Evaluation of the antioxidant and antityrosinase activities of Prosopis juliflora fruit extract as a novel multifunctional bioactive ingredient and its potential applicability in pro-ageing and skin colour harmonization cosmetic products.

OBJECTIVE: Prosopis juliflora, commonly known as algaroba or mesquite, was introduced and has since proliferated throughout the semi-arid region of the Caatinga biome. Various studies have documented its properties, including antimicrobial, antioxidant, and antitumor activities, attributed to the presence of diverse secondary metabolites such as alkaloids, terpenoids, tannins, and flavonoids. The objective of this study was to evaluate the antioxidant and antityrosinase activities of P. juliflora fruit extract as a multifunctional active ingredient, and to develop cosmetic formulations containing this vegetal extract for potential applications in skincare products targeting pro-ageing and skin colour homogenization properties. METHODS: The extraction process followed established protocols. Chemical characterization of the extract involved quantification of total flavonoids and phenolic compounds, along with Liquid Chromatography-Mass Spectrometry (LC-MS) analysis. In vitro antioxidant activity was assessed using different methods. Antityrosinase activity was determined by employing enzymatic assays. Cosmetic formulations containing Disodium EDTA, Phenoxyethanol (and) Ethylhexyl Glycerin, Distilled Water, Sodium Acrylates Copolymer Lecithin, Polyacrylamide (and) C13-14 Isoparaffin (and) Laureth-7, and 3.0% of the investigated plant extract were subjected to preliminary and accelerated stability tests. RESULTS: The extract demonstrated a concentration of total flavonoids (1.71 ± 0.26 µg EQ/mg) and exhibited concentrations of phenolic compounds at 0.21 ± 0.01 mg EAG/g. Metabolites such as flavonoids and saponins were annotated, as well as some of their respective glycosidic derivatives. The extract showed antioxidant potential and the ability to inhibit the oxidation cascade in both the initiation and propagation phases. Moreover, the extract exhibited noteworthy inhibition of antityrosinase activity, presenting 62.48 ± 2.09 at a concentration of 30.00 mg/mL. The formulations were stable in accelerated stability tests over a 60-day period. CONCLUSION: This research not only demonstrates scientifically by demonstrating the potential of a plant from the Caatinga biome with antioxidant and antityrosinase properties in the development of cosmetic products aimed at pro-ageing effects and skin colour harmonization, but also adds value to the P. juliflora production chain. This valorization encompasses various aspects which include environmental, social, and biodiversity responsibilities.

OBJECTIF: Prosopis juliflora, communément appelée algaroba ou mesquite, a été introduite et s'est depuis proliférée dans la région semi­aride du biome de la Caatinga. Diverses études ont documenté ses propriétés, y compris des activités antimicrobiennes, antioxydantes et antitumorales, attribuées à la présence de divers métabolites secondaires tels que les alcaloïdes, les terpénoïdes, les tanins et les flavonoïdes. L'objectif de cette étude était d'évaluer les activités antioxydantes et antityrosinases de l'extrait de fruit de P. juliflora en tant qu'ingrédient actif multifonctionnel, et de développer des formulations cosmétiques contenant cet extrait végétal pour des applications potentielles dans des produits de soins de la peau ciblant les propriétés anti­âge et d'homogénéisation de la couleur de la peau. MÉTHODES: Le processus d'extraction a suivi des protocoles établis. La caractérisation chimique de l'extrait a impliqué la quantification des flavonoïdes totaux et des composés phénoliques, ainsi qu'une analyse par chromatographie liquide­spectrométrie de masse. L'activité antioxydante in vitro a été évaluée en utilisant différentes méthodes. L'activité antityrosinase a été déterminée en utilisant des essais enzymatiques. Les formulations cosmétiques contenant du Disodium EDTA, du Phenoxyethanol (et) Ethylhexyl Glycerin, de l'Eau Distillée, du Copolymère de Sodium Acrylates Lecithin, du Polyacrylamide (et) C13­14 Isoparaffin (et) Laureth­7, et 3.0 % de l'extrait végétal investigué ont été soumises à des tests de stabilité préliminaires et accélérés. RÉSULTATS: L'extrait a montré une concentration totale de flavonoïdes (1.71 ± 0.26 µg EQ/mg) et des concentrations de composés phénoliques à 0.21 ± 0.01 mg EAG/g. Des métabolites tels que les flavonoïdes et les saponines ont été annotés, ainsi que certains de leurs dérivés glycosidiques respectifs. L'extrait a montré un potentiel antioxydant et la capacité d'inhiber la cascade d'oxydation tant dans les phases d'initiation que de propagation. De plus, l'extrait a présenté une inhibition notable de l'activité antityrosinase, avec un résultat de 62.48 ± 2.09 à une concentration de 30.00 mg/mL. Les formulations ont été stables lors des tests de stabilité accélérés sur une période de 60 jours. CONCLUSION: Cette recherche démontre scientifiquement le potentiel d'une plante du biome de la Caatinga avec des propriétés antioxydantes et antityrosinases dans le développement de produits cosmétiques visant les effets anti­âge et l'harmonisation de la couleur de la peau, tout en ajoutant de la valeur à la chaîne de production de P. juliflora. Cette valorisation englobe divers aspects incluant des responsabilités environnementales, sociales et liées à la biodiversité.

