Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 31
Filtrar
1.
Kathmandu Univ Med J (KUMJ) ; 20(77): 119-121, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36273306

RESUMO

This is a case report of inadvertent right celiac plexus denudation during triangle dissection during the surgery for carcinoma of pancreas under combined general epidural anaesthesia. Operative removal of the ganglia has its own autonomic effects, which are important to observe for anesthesiologists and perioperative critical care physicians alike.


Assuntos
Anestésicos , Carcinoma , Plexo Celíaco , Humanos , Anestesia Geral
2.
Kathmandu Univ Med J (KUMJ) ; 19(73): 148-151, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34812176

RESUMO

This is a case report of successful use of ultrasound for stellate ganglion (SG) blocks in CRPS I in 11 patients using local anesthetic bupivacaine with injection dexmedetomidine as an adjunct. Ultrasound helped us to deposit Local anesthetics in target area without any noticeable side effects and trauma to adjacent structures.


Assuntos
Bloqueio Nervoso Autônomo , Síndromes da Dor Regional Complexa , Dexmedetomidina , Anestésicos Locais , Humanos , Gânglio Estrelado/diagnóstico por imagem , Ultrassonografia de Intervenção
3.
Kathmandu Univ Med J (KUMJ) ; 17(68): 350-351, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-33311049

RESUMO

Endourological procedures are commonly performed in our daily practice. Most of the time, this type of surgery is usually performed under regional anesthesia and is usually not associated with any complications. The irrigation pump used in such procedures consists of irrigating fluid flowing in high pressure. If left unnoticed, sometimes irrigating fluid can lead to passage of air into the patient venous system leading to air embolism. This can be a disastraous complication leading to even sudden mortality. Here we present a case of such incident where patient has sudden coughing followed by drop in oxygen saturation.


Assuntos
Embolia Aérea , Tosse , Humanos
4.
JNMA J Nepal Med Assoc ; 56(206): 265-267, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-28746327

RESUMO

In routine practice, regional anaesthesia is less commonly used for clavicular fracture compared to general anaesthesia. We report two cases of clavicle fracture for which operative treatment was done under combined superficial cervical plexus and interscalene brachial plexus block. In both the cases combination of ropivacaine and dexmeditomidine was used for block. Both the patients exhibited comfort and there was no additional analgesic demand in both the cases. Thus combination of interscalene and superficial cervical plexus block can prove to be useful in patients with clavicle fracture where administration of general anaesthesia and its adverse effects could be avoided.


Assuntos
Anestesia por Condução/métodos , Bloqueio do Plexo Braquial , Bloqueio do Plexo Cervical , Clavícula , Fixação de Fratura , Fraturas Ósseas/cirurgia , Dor Pós-Operatória/prevenção & controle , Ropivacaina/administração & dosagem , Adulto , Anestésicos Locais/administração & dosagem , Bloqueio do Plexo Braquial/instrumentação , Bloqueio do Plexo Braquial/métodos , Bloqueio do Plexo Cervical/instrumentação , Bloqueio do Plexo Cervical/métodos , Clavícula/lesões , Clavícula/cirurgia , Fixação de Fratura/efeitos adversos , Fixação de Fratura/métodos , Humanos , Masculino , Cirurgia Assistida por Computador/métodos , Resultado do Tratamento , Ultrassonografia/métodos
5.
Faraday Discuss ; 180: 191-204, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-25920488

RESUMO

The structure and chemistry of thiol or selenol self-assembled organic monolayers have been frequently addressed due to the unique opportunities in functionalization of materials. Such organic films can also act as effective inhibition layers to mitigate oxidation or corrosion. Cu-Au alloy substrates covered by self-assembled monolayers show a different dealloying mechanism compared to bare surfaces. The organic surface layer inhibits dealloying of noble metal alloys by a suppression of surface diffusion at lower potentials but at higher applied potentials dealloying proceeds in localized regions due to passivity breakdown. We present an in situ atomic force microscopy study of a patterned thiol layer applied on Cu-Au alloy surfaces and further explore approaches to change the local composition of the surface layers by exchange of molecules. The pattern for the in situ experiment has been applied by micro-contact printing. This allows the study of corrosion protection with its dependence on different molecule densities at different sites. Low-density thiol areas surrounding the high-density patterns are completely protected and initiation of dealloying proceeds only along the areas with the lowest inhibitor concentration. Dealloying patterns are highly influenced and controlled by molecular thiol to selenol exchange and are also affected by introducing structural defects such as scratches or polishing defects.


