1.
Beilstein J Org Chem
; 14: 182-186, 2018.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29441140
RESUMO
Discribed in this article is a versatile and practical method for the synthesis of C3-perfluoroalkyl-substituted phthalides in a one-pot manner. Upon treatment of KF or triethylamine, 2-cyanobenzaldehyde reacted with (perfluoroalkyl)trimethylsilanes via nucleophilic addition and subsequent intramolecular cyclization to give perfluoroalkylphthalides in good yields.