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1.
Kathmandu Univ Med J (KUMJ) ; 19(74): 195-199, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34819435

RESUMO

Background With increasing age, the older population becomes more susceptible to mental disorders. It is important to recognize and develop an understanding of psychiatric morbidity particularly among the residents of geriatric homes in resource-poor settings. Objective To assess the prevalence and associated factors of dementia symptoms among Nepalese senior citizens living in geriatric homes of Kathmandu valley. Method A cross-sectional study was conducted among 304 senior citizens living in geriatric homes of Kathmandu valley. Cognitive Impairment Test (CIT), was used to assess dementia symptoms. Bivariate and multivariate logistic regressions were performed. All the variables that were significant at p < 0.05 level in the bivariate analysis were included in the multivariate regression model and statistical significance was declared at p < 0.05 with a 95.00% confidence interval (CI). Result This study showed 75.65%, of the participants, had dementia symptoms. In the multivariate logistic regression analysis, female respondents (AOR=2.94, 95% CI=1.31-6.57), respondents never received geriatric allowances (AOR=2.46, 95% CI=1.22-4.98), respondent's history of alcohol consumption habits (AOR=2.04, 95% CI=1.01-4.11) and non-vegetarian diet habits (AOR= 2.31, 95% CI=1.12-4.76) were found more likely to had higher dementia symptoms whereas, literate participants (AOR=0.19, 95% CI=0.08-0.43) were less likely to had dementia symptoms. Conclusion The high prevalence of dementia symptoms among senior citizens living in geriatric homes in the Kathmandu valley indicates an urgent need for early diagnosis and treatment of mental disorders among senior citizens to improve their quality of life and well-being.


Assuntos
Demência , Qualidade de Vida , Idoso , Estudos Transversais , Demência/epidemiologia , Feminino , Humanos , Modelos Logísticos , Prevalência
2.
Kathmandu Univ Med J (KUMJ) ; 17(68): 322-328, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-33311043

RESUMO

Background Thyroid disorders are emerging public health issues. Clients' awareness is crucial for prevention, early diagnosis, and treatment of the thyroid disorders. Studies, assessing knowledge on thyroid disorders among Nepalese population, is lacking. Objective To assess the awareness of thyroid disorders among women, a susceptible subgroup, and find the correlates of poor knowledge. Method A cross-sectional study was conducted among 423 women at the gynecological outpatient department of Tribhuvan University Teaching Hospital. Eighteen-item scale, with a Cronbach's Alpha of 0.913, was developed to assess participant's knowledge on various constructs of thyroid disorder. A linear regression model with Bootstrap approach was used to identify the predictors of the total knowledge score. Result The mean (±SD) age of the participant was 29.2 ± 7.0 years. About 49% of the women had inadequate knowledge, defined at or below the mean cumulative knowledge score. In linear regression, the total knowledge score was significantly lower among participants who were Janajati (ß=-2.87, BCa 95%CI=-4.61, -1.11), illiterate (ß=- 6.37, BCa 95%CI =-9.14, -3.21), and low income (ß=-3.76, BCa 95%CI=-5.68, -1.83). Likewise, a university education (ß=5.94, BCa 95%CI=3.50, 8.26), working status (ß=4.04, BCa 95%CI=2.19, 5.81), urban residence (ß=2.06, BCa 95%CI=0.02, 3.96) and family history (ß=2.20, BCa 95%CI=0.71, 3.63) of thyroid disorder predicted higher knowledge score. Conclusion This study identified a poor level of knowledge on thyroid disorders among Nepali women and thus proposes them to be an important subgroup for an intervention or policy aimed at promoting awarenessof thyroid disorders. The findings also warrant increased awareness among these population through hospital and communitybased behavior change communication campaigns.


Assuntos
Doenças da Glândula Tireoide , Mulheres , Estudos Transversais , Feminino , Conhecimentos, Atitudes e Prática em Saúde , Humanos
3.
JNMA J Nepal Med Assoc ; 56(206): 221-225, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-28746319

RESUMO

INTRODUCTION: Systemic inflammatory response syndrome symptoms immediately after surgery have lately been regarded as potential warnings of impending post-operative complications and multiple organ failure. This study was conducted to find out the clinical significance of systemic inflammatory response syndrome in postoperative patients and to investigate the relationship between the duration of post-operative systemic inflammatory response syndrome and the post-operative morbidity and mortality. METHODS: Total 30 patients who received different gastrointestinal surgery and fulfilled the diagnostic criteria for systemic inflammatory response syndrome between 2006 and 2008 at Kathmandu Medical College Teaching Hospital were included. Patients were analyzed for preoperative physiologic status, surgical stress parameters, and postoperative status of systemic inflammatory response syndrome, complications, and end-organ dysfunction. RESULTS: Duration of systemic inflammatory response syndrome or positive criteria's number of systemic inflammatory response syndrome after surgery significantly correlated with surgical stress parameters (blood loss/body weight and operation time). Septic complications and prolongation of systemic inflammatory response syndrome were associated with multiple organ dysfunction syndrome and increased mortality. CONCLUSIONS: Systemic inflammatory response syndrome is a useful criterion for the recognition of postoperative complications and end-organ dysfunctions. Early recovery from systemic inflammatory response syndrome may arrest the progression of organ dysfunction, thus reducing the mortality.