Assuntos
Ligas/química , Cobre/química , Corrosão , Ouro/química , Microscopia de Força Atômica
6.
Public Health Action ; 3(1): 90-2, 2013 Mar 21.
Artigo em Inglês | MEDLINE | ID: mdl-26393004

RESUMO

This study assessed the characteristics of beneficiaries of a government-led policy of exemption for payment being provided in a regional hospital in Nepal. In January and February 2012, 9547 patients sought services at the out-patient clinic, the majority (83%) of whom were from the same district although this was a referral hospital for 15 districts. Only 10.8% received exemption from payment; 66% of the individuals aged >60 years and eligible for exemption were missed. These shortcomings highlight intrinsic weaknesses in the current implementing mechanisms for payment exemption, which may not be providing financial protection. This hampers efforts towards achieving universal health coverage.


Cette étude a évalué les caractéristiques des bénéficiaires d'une politique d'exemption de paiement menée par le Gouvernement du Népal dans un hôpital régional. Pendant les mois de janvier et février 2012, 9547 patients ont bénéficié des services de la polyclinique externe ; la majorité d'entre eux (83%) provenaient du même district en dépit du fait que l'hôpital régional servait d'hôpital de référence pour 15 districts. Seuls 10,8% des patients ont bénéficié de l'exception de paiement. Celle-ci n'a pas été attribuée à 66% des individus âgés de >60 ans et éligibles pour cette exemption. Ces déficiences témoignent de la faiblesse intrinsèque des mécanismes actuels de mise en œuvre de l'exemption de payement, ce qui pourrait entraîner l'absence d'apport d'une protection financière et entraver les efforts visant à réaliser la couverture universelle de santé.


En el presente estudio se evaluaron las características de los beneficiarios de una política gubernamental de exoneración del pago en un hospital regional de Nepal. Entre enero y febrero del 2012, 9547 pacientes recurrieron a los servicios de un dispensario clínico; la mayoría de las personas (83%) provenía de un mismo distrito, aunque el hospital de referencia atiende a la población de 15 distritos. Solo 10,8% se beneficiaron de la exención de pago; 66% de las personas > 60 años que cumplían con los requisitos de adjudicación no recibieron la ayuda. Estas fallas indican debilidades intrínsecas en los mecanismos vigentes de aplicación de la medida de exoneración de pago, con lo cual tal vez no se ofrece la protección económica adecuada y se obstaculizan las iniciativas encaminadas a lograr la cobertura universal de salud.

7.
J Nepal Health Res Counc ; 10(1): 41-6, 2012 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-22929636

RESUMO

BACKGROUND: The aim of the study is to investigate the effect of oral gabapentin or clonidine versus placebo premedication on haemodynamic and endocrine responses in patients of American Society of Anesthesiology (ASA) physical status I and II undergoing laparoscopic cholecystectomy. METHODS: This was a randomized prospective double-blinded comparative study of 75 ASA I and II patients with three groups: clonidine, gabapentin and placebo group having 25 patients in each. They were randomly allocated to receive 600 mg oral gabapentin or clonidine 150 mcg one hour prior to induction of anesthesia and a placebo group. Hemodynamic parameters were recorded before pneumoperitonium (PP) and every 5 minutes till 35 minutes of post PP. Blood samples for serum glucose and cortisol were collected before PP and 10 mins after PP. The investigators were blinded to what the patients received. RESULTS: With similar demographic profiles and baseline haemodynamics in three groups (p>0.05) significant rise in haemodynamic parameters were observed in placebo group at different time points before and following PP where as those parameters remained stable in gabapentin and clonidine group (p<0.05). The serum cortisol level was high in placebo group before PP than in two other groups, p<0.05. The same marker measured at 10th minute after PP was significantly higher in placebo group than that in clonidine or gabapentin group, p<0.05. CONCLUSIONS: Oral clonidine or gabapentin premedication offers intraoperative haemodynamic stability in laparoscopic cholecystectomy. When serum cortisol is taken as a stress marker, gabapentin group exhibited significant attenuation of stress of PP, p<0.05.


