Evaluating handwriting in children with developmental coordination disorder (DCD): Temporal, spatial, pressure and grip-force measures.

BACKGROUND: Writing involves complex sensorimotor and biomechanical processes that regulate pressure on the writing surface. Researchers analyze writing to understand kinetics and kinematics by evaluating temporal, spatial, and pressure aspects, yet discerning writing surface pressure and pen-grip force remains challenging. AIMS: To compare handwriting kinetics (pen grip-force and surface pressure) and kinematics (temporal-spatial) of children with developmental coordination disorder (DCD) with those of typically developing (TD) children. METHODS AND PROCEDURES: Twenty-seven children with DCD aged 7-12 years and 27 TD children matched by age and gender copied a 29-word passage onto a computerized tablet. Temporal, spatial and surface pressure as well as pen grip-force were measured with a tablet and a wearable device respectively. OUTCOMES AND RESULTS: The DCD group displayed significantly longer total writing time, mean letter time, and greater letter height, width, variance, spacing, area, and erasures than the TD group. Although there were no significant between-group differences in the surface pressure or maintaining pressure, the DCD group displayed weaker grip-force, p = .01, with greater variance. CONCLUSIONS AND IMPLICATIONS: The DCD group's weaker grip-force dynamics correlated with reduced legibility, form, and prolonged writing duration, revealing insights into handwriting mechanisms, particularly grip force, crucial for effective clinical interventions.

Enhancing Handwriting Performance of Children with Developmental Coordination Disorder (DCD) Using Computerized Visual Feedback.

Recent studies have analyzed the writing metrics of children with developmental coordination disorder (DCD) using computerized systems. To date, the use of computerized visual feedback to improve handwriting has not been investigated. This study aimed to examine the effects of computerized visual feedback on handwriting performance in time, spatial orientation, and pressure indices for children with DCD. Twenty-seven children aged 7 to 12 years with DCD assessed by the Movement Assessment Battery for Children and the Developmental Coordination Disorder Questionnaire received one weekly intervention session for 8 weeks, during which they twice copied an excerpt onto a tablet. Once, they received visual feedback where the writing color corresponded to the degree of pressure on the writing surface, and once they received no visual feedback. The two conditions were counterbalanced throughout the sessions. Pre-intervention sessions were compared with post-intervention sessions and with new texts for time, spatial orientation, and pressure measures. The findings revealed significantly decreased total and mean letter writing, in-air, and writing time and increased capacity in the visual feedback condition. In the spatial variables, a significant decrease in letter height variance was found. Pressure increased significantly throughout the intervention with visual feedback, whereas it decreased post-test in the writing task in both conditions and was maintained in the new text. Visual feedback intervention can increase the kinesthetic-haptic feedback required to regulate pressure during writing, promoting more efficient feedforward processes and improving output quality and capacity. The training effectiveness was transferable, and the intervention accessibility could increase student autonomy.

Apple-like Shape of Freezing Paraffin Wax Droplets and Its Origin.

Paraffin wax stores energy in the form of latent heat at a nearly constant temperature during melting and releases this energy during solidification. This effect is used in industrial energy storage. At the same time, the possible deformation of even small volumes of material as a result of phase change is insufficiently studied. In this paper, the physical nature of such deformation, probably for the first time, is studied on the example of a droplet of paraffin wax. An unusual change in the shape of a melted droplet of paraffin wax placed on a relatively cold glass plate was observed in the laboratory experiments. As the droplet solidifies, its upper surface becomes nearly flat, and a dimple is formed in the center of this surface, making the droplet look like a fruit (pumpkins are more commonly shaped like this, but the authors prefer apples). A series of experiments, as well as physical and numerical modeling of the droplet's thermal state, taking into account the formation of a mushy zone between liquidus and solidus, made it possible to understand the role of gravity and gradual increase in viscosity and density of paraffin wax on changing the droplet shape and, in particular, to clarify the mechanism of formation of the dimple on its upper. It was shown that the mushy zone between the liquidus and solidus of the paraffin wax is responsible for the dimple formation.

Blood pressure in girls with central precocious puberty receiving GnRH analogue therapy.

