Burnout e níveis de proteína c-reativa: revisão integrativa da literatura / Burnout y niveles de proteína C reactiva: revisión integradora de la literatura / Burnout and c-reactive protein levels: an integrative literature review

Resumo Objetivo Identificar as evidências científicas disponíveis na literatura sobre a associação entre Síndrome de Burnout (SB) e níveis de proteína C-reativa. Métodos Revisão integrativa da literatura de artigos publicados em português, espanhol e inglês, sem limite de data, com diferentes desenhos de estudo, disponíveis eletronicamente nas bases de dados do Cumulative Index to Nursing and Allied Health Literature (CINAHL), National Library of Medicine National Institutes of Health (PubMed), Scopus, Latin American and Caribbean Center on Health Sciences Information (LILACS), Science Direct e Springer Link. Os artigos selecionados foram analisados de acordo com a Agency for Healthcare Research and Quality. Resultados Foram analisados 7 artigos. Na maior parte dos estudos, houve associação positiva entre Burnout e níveis elevados de proteína c-reativa, apesar dos resultados gerais serem contraditórios. A maioria dos artigos que atenderam aos critérios de seleção encontrava-se em língua inglesa e indexados na base de dados CINAHL. O continente europeu concentrou a maior parte de produção. Houve predominância de desenho de estudo transversal. Conclusão Apesar da associação positiva entre Burnout e níveis elevados de proteína c-reativa os resultados dessa revisão sugerem a realização de novos estudos mais robustos na tentativa de explicar a relação entre SB e PCR.

Resumen Objetivo Identificar las evidencias científicas disponibles en la literatura sobre la relación entre el síndrome de burnout (SB) y los niveles de proteína C reactiva. Métodos Revisión integradora de la literatura de artículos publicados en portugués, español e inglés, sin límite de fecha, con diferentes diseños de estudio, disponibles electrónicamente en las bases de datos del Cumulative Index to Nursing and Allied Health Literature (CINAHL), National Library of Medicine National Institutes of Health (PubMed), Scopus, Latin American and Caribbean Center on Health Sciences Information (LILACS), Science Direct y Springer Link. Los artículos seleccionados fueron analizados de acuerdo con la Agency for Healthcare Research and Quality. Resultados Se analizaron siete artículos. En la mayor parte de los estudios, hubo asociación positiva entre burnout y niveles elevados de proteína C reactiva, aunque los resultados generales eran contradictorios. La mayoría de los artículos que cumplieron los criterios de selección estaban en idioma inglés e indexados en la base de datos CINAHL. El continente europeo concentró la mayor parte de la producción. Hubo predominancia de diseño de estudio transversal. Conclusión A pesar de la asociación positiva entre burnout y niveles elevados de proteína C reactiva, los resultados de esta revisión sugieren la realización de nuevos estudios más sólidos para explicar la relación entre SB y PCR.

Abstract Objective To identify the scientific evidence available in the literature on the association between Burnout Syndrome (BS) and C-reactive protein levels. Methods This is an integrative literature review of articles published in Portuguese, Spanish and English, with no date limit, with different study designs, available electronically in the Cumulative Index to Nursing and Allied Health Literature (CINAHL), National Library of Medicine, National Institutes of Health (PubMed), Scopus, Latin American and Caribbean Center on Health Sciences Information (LILACS), Science Direct, and Springer Link databases. The selected articles were analyzed according to the Agency for Healthcare Research and Quality. Results Seven articles were analyzed. In most studies, there was a positive association between Burnout and high c-reactive protein levels, despite the general results being contradictory. Most articles that met the selection criteria were in English and indexed in the CINAHL database. The European continent concentrated most of studies. There was a predominance of cross-sectional study design. Conclusion Despite the positive association between Burnout and high c-reactive protein levels, the results of this review suggest that new, more robust studies be carried out in an attempt to explain the relationship between BS and CRP.

