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2.
J Electrocardiol ; 48(3): 423-5, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-25804484

RESUMO

Electrocardiographic characteristics of Wellens syndrome (WS) consist of deeply inverted T waves or biphasic T waves in anterior precordial leads. Studies have shown that patients with WS have critical stenosis or complete obstruction of the proximal left anterior descending coronary artery (LAD) and high risk for the development of extensive anterior myocardial infarction. Here, we reported a case presenting with WS and with a small plaque in the proximal LAD and slow flow in the LAD other than significant stenosis of the proximal LAD detected by coronary angiography. The mechanisms for WS of our case are discussed.


Assuntos
Arritmias Cardíacas/diagnóstico , Arritmias Cardíacas/etiologia , Vasoespasmo Coronário/complicações , Vasoespasmo Coronário/diagnóstico , Eletrocardiografia/métodos , Adulto , Diagnóstico Diferencial , Humanos , Masculino , Síndrome
3.
Acta Cardiol ; 64(6): 779-85, 2009 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-20128155

RESUMO

OBJECTIVE: The objective of this study was to investigate the effect of simvastatin on TLR4,TNF-alpha and IL-6 expression in the myocardium and its relation to left ventricular (LV) remodelling in a rat model of myocardial infarction (MI) and to investigate the mechanism by which simvastatin improves LV remodelling in rats after MI. METHODS AND RESULTS: The rat MI models were established by ligation of the left anterior descending coronary artery and divided into three groups: (I) an untreated MI group; (2) a group treated with simvastatin [40 mg/(kg/d)] for 4 weeks; (3) the sham group. Cardiac geometry and function were determined by echocardiography and infarct size was determined by the histomorphometric analysis; the expression ofTLR4 in the myocardium was measured by RT-PCR and western blotting;TNF-alpha and IL-6 levels in myocardial homogenate and serum were measured by ELISA. LVEDD and LVESD significantly increased and fractional shortening (FS) markedly decreased in the MI group. It was clear that simvastatin inhibited LV dilation and improved LV function after MI without affecting infarct size. The expression of TLR4, TNF-alpha and IL-6 in the myocardium significantly increased in the MI group and simvastatin markedly inhibits the expression of TLR4, TNF-alpha, and IL-6 in the myocardium after MI. Serum TNF-alpha and IL-6 levels between the MI group and the simvastatin group remained unchanged. Both in the MI group and the simvastatin group,TLR4 protein positively related to LVEDD and to the levels of TNF-alpha and IL-6 in the myocardium, respectively. CONCLUSION: Amelioration of LV remodelling in rats after MI by simvastatin might be associated with its effect on the TLR4-mediated signalling pathway in the myocardium.


Assuntos
Anticolesterolemiantes/farmacologia , Infarto do Miocárdio/fisiopatologia , Sinvastatina/farmacologia , Receptor 4 Toll-Like/efeitos dos fármacos , Remodelação Ventricular/fisiologia , Animais , Dilatação Patológica , Endotélio Vascular/efeitos dos fármacos , Proteínas de Choque Térmico HSP70/sangue , Interleucina-6/sangue , Masculino , Infarto do Miocárdio/patologia , Ratos , Fator de Necrose Tumoral alfa/sangue , Remodelação Ventricular/efeitos dos fármacos
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