OBJECTIVES: Case reports show hypertension in children treated with GnRH analogues for central precocious puberty (CPP). However, relevant data on blood pressure are scarce. We aimed to evaluate blood pressure (BP) among girls with idiopathic CPP and early-onset puberty before and during GnRH analogue therapy; and to examine associations of blood pressure with clinical parameters. METHODS: For this retrospective longitudinal cohort study, demographic, anthropometric, clinical, and laboratory data were collected from electronic files. The study group included 112 girls with idiopathic CPP or early-onset puberty followed in a tertiary pediatric endocrinology institute, and a control group of 37 healthy pre-pubertal girls. The main outcome measures were BP percentile, before, and during treatment with GnRH analogue. RESULTS: At baseline, similar proportions of the study and control groups had BP values>90th percentile: 64 (53 %) and 17 (46 %), respectively (p=0.57). The mean systolic and diastolic BP percentiles measured under treatment remained unchanged. In the study group, baseline BP>90th percentile compared to normal baseline BP was associated with lower birthweight and a higher body mass index-standard deviation score: 2,821 ± 622 vs. 3,108 ± 485 g and 1.0 ± 0.7 vs. 0.70 ± 0.8, respectively, p=0.01 for both. CONCLUSIONS: GnRH analogue therapy for precocious or early puberty was not associated with increased blood pressure. The stability of mean blood pressure percentile during treatment is reassuring.

Evolutionary roots of the risk of hip fracture in humans.

The transition to bipedal locomotion was a fundamental milestone in human evolution. Consequently, the human skeleton underwent substantial morphological adaptations. These adaptations are responsible for many of today's common physical impairments, including hip fractures. This study aims to reveal the morphological changes in the proximal femur, which increase the risk of intracapsular hip fractures in present-day populations. Our sample includes chimpanzees, early hominins, early Homo Neanderthals, as well as prehistoric and recent humans. Using Geometric Morphometric methods, we demonstrate differences in the proximal femur shape between hominids and populations that practiced different lifestyles. We show that the proximal femur morphology is a risk factor for intracapsular hip fracture independent of osteoporosis. Changes in the proximal femur, such as the shortening of the femoral neck and an increased anterolateral expansion of the greater trochanter, are associated with an increased risk for intracapsular hip fractures. We conclude that intracapsular hip fractures are a trade-off for efficient bipedal walking in humans, and their risk is exacerbated by reduced physical activity.

Ramsey theory and thermodynamics.

Re-shaping of thermodynamics with the graph theory and Ramsey theory is suggested. Maps built of thermodynamic states are addressed. Thermodynamic states may be attainable and non-attainable by the thermodynamic process in the system of constant mass. We address the following question how large should be a graph describing connections between discrete thermodynamic states to guarantee the appearance of thermodynamic cycles? The Ramsey theory supplies the answer to this question. Direct graphs emerging from the chains of irreversible thermodynamic processes are considered. In any complete directed graph, representing the thermodynamic states of the system the Hamiltonian path is found. Transitive thermodynamic tournaments are addressed. The entire transitive thermodynamic tournament built of irreversible processes does not contain a cycle of length 3, or in other words, the transitive thermodynamic tournament is acyclic and contains no directed thermodynamic cycles.

Voronoi Tessellations and the Shannon Entropy of the Pentagonal Tilings.

We used the complete set of convex pentagons to enable filing the plane without any overlaps or gaps (including the Marjorie Rice tiles) as generators of Voronoi tessellations. Shannon entropy of the tessellations was calculated. Some of the basic mosaics are flexible and give rise to a diversity of Voronoi tessellations. The Shannon entropy of these tessellations varied in a broad range. Voronoi tessellation, emerging from the basic pentagonal tiling built from hexagons only, was revealed (the Shannon entropy of this tiling is zero). Decagons and hendecagon did not appear in the studied Voronoi diagrams. The most abundant Voronoi tessellations are built from three different kinds of polygons. The most widespread is the combination of pentagons, hexagons, and heptagons. The most abundant polygons are pentagons and hexagons. No Voronoi tiling built only of pentagons was registered. Flexible basic pentagonal mosaics give rise to a diversity of Voronoi tessellations, which are characterized by the same symmetry group. However, the coordination number of the vertices is variable. These Voronoi tessellations may be useful for the interpretation of the iso-symmetrical phase transitions.