Assuntos
Aminas/uso terapêutico , Ansiolíticos/uso terapêutico , Clonidina/uso terapêutico , Ácidos Cicloexanocarboxílicos/uso terapêutico , Hemodinâmica/efeitos dos fármacos , Pneumoperitônio Artificial/métodos , Simpatolíticos/uso terapêutico , Ácido gama-Aminobutírico/uso terapêutico , Adulto , Aminas/administração & dosagem , Ansiolíticos/administração & dosagem , Glicemia/análise , Glicemia/efeitos dos fármacos , Dióxido de Carbono , Colecistectomia Laparoscópica , Clonidina/administração & dosagem , Ácidos Cicloexanocarboxílicos/administração & dosagem , Método Duplo-Cego , Feminino , Gabapentina , Humanos , Hidrocortisona/sangue , Masculino , Pessoa de Meia-Idade , Nepal , Pré-Medicação , Estudos Prospectivos , Simpatolíticos/administração & dosagem , Resultado do Tratamento , Ácido gama-Aminobutírico/administração & dosagem
8.
JNMA J Nepal Med Assoc ; 51(182): 56-61, 2011.
Artigo em Inglês | MEDLINE | ID: mdl-22916513

RESUMO

OBJECTIVE: The aim of this study is to find out if an ultrasound technique has advantages over the conventional landmark technique. METHODS: This is a prospective randomized comparative study on 120 patients requiring central venous cannulation of the right internal jugular vein. The study comprised of two groups: ultrasound and landmark groups, each consisting of 60 patients. The outcome measures were compared between the groups. RESULTS: Cannulation of the internal jugular vein was successful in 58 patients in the ultrasound group and in 53 in the landmark group. The number of attempts was 1.5 (1 - 3) and 2 (1 - 3) in the ultrasound and landmark group respectively (p = 0.001). The time taken for the successful cannulation was 4.9 +/- 1.7 minutes in the ultrasound approach and 8.0 +/- 2.8 minutes in the landmark approach (p = 0.00). The internal jugular vein diameter in the supine position was 11.2 +/- 1.5 mm which increased to 15.04 +/- 1.5 mm with a 15 degrees head-down position in the USG group (p = 0.001). The first attempt success rate was 39/60 (63%) in the ultrasound group and 19/60 (32%) with the landmark technique. The seven (12%) failure cases in the landmark group were rescued by the ultrasound technique. Inadvertent carotid artery puncture occurred in 2/60 (3%) and 6/60 (10%) of patients in the ultrasound and land mark group respectively. CONCLUSIONS: Ultrasound improves success rate, minimizes cannulation time and complications during internal jugular vein cannulation. It can be employed as a rescue technique in cases of a failed landmark technique.


Assuntos
Cateterismo Venoso Central/métodos , Veias Jugulares , Adulto , Lesões das Artérias Carótidas/etiologia , Cateterismo Venoso Central/efeitos adversos , Feminino , Hematoma/etiologia , Humanos , Unidades de Terapia Intensiva , Veias Jugulares/anatomia & histologia , Veias Jugulares/diagnóstico por imagem , Masculino , Pessoa de Meia-Idade , Ultrassonografia , Adulto Jovem
9.
J Nepal Health Res Counc ; 9(2): 145-9, 2011 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-22929843

RESUMO

BACKGROUND: Axillary block is popular technique in upper extremity surgery. Nerve stimulation is used for location of nerves to provide effective blockade. The advent of ultrasound imaging technique in regional anaesthesia has increased the accuracy of needle placement and local anaesthetic deposition around the nerve. The aim of this study is to find out if the nerve stimulation technique with ultrasound guidance has advantages over sole nerve stimulation technique. The outcome measures studied were onset of sensory and motor block, procedure time, number of skin puncture, vascular puncture and paresthesia during nerve stimulation. METHODS: This is a prospective randomized comparative study conducted in KMCTH from June 2009 to March 2010 on patients of American Society of Anaesthesiologist I and II requiring upper arm surgery under axillary block. The study comprised of two groups: ultrasound with nerve stimulation group (n=35) and nerve stimulation group (n=35). 24 ml of Bupivacaine 0.5% with injection Dexamethasone 4 mg was used to block the individual four nerves with 6 ml of the local anaesthetic solution per nerve namely ulnar, radial, median and musculocutaneous. The data were recorded by blinded observer. In case of partial block or block failure, the patients were supplemented with Fentanyl or subjected to laryngeal mask placement. RESULTS: Demographic characteristics (age, weight) in either group were similar (p>0.05). The male and female ratio (M: F) in ultrasound with nerve stimulation group was 12:16. The ratio was 18:17 in nerve stimulation group. The onset of complete sensory block was earlier and the onset of motor block was faster in ultrasound with nerve stimulation group than in sole nerve stimulation group (p=0.001). Ultrasound guidance decreased the number of skin puncture during the nerve stimulation, p= 0.02. The incidence of paresthesia was encountered during nerve location (14%), which could be minimized using ultrasound (7%). The success rate of the block was 93% with ultrasound assistance. The procedure time was not different in both techniques. The surgery duration was not significant statistically in either of the group, p=0.715. CONCLUSIONS: This study showed that the onset of sensory and motor block was faster with ultrasound assistance nerve stimulation. Complications can be decreased with the use of ultrasound in axillary block.


