characteristics of the proposed method. The results show that the proposed method can yield compact and high-performance illumination systems in both the near field and far field.

High-performance imaging with an advanced non-imaging lens based on full-path optical diffraction calculation in two-dimensional space.

High-performance image-forming systems often require high system complexity due to the overdetermined nature of optical aberration correction. What we present here is a novel computational imaging modality which can achieve high-performance imaging using a simple non-image-forming optical system. The presented optical system contains an aspherical non-imaging lens which is designed with the optimal transfer of light radiation between an object and a detector. All spatial frequencies of the object collected by the non-imaging lens are delivered to the detector. No image is formed on the detector, and a full-path optical diffraction calculation method is developed to recover a high-quality image of the object from multiple intensity measurements. The effectiveness and high performance of the proposed imaging modality is verified by the examples.

Calculation of aberration fields for freeform imaging systems using field-dependent footprints on local tangent planes.

Aberration theory is a fundamental understanding of the optical aberrations and remains the best way to guide optical system design. The nodal aberration theory, which can be used to describe the aberration fields of freeform imaging systems, is limited by the small field of view (FOV) of the imaging system. In this paper, we propose a method to predict the induced aberration of Fringe Zernike terms with field-dependent footprints. The footprint of each field point is calculated in its corresponding local tangent plane of the optical surface; therefore, a more accurate prediction of the induced aberrations of Fringe Zernike terms can be achieved. Both the FOV and highly tilted architecture of freeform imaging systems are considered when calculating the footprints. Two examples are presented to verify the effectiveness of the proposed method, which we believe can provide good guidance for the design of freeform imaging systems with a relatively large FOV.

Freeform optical design of beam shaping systems with variable illumination properties.

Freeform optics constitutes a new technology that is currently driving substantial changes in beam shaping. Most of the current beam shaping systems are elaborately tailored for fixed optical properties, which means the output light distribution of a beam shaping system usually cannot be changed. What we present here is a class of beam shaping systems, the optical properties of which can be changed to meet the requirements for different applications. The proposed beam shaping system is composed of a freeform lens and a non-classical zoom system which is designed by ray aiming and the conservation of energy instead of aberration control. The freeform lens includes two elaborately designed freeform optical surfaces, by which both the intensity distribution and wave-front of an incident light beam are manipulated in a desired manner. The light beam after propagating through the non-classical zoom system produces an illumination pattern on a fixed observation plane with a variable pattern size and an unchanged irradiance distribution at different zoom positions. Two design examples are presented to demonstrate the effectiveness of the proposed beam shaping systems.