Synthesis of ultra-high molecular weight homo- and copolymers via an ultrasonic emulsion process with a fast rate.

In the forefront of advanced materials, ultra-high molecular weight (UHMW) polymers, renowned for their outstanding mechanical properties, have found extensive applications across various domains. However, their production has encountered a significant challenge: the attainment of UHMW polymers with a low dispersity (Ɖ). Herein, we introduce the pioneering technique of ultrasound (US) initiated polymerization, which has garnered attention for its capability to successfully polymerize a multitude of monomers. This study showcases the synthesis of UHMW polymers with a comparatively low Ɖ ( ≤ 1.1) within a remarkably short duration ( ~ 15 min) through the amalgamation of emulsion polymerization and high-frequency ultrasound-initiated polymerization. Particularly noteworthy is the successful copolymerization of diverse monomers, surpassing the molecular weight and further narrowing the Ɖ compared to their respective homopolymers. Notably, this includes monomers like vinyl acetate, traditionally deemed unsuitable for controlled polymerization. The consistent production and uniform dispersion of radicals during ultrasonication have been identified as key factors facilitating the swift fabrication of UHMW polymers with exceptionally low Ɖ.

Designing a New Class of Mechanophoric Polymer Based on Epoxy-Functionalized Rhodamine Derivative.

Mechanophoric polymers are an interesting class of smart polymers which contains a special force-sensitive molecular motif that can lead to a chemical change within the polymer network in response to mechanical force. This investigation reports the design of a mechanophoric polymer based on epoxy-functionalized rhodamine via a monomeric approach. In this case, rhodamine (Rh) is modified with glycidyl methacrylate (GMA) through an epoxy-amine reaction to design a vinyl-functionalized multi-armed macromonomer (Rh-GMA), which is reacted with butyl acrylate (BA) to prepare the crosslinked polymeric film. The crosslinked polymeric film demonstrates mechanophoric properties under UV and stretching conditions.

Supramolecular Polymer Network based on Electrophilic Substitution (ES) Adduct of Furan-Triazolinedione.

Polymers with furan functionality have been the subject of extensive research on developing sustainable materials applying a limited number of dynamic covalent approaches. Herein, we introduce a facile, dynamic non-covalent approach to make a furan polymer readily accessible for self-healing applications based on its electrophilic substitution (ES) with a commercially available 1,2,4-triazoline-3,5-dione (TAD) derivative, 4-phenyl-TAD (PTAD). A tailor-made furan polymer, poly(furfuryl methacrylate) (PFMA), considering it an initial illustrative example, was rapidly ES modified with PTAD to produce furfuryl-tagged triazolidine that subsequently associated via inter-molecular hydrogen (H-) bonding to produce a thermally reversible supramolecular polymer network under ambient conditions. The H-bonded network was experimentally quantified via ATR-IR analysis and theoretically rationalized via the density functional theory (DFT) study using smaller organic model compounds analogous to the macromolecular system. Thermoreversible feature of the H-bonded triazolidine-derived supramolecular polymer network enabled the solution reprocessing and self-healing of the polymer material.

Visible Light-Accelerated Photoiniferter Polymerization in Ionic Liquid.

The effect of ionic liquids on the reversible addition-fragmentation chain transfer (RAFT) polymerization mediated by a visible-light-induced photoiniferter mechanism was investigated. N,N-Dimethyl acrylamide was polymerized by photoiniferter polymerization in 1-ethyl-3-methylimidazolium ethylsulfate [EMIM][EtSO4] ionic liquid. We observed a considerable increase in the polymerization rate constants in ionic liquids (ILs), as well as in the mixed solvent of water and the IL, compared to those observed with water alone as the solvent. To demonstrate the robustness of the process, block copolymers with varying block ratios were synthesized with precise control over their molecular weight and mass dispersity (D). The very high chain-end fidelity provided by the photoiniferter polymerization in IL was described by using MALDI-ToF MS analysis.

Beyond traditional therapy: Mucoadhesive polymers as a new frontier in oral cancer management.