Assuntos
Braço/cirurgia , Plexo Braquial , Bloqueio Nervoso/métodos , Ultrassonografia de Intervenção/métodos , Anestésicos Locais/administração & dosagem , Braço/inervação , Plexo Braquial/diagnóstico por imagem , Bupivacaína/administração & dosagem , Feminino , Humanos , Masculino , Nervo Mediano , Nervo Musculocutâneo , Nervo Radial , Nervo Ulnar
10.
JNMA J Nepal Med Assoc ; 49(179): 191-4, 2010.
Artigo em Inglês | MEDLINE | ID: mdl-22049821

RESUMO

INTRODUCTION: The day care laparoscopic cholecystectomy (DCLC) is found to be safe and effective in developed countries. However, it has not been well accepted in our part of the world probably because of lack of infrastructures,established norms and published reports. We have analyzed the safety and feasibility of the procedure in the recently established first dedicated day care surgery centre of the country. METHODS: All the patients with American society of anaesthesiologist (ASA) score I and II admitted for laparoscopic cholecystectomy are included. Operation are performed in the morning and closely observed till evening. Patients found to be medically fit to discharge; having a responsible person at home and who can make their own arrangements in case of problems were advised for discharge. Follow up was done by telephone call from next morning. RESULTS: Total 35 patients underwent laparoscopic cholecystectomy. Age range was between 16-65 years and most of them were females (88%). Only 30 patients were operated in early morning and were eligible for day care surgery. 25 (83%) Patients were advised for discharge but only 10 (33%) could make arrangement. Other 15 patients could not go home mainly due to different psychosocial reasons. Only one patient needed readmission and Complications observed were minor and relatively few. CONCLUSIONS: Day care laparoscopic cholecystectomy is safe and feasible in our set up. Acceptance of the procedure is expected to increase once it is regularly practiced and awareness in improved.


Assuntos
Procedimentos Cirúrgicos Ambulatórios/métodos , Colecistectomia Laparoscópica , Adolescente , Adulto , Idoso , Estudos Transversais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Nepal , Complicações Pós-Operatórias , Estudos Prospectivos , Resultado do Tratamento
11.
Kathmandu Univ Med J (KUMJ) ; 7(27): 280-8, 2009.
Artigo em Inglês | MEDLINE | ID: mdl-20071877

RESUMO

Laparoscopic cholecystectomy (LapChole) has virtually superseded the more conventional open abdomen approach for the surgical treatment of symptomatic cholelithiasis. LapChole is however not a risk free procedure and serious, potentially fatal intra-operative complications can occur. Here we present case reports of four patients who suffered from intra-operative cardiac arrest during LapChole. All four recovered without residual morbidity and three of them underwent successful surgery in the same setting. No definite cause could be identified in any of the patients. We outline several possible mechanisms that could have been involved and discuss these events in face of published reports describing similar incidences. We infer that the creation of carbon-dioxide (CO(2)) pneumoperitoneum was involved in the causation of the cardiac arrest because all four incidences occurred within minutes thereafter. Although rare, such complications can be fatal and are thus demanding to the anaesthesiologist.