Assuntos
Procedimentos Cirúrgicos do Sistema Digestório/efeitos adversos , Insuficiência de Múltiplos Órgãos , Complicações Pós-Operatórias , Síndrome de Resposta Inflamatória Sistêmica , Perda Sanguínea Cirúrgica/estatística & dados numéricos , Procedimentos Cirúrgicos do Sistema Digestório/métodos , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Insuficiência de Múltiplos Órgãos/diagnóstico , Insuficiência de Múltiplos Órgãos/etiologia , Nepal/epidemiologia , Duração da Cirurgia , Complicações Pós-Operatórias/diagnóstico , Complicações Pós-Operatórias/epidemiologia , Prognóstico , Estudos Retrospectivos , Síndrome de Resposta Inflamatória Sistêmica/diagnóstico , Síndrome de Resposta Inflamatória Sistêmica/epidemiologia , Síndrome de Resposta Inflamatória Sistêmica/etiologia , Fatores de Tempo
4.
JNMA J Nepal Med Assoc ; 56(205): 117-123, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-28598447

RESUMO

INTRODUCTION: Concomitant cholelithiasis and choledocholithiasis are commonly managed in two stage procedure, endoscopic management of common bile duct stone followed by laparoscopic cholecystectomy in different time and setting. We perform these two procedures in same sitting in operating room set up. We evaluated the procedure in terms of outcome, feasibility and complications. METHODS: Prospective cross-sectional study carried out since April 2013 to August 2016 in all patients who had undergone single stage endoscopic and laparoscopic management of concomitant cholelithiasis and choledocholithiasis. Patient's demography, procedural time for different procedure and procedure in total and post-operative complications were recorded and analyzed with suitable statistical methods. RESULTS: Out of 50 cases enrolled, 2 patients were converted to open. Out of 48 patients, 3 needed re-attempt for completion. Majority were female 36 (72%), mean age was 39.48years. Mean common bile duct diameter and mean stone size was 11.43±2.63 cm and 7.99±2.01cm, respectively. Mean of total procedural time was 90.93± 33.68 minutes. In most of the cases, laparoscopic cholecystectomy performed first followed by endoscopic method (66.7%). Total procedural time was less in the patients who underwent laparoscopy first in comparison to endoscopy first. Clinically significant complications like cholangitis, pancreatitis and duodenal perforation occurred in 7 patients. Out of 4 patients who developed pancreatitis, one had severe acute pancreatitis requiring prolonged hospitalization. CONCLUSION: Single stage management of common bile duct and gall bladder stone by laparoscopic and endoscopic method is feasible in our setup with acceptable results. Endoscopic treatment of common bile duct stone if performed first, is associated with longer procedural time.


Assuntos
Colangiopancreatografia Retrógrada Endoscópica , Colecistectomia Laparoscópica , Coledocolitíase/cirurgia , Colelitíase/cirurgia , Adolescente , Adulto , Idoso , Coledocolitíase/complicações , Colelitíase/complicações , Estudos Transversais , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Resultado do Tratamento
5.
Kathmandu Univ Med J (KUMJ) ; 14(53): 54-57, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-27892442

RESUMO

Background Being the most backward region, The Far Western Development Region has high illiteracy rate, low socioeconomic status and high migration rate contributing the progression of epidemiological status of Human Immunodeficiency Virus (HIV) towards generalized form. Objective To study the demographic profile of the HIV positive patients, along with their CD4 status and tuberculosis during diagnosis. Method A retrospective descriptive study carried out from May 2006 to July 2012 in 271 HIV patients registered in HIV clinic of Mahakali Zonal Hospital, Mahendranagar. Result Among 271 patients enrolled, 48.30% (131) were male and 51.7% (140) were females. Thirty seven (13.7%) were less than 15 years and 76.3% (207) were of age 16-45 years. 38.7% were household workers by occupation and 34.50% were involved in agriculture and 3.70%were migrant labour. At the time of presentation, 22.4% (60) were stage I according to WHO staging and 18.5% (50), 58.5 (158) and 0.7% (2) were of stage II, III and IV respectively. Similarly, 33.0% (89) had more than 350 CD4 count at the time of presentation. 20.8% (56) of patients were infected with tuberculosis. Among 236 families, 2 or more members were found to be affected in 24 families. In most of the cases, female were diagnosed first followed by male in the families, where both the couple were infected. Conclusion Most of the HIV infected patients were of productive age group. Majority of patients were uneducated and Tuberculosis was found to be common opportunistic infections associated with HIV infection.