In recent times mucoadhesive drug delivery systems are gaining popularity in oral cancer. It is a malignancy with high global prevalence. Despite significant advances in cancer therapeutics, improving the prognosis of late-stage oral cancer remains challenging. Targeted therapy using mucoadhesive polymers can improve oral cancer patients' overall outcome by offering enhanced oral mucosa bioavailability, better drug distribution and tissue targeting, and minimizing systemic side effects. Mucoadhesive polymers can also be delivered via different formulations such as tablets, films, patches, gels, and nanoparticles. These polymers can deliver an array of medicines, making them an adaptable drug delivery approach. Drug delivery techniques based on these mucoadhesive polymers are gaining traction and have immense potential as a prospective treatment for late-stage oral cancer. This review examines leading research in mucoadhesive polymers and discusses their potential applications in treating oral cancer.

Multifunctional Layer-by-Layer Coating Based on a New Amphiphilic Block Copolymer via RAFT-Mediated Polymerization-Induced Self-Assembly Process.

In this hi-tech world, the "smart coatings" have sparked significant attention among materials scientists because of their versatile applications. Various strategies have been developed to generate smart coatings in the past 2 decades. The layer-by-layer (LbL) technique is the most commonly employed strategy to produce a smart coating for suitable applications. Here, we present a smart coating with healing, antifogging, and fluorescence properties fabricated by the LbL assembly of an anionic amphiphilic block copolymer latex and cationic inorganic POSS (polyhedral-oligomeric-silsesquioxane) nanoparticles. In this case, a new anionic block copolymer (BCP), {poly(sodium styrene sulfonate)-block-poly[2-(acetoacetoxy)ethyl methacrylate]}, (PSS-b-PAAEMA) was synthesized via surfactant-free RAFT-mediated emulsion polymerization using the PISA technique. The PSS-b-PAAEMA was characterized by 1H NMR, dynamic light scattering, scanning electron microscopy, and transmission electron microscopy analyses as well as by UV-vis and photoluminescence spectroscopy. For LbL coating fabrication, an amine-modified glass was successively dipped in the anionic latex and cationic POSS solution. The transparent coating exhibited good fluorescence properties under UV light (blue color). The antifogging performance of the coating was also investigated using both cold-warm and hot-vapor techniques. Additionally, the coating surface showed a significant healing activity with a healing efficiency of >75% through ionic interaction. Thus, this finding provides a simple low volatile organic compound (VOC) water-based LbL coating with multifunctional properties that can be a potential material for versatile applications.

Glycopolymer Decorated pH-Dependent Ratiometric Fluorescent Probe Based on Förster Resonance Energy Transfer for the Detection of Cancer Cells.

Development of fluorescent imaging probes is an important topic of research for the early diagnosis of cancer. Based on the difference between the cellular environment of tumor cells and normal cells, several "smart" fluorescent probes have been developed. In this work, a glycopolymer functionalized Förster resonance energy transfer (FRET) based fluorescent sensor is developed, which can monitor the pH change in cellular system. One-pot sequential reversible addition-fragmentation chain transfer (RAFT)polymerization technique is employed to synthesize fluorescent active triblock glycopolymer that can undergo FRET change on the variation of pH. A FRET pair, fluorescein o-acrylate (FA) and 7-amino-4-methylcoumarin (AMC) is linked via a pH-responsive polymer poly [2-(diisopropylamino)ethyl methacrylate] (PDPAEMA), which can undergo reversible swelling/deswelling under acidic/neutral condition. The presence of glycopolymer segment provides stability, water solubility, and specificity toward cancer cells. The cellular FRET experiments on cancer cells (MDA MB 231) and normal cells (3T3 fibroblast cells) demonstrate that the material is capable of distinguishing cells as a function of pH change.

Gold Nanoparticle Embedded Stimuli-Responsive Functional Glycopolymer: A Potential Material for Synergistic Chemo-Photodynamic Therapy of Cancer Cells.