Assuntos
Anestesia Geral/métodos , Colecistectomia Laparoscópica/métodos , Parada Cardíaca/etiologia , Complicações Intraoperatórias , Pneumoperitônio Artificial/efeitos adversos , Adulto , Colecistectomia Laparoscópica/efeitos adversos , Colelitíase/cirurgia , Feminino , Seguimentos , Humanos , Pessoa de Meia-Idade
12.
Kathmandu Univ Med J (KUMJ) ; 6(1): 41-8, 2008.
Artigo em Inglês | MEDLINE | ID: mdl-18604114

RESUMO

BACKGROUND: Though electroconvulsive therapy (ECT) has been used in Nepal for last twenty years, researches regarding its use, its efficacy and other data are non-existent. AIMS: The objective of this study was to know about diagnostic variability and therapeutic efficacy of the use of ECT in hospitalized patients. METHODS: This is a prospective comparative study between patients who received ECT and who did not using ICD-10 as diagnostic confirmation. Psychopathology was evaluated using Brief Psychiatric Research Scale (BPRS), Hamilton Depression Rating Scale (HAM-D) and Young Mania Rating Scale (YMRS) between the groups at admission, at discharge, at 1st month, at 6th month and at 12th month. Functional assessment of patients was done using Global Assessment of Function (GAF). Modified ECT was performed using general anaesthetic agent. RESULTS: 47 patients received ECT as compared to 78 patients who were non-receivers. The patients with most common five diagnosis were paranoid schizophrenia (14.4%); psychotic depression (13.6%) ; undifferentiated schizophrenia (8.8%) ; bipolar mania (7.2% ) ;severe depression without psychosis (5.6%) . There was significant decrease in BPRS in ECT receiver as compared to non-receivers at discharge (p=0.0001), 1st month (p=0.0001), 6th month (p=0.0001) and 12th month (p=0.0001) ; in YMRS at discharge (p=.008), 1st month (p=.002) and at 12th month (p=.015) ; in HAMD-M at discharge (p=0.0001), at 1st month (p=0.0001), at 6th month (p=0.0001) and at 12th month (p=0.0001) ; in GAF at discharge (p=0.0001), at 6th month (p=0.0001) and at 12th month (p=0.0001). CONCLUSION: There was significant improvement in overall psychopathology of patients who received ECT as compared to non-receivers. The improvement was shown by decrement in scores in BPRS, YMRS, HDRS and GAF at the time of discharge, 1st month, 6th month and 12th month which were statistically significant. Day to day functional status of patients also improved as shown by GAF. The efficacy of ECT was very significantly shown in this study with all the psychiatric spectrum disorders.


Assuntos
Eletroconvulsoterapia , Transtornos Mentais/diagnóstico , Transtornos Mentais/terapia , Adolescente , Adulto , Distribuição por Idade , Idoso , Criança , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Nepal , Estudos Prospectivos , Escalas de Graduação Psiquiátrica , Distribuição por Sexo , Adulto Jovem
13.
Kathmandu Univ Med J (KUMJ) ; 6(24): 516-9, 2008.
Artigo em Inglês | MEDLINE | ID: mdl-19483438

RESUMO

Inserting a retrograde wire into the pharynx through a cricothyroid puncture can facilitate tracheal intubation in difficult situations where either a flexible fiber-optic bronchoscope or an expert user of such a device is not available. Even in cases when fibropric can not be negotiated for the purpose, this method has been claimed to be useful to manage the airway. Some mouth opening is essential for the oral or nasal retrieval of the wire from the pharynx. Here, a case of post mandibular reconstructed wound infection required surgical debridement and plate removal from reconstructed lower mandible under general anesthesia. We retrieved the guide wire passed through a cricothyroid puncture and subsequently accomplished wire-guided oro-tracheal intubation. In the absence of a flexible fiber-optic bronchoscope, this technique is a very useful aid to intubate patients with limited mouth opening.


Assuntos
Queimaduras/cirurgia , Cartilagem Cricoide/cirurgia , Traumatismos Mandibulares/cirurgia , Adulto , Queimaduras/complicações , Humanos , Masculino , Traumatismos Mandibulares/etiologia , Procedimentos de Cirurgia Plástica , Traqueostomia
14.
Kathmandu Univ Med J (KUMJ) ; 6(23): 319-28, 2008.
Artigo em Inglês | MEDLINE | ID: mdl-20071813

