RESUMO
With an increasing number of interventional radiology (IVR) procedures, it is a critical issue to control and reduce the radiation dose for patients by radiological technologists. In our study, we analyzed the usefulness of a provision for radiation reduction on catheter ablation and percutaneous coronary intervention (PCI) procedures based on the data from radiation information system (RIS). With regard to catheter ablation, 50% reduction was enabled with decreasing fluoroscopic and radiographic conditions regardless of each technique. Radiation reduction enabled a decrease in the fluoroscopic dose during PCI procedure. However, note that excessive radiation reduction does not show positive results of the radiation dose reduction. Moreover it leads to an increase in fluoroscopic time.
Assuntos
Ablação por Cateter/métodos , Intervenção Coronária Percutânea/métodos , Doses de Radiação , Feminino , Fluoroscopia , Humanos , Masculino , Pessoa de Meia-Idade , Proteção Radiológica/métodos , Sistemas de Informação em RadiologiaRESUMO
A new class of dye-based MRI contrast agents, EB-DTPA-Gd, was designed and synthesized. The contrast agent was found to accumulate at the site of endothelial injury when the reagent was applied to isolated porcine blood vessels or in an ex vivo experiment using rat. In vivo MR detection of vascular endothelial injury was also successful in rat with its common carotid artery injured by balloon treatment. These results indicate that EB-DTPA-Gd is potentially useful for the diagnosis of vascular diseases.
Assuntos
Meios de Contraste/química , Gadolínio DTPA/análogos & derivados , Imageamento por Ressonância Magnética/métodos , Doenças Vasculares/diagnóstico , Animais , Aorta/patologia , Lesões das Artérias Carótidas/diagnóstico , Cateterismo/efeitos adversos , Meios de Contraste/farmacocinética , Modelos Animais de Doenças , Desenho de Fármacos , Endotélio Vascular/patologia , Gadolínio DTPA/farmacocinética , Ratos , Suínos , Distribuição TecidualRESUMO
A new MRI-contrast agent, EB-DTPA-Gd, that has an Evans Blue analogue as a sensing unit for endothelium lesions, was designed and synthesized. The agent also has diethylenetriamine-N,N,N',N",N"-pentaacetic acid-Gd complex (Gadolinium-DTPA) units, which have been used as detection units for T1-weighted MRI. The EB-DTPA-Gd was able to recognize and adsorb to the vascular endothelium-denuded region of porcine aorta, and to decrease the relaxation time of circumferential water's protons, making possible MR imaging of the endothelium-denuded region. The compound can be employed as a contrast agent for the imaging of vascular lesions using MRI.