Evaluation of fatigue and quality of life of colorectal cancer patients in chemotherapy.

OBJECTIVE: To evaluate fatigue and health-related quality of life of colorectal cancer patients undergoing chemotherapy. METHOD: Descriptive study conducted with 69 patients between January and September/2019 in a public hospital in Minas Gerais. Instruments used: sociodemographic and clinical questionnaire, Quality of Life Questionnaire-Core30 and Piper Fatigue Scale, analyzed according to measures of frequency, mean and standard deviation by the software PSPP. RESULTS: Most patients were women over 60 years old, married, retired and housewives, with an average level of education. The scores of general health status, social, physical, emotional and role functioning were considered satisfactory (means 50 to 70), cognitive function was good (mean higher than 70); the most prevalent symptoms were loss of appetite, fatigue, pain and insomnia. As for fatigue, all dimensions had a mean value <4, considered mild fatigue. CONCLUSION: Quality of life had satisfactory scores and fatigue was classified as mild in patients undergoing chemotherapy.

Evaluation of fatigue and quality of life of colorectal cancer patients in chemotherapy / Evaluación de la fatiga y la calidad de vida de los pacientes con con cáncer colorrectal en quimioterapia / Avaliação da fadiga e da qualidade de vida de pacientes com câncer colorretal em quimioterapia

ABSTRACT Objective: To evaluate fatigue and health-related quality of life of colorectal cancer patients undergoing chemotherapy. Method: Descriptive study conducted with 69 patients between January and September/2019 in a public hospital in Minas Gerais. Instruments used: sociodemographic and clinical questionnaire, Quality of Life Questionnaire-Core30 and Piper Fatigue Scale, analyzed according to measures of frequency, mean and standard deviation by the software PSPP. Results: Most patients were women over 60 years old, married, retired and housewives, with an average level of education. The scores of general health status, social, physical, emotional and role functioning were considered satisfactory (means 50 to 70), cognitive function was good (mean higher than 70); the most prevalent symptoms were loss of appetite, fatigue, pain and insomnia. As for fatigue, all dimensions had a mean value <4, considered mild fatigue. Conclusion: Quality of life had satisfactory scores and fatigue was classified as mild in patients undergoing chemotherapy.

RESUMEN Objetivo: Evaluar la fatiga y la calidad de vida relacionada con la salud de los pacientes con cáncer colorrectal sometidos a quimioterapia. Método: Estudio descriptivo, realizado con 69 pacientes entre Enero y Septiembre/2019 en un hospital público de Minas Gerais. Instrumentos utilizados: cuestionario sociodemográfico y clínico, Quality of Life Questionnaire-Core30 y Piper Fatigue Scale, analizados según medidas de frecuencia, media y desviación estándar por el software PSPP. Resultados: La mayoría eran mujeres, mayores de 40 años, casadas, jubiladas y amas de casa, con un nivel medio de educación. Los puntajes del estado general de salud, las funciones social, física, emocional y desempeño del papel se consideraron satisfactorias (media 50 a 70), la función cognitiva fue buena (media superior a 70); los síntomas más prevalentes fueron pérdida de apetito, fatiga, dolor e insomnio. En cuanto a la fatiga, todas las dimensiones tienen una media de <4, considerada fatiga leve. Conclusión: La calidad de vida presentaba puntuaciones satisfactorias y la fatiga se clasificó como leve en pacientes sometidos a quimioterapia.

RESUMO Objetivo: Avaliar a fadiga e a qualidade de vida relacionada à saúde de pacientes com câncer colorretal em quimioterapia. Método: estudo descritivo, realizado com 69 pacientes entre janeiro a setembro/2019, em um hospital público de Minas Gerais. Instrumentos utilizados: questionário sociodemográfico e clínico, Quality of Life Questionnaire-Core30 e Escala de Fadiga de Piper, analisados segundo medidas de frequência, média e desvio padrão pelo softwarePSPP. Resultados: A maioria era mulheres, acima de 60 anos, casadas, aposentadas, donas de casa, com médio nível de escolaridade. Os escores de estado geral de saúde, das funções social, física, emocional e desempenho de papel foram considerados satisfatórios (médias50-70), da função cognitiva foi boa (média>70); sintomas mais prevalentes foram perda de apetite, fadiga, dor e insônia. Quanto à fadiga, todas as dimensões tiveram média <4, considerado fadiga leve. Conclusão: A qualidade de vida apresentou escores satisfatórios e a fadiga foi classificada como leve nos pacientes em quimioterapia.

Cooperative behavior and management of a patient care team in an oncohematology hospital service.

OBJECTIVE: to identify the perceptions of teamwork according to professionals of an oncohematology unit. METHODS: this is an exploratory study/qualitative approach. Nineteen health professionals from the oncohematology unit of a public teaching hospital participated. Data collection took place through semi-structured interviews, from September to December 2018. Data analysis followed Content Analysis, thematic modality, and the work process theoretical framework. RESULTS: two categories emerged: Cooperative behavior of professionals from an oncohematology unit, revealing meanings of teamwork and its facilitating/hindering factors in the unit, and Composition, characteristics and management of the unit, presenting teamwork in the perspective of organization/dynamics of work at the unit, material instruments, qualification/training, team composition and organizational management. FINAL CONSIDERATIONS: there is a need for management to know and better understand the work of workers and their difficulties, providing psychological support to the team.

Cooperative behavior and management of a patient care team in an oncohematology hospital service / Comportamiento cooperativo y gestión del equipo de atención al paciente en un servicio hospitalario de oncohematología / Comportamento cooperativo e gestão da equipe deassistência ao paciente em serviço hospitalar deoncohematologia

ABSTRACT Objective: to identify the perceptions of teamwork according to professionals of an oncohematology unit. Methods: this is an exploratory study/qualitative approach. Nineteen health professionals from the oncohematology unit of a public teaching hospital participated. Data collection took place through semi-structured interviews, from September to December 2018. Data analysis followed Content Analysis, thematic modality, and the work process theoretical framework. Results: two categories emerged: Cooperative behavior of professionals from an oncohematology unit, revealing meanings of teamwork and its facilitating/hindering factors in the unit, and Composition, characteristics and management of the unit, presenting teamwork in the perspective of organization/dynamics of work at the unit, material instruments, qualification/training, team composition and organizational management. Final considerations: there is a need for management to know and better understand the work of workers and their difficulties, providing psychological support to the team.

RESUMEN Objetivo: identificar las percepciones del trabajo en equipo según los profesionales de una unidad de oncohematología. Métodos: estudio exploratorio/abordaje cualitativo. Participaron 19 profesionales de la salud de la unidad de oncohematología de un hospital universitario público. La recolección de datos se realizó a través de entrevistas semiestructuradas, de septiembre a diciembre de 2018. El análisis de los datos siguió el Análisis de Contenido, la modalidad temática y el marco teórico del proceso de trabajo. Resultados: surgieron dos categorías temáticas: Comportamiento cooperativo de los profesionales de la unidad de oncohematología, revelando significados del trabajo en equipo y sus factores facilitadores/obstaculizadores en la unidad, y Composición, características y gestión de la unidad, presentando el trabajo en equipo en la perspectiva de la organización/dinámica. de trabajo en la unidad, instrumentos materiales, cualificación/formación, composición del equipo y gestión organizativa. Consideraciones finales: existe la necesidad de que la gerencia comprenda y comprenda mejor el trabajo de los agentes y sus dificultades, brindando apoyo psicológico al equipo.

RESUMO Objetivo: identificar as percepções do trabalho em equipe segundo os profissionais de uma unidade de oncohematologia. Métodos: estudo exploratório/abordagem qualitativa. Participaram 19 profissionais de saúde da unidade de oncohematologia de um hospital público de ensino. A coleta de dados ocorreu por meio de entrevistas semiestruturadas, de setembro a dezembro de 2018. Análise de dados seguiu a Análise de Conteúdo, modalidade temática, e o referencial teórico de processo de trabalho. Resultados: emergiram duas categorias temáticas: Comportamento cooperativo dos profissionais da unidade de oncohematologia, revelando significados do trabalho em equipe e seus fatores facilitadores/dificultadores na unidade, e Composição, características e gestão da unidade, apresentando o trabalho em equipe na perspectiva da organização/dinâmica do trabalho na unidade, instrumentos materiais, capacitação/treinamento, composição da equipe e gestão organizacional. Considerações finais: destaca-se necessidade de a gestão conhecer e entender melhor o trabalho dos agentes e suas dificuldades, disponibilizando o amparo psicológico à equipe.