RESUMO

BACKGROUND: Postoperative nausea and vomiting (PONV) is a common distressing experience in patients following laparoscopic surgeries. This study was aimed at comparing the efficacies of Ondansetron-Dexamethasone combination with each drug alone as a prophylaxis against PONV in patients after elective laparoscopic cholecystectomy done under general anaesthesia. MATERIALS AND METHODS: Hundred and fifty ASA I and II patients, aged 23 to 65 yrs, were enrolled in this prospective, randomized, double-blind trial to receive one of three treatment regimens: 4 mg Ondansetron (Group O), 8 mg Dexamethasone (Group D) or 4 mg Ondansetron plus 8 mg Dexamethasone (Group OD) (n=50 for each). A standardized balanced general anaesthetic technique was employed. Any episode of PONV and need for rescue antiemetic were assessed at six, 12 and 24 hrs post operation. Complete response was defined as no PONV in 24 hrs and need for rescue antiemetic was considered as failure of prophylaxis. Pain scores, time to first analgesia demand, amount of Meperidine consumption, adverse event(s) and duration of hospital stay were recorded. RESULTS: Complete response occurred in 66.7, 66.0 and 89.4% in Groups O, D and OD respectively. Rescue antiemetics were required in 29.2, 31.9 and 8.5% of patients in Groups O, D, and OD respectively. Significantly high incidence of vomiting and failure of prophylaxis (19.1%) occurred in group D during the fi rst six hrs (P=0.023 versus O & 0.008 versus OD). More frequent antiemetic rescue was required in group O at 6 to 24 hr interval as compared to group OD (P=0.032). CONCLUSION: Combination of Ondansetron and Dexamethasone is better than each drug alone in preventing PONV after laparoscopic cholecystectomy. Dexamethasone alone is significantly less effective in preventing early vomiting compared to its combination with Ondansetron; whereas Ondansetron alone is less effective against late PONV as compared with combination therapy.


Assuntos
Antieméticos/administração & dosagem , Colecistectomia Laparoscópica , Dexametasona/administração & dosagem , Ondansetron/administração & dosagem , Náusea e Vômito Pós-Operatórios/tratamento farmacológico , Adulto , Método Duplo-Cego , Quimioterapia Combinada , Feminino , Humanos , Masculino , Estudos Prospectivos , Resultado do Tratamento
15.
Plant Cell Rep ; 26(6): 719-25, 2007 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-17219104

RESUMO

Protoplasts isolated from cell suspension culture of Phalaenopsis "Wataboushi" were cultured by (a) embedding in gellan gum-solidified hormone-free 1/2 New Dogashima medium (1/2 NDM) containing 0.44 M sorbitol, 0.06 M sucrose and 0.1 g/l L-glutamine (standard method) and (b) beads method using beads of gellan gum or sodium alginate as the gelling agents which were surrounded by liquid NDM. Although, the two beads methods gave less frequency of initial protoplast division than the standard method, the former finally resulted in higher frequency of microcolony formation than the latter. The highest frequency of microcolony formation (23%) was obtained when protoplasts were embedded in 1% Ca-alginate beads and subcultured every two weeks by replacing the surrounding liquid culture medium with a decrease in sorbitol concentration by 0.1 M. Colonies visible to the naked eyes were observed within 2 months of culture and the regenerated calluses were transferred onto hormone-free NDM supplemented with 10 g/l maltose and 0.3% (w/v) gellan gum, on which PLBs were formed and proliferated profusely. The PLBs were regenerated into plantlets after changing the carbon source to 10 g/l sorbitol and successfully acclimatized to greenhouse conditions.


Assuntos
Orchidaceae/fisiologia , Protoplastos , Regeneração , Orchidaceae/citologia
16.
JNMA J Nepal Med Assoc ; 46(168): 158-64, 2007.
Artigo em Inglês | MEDLINE | ID: mdl-18340366

RESUMO

This is a prospective, randomized, double blind study to evaluate the postoperative analgesia following supraclavicular brachial plexus block with Tramadol or Dexamethasone as an admixture to bupivacaine in upper extremity surgery. Total 60 patients of ASA I and II undergoing upper extremity surgery under brachial plexus block with Bupivacaine were randomly divided in to two groups; one group received Tramadol (2 mg/kg) and the other group received Dexamethasone (8 mg) as an admixture to Bupivacaine. The duration of postoperative analgesia was recorded in both groups using pain VAS score which was determined by maximum VAS score of 8-10 and when patient demands for additional analgesics. The mean duration of postoperative analgesia in the Dexamethasone group was 1028.00 minutes while in the tramadol group it was 453.17 minutes We concluded that Dexamethasone with local anaesthetic prolongs postoperative analgesia significantly than Tramadol (P<0.05) when used as admixture to local anaesthetic in brachial plexus block in upper extremity surgery.