Assuntos
Infecções por HIV/epidemiologia , Infecções Oportunistas Relacionadas com a AIDS , Adolescente , Adulto , Fatores Etários , Contagem de Linfócito CD4 , Progressão da Doença , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Nepal/epidemiologia , Estudos Retrospectivos , Índice de Gravidade de Doença , Fatores Sexuais , Fatores Socioeconômicos , Tuberculose/epidemiologia , Adulto Jovem
6.
Food Chem ; 176: 244-53, 2015 Jun 01.
Artigo em Inglês | MEDLINE | ID: mdl-25624230

RESUMO

The present study investigated the changes in phytochemicals and antioxidant activities in 25 leafy vegetables with two common boiling practices viz., with 5% NaCl solution (BSW) and normal water (BNW) in a domestic microwave oven. Fresh samples (100g) were rich in polyphenols (58.8-296.9mg), tannin (402.0-519.4mg), flavonoids (148.9-614.4mg), carotenoids (69.0-786.3mg), anthocyanin (11.7-493.7mg) and ascorbic acid (245.0-314.2mg). Microwave boiling significantly (p<0.05) decreased/increased phytochemicals but none of the compounds followed same trend in all vegetables. Boiling process reduced anti-nutrients from fresh samples (FS) as observed for nitrate (4.5-73.6% by BSW and 22.5-98.8% by BNW); phytate (6.2-69.7% by BSW and 10.6-57.3% by BNW) and oxalate (14.7-88.9% by BSW and 14.5-87.3% by BNW) but saponin increased in 18 vegetables by BNW while 8 vegetables by BSW. The study revealed differential pattern of change in phytochemical matrix and anti-nutrients in vegetables by microwave boiling which will help in devising efficient cooking practices and contribute in health and nutritional security.


Assuntos
Antioxidantes/farmacologia , Compostos Fitoquímicos/análise , Verduras/química , Antocianinas/análise , Flavonoides/análise , Micro-Ondas , Fenóis/análise , Folhas de Planta/química , Cloreto de Sódio/farmacologia , Taninos/análise
7.
Int J Food Sci Nutr ; 63(4): 446-52, 2012 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-22080844

RESUMO

The present study aimed to determine the antioxidant activity and phytochemical contents in 10 underutilized fruits of Andaman Islands (India) namely Malpighia glabra L., Mangifera andamanica L., Morinda citrifolia L., Syzygium aqueum (Burm.f) Alst., Annona squamosa L., Averrhoa carambola L., Averrhoa bilimbi L., Dillenia indica L., Annona muricata L. and Ficus racemosa L. The antioxidant activity varied from 74.27% to 98.77%, and the methanol extract of M. glabra showed the highest antioxidant activity (98.77%; inhibitory concentration, IC(50) = 262.46 µg/ml). Methanol was found to be a better solvent than acetone and aqueous for estimating the antioxidant activity. M. glabra was found to be rich in phytochemicals viz. polyphenol (355.74 mg/100 g), anthocyanin (91.31 mg/100 g), carotenoids (109.16 mg/100 g), tannin (24.39 mg/100 g) and ascorbic acid (394.23 mg/100 g). Carbohydrate content was estimated to be highest in M. glabra (548 mg/100 g). Phenols, tannins, anthocyanins and carotenoids contents showed positive correlation (r² = 0.846, r² = 0.864, r² = 0.915 and r² = 0.806, respectively) with antioxidant activity. The information generated in present study will be useful for bioprospecting of underutilized fruits of Andaman Islands.


