Assuntos
Neoplasias Encefálicas/prevenção & controle , Leucemia-Linfoma Linfoblástico de Células Precursoras/prevenção & controle , Neoplasias da Medula Espinal/prevenção & controle , Adolescente , Encéfalo/efeitos da radiação , Neoplasias Encefálicas/radioterapia , Criança , Pré-Escolar , Feminino , Humanos , Injeções Espinhais , Masculino , Metotrexato/administração & dosagem , Metotrexato/uso terapêutico , Leucemia-Linfoma Linfoblástico de Células Precursoras/radioterapia , Recidiva , Estudos Retrospectivos , Neoplasias da Medula Espinal/radioterapiaRESUMO
Any significant change in the pharmacokinetics of an anticancer drug would have a bearing on its therapeutic efficacy and toxicity. Nutritional deficiencies have been shown to affect the pharmacokinetics of a drug. Since malnutrition and undernutrition are widely prevalent in India, the effect of initial nutritional status on the overall kinetics of methotrexate (MTX) administered to cancer patients appeared to be of practical importance. A study of 6 Indian children with malignancies was made to examine the pharmacokinetics of low dose MTX and its relationship to the nutritional status. The results indicate that the relative weight correlates well with the anthropometric parameters, nutritional parameters and dietary intake and may be used as a marker of nutritional status.
Assuntos
Metotrexato/metabolismo , Estado Nutricional , Adolescente , Antropometria , Proteínas Sanguíneas/análise , Criança , Pré-Escolar , Feminino , Humanos , Índia , Lactente , Cinética , Masculino , Metotrexato/uso terapêutico , Neoplasias/tratamento farmacológicoAssuntos
Leucemia Linfoide/patologia , Linfócitos/patologia , Adolescente , Adulto , Medula Óssea/patologia , Criança , Pré-Escolar , Feminino , Humanos , Lactente , Masculino , Pessoa de Meia-Idade , RecidivaRESUMO
Cardiac involvement in the form of pericardial effusion or tamponade as the initial feature of extracardiac malignancy is extremely rare. An extensive search of medical literature yielded only 36 such cases. A case is presented and literature reviewed.
Assuntos
Adenocarcinoma/complicações , Tamponamento Cardíaco/etiologia , Derrame Pericárdico/etiologia , Adenocarcinoma/diagnóstico , Adenocarcinoma/tratamento farmacológico , Adulto , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Resfriado Comum/etiologia , Doxorrubicina/administração & dosagem , Dispneia/etiologia , Feminino , Fluoruracila/administração & dosagem , Humanos , Masculino , Mitomicina , Mitomicinas/administração & dosagem , Derrame Pericárdico/complicaçõesAssuntos
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Neoplasias da Mama/tratamento farmacológico , Neoplasias da Mama/patologia , Terapia Combinada , Ciclofosfamida/administração & dosagem , Feminino , Fluoruracila/administração & dosagem , Humanos , Índia , Metotrexato/administração & dosagem , Estadiamento de NeoplasiasAssuntos
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Leucemia Linfoide/tratamento farmacológico , Criança , Terapia Combinada , Doxorrubicina/administração & dosagem , Feminino , Humanos , Masculino , Metotrexato/administração & dosagem , Prednisolona/administração & dosagem , Indução de Remissão , Vincristina/administração & dosagemRESUMO
The activity of a heat labile variant of Regan type alkaline phosphatase (HLRI) was studied in the serum of 38 histologically proved patients with Hodgkin's disease. The activity was also studied in 40 normal healthy adults matched for age and sex as control. HLRI was significantly elevated in patients with Hodgkin's disease in comparison with normal controls (1.12 +/- 0.12 units/ml vs 0.09 +/- 0.01 units/ml; P less than 0.001). The mean values of the isoenzyme tended to increase progressively with increasing stages of disease, reflecting a significant linear trend (P less than 0.001). The serial measurement of this variant may serve as a useful parameter in assessing disease activity and response to chemotherapy.
Assuntos
Doença de Hodgkin/enzimologia , Isoenzimas/sangue , Placenta/enzimologia , Adulto , Fosfatase Alcalina , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Proteínas Ligadas por GPI , Doença de Hodgkin/tratamento farmacológico , Doença de Hodgkin/patologia , Temperatura Alta , Humanos , Isoenzimas/genética , Mecloretamina/administração & dosagem , Estadiamento de Neoplasias , Prednisona/administração & dosagem , Procarbazina/administração & dosagem , Vincristina/administração & dosagemRESUMO
Since anticancer drugs have a low therapeutic index, any significant change in the pharmacokinetics of a drug would have a bearing on therapeutic efficacy and drug toxicity. Nutritional deficiencies have been shown to affect the four processes of pharmacokinetics, ie, absorption, distribution, biotransformation, and excretion. Malnutrition and undernutrition are widely prevalent in India and thus it was thought to be of practical importance to study the effect of initial nutritional status on the overall kinetics of methotrexate, a widely used anticancer drug. The results of the study reveal that relative weight correlates well with the anthropometric parameters, nutritional parameters, and dietary intake and may be used as a marker of nutritional status. When grouped on the basis of relative weights, the undernourished patients revealed a significant (P less than 0.01) prolongation of biological half-life and a significant (P less than 0.001) reduction in clearance. Based on these results, relative weight has been proposed as a basis for drug dosage determinations in place of the existing practice of administering antineoplastic drugs on the basis of body surface area or body weight alone.