Assuntos
Analgesia/métodos , Bupivacaína/administração & dosagem , Dexametasona/administração & dosagem , Bloqueio Nervoso/métodos , Dor Pós-Operatória/tratamento farmacológico , Dor de Ombro/tratamento farmacológico , Tramadol/administração & dosagem , Adolescente , Adulto , Idoso , Analgésicos Opioides/administração & dosagem , Anestésicos Locais/administração & dosagem , Método Duplo-Cego , Quimioterapia Combinada , Feminino , Seguimentos , Glucocorticoides/administração & dosagem , Humanos , Injeções , Masculino , Pessoa de Meia-Idade , Medição da Dor , Cuidados Pós-Operatórios/métodos , Estudos Prospectivos , Dor de Ombro/diagnóstico , Dor de Ombro/fisiopatologia , Resultado do Tratamento
17.
Kathmandu Univ Med J (KUMJ) ; 5(2): 166-72, 2007.
Artigo em Inglês | MEDLINE | ID: mdl-18604013

RESUMO

OBJECTIVE: To study early hemodynamic changes and duration of postoperative analgesia between two study groups of intrathecal pethidine and bupivacaine heavy in patients undergoing caesarean section. METHODOLOGY: Total number of 60 patients of ASA I and II, undergoing caesarean section were enrolled in the study. All the patients were divided into two groups: Pethidine and Bupivacaine heavy. The dose of pethidine for subarachnoid block was 1mg/kg and in Bupivacaine group 2.2 ml of 0.5% bupivacaine heavy was given intrathecally. Heart rate and blood pressure of all the patients were recorded before subarachnoid block. After giving spinal anesthesia, the heart rate and blood pressure were monitored and recorded in different time intervals. The duration of postoperative analgesia in all patients was recorded in postoperative ward. The APGAR Scores of the babies were recorded in 1 and 5 minutes after delivery. The data were statistically compared using independent sample t-test. CONCLUSION: The hemodynamic parameters (HR & BP) were compared in different time intervals. The difference in heart rate and blood pressure at different time intervals in the two study groups were statistically insignificant as (p > 0.05). The total duration of postoperative analgesia in patients receiving sole intrathecal pethidine was 8 hours and 30 minutes. Where as, in Bupivacaine group the duration was 2 hrs and 36 minutes. This has been found statistically significant (p<0.05).


Assuntos
Anestésicos Locais/administração & dosagem , Bupivacaína/administração & dosagem , Cesárea , Hemodinâmica/efeitos dos fármacos , Meperidina/administração & dosagem , Dor Pós-Operatória/tratamento farmacológico , Anestésicos Locais/farmacologia , Índice de Apgar , Pressão Sanguínea/efeitos dos fármacos , Bupivacaína/farmacologia , Feminino , Frequência Cardíaca/efeitos dos fármacos , Humanos , Recém-Nascido , Injeções Espinhais , Meperidina/farmacologia , Gravidez
18.
Kathmandu Univ Med J (KUMJ) ; 5(3): 307-11, 2007.
Artigo em Inglês | MEDLINE | ID: mdl-18604045

RESUMO

PURPOSE: The purpose of this study was to assess the effects of hyperventilation on patients undergoing laparoscopic surgeries on haemodynamics, partial pressure of carbon dioxide and acid base status. METHODS: 60 patients undergoing laparoscopic surgeries under General Anaesthesia were randomized into two groups, "control group" ventilated with tidal volume of 10 ml/kg and respiratory rate of 12/minute and "study group" same tidal volume with respiratory rate of 15/ minute. Hemodynamic variables (heart rate and mean arterial pressure) recorded and End tidal C02, PaC02, pH and Bicarbonate estimation done before, during and after C02 pneumoperitoneum and analyzed. RESULTS: There was no significant difference in hemodynamic variables but there was linear increase in ETC02 and PaC02 measurements in higher normal levels in control group (ETC02 33.3+/-3.20, 37.93+/-3.95 and 43.20+/-3.40; PaC02 30.08+/-2.35, 34.80+/-4.01 and 41.94+/-3.66 mmHg before, during, and after pneumoperitoneum respectively) compared to study group in which these parameters were in lower normal levels (ETC02 33.33+/-4.11, 28.00+/-4.10 and 36.73+/-2.49 mmHg and PaC02 31.80+/-2.73, 29.36+/-3.16 and 35.15+/-1.32 mmHg before, during, and after pneumoperitoneum respectively). There was highly significant difference in these parameters when intergroup comparison was done during and after pneumoperitoneum period. pH and bicarbonate levels were within normal limits but there was decreasing tendency towards acidosis side in control group. CONCLUSION: 10-15% increment in Minute Volume is beneficial during C02 pneumoperitoneum to prevent adverse effects of hypercarbia and acidosis.