Assessment of children's writing features: A pilot method study of pen-grip kinetics and writing surface pressure.

The writing process is a complex task involving dexterous manipulation of the writing instrument by the hand digits and biomechanical ergonomic factors that contribute to handwriting efficiency and productivity. We describe a pilot study using an instrumented writing apparatus - a sensor (pen) and a digitized writing surface (tablet) - to measure the pen-grip kinetics (digit forces) and the pen pressure applied to the tablet during a writing task. Eight elementary school students with no handwriting difficulties copied a short story. The mean digit forces on the pen were compared with the mean pen pressure on the tablet at five interval points. Results revealed that the digit forces on the pen were significantly stronger than the pen pressure on the tablet. Results also showed significantly less digit-force variability throughout the writing task than the pen-pressure variability on the writing surface, which significantly lessened toward the end of the writing task. Information on these properties can broaden understanding of the elements that influence nonproficient handwriting in children with dysgraphia. Results also indicate the possible efficacy of a therapeutic tool for handwriting assessment and intervention using objective measurements during writing, warranting future studies with children with and without dysgraphia.

From Chaos to Ordering: New Studies in the Shannon Entropy of 2D Patterns.

Properties of the Voronoi tessellations arising from random 2D distribution points are reported. We applied an iterative procedure to the Voronoi diagrams generated by a set of points randomly placed on the plane. The procedure implied dividing the edges of Voronoi cells into equal or random parts. The dividing points were then used to construct the following Voronoi diagram. Repeating this procedure led to a surprising effect of the positional ordering of Voronoi cells, reminiscent of the formation of lamellae and spherulites in linear semi-crystalline polymers and metallic glasses. Thus, we can conclude that by applying even a simple set of rules to a random set of seeds, we can introduce order into an initially disordered system. At the same time, the Shannon (Voronoi) entropy showed a tendency to attain values that are typical for completely random patterns; thus, the Shannon (Voronoi) entropy does not distinguish the short-range ordering. The Shannon entropy and the continuous measure of symmetry of the patterns demonstrated the distinct asymptotic behavior, while approaching the close saturation values with the increase in the number of iteration steps. The Shannon entropy grew with the number of iterations, whereas the continuous measure of symmetry of the same patterns demonstrated the opposite asymptotic behavior. The Shannon (Voronoi) entropy is not an unambiguous measure of order in the 2D patterns. The more symmetrical patterns may demonstrate the higher values of the Shannon entropy.

Improved GNSS Localization and Byzantine Detection in UAV Swarms.

Many tasks performed by swarms of unmanned aerial vehicles require localization. In many cases, the sensors that take part in the localization process suffer from inherent measurement errors. This problem is amplified when disruptions are added, either endogenously through Byzantine failures of agents within the swarm, or exogenously by some external source, such as a GNSS jammer. In this paper, we first introduce an improved localization method based on distance observation. Then, we devise schemes for detecting Byzantine agents, in scenarios of endogenous disruptions, and for detecting a disrupted area, in case the source of the problem is exogenous. Finally, we apply pool testing techniques to reduce the communication traffic and the computation time of our schemes. The optimal pool size should be chosen carefully, as very small or very large pools may impair the ability to identify the source/s of disruption. A set of simulated experiments demonstrates the effectiveness of our proposed methods, which enable reliable error estimation even amid disruptions. This work is the first, to the best of our knowledge, that embeds identification of endogenous and exogenous disruptions into the localization process.

The paradox of pedestrian's risk aversion.