Photodynamic therapy has emerged as a noninvasive treatment modality for several types of cancers. However, conventional hydrophobic photosensitizers (PS) suffer from low water solubility and poor tumor-targeting ability. Therefore, PS modified with glycopolymers can offer adequate water solubility, biocompatibility, and tumor-targeting ability due to the presence of multiple sugar units. In this study, a well-defined block copolymer poly(3-O-methacryloyl-d-glucopyranose)-b-poly(2-(4-formylbenzoyloxy)ethylmethacrylate) (PMAG-b-PFBEMA) containing pendant glucose and aldehyde units is synthesized via reversible addition-fragmentation chain transfer polymerization method. A water-soluble PS (toluidine blue O; TBO) and a potent anticancer drug, Doxorubicin (Dox) are introduced to the polymer backbone via acid-labile Schiff-base reaction (PMAG-b-PFBEMA_TBO_Dox). The PMAG-b-PFBEMA_TBO_Dox is then anchored on the surface of gold nanoparticles (AuNPs) via electrostatic interaction. This hybrid system exhibits excellent reactive oxygen species (ROS) generating ability under exposure of 630 nm light-emitting diode along with triggered release of Dox under the acidic pH of tumor cells. The in vitro cytotoxicity study on human breast cancer cell line, MDA MB 231, for this hybrid system shows promising results due to the synergistic effect of ROS and Dox released. Thus, this glycopolymer-based dual (chemo-photodynamic) therapy model can work as potential material for future therapeutics.

Stimuli-Responsive Block Copolymer Micelles Based on Mussel-Inspired Metal-Coordinated Supramolecular Networks.

Amphiphilic diblock copolymers containing dopamine and zwitterions are synthesized via the RAFT polymerization method, which undergo temperature-mediated micellization in aqueous media. The presence of catechol moiety in dopamine is exploited to form pH-responsive cross-links with ferric ions (Fe3+ ) at different pH value. Herein, a comprehensive study of the effect of pH as well as temperature on the size and solution behavior of these cross-linked micelles is presented. These micelles cross-linked via metal-catechol coordination bonds can have several important biomedical applications such as degradable scaffolds for payload delivery.

Graphene Quantum Dots-Ornamented Waterborne Epoxy-Based Fluorescent Adhesive via Reversible Addition-Fragmentation Chain Transfer-Mediated Miniemulsion Polymerization: A Potential Material for Art Conservation.

Epoxy-based adhesives have gotten significant attention in the conservation of antiquities and repair or reconstruction of artifacts due to their excellent adhesion strength. However, it has become hard to detect repaired work in artifacts due to the transparent nature of epoxy-based adhesives. Hence, the making of fluorescent adhesives has become an exciting topic for art conservators. Here, we have synthesized a new kind of waterborne epoxy-based fluorescent adhesive decorated with graphene quantum dots (GQDs) via reversible addition-fragmentation chain transfer (RAFT)-mediated surfactant-free miniemulsion polymerization. In this case, a new block copolymer (BCP), poly(1-vinyl-2-pyrrolidone)-block-poly(glycidyl methacrylate), has been synthesized via surfactant-free RAFT-mediated miniemulsion polymerization using a polymerization-induced self-assembly technique. The GQDs were prepared from citric acid by a hydrothermal process, and this was used for making a fluorescence-active BCP/GQD nanocomposite emulsion. The obtained BCP/GQD nanocomposite adhesive was transparent and showed blue fluorescence under ultraviolet-visible light, indicating the easy detection of its mark on the artifacts. The BCP and BCP/GQD emulsions were applied to adhere ceramic and glass substrates, and their adhesion strength was evaluated by lap shear tests. The BCP/GQDs showed better adhesion strength than the BCP only, indicating better adhesive performance. Additionally, the synthesis process was carried out in aqueous media, indicating the sustainability and environment-friendliness of the process. We believe that this kind of new waterborne epoxy-based fluorescent adhesive will provide a new contrivance among art conservators to repair or reconstruct artifacts.

Zwitterionic Nanogels and Microgels: An Overview on Their Synthesis and Applications.