Assuntos
Laparoscopia , Pneumoperitônio Artificial , Respiração Artificial/métodos , Equilíbrio Ácido-Base , Adulto , Anestesia Geral , Dióxido de Carbono/metabolismo , Feminino , Hemodinâmica , Humanos , Concentração de Íons de Hidrogênio , Masculino , Pessoa de Meia-Idade , Pressão Parcial , Volume de Ventilação Pulmonar
19.
Kathmandu Univ Med J (KUMJ) ; 5(3): 318-23, 2007.
Artigo em Inglês | MEDLINE | ID: mdl-18604047

RESUMO

OBJECTIVE: The study was designed to evaluate the hemodynamic effects of Esmolol and labetalol in patients undergoing electroconvulsive therapy. MATERIALS AND METHODS: Ninety patients undergoing electroconvulsive therapy treatment were studied according to randomized, double blind placebo controlled protocol. Ninety patients were divided into three groups with thirty patients in each group. Patients received either Esmolol (1 mg/kg), Labetalol (0.25 mg/kg) or Normal Saline (placebo) intravenously just after induction with propofol. The baseline heart rate and blood pressure were recorded. Hemodynamic parameters before and after drug therapy and after the ECT current application, were recorded at different time intervals. RESULTS: It was found that Esmolol significantly attenuated the degree of tachycardia and hypertension after ECT in comparison with placebo in the first three minutes (p<0.05), whereas the rise in HR and blood pressure was significantly blunted in the labetalol group in comparison to placebo, from three minutes onward till ten minutes. (p<0.05). CONCLUSION: It was concluded that Esmolol is effective in blunting the hemodynamic response after ECT stimulus in the first three minutes after application of the electrical current, whereas Labetalol is effective after five minutes onwards till ten minutes.


Assuntos
Antagonistas Adrenérgicos beta/administração & dosagem , Transtorno Depressivo/terapia , Eletroconvulsoterapia , Hemodinâmica/efeitos dos fármacos , Labetalol/administração & dosagem , Propanolaminas/administração & dosagem , Pressão Sanguínea/efeitos dos fármacos , Método Duplo-Cego , Frequência Cardíaca/efeitos dos fármacos , Humanos , Placebos , Resultado do Tratamento
20.
Kathmandu Univ Med J (KUMJ) ; 5(3): 339-42, 2007.
Artigo em Inglês | MEDLINE | ID: mdl-18604051

RESUMO

AIMS AND OBJECTIVES: To study the impact the use of portable ultrasound can have for the benefit of the patients when used by doctors other than radiologist, in this case surgeons. METHODS: Ultrasound performed by surgeons in the pre-operative, operative and post-operative period was studied. Patients presenting to the Hospital with acute abdomen was subjected to ultrasound. They were either pre-operative or post-operative patients. Five patients were scanned intraoperatively. The impact of these scans to the patients as well as the clinicians was studied. RESULTS: This is an ongoing study and preliminary results of the scans show two pre-operative diagnosis of acute appendicular collection and one acute hydronephrosis. In the operation room, ultrasound was done on 5 cases. On three occasions, it was to locate renal stones so that it could be extracted with ease. On two of the case, it was t to confirm the adequacy of common bile duct exploration thereby allowing primary closure of the common bile duct. Post-operatively, it was used in four cases of which in two cases post-operative hemorrhage were detected timely within hours. In the other two cases, the surgical team was assured that the patient's complaint was not surgically related. CONCLUSION: Ultrasound should be an extension of the clinical examination when indicated and all clinicians should be proficient in its use in their respective fields.


Assuntos
Abdome Agudo/diagnóstico por imagem , Abdome Agudo/cirurgia , Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Complicações Pós-Operatórias/diagnóstico por imagem , Ultrassonografia
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA