RESUMO
Health consequences that persist beyond the acute infection phase of COVID-19, termed post-COVID-19 condition (also commonly known as long COVID), vary widely and represent a growing global health challenge. Research on post-COVID-19 condition is expanding but, at present, no agreement exists on the health outcomes that should be measured in people living with the condition. To address this gap, we conducted an international consensus study, which included a comprehensive literature review and classification of outcomes for post-COVID-19 condition that informed a two-round online modified Delphi process followed by an online consensus meeting to finalise the core outcome set (COS). 1535 participants from 71 countries were involved, with 1148 individuals participating in both Delphi rounds. Eleven outcomes achieved consensus for inclusion in the final COS: fatigue; pain; post-exertion symptoms; work or occupational and study changes; survival; and functioning, symptoms, and conditions for each of cardiovascular, respiratory, nervous system, cognitive, mental health, and physical outcomes. Recovery was included a priori because it was a relevant outcome that was part of a previously published COS on COVID-19. The next step in this COS development exercise will be to establish the instruments that are most appropriate to measure these core outcomes. This international consensus-based COS should provide a framework for standardised assessment of adults with post-COVID-19 condition, aimed at facilitating clinical care and research worldwide.
Assuntos
COVID-19 , Adulto , COVID-19/complicações , Técnica Delphi , Humanos , Avaliação de Resultados em Cuidados de Saúde , Projetos de Pesquisa , Resultado do Tratamento , Síndrome de COVID-19 Pós-AgudaRESUMO
Background: Whether long coronavirus disease pertains to children as well is not yet clear. Methods: The authors performed a survey in children suffering from persistent symptoms since initial infection. A total of 510 children infected between January 2020 and January 2021 were included. Results: Symptoms such as fatigue, headache, muscle and joint pain, rashes and heart palpitations and issues such as lack of concentration and short-term memory problems were particularly frequent and confirm previous observations, suggesting that they may characterize this condition. Conclusion: A better comprehension of long coronavirus disease is urgently needed.
Assuntos
COVID-19 , Saúde Mental , Criança , Fadiga/diagnóstico , Humanos , SARS-CoV-2 , Inquéritos e QuestionáriosRESUMO
BACKGROUND: A substantial portion of people with COVID-19 subsequently experience lasting symptoms including fatigue, shortness of breath, and neurological complaints such as cognitive dysfunction many months after acute infection. Emerging evidence suggests that this condition, commonly referred to as long COVID but also known as post-acute sequelae of SARS-CoV-2 infection (PASC) or post-COVID-19 condition, could become a significant global health burden. MAIN TEXT: While the number of studies investigating the post-COVID-19 condition is increasing, there is no agreement on how this new disease should be defined and diagnosed in clinical practice and what relevant outcomes to measure. There is an urgent need to optimise and standardise outcome measures for this important patient group both for clinical services and for research and to allow comparing and pooling of data. CONCLUSIONS: A Core Outcome Set for post-COVID-19 condition should be developed in the shortest time frame possible, for improvement in data quality, harmonisation, and comparability between different geographical locations. We call for a global initiative, involving all relevant partners, including, but not limited to, healthcare professionals, researchers, methodologists, patients, and caregivers. We urge coordinated actions aiming to develop a Core Outcome Set (COS) for post-COVID-19 condition in both the adult and paediatric populations.
Assuntos
COVID-19 , Adulto , COVID-19/complicações , Criança , Progressão da Doença , Humanos , Avaliação de Resultados em Cuidados de Saúde , SARS-CoV-2 , Síndrome de COVID-19 Pós-AgudaRESUMO
BACKGROUND: The long-term sequelae of coronavirus disease 2019 (COVID-19) in children remain poorly characterised. This study aimed to assess long-term outcomes in children previously hospitalised with COVID-19 and associated risk factors. METHODS: This is a prospective cohort study of children (≤18â years old) admitted to hospital with confirmed COVID-19. Children admitted between 2 April 2020 and 26 August 2020 were included. Telephone interviews used the International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC) COVID-19 Health and Wellbeing Follow-up Survey for Children. Persistent symptoms (>5â months) were further categorised by system(s) involved. RESULTS: 518 out of 853 (61%) eligible children were available for the follow-up assessment and included in the study. Median (interquartile range (IQR)) age was 10.4 (3-15.2)â years and 270 (52.1%) were girls. Median (IQR) follow-up since hospital discharge was 256 (223-271)â days. At the time of the follow-up interview 126 (24.3%) participants reported persistent symptoms, among which fatigue (53, 10.7%), sleep disturbance (36, 6.9%) and sensory problems (29, 5.6%) were the most common. Multiple symptoms were experienced by 44 (8.4%) participants. Risk factors for persistent symptoms were: older age "6-11â years" (OR 2.74, 95% CI 1.37-5.75) and "12-18â years" (OR 2.68, 95% CI 1.41-5.4), and a history of allergic diseases (OR 1.67, 95% CI 1.04-2.67). CONCLUSIONS: A quarter of children experienced persistent symptoms months after hospitalisation with acute COVID-19 infection, with almost one in 10 experiencing multisystem involvement. Older age and allergic diseases were associated with higher risk of persistent symptoms at follow-up.
Assuntos
COVID-19 , Adolescente , Idoso , Criança , Criança Hospitalizada , Feminino , Seguimentos , Humanos , Estudos Prospectivos , Fatores de Risco , SARS-CoV-2Assuntos
COVID-19 , COVID-19/complicações , Criança , Humanos , Pais , SARS-CoV-2 , Síndrome de COVID-19 Pós-AgudaRESUMO
BACKGROUND AND PURPOSE: A three module online self-paced educational resource was developed for entry to practice students transitioning from the classroom to their inpatient practicums. The objective of this study was to determine the benefits of the transition modules on students' self-perceived competency as related to onsite performance and reduction in anxiety during their inpatient practicum. EDUCATIONAL ACTIVITY AND SETTING: Evaluations of the three transition modules were conducted in two phases via electronic surveys distributed to final year advanced pharmacy practice students and focus group members including faculty, pharmacy practice educators, and pharmacy residents. FINDINGS: Based on our findings, the modules addressed common learning needs. While 69.7% of student respondents from Phase II of the evaluation found the modules to have positively impacted their onsite performance, only 24.7% believed the modules reduced their anxiety. DISCUSSION: The study indicates that students found the modules to be relevant to inpatient practice and of appropriate difficulty. Although most students perceived the modules to enhance performance on practicum, student anxiety levels appeared to remain unchanged. SUMMARY: Based on feedback and results, it may be beneficial to expose students to transition modules earlier in the curriculum in tandem with other inpatient preparatory activities. The results from this study may be of interest or benefit other universities and healthcare educators pursuing work on transition activities.
Assuntos
Currículo/normas , Educação a Distância/normas , Estudantes de Farmácia/psicologia , Educação a Distância/métodos , Educação de Pós-Graduação em Farmácia/métodos , Avaliação Educacional/métodos , Retroalimentação , Humanos , Internet , Avaliação de Programas e Projetos de Saúde/métodos , Autoimagem , Estudantes de Farmácia/estatística & dados numéricos , Inquéritos e QuestionáriosRESUMO
BACKGROUND AND PURPOSE: The purpose of this paper is to describe the development of a series of six, self-paced online practice educator development modules and to describe the preliminary program evaluation conducted for them. EDUCATIONAL ACTIVITY AND SETTING: Six online learning modules were developed. In the preliminary program evaluation, a mixed methods approach was used to investigate whether module content was effective in conveying useful information to practice educators and was reaching those at a geographic distance from the University of British Columbia (UBC) in Vancouver, Canada. User demographic data, module completion results, user evaluation survey responses, and content expert reviews of the modules were collected and analyzed for quality assurance and program evaluation. FINDINGS: The preliminary evaluation results indicated a positive response. The evaluation survey results showed that most practice educators found their understanding of the subject had increased from their personal baseline after completing the module. From the total of 197 users that had registered for the Practice Educator Resource Centre and self-declared their geographic location, 56% were categorized as being within the Lower Mainland, while 44% were located outside of this area, at a geographic distance from UBC. DISCUSSION: This early data indicated the modules were reaching practice educators across BC. Continual evaluation will be needed to support the preliminary positive practice educator user experience. SUMMARY: The self-paced online practice educator modules are an accessible and possibly effective means of providing skills and training to new and current pharmacy practice educators.