Zwitterionic polymers by virtue of their unique chemical and physical attributes have attracted researchers in recent years. The simultaneous presence of positive and negative charges in the same repeat unit renders them of various interesting properties such as superhydrophilicity, which has significantly broadened their scope for being used in different applications. Among polyzwitterions of different architectures, micro- and/or nano-gels have started receiving attention only until recently. These 3D cross-linked colloidal structures show peculiar characteristics in context to their solution properties, which are attributable either to the comonomers present or the presence of different electrolytes and biological specimens. In this review, a concise yet detailed account is provided of the different synthetic techniques and application domains of zwitterion-based micro- and/or nanogels that have been explored in recent years. Here, the focus is kept solely on the "polybetaines," which have garnered maximum research interest and remain the extensively studied polyzwitterions in literature. While their vast application potential in the biomedical sector is being detailed here, some other areas of scope such as using them as microreactors for the synthesis of metal nanoparticles or making smart membranes for water-treatment are discussed in this minireview as well.

A dual thermoresponsive and antifouling zwitterionic microgel with pH triggered fluorescent "on-off" core.

A unique, tailor-made, zwitterionic, dual thermoresponsive and fluorescent microgel probe was synthesized via Reversible Addition Fragmentation chain-Transfer (RAFT) polymerization. Microgels were prepared via oil in water (o/w) emulsion polymerization where poly(carboxybetaine) (PCB) acted as a macro-RAFT reagent as well as an emulsifier. The presence of poly(N-vinylcaprolactam) (PNVCL) in the microgel system imparts the thermoresponsiveness to the system and the presence of a rhodamine derivative as fluorophore makes it responsive to pH change of the system by showing a fluorescence emission at 580 nm (reddish orange color). The dual thermoresponsiveness [i.e. the presence of upper critical solution temperature (UCST @ 12 °C) as well as lower critical solution temperature (LCST @ 33 °C)] of the microgels was studied via UV-visible spectroscopy (UV-vis) and temperature responsive dynamic light scattering (DLS) analyses. Presence of the PCB in the corona-crosslinked microgel, played a vital role in the formation of self-assembled structure as well as in protein immobilization (antifouling activity). Antifouling property was studied using UV-vis spectroscopy where bovine serum albumin (BSA) was taken as a model protein. The presence of the pH-responsive fluorescence, thermoresponsiveness as well as antifouling properties makes this zwitterionic microgel system a potential a potential candidate for medical diagnostics and for drug delivery vehicles.

Self-healable hydrophobic polymer material having urethane linkages via a non-isocyanate route and dynamic Diels-Alder 'click' reaction.

Conventional synthesis of polyurethane (PU) often involves the use of inherently toxic and overly moisture-sensitive isocyanates. Herein, we report the preparation of a self-healable hydrophobic polymer network having urethane linkages via a facile non-isocyanate route based on carbonylimidazole-amine reaction and dynamic Diels-Alder (DA) 'click' reaction based on furan-maleimide cycloaddition. This isocyanate-free DA 'clicked' polymer material showed excellent self-healing and hydrophobic characteristics.

Stimuli-Responsive Zwitterionic Core-Shell Microgels for Antifouling Surface Coatings.