Assuntos
Antioxidantes/farmacologia , Dieta , Análise de Alimentos , Frutas/química , Magnoliopsida/química , Extratos Vegetais/farmacologia , Antocianinas/análise , Antocianinas/farmacologia , Antioxidantes/análise , Carotenoides/análise , Carotenoides/farmacologia , Carboidratos da Dieta/análise , Humanos , Índia , Fenóis/análise , Fenóis/farmacologia , Extratos Vegetais/química , Taninos/análise , Taninos/farmacologia
8.
Int J Food Sci Nutr ; 62(7): 765-73, 2011 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-21615278

RESUMO

In present study, 10 preferred traditional vegetables from Andaman and Nicobar Islands, India, were analysed for nutritional profiles. Moisture content in their edible parts ranged from 83.43 to 94.78%. Maximum ash content was recorded in Portulaca oleracea, crude protein in Colocasia esculenta, crude fibre in Eryngium foetidum and fat in E. foetidum. Phosphorus was maximum in Ipomea aquatica, potassium in C. esculenta, zinc, calcium and manganese in Centella asiatica, copper in Sauropus androgynous, sodium and iron in P. oleracea, magnesium in Amaranthus viridi and cobalt in C. esculenta. Maximum polyphenol was recorded in Hibiscus sabdariffa, carotenoids in A. viridi, ascorbic acid in Saursops androgynus, anthocyanin in C. esculenta and chlorophyll in S. androgynus. Antioxidant activity was maximum in P. oleracea. Positive correlation was observed between polyphenol and tannin content and also between antioxidant activity and photochemicals. The developed nutritional profiles is being used in health and nutrition related schemes in Islands.


Assuntos
Antioxidantes/análise , Fibras na Dieta/análise , Proteínas Alimentares/análise , Magnoliopsida/química , Micronutrientes/análise , Oligoelementos/análise , Verduras/química , Ácido Ascórbico/análise , Clorofila/análise , Índia , Valor Nutritivo , Proteínas de Plantas/análise , Polifenóis/análise , Taninos/análise , Vitaminas/análise , Água/análise
9.
J Nepal Health Res Counc ; 9(1): 17-20, 2011 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-22929706

RESUMO

BACKGROUND: A current assessment of liver abscesses should allow for better understanding of the pathogenesis of the disease and improve the effectiveness of diagnosis and treatment. Amoebic liver abscess occurs more commonly than the pyogenic liver abscess on a worldwide basis. The purpose of the study is to investigate the clinical presentation and management option for liver abscess. METHODS: A prospective observational study was conducted from January 2007 to December 2010, in Kathmandu Medical College Teaching Hospital. We recorded and analyzed the clinical presentations, diagnostic modalities, treatment programmes of all liver abscesses. RESULTS: Liver abscess was more common in males, 24(85.7%) males and 4(14.3%) females, occurring more frequently in right lobe of liver. Most patients presented with nonspecific clinical and biochemical features. Twenty (71.4%) patients presented with chills & rigors. Five patients (17.8%) presented jaundice and none had transaminases raised but 15(56.3%) had raised alkaline phospahatases. Eight (28.5%) patients were treated with antibiotics alone. USG guided drainage was done in 12(42.8%) patients and 6(21.4%) required surgical exploration with laparoscopic deroofing in 2(7.1%) patients. The largest size was 1100cc.with right lobe predominance in 20(76.9%) patients and single lobe involvement in 22(78.4%) patients. Six (21.4%) patients had multiple liver lobes involved. Three (7.1%) patients had ruptured liver abscess and 3(7.1%) had right sided pleural effusion. Seventeen (60.7%) patients were diagnosed have amoebic liver abscess. Ten (35.7%) patients were found to have pyogenic liver abscess. One (3.5%) had tuberculosis. CONCLUSIONS: Liver abscess requires a high degree of suspicion for early diagnosis. When appropriate therapy in the form of antibiotics in combination with percutaneous drainage or surgery is administered the mortality is very low. However, significant morbidity is still a problem in old debilitated persons with other core morbidities.


Assuntos
Abscesso Hepático/diagnóstico , Abscesso Hepático/terapia , Adolescente , Adulto , Idoso , Criança , Feminino , Hospitais de Ensino , Humanos , Masculino , Pessoa de Meia-Idade , Nepal , Estudos Prospectivos , Pesquisa Qualitativa , Adulto Jovem
10.
J Nepal Health Res Counc ; 9(1): 21-4, 2011 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-22929707