Covid-19 e as dimensões do trabalho: análise sócio-histórica dos impactos vivenciados por homens na pandemia / Covid-19 and work dimensions: a socio-historical analysis of impacts affecting men during the pandemic / COVID-19 y las dimensiones del trabajo: análisis sociohistórico de los impactos experimentados por los hombres en la pandemia

OBJETIVO: Apreender os impactos vivenciados por homens residentes no Brasil na pandemia da Covid-19 em relação às dimensões do trabalho. MÉTODO: Estudo sócio-histórico, qualitativo, realizado durante a pandemia da Covid-19 com 400 adultos e idosos residentes no Brasil. Aplicou-se um formulário on-line. Os dados foram analisados com base no Discurso do Sujeito Coletivo, interpretados à luz do Materialismo Histórico Dialético. RESULTADOS: A pandemia da Covid-19 provocou e intensificou impactos: sobrecarga provocada pelo trabalho home office; inadequações no trabalho e exposição à contaminação pelo Coronavírus; estresse e medo de ser contaminado no trabalho e de perder o emprego; dificuldade na manutenção econômica/financeira e adaptações repentinas no desempenho do trabalho. CONCLUSÃO: As dimensões do mundo do trabalho intensificaram as vulnerabilidades sociais e em saúde de homens no contexto da pandemia da Covid-19. Repercutiram em maior exposição ao SARS-CoV-2 e vivência de estressores na vida cotidiana.

OBJECTIVE: To apprehend the impacts affecting men residing in Brazil during the Covid-19 pandemic concerning work dimensions. METHOD: A socio-historical, qualitative study carried out during the Covid-19 pandemic with 400 adult and old males residing in Brazil. An on-line form was applied. Data were analyzed based on the Discourse of the Collective Subject, interpreted according to the Dialectic Historical Materialism. RESULTS: The Covid-19 pandemic did cause and intensify impacts: overload resulting from home-office jobs; inadequacies as to the work and exposition to contamination by the Coronavirus; stress and fear to be contaminated at work and losing employment; difficulties to maintain economic/financial conditions and unexpected adaptations in work performance. CONCLUSION: The dimensions of the work environment did intensify both social and health vulnerabilities for men in the context of the Covid-19 pandemic, rebounding on even higher exposure to SARS-CoV 2 and daily life stressors.

OBJETIVO: Comprender los impactos experimentados por los hombres residentes en Brasil en la pandemia de COVID-19 respecto a las dimensiones del trabajo. MÉTODO: Estudio sociohistórico, cualitativo, realizado durante la pandemia de COVID-19, con 400 adultos y personas mayores residentes en Brasil. Se aplicó un formulario online. Los datos se analizaron con base en el Discurso del Sujeto Colectivo y fueron interpretados a la luz del Materialismo Histórico Dialéctico. RESULTADOS: La pandemia de COVID-19 ha ocasionado e intensificado los impactos: sobrecarga causada por el teletrabajo; inadecuaciones en el trabajo y exposición a la contaminación por el coronavirus; estrés y miedo a contaminarse en el trabajo y a perder el empleo; dificultad en el mantenimiento económico/financiero y adaptaciones repentinas en el rendimiento del trabajo. CONCLUSIÓN: Las dimensiones del mundo del trabajo han intensificado las vulnerabilidades sociales y de salud de los hombres en el contexto de la pandemia de COVID-19. Han repercutido en una mayor exposición al SARS-CoV-2 y vivencia de estresores en la vida cotidiana.

Effect of immunonutrition on serum levels of C-reactive protein and lymphocytes in patients with COVID-19: a randomized, controlled, double-blind clinical trial.

INTRODUCTION: Introduction: patients with COVID-19 undergo changes in leukocyte count, respiratory disorders, and an increase in inflammatory substances. To improve the inflammatory condition, some nutrients can be used, including arginine, omega-3 fatty acids and nucleotides. This study aims to evaluate how oral immunonutrient supplements affects serum C-reactive protein (CRP) levels and lymphocyte count in patients with COVID-19. Methods: in this double-blind clinical trial, we randomized 43 adult patients with COVID-19 to receive a standard high-protein normocaloric supplement (control) or an immunonutrient-enriched supplement (experiment) for 7 days. The primary outcome was to evaluate changes in total lymphocyte count and serum level of CRP. The assessment of risk and nutritional status of these patients was also performed. Results: forty-three patients with mean age of 41.5 (± 1.8) years were followed up, 39.5 % of them women. The mean body mass index was 27.6 (± 0.8) kg/m² and 58.1 % had low nutritional risk. In the experiment group, there was a CRP reduction of 23.6 (± 7.5) mg/L, while in the control branch the decrease was 14.8 (± 12.1) mg/L (p = 0.002). There was an increase in lymphocytes in the experiment group (+367.5 ± 401.8 cells/mm³) and a reduction in the control group (-282.8 ± 327.8 cells/mm³), although there was no statistical significance (p = 0.369). Relative risk (RR) of treatment in reducing CRP by 30 % or more was 4.45 (p < 0.001; 95 % CI, 1.79-11.07). RR in increasing lymphocyte count by 30 % or more was 1.28 (p = 0.327; 95 % CI, 0.67-2.45). Conclusion: we conclude that immunonutrient supplements seem to reduce CRP levels more than standard high-protein normocaloric supplements.

