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1.
Food Chem Toxicol ; 121: 396-403, 2018 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-30213553

RESUMO

Cumulative dietary risks for the German population owing to pesticide residues in foods were assessed using food monitoring and consumption data. Based on grouping principles for cumulative assessment groups (CAG) as defined by the European Food Safety Authority, probabilistic modelling gave cumulative long- and short-term dietary exposures relevant to the nervous and thyroid system. Compound specific toxicological reference values were considered to assess the total margins of exposure (MoEs) for each CAG, allowing an assessment of the cumulative dietary consumer risk. For the German population, no public health concerns were identified for 6 of 11 CAGs. For three CAGs high uncertainties remained, since MoEs were less than the usually required threshold of 100 for the upper confidence interval of the modelling uncertainty. For two CAGs relevant to the nervous and thyroid system, possible health risks cannot be excluded with the selected approach. Most potent risk drivers were chlorpyrifos and the group of dithiocarbamates (expressed as propineb). For regulatory decisions on possible cumulative dietary health risks the limitations of the published approaches and the absence of harmonized data sources for robust refinements have to be considered. Future research to reduce this high uncertainty is considered necessary in this area.


Assuntos
Dieta , Contaminação de Alimentos/análise , Resíduos de Praguicidas , Praguicidas/química , Sistema Nervoso Central/efeitos dos fármacos , Exposição Ambiental , Monitoramento Ambiental , Análise de Alimentos , Alemanha , Humanos , Medição de Risco , Glândula Tireoide/citologia , Glândula Tireoide/efeitos dos fármacos , Fatores de Tempo
2.
Artigo em Alemão | MEDLINE | ID: mdl-15650910

RESUMO

The risk assessment of pesticide residues is based on the estimation of their dietary intake. Models based on a new national consumption survey were developed to estimate the short- and long-term dietary intake of pesticide residues for children from 2 to under 5 years, allowing a realistic risk assessment to be made. The recommended methods are described. At the national level, the new models shall replace the previous methods for evaluating dietary intake.


Assuntos
Contaminação de Alimentos/análise , Resíduos de Praguicidas/toxicidade , Criança , Pré-Escolar , Relação Dose-Resposta a Droga , Comportamento Alimentar , Feminino , Alemanha , Humanos , Masculino , Concentração Máxima Permitida , Medição de Risco
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