RESUMO

BACKGROUND: Ureteral stones present with acute loin to groin pain. The objective of this study is to find out the outcome and safety of semi-rigid ureterscopy with pneumatic lithotripsy for treatment of ureteral stones of >30 mm(2) and to assess the impact of size and location on stone free (SF) rate. METHODS: Total 110 patients with isolated ureteral stone size>30 mm(2) were included in this study and treated with pneumatic lithotripsy using 8/9.8 Fr. Semi-rigid ureteroscope (Stiema Germany). Stones were fragmented into 2-3 mm particles and removed. Outcome parameters assessed at 3 months follow up were stone free rate(SF),Efficiency Quotient (EQ), and impact of stone size and site on SF/EQ was also analyzed. Similarly, patient demographics, procedures, patient related parameters and complications were also noted. RESULTS: The overall SF rate at 3 months follow up was 69.33% and efficient Quotient (EQ) 52.52%. The SF/EQ for upper, middle and lower third of ureteral stone was 55/37.67, 61/43.57, 92/84.40 respectively (P-value< 0.001). The SF for stone size 30-110 mm(2) and >110 mm(2) was 78% and 67% respectively. There were no major complications seen. Overall minor complication rate was 5.45 % (minor ureteral perforations-5, urinoma formation 1). CONCLUSIONS: Semi-rigid ureteroscopy with pneumatic lithotripsy is a safe, simple and effective procedure for ureteral stones with excellent success rate for distal ureteral stones. The stone free rate and EQ are statistically significant (P value<0.001) between upper, middle and lower ureteral stones. Stone size has a direct impact on the SF rate and EQ.


Assuntos
Litotripsia/métodos , Cálculos Ureterais/cirurgia , Ureteroscopia/métodos , Adolescente , Adulto , Idoso , Estudos Transversais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Resultado do Tratamento , Ureteroscópios , Adulto Jovem
11.
J Nepal Health Res Counc ; 9(1): 38-43, 2011 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-22929711

RESUMO

BACKGROUND: The reported prevalence of biliary tract disruption following laparoscopic cholecystectomy has ranged from 0% to 7% in early reports. Bile leaks are the most common biliary complication of laparoscopic cholecystectomy. METHODS: Total 530 patients who had undergone laparoscopic cholecystectomy from January 2004 to November 2006 at Kathmandu Medical College Teaching Hospital were studied for biliary complications after laparoscopic cholecystectomy. RESULTS: We reviewed 500 laparoscopic cholecystectomies performed at our institution and found 13 cases of bile extravasation and/or biloma formation and/or bile duct injuries (prevalence, 2.6%). One bile duct transection was acutely recognized and treated with hepaticojejunostomy. Three lateral bile duct injuries were also acutely recognized, two of them were managed with primary repair of CBD without T tube and the other was managed with repair and T-tube drainage. Two patients had postoperative generalized biliary peritonitis, one of whom was undergone exploratory laparotomy and found to have lateral injury on CBD which was managed with repair and T-tube drainage, whereas the other was undergone diagnostic laparoscopy with clipping of duct of Lushka. Two patients presented within seven days with biloma, one was treated with percutaneous drainage alone, the other treated with percutanous drainage was found to be complete transection of CBD on subsequent ERCP and managed with late hepaticojejunostomy. One patient with continued bile leak from surgical drainage tube for more than one week was managed with ERCP, diagnosed to be bile leak from duct of Lushka, managed by sphincterotomy and bile duct stenting. One patient presented with obstructive jaundice 6 months after laparoscopic cholecystectomy was found to have Bismuth type II bile duct stricture and was undergone hepaticojejunostomy. The remaining three had bile leak from surgical drainage which resolved within one week without further complication. CONCLUSIONS: Laparoscopic cholecystectomy appears to be associated with a higher incidence of bile duct injury than previous reports of open cholecystectomy. Possible explanations include variant anatomy plus failure to obtain an operative cholangiogram, inadequate dissection, injudicious use of cautery or clip placement, inherent limitations of the procedure, or the learning curve associated with a new technology.


Assuntos
Ductos Biliares/lesões , Colecistectomia Laparoscópica/efeitos adversos , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Criança , Estudos Transversais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Nepal/epidemiologia , Estudos Prospectivos , Adulto Jovem
12.
J Nepal Health Res Counc ; 9(2): 165-8, 2011 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-22929847

RESUMO

BACKGROUND: The aim of this study is to investigate the bacteriology of urinary tract infection associated with indwelling DJ stent. METHODS: A total of 60 patients were included and 14 lost during follow up. Study period was for 6 months carried out in the department of surgery, Kathmandu Medical College. Prophylactic antibiotic was given at the time of intervention. Mid stream urine samples for routine and culture were sent before intervention. Urine samples during DJ removal and DJ tip cultures were also sent. All patients were "stented" during the various open and endourolgical procedures. Patients were clinically followed for a period till the DJ was removed. Statistical Package for Scientific Study (SPSS) 11, Chi square Test was used for statistical analysis. RESULTS: A total of 46 cases were included. Mean age in years was 35.70 (10-78 years). Male were 22 and female 24. Eleven patients (23.91%) had stent placed less than 30 days and 35 patients (76.08%) had it for equal or more than 30 days. DJ indwelling time was in between 12-86 days. Bacterial colonies were found in 28.3% (13 of 46) of the urine samples and 30.4% (14 of 46) from the tip of the DJ stent segment. Of the pathogens identified, E. coli was found to be the most common. An increased stent colonization rate was associated with implantation time, female sex. On urine culture 70.21% had no growth, 14.89% E. coli, 4.25% Klebsiella, Actinobacter, 2.12% E. coli/kleb, multiple org, psuedomonas. Ten patients (21.7%) had positive urine culture before stent insertion. Thirteen patients (28.3%) were shown to have positive urine culture on stent removal. Fourteen patients (30.4%) had positive DJ stent culture. CONCLUSIONS: Positive urine culture and positive DJ tip cultures had strong correlation. Longer duration of placement of stent showed stent colonization. The commonest pathogen was E. coli.


Assuntos
Stents/efeitos adversos , Ureter/microbiologia , Infecções Urinárias/etiologia , Adolescente , Adulto , Idoso , Criança , Infecções por Escherichia coli/etiologia , Infecções por Escherichia coli/microbiologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Stents/microbiologia , Fatores de Tempo , Infecções Urinárias/microbiologia , Adulto Jovem
13.
JNMA J Nepal Med Assoc ; 49(179): 199-203, 2010.
Artigo em Inglês | MEDLINE | ID: mdl-22049823

RESUMO

INTRODUCTION: Closure of the common bile duct over T-tube after exploration is a widely practiced traditional method. However, its use may give rise to many complications. We do primary closure of common bile duct after exploration. Aim of the study is to see the efficacy and safety of the primary closure. METHODS: Study was carried out to compare the results of both the techniques from 2006 to 2009 in the cases proven to have common bile duct stone with or without the features of obstructive jaundice. Post operative hospital stay and morbidities related to both the groups were recorded and analyzed. RESULTS: There were total 71 cases included in the study. Thirty one in T-tube group and 40 in primary closure group. T-tube was removed in most of the cases after three weeks where as average time of drain removal in primary closure group is 5.79 +/-1.79 days. Incidence of retained stone was equal in each group. Major complication in T-tube group is biliary peritonitis in four patients at the time of T-tube removal whereas none of the patient from primary closure group suffered from such major complication. CONCLUSIONS: Primary closure after the common bile duct exploration is safe and it helps to avoid the morbidities related to T-tube.


Assuntos
Procedimentos Cirúrgicos do Sistema Biliar/métodos , Drenagem/instrumentação , Cálculos Biliares/cirurgia , Icterícia/cirurgia , Adulto , Idoso , Feminino , Cálculos Biliares/complicações , Humanos , Icterícia/etiologia , Tempo de Internação/estatística & dados numéricos , Masculino , Pessoa de Meia-Idade , Nepal , Complicações Pós-Operatórias , Estudos Prospectivos , Resultado do Tratamento
14.
JNMA J Nepal Med Assoc ; 49(179): 191-4, 2010.
Artigo em Inglês | MEDLINE | ID: mdl-22049821

RESUMO

INTRODUCTION: The day care laparoscopic cholecystectomy (DCLC) is found to be safe and effective in developed countries. However, it has not been well accepted in our part of the world probably because of lack of infrastructures,established norms and published reports. We have analyzed the safety and feasibility of the procedure in the recently established first dedicated day care surgery centre of the country. METHODS: All the patients with American society of anaesthesiologist (ASA) score I and II admitted for laparoscopic cholecystectomy are included. Operation are performed in the morning and closely observed till evening. Patients found to be medically fit to discharge; having a responsible person at home and who can make their own arrangements in case of problems were advised for discharge. Follow up was done by telephone call from next morning. RESULTS: Total 35 patients underwent laparoscopic cholecystectomy. Age range was between 16-65 years and most of them were females (88%). Only 30 patients were operated in early morning and were eligible for day care surgery. 25 (83%) Patients were advised for discharge but only 10 (33%) could make arrangement. Other 15 patients could not go home mainly due to different psychosocial reasons. Only one patient needed readmission and Complications observed were minor and relatively few. CONCLUSIONS: Day care laparoscopic cholecystectomy is safe and feasible in our set up. Acceptance of the procedure is expected to increase once it is regularly practiced and awareness in improved.