INTRODUCCIÓN: Introducción: los pacientes con COVID-19 sufren cambios en el recuento de leucocitos, trastornos respiratorios y aumento de sustancias inflamatorias. Para mejorar la condición inflamatoria se pueden usar algunos nutrientes, como la arginina, los ácidos grasos omega-3 y los nucleótidos. Este estudio tiene como objetivo evaluar cómo los suplementos de inmunonutrientes orales afectan a los niveles séricos de proteína C-reactiva (PCR) y al recuento de linfocitos en pacientes con COVID-19. Métodos: en este ensayo clínico doble ciego, aleatorizamos a 43 pacientes adultos con COVID-19 para recibir un suplemento normocalórico estándar alto en proteínas (control) o un suplemento enriquecido con inmunonutrientes (experimento) durante 7 días. El resultado primario fue evaluar los cambios en el recuento total de linfocitos y el nivel sérico de PCR. También se realizó la evaluación del riesgo y el estado nutricional de estos pacientes. Resultados: cuarenta y tres pacientes con edad media de 41,5 (± 1,8) años fueron seguidos, el 39,5 % de ellos mujeres. El índice de masa corporal medio fue de 27,6 (± 0,8) kg/m² y el 58,1 % tenían bajo riesgo nutricional. En el grupo experimental hubo una reducción de la PCR de 23,6 (± 7,5) mg/L, mientras que en la rama de control la disminución fue de 14,8 (± 12,1) mg/L (p = 0,002). Hubo un aumento de linfocitos en el grupo experimental (+367,5 ± 401,8 células/mm³) y una reducción en el grupo de control (-282,8 ± 327,8 células/mm³), aunque no hubo significación estadística (p = 0,369). El riesgo relativo (RR) del tratamiento para reducir la PCR en un 30 % o más fue de 4,45 (p < 0,001; IC 95 %: 1,79-11,07). El RR en el aumento del recuento de linfocitos en un 30 % o más fue de 1,28 (p = 0,327; IC 95 %: 0,67-2,45). Conclusión: se concluye que los suplementos de inmunonutrientes parecen reducir los niveles de PCR más que los suplementos normocalóricos estándar altos en proteína.

The Prevalence of Abdominal Adiposity among Primary Health Care Physicians in Bahia, Brazil: An Epidemiological Study.

BACKGROUND: Labor activities are demanding for workers and can induce occupational stress. Primary health care (PHC) workers have faced problems that can lead to the development of stress and abdominal obesity. The aim of this study was to estimate the prevalence of abdominal adiposity among primary health care physicians in the metropolitan mesoregion of Salvador, Bahia. METHODS: This is a cross-sectional study conducted with physicians from the family health units (FHUs) of the metropolitan mesoregion of Salvador, Bahia, Brazil. The number of FHUs corresponded to 41 teams (52 physicians). Anamnesis was performed and a questionnaire was applied. The clinical examination consisted of measuring waist circumference (WC), blood pressure levels (BP), and body mass index (BMI), as well as examining for acanthosis nigricans. Blood samples were collected for biochemical dosages. The data obtained were analyzed by SPSS version 22.0. RESULTS: The sample included 41 physicians (response rate: 78.8%), of which 18 were women (44.0%). The percentage of overweight participants represented by BMI was 31.7%. The hypertriglyceridemia prevalence was 29.2%. HDL-c was low in 48.7% of the participants. The waist circumference measurement revealed a prevalence of abdominal adiposity of 38.8% (women) and 34.8% (men). CONCLUSIONS: Medical professionals in PHC are more susceptible to having higher abdominal adiposity, especially female physicians.