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Science ; 385(6705): 154-156, 2024 Jul 12.
Artigo em Inglês | MEDLINE | ID: mdl-38991082

RESUMO

Highlights from the Science family of journals.

3.
Science ; 385(6707): 402-404, 2024 Jul 26.
Artigo em Inglês | MEDLINE | ID: mdl-39052784

RESUMO

Highlights from the Science family of journals.

4.
Science ; 384(6699): 972-974, 2024 May 31.
Artigo em Inglês | MEDLINE | ID: mdl-38815036

RESUMO

Highlights from the Science family of journals.

5.
Science ; 383(6689): 1305-1307, 2024 Mar 22.
Artigo em Inglês | MEDLINE | ID: mdl-38513033

RESUMO

Highlights from the Science family of journals.

7.
Science ; 383(6678): 39-41, 2024 Jan 05.
Artigo em Inglês | MEDLINE | ID: mdl-38175883

RESUMO

Highlights from the Science family of journals.

11.
Science ; 382(6674): 1009-1011, 2023 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-38033083

RESUMO

Highlights from the Science family of journals.

12.
Science ; 382(6666): 46-47, 2023 10 06.
Artigo em Inglês | MEDLINE | ID: mdl-37797029
13.
Science ; 382(6668): 278-280, 2023 Oct 20.
Artigo em Inglês | MEDLINE | ID: mdl-37856611

RESUMO

Highlights from the Science family of journals.

14.
Res Sq ; 2023 Oct 12.
Artigo em Inglês | MEDLINE | ID: mdl-37886553

RESUMO

Men of African descent have the highest prostate cancer (CaP) incidence and mortality rates, yet the genetic basis of CaP in African men has been understudied. We used genomic data from 3,963 CaP cases and 3,509 controls recruited in Ghana, Nigeria, Senegal, South Africa, and Uganda, to infer ancestry-specific genetic architectures and fine-mapped disease associations. Fifteen independent associations at 8q24.21, 6q22.1, and 11q13.3 reached genome-wide significance, including four novel associations. Intriguingly, multiple lead SNPs are private alleles, a pattern arising from recent mutations and the out-of-Africa bottleneck. These African-specific alleles contribute to haplotypes with odds ratios above 2.4. We found that the genetic architecture of CaP differs across Africa, with effect size differences contributing more to this heterogeneity than allele frequency differences. Population genetic analyses reveal that African CaP associations are largely governed by neutral evolution. Collectively, our findings emphasize the utility of conducting genetic studies that use diverse populations.

15.
Science ; 381(6665): 1423-1425, 2023 Sep 29.
Artigo em Inglês | MEDLINE | ID: mdl-37769098

RESUMO

Highlights from the Science family of journals.

16.
Science ; 381(6658): 642-644, 2023 Aug 11.
Artigo em Inglês | MEDLINE | ID: mdl-37561853

RESUMO

Highlights from the Science family of journals.

17.
Science ; 381(6657): 496-498, 2023 Aug 04.
Artigo em Inglês | MEDLINE | ID: mdl-37535714

RESUMO

Highlights from the Science family of journals.

18.
Science ; 381(6655): 280-282, 2023 Jul 21.
Artigo em Inglês | MEDLINE | ID: mdl-37471541

RESUMO

Highlights from the Science family of journals.

19.
Science ; 380(6652): 1333-1335, 2023 Jun 30.
Artigo em Inglês | MEDLINE | ID: mdl-37384678

RESUMO

Highlights from the Science family of journals.

20.
Science ; 380(6650): 1142-1144, 2023 Jun 16.
Artigo em Inglês | MEDLINE | ID: mdl-37319225

RESUMO

Highlights from the Science family of journals.

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