1.
Mar Drugs
; 16(11)2018 Oct 30.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30380702
RESUMO
Alotamide is a cyclic depsipetide isolated from a marine cyanobacterium and possesses a unique activation of calcium influx in murine cerebrocortical neurons (EC50 4.18 µM). Due to its limited source, the three stereocenters (C19, C28, and C30) in its polyketide fragment remain undetermined. In this study, the first asymmetric synthesis of its polyketide fragment was achieved. Four relative possible diastereomers were constructed with a boron-mediated enantioselective aldol reaction and Juliaâ»Kocienski olefination as the key steps. Comparison of 13C NMR spectra revealed the relative structure of fragment C15â»C32 of alotamide.