Traffic accidents are becoming a significant cause for unnatural deaths around the world, with more than 1.25 million fatalities in road accidents each year, and over 20 million people severely injured. A large portion of accidents that result in fatalities involve interaction between vehicles and pedestrians. In the literature, researchers speculate on a wide range of reasons for these figures. This paper focuses on the relationship between pedestrians' urgency to cross a busy road and the resulting level of risk for an accident. The probability for an accident is determined by a prediction model for a collision between drivers and pedestrians at congested conflict spots. The model is based on a motion planner called the Probabilistic Navigation Function (PNF), initially designed for robot navigation in dynamic cluttered and uncertain environments. The model predicts pedestrians' trajectories when crossing a busy road in a sub-meter accuracy, based on the risk they are willing to take (a reflection of the level of urgency to cross the road). The paper describes an unexpected and surprising pedestrian behavior in simple road crossings scenarios. When the model is given a loose risk boundary (that reflects a high level of pedestrian urgency to cross), the resulting trajectory exposes the pedestrian to a lower risk compared with a trajectory constructed with a strict risk boundary (that reflects a more conservative pedestrian). This is equivalent to claiming that, paradoxically, pedestrians in some scenarios who are willing to take higher levels of risk, face a decreased probability for an accident while crossing a congested road. The paper introduces the PNF model for crossing pedestrians, analyses their performance in a set of simulations, and explains its rationale. Next, an analytic estimation for the risk level as a function of the crossing angle of the selected trajectory is provided. A series of experiments conclude the paper and support the claim that this phenomenon is frequent among crossing pedestrians. The experimental results suggest that in some common scenarios, more cautious pedestrians may lower the initial risk for an accident at the expense of a total higher risk for an accident during the entire road crossing process, compared with a pedestrian who takes an initial higher level of risk that results in, overall, a decreased probability for an accident. A statistical analysis implies that there are significant differences in this occurrence between adults and children.

The Effect of the Pressure Exerted on the Maternal Abdominal Wall by the US Probe on Fetal MCA Peak Systolic Velocity.

Purpose To quantify the pressure exerted on the maternal abdominal wall during ultrasound examination and evaluate its effect on the fetal middle cerebral artery (MCA) peak systolic velocity (PSV). Materials and Method Gravid women with singleton pregnancies in their 2nd-3 rd trimester undergoing fetal sonographic evaluation for various indications were recruited. Each subject underwent transabdominal US measuring fetal distance from the probe, abdominal thickness, amniotic fluid index and biophysical profile. The applied pressure was measured simultaneously using an electronic pressure sensor attached directly to the US probe. For each subject baseline values of the pressure required for proper visualization were obtained. Fetal MCA was then demonstrated using color Doppler US. The PSV was measured at different pressure ranges with each subject used as her own control. Care was taken not to exceed the baseline pressure for each subject. Results 29 women were recruited. 24 subjects (82.7 %) demonstrated a statistically significant positive correlation between the pressure exerted and MCA-PSV (R-0.37, p < 0.0001). Of these, 4 subjects (13.8 % of study population) demonstrated elevation of PSV values above 1.29 MOM and 5 subjects (17.2 %) demonstrated elevation of PSV values above 1.5 MOM for gestational age with increasing pressure. In total, 9 subjects (31 %) demonstrated significant changes in the MCA-PSV measurements (owing to increase in pressure applied) that could potentially falsely influence clinical obstetric diagnosis and management. Conclusion The pressure exerted on the maternal abdominal wall during US examination is an important parameter, producing clinically significant measurable changes in fetal MCA hemodynamics. Further study is needed in order to demonstrate the potential effect of pressure as a parameter influencing the diagnostic accuracy of the MCA-PSV in the setting of fetal anemia.

Proximal attrition facets: morphometric, demographic, and aging characteristics.

Although interproximal attrition is considered to be limited in modern populations, it has important clinical implications. However, in contrast to occlusal attrition, proximal attrition receives limited scientific attention. The main purpose of the current study was to fill this void. Seven-hundred and sixty-five teeth were collected from 255 skulls of subjects 18-75 yr of age. For each individual, three mandibular teeth (the first and second premolars and the first molar) were examined for proximal attrition facets (PAFs). The results provide detailed information on the size, shape, and location of the facets according to age cohort, gender, and ethnicity. The validity of the method used to measure the facets was also examined. The major findings were as follows: PAFs are usually located on the upper half of the crown proximal aspect; in each tooth, the mesial facet is more lingually positioned and the distal facet is more buccally positioned; the majority of the facets are subrectangular in shape; the size of the facets tends to increase in an anteroposterior direction (from premolars to molars); and facet size and location are age- and sex-dependent and ethnicity-independent. It is our recommendation that dentists bear in mind that interproximal attrition is a dynamic, long-term process and needs to be considered in many clinical scenarios.