Assuntos
Procedimentos Cirúrgicos Ambulatórios/métodos , Colecistectomia Laparoscópica , Adolescente , Adulto , Idoso , Estudos Transversais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Nepal , Complicações Pós-Operatórias , Estudos Prospectivos , Resultado do Tratamento
15.
JNMA J Nepal Med Assoc ; 49(179): 216-9, 2010.
Artigo em Inglês | MEDLINE | ID: mdl-22049826

RESUMO

INTRODUCTION: Use of laparoscopic surgery has demanded principles of less trauma of access hence less scar and so probably less complications. Hence conventional laparoscopic surgeries were tried with natural orifice transluminal surgery (NOTES) and then single incision laparoscopic surgery (SILS). With refinement in instruments and surgeons skills SILS have bridged up between conventional and NOTES in order to quench the desire of less or no scar at all. METHODS: Comparative case control study between conventional laparoscopic cholecystectomy and SILS in public teaching hospital. RESULTS: Total 20 patients underwent SILS cholecystectomy and 20 underwent conventional cholecystectomy and found that no difference between both in terms of post operative pain score, hospital stay and post operative wound infection except significant difference in mean operative time and patient's level of satisfaction was less in patient with SILC if were subjected to pay for instruments in order to maintain cosmesis. CONCLUSIONS: Though SILS have gained rapid acceptance in surgical fraternity, large number of randomized controlled trials are necessary to show its benefit over conventional laparoscopic cholecystectomy.


Assuntos
Colecistectomia/métodos , Adulto , Estudos de Casos e Controles , Colecistectomia Laparoscópica , Estudos Transversais , Feminino , Humanos , Tempo de Internação/estatística & dados numéricos , Masculino , Pessoa de Meia-Idade , Nepal/epidemiologia , Medição da Dor , Dor Pós-Operatória/epidemiologia , Satisfação do Paciente , Estudos Prospectivos , Infecção da Ferida Cirúrgica/epidemiologia , Resultado do Tratamento
16.
J Nepal Health Res Counc ; 8(2): 78-81, 2010 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-21876567

RESUMO

BACKGROUND: The serum level of gamma glutaryl transferase and alkaline phosphatase is raised in acute calculus cholecystitis and common bile duct stone. However, the rise in serum level of these enzymes in acute cholecystitis implies stone in the common bile duct is not well studied. Thus, it may lead to retained CBD stone on one side and unnecessary CBD exploration on the other during emergency laparoscopic cholecystectomy. The objective of the study is to predict presence of CBD stone by assessing serum level of gamma-glutamyltransferase (gamma-GT)and alkaline phosphatase. METHODS: A prospective study was designed which included 40 patients with clinically diagnosed and radiologically confirmed acute cholecystitis and 40 patients who had choledocholithiasis with or without cholangitis. Their serumgamma glutaryl transferase and alkaline phosphatase were analyzed. RESULTS: Both acute cholecystitis and CBD pathology had significant increase in alkaline phosphatase (p-value: 0.05). However, in acute cholecystitis there was 1.69±0.118 fold increase and in CBD pathology there was 2.5±0.57 fold increase in alkaline phosphatase than normal.(130 IU /L). There was no statistically significant difference ingamma- GT in both acute cholecystitis and CBD pathology(p-value: 0.390). However it increases by 2.8±0.47fold in acute cholecystitis and by 2.2±0.16 in CBD pathology(p value: 0.627). CONCLUSIONS: Although there is rise in serumγ-GT and alkaline phosphatase level in acute cholecystitis and CBD stone,only more than 2.5 fold rise in serum alkaline phosphatase level predicts CBD stone.


Assuntos
Fosfatase Alcalina/sangue , Colangite/sangue , Colecistite Aguda/sangue , Coledocolitíase/sangue , gama-Glutamiltransferase/sangue , Fosfatase Alcalina/metabolismo , Estudos de Casos e Controles , Colangite/diagnóstico , Colangite/enzimologia , Colecistectomia , Colecistite Aguda/diagnóstico , Colecistite Aguda/enzimologia , Coledocolitíase/diagnóstico , Coledocolitíase/enzimologia , Indicadores Básicos de Saúde , Humanos , Testes de Função Hepática , Valor Preditivo dos Testes , Estudos Prospectivos , Sensibilidade e Especificidade , gama-Glutamiltransferase/metabolismo
17.
Kathmandu Univ Med J (KUMJ) ; 5(1): 63-7, 2007.
Artigo em Inglês | MEDLINE | ID: mdl-18603988

RESUMO

INTRODUCTION: Laparoscopic appendectomy, although not as widely performed as laparoscopic cholecystectomy, it has got definite advantage over the conventional open procedure. Controversy exists regarding the closure of stump. Our institute practices intracorporeal knot tying using 3 ports. Difficulties are observed in three port technique to hold the appendix during knot tying. We use a percutaneous thread loop. Advantage of the use of loop was evaluated. PATIENTS AND METHOD: Prospective study was carried out during 18 months. Total cases were randomly divided in non-loop and with loop group. Operative procedure was same. Cases were compared in terms of operating time, post-operative hospital stay and complications. RESULTS: Total patients were 66. Thirty two in non-loop group and 34 in with loop group. Mean age was 27.89 yrs. Most of the cases were females (62%). Mean operating time was less in loop group although statistically not significant. There was no difference in post operative hospital stay. Use of loop was not associated with added complications. CONCLUSION: Use of percutaneous loop to hold the appendix reduces the operating time and replaces the need of fourth port. It is safe and effective without any increased morbidity. Key words: Laparoscopic appendectomy, Intracorporeal knot, Percutaneous loop.


Assuntos
Apendicectomia/métodos , Apendicite/cirurgia , Apêndice/cirurgia , Laparoscopia/métodos , Técnicas de Sutura , Adolescente , Adulto , Idoso , Criança , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Resultado do Tratamento
18.
Kathmandu Univ Med J (KUMJ) ; 5(3): 339-42, 2007.
Artigo em Inglês | MEDLINE | ID: mdl-18604051

RESUMO

AIMS AND OBJECTIVES: To study the impact the use of portable ultrasound can have for the benefit of the patients when used by doctors other than radiologist, in this case surgeons. METHODS: Ultrasound performed by surgeons in the pre-operative, operative and post-operative period was studied. Patients presenting to the Hospital with acute abdomen was subjected to ultrasound. They were either pre-operative or post-operative patients. Five patients were scanned intraoperatively. The impact of these scans to the patients as well as the clinicians was studied. RESULTS: This is an ongoing study and preliminary results of the scans show two pre-operative diagnosis of acute appendicular collection and one acute hydronephrosis. In the operation room, ultrasound was done on 5 cases. On three occasions, it was to locate renal stones so that it could be extracted with ease. On two of the case, it was t to confirm the adequacy of common bile duct exploration thereby allowing primary closure of the common bile duct. Post-operatively, it was used in four cases of which in two cases post-operative hemorrhage were detected timely within hours. In the other two cases, the surgical team was assured that the patient's complaint was not surgically related. CONCLUSION: Ultrasound should be an extension of the clinical examination when indicated and all clinicians should be proficient in its use in their respective fields.


Assuntos
Abdome Agudo/diagnóstico por imagem , Abdome Agudo/cirurgia , Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Complicações Pós-Operatórias/diagnóstico por imagem , Ultrassonografia
19.
Kathmandu Univ Med J (KUMJ) ; 5(4): 521-5, 2007.
Artigo em Inglês | MEDLINE | ID: mdl-18604087

RESUMO

OBJECTIVE: To review the management of Empyema Thoracis in the surgical department of Kathmandu Medical College Teaching Hospital. METHODS: Thirteen cases with Empyema thoraces treated in the surgical department of the hospital with different modalities of treatment was taken for study and analyzed for morbidity, mortality, and hospital stay. RESULTS: there was a single mortality in the thoracotomy group. Video assisted thoracic surgery or VATS debridement or deloculation was successful in the eight of the patients with shorter stay in the hospital. One patient who refused surgery was treated with streptokinase with good result. CONCLUSION: Streptokinase may be effective in the treatment of empyemas. Video assisted thoracic surgery or VATS has definite advantage over traditional surgery in terms decreased morbidity, mortality, earlier hospital discharge and cosmesis in the treatment of empyema.


Assuntos
Empiema Pleural/terapia , Adolescente , Adulto , Idoso , Distribuição de Qui-Quadrado , Terapia Combinada , Feminino , Fibrinolíticos/uso terapêutico , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Estreptoquinase/uso terapêutico , Toracotomia , Cirurgia Vídeoassistida
20.
JNMA J Nepal Med Assoc ; 45(162): 258-61, 2006.
Artigo em Inglês | MEDLINE | ID: mdl-17189972

RESUMO

Management of intractable ascites has always been a challenge. Peritoneovenous shunt (PVS) plays a major role in the surgery of intractable ascites in patients with liver cirrhosis. Positive pressure gradient between the ascitic fluid and venous pressure leading to one-way drainage of ascitic fluid into venous circulation is the mainstay. Over decades, various modifications of shunting technique have been done. Here we report our experience with this procedure which is safe, easy and effective. Here the long saphenous vein is used as a drainage system. One-way ascites flow is ensured by a natural valve in the saphenous orifice.


Assuntos
Ascite/cirurgia , Hepatopatias Alcoólicas/cirurgia , Derivação Peritoneovenosa/instrumentação , Veia Safena , Humanos , Masculino , Pessoa de Meia-Idade , Derivação Peritoneovenosa/métodos , Recidiva
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