Fouling on filtration membranes is induced by the nonspecific interactions between the membrane surface and the foulants, and effectively hinders their efficient use in various applications. Here, we established a facile method for the coating of membrane surface with a dual stimuli-responsive antifouling microgel system enriched with a high polyzwitterion content. Different poly(sulfobetaine) (PSB) zwitterionic polymers with defined molecular weights and narrow dispersities were synthesized by reversible addition-fragmentation chain transfer (RAFT) polymerization and integrated onto poly(N-vinylcaprolactam) (PVCL) microgels via a controlled dosage of a cross-linker, adapting a precipitation polymerization technique to obtain a core-shell microstructure. Increasing the PSB macro-RAFT concentration resulted in a shift of both upper critical solution temperature and lower critical solution temperature toward higher temperatures. Cryogenic transmission electron microscopy at different temperatures suggested the formation of a core-shell morphology with a PVCL-rich core and a PSB-rich shell. On the other hand, the significant variations of different characteristic proton signals and reversible phase transitions of the microgel constituents were confirmed by temperature-dependent 1H NMR studies. Utilizing a quartz crystal microbalance with dissipation monitoring, we have been able to observe and quantitatively describe the antipolyelectrolyte behavior of the zwitterionic microgels. The oscillation frequency of the sensor proved to change reversibly according to the variations of the NaCl concentration, showing, in fact, the effect of the interaction between the salt and the opposite charges present in the microgel deposited on the sensor. Poly(ethersulfone) membranes, chosen as the model surface, when functionalized with zwitterionic microgel coatings, displayed protein-repelling property, stimulated by different transition temperatures, and showed even better performances at increasing NaCl concentration. These kinds of stimuli-responsive zwitterionic microgel can act as temperature-triggered drug delivery systems and as potential coating materials to prevent bioadhesion and biofouling as well.

Glycopolymer ornamented octa-arm POSS based organic-inorganic hybrid star block copolymer as a lectin binding ligand.

In this study, a polyhedral oligomeric silsesquioxane-polycaprolactone (POSS-PCL)-cored octa-arm star-shaped glyco block copolymer (BCP), poly(ε-caprolactone)-b-poly(glucopyranose) (Star-POSS-PCL-b-PGlc) was successfully synthesized via the combination of ring opening polymerization (ROP) and MADIX (macromolecular design by interchange of xanthate) polymerization technique. Herein, initially octa(3-hydroxy-3-methylbutyl dimethylsiloxy) POSS (Star-POSS) was utilized to initiate the ROP of the ε-caprolactone to get octa-arm star-shaped Star-POSS-PCL. A successive bromination followed by xanthation of the synthesized Star-POSS-PCL polymer allowed us to further polymerize 3-O-acryloyl-1,2:5,6-di-O-isopropylidene-α-D-glucofuranose (AIpGlc) via MADIX polymerization. Formation of the star-shaped block copolymer (BCP) was characterized using 1H NMR, FT-IR and DSC analyses. The morphology and the aqueous solution behavior of the Star-POSS-PCL-b-PGlc were analyzed using FESEM, HRTEM and DLS analyses, respectively. The lectin-binding efficiency of the star-shaped BCP having different glycopolymer block length was studied using turbidimetry assay and fluorescence quenching titration (FQT) using photoluminescence spectroscopy (PL). Here, FITC labeled concanavalin A (FITC-Con A) was used as a model lectin. The cytotoxicity study of the star-shaped BCPs over the human fibroblast cells revealed the non-toxic nature of the BCPs which open up its great potential towards drug delivery vector.

Dual-Temperature-Responsive Microgels from a Zwitterionic Functional Graft Copolymer with Superior Protein Repelling Property.

In this work, we developed a synthetic strategy to synthesize dual-temperature-responsive low surface fouling zwitterionic microgels. Statistical poly(N-vinylcaprolactam-co-glycidyl methacrylate) copolymers were synthesized by RAFT polymerization and post-modified by thiol-epoxy click reaction with thiol end-group-modified poly(sulfobetaine) macro-RAFT (PSB-SH) to obtain poly(N-vinylcaprolactam-co-glycidyl methacrylate)-graft-poly(sulfobetaine) (PVCL-co-PGMA-g-PSB) graft copolymers. Synthesized graft copolymers were cross-linked by diamine cross-linker in water-in-oil (w/o) inverse mini-emulsion to obtain zwitterionic microgels. Using this approach, we synthesized microgels with unique microstructure, high loading and uniform distribution of poly(sulfobetaine) chains, which exhibits tunable dual-volume phase transition temperatures. The microgels also showed excellent antifouling property reflected in strongly reduced protein absorption on a microgel-coated surface observed in real time by a Quartz Crystal Microbalance with Dissipation (QCM-D) monitoring experiment with continuous flow of protein solution. Therefore, this kind of zwitterionic microgel can be potentially used for temperature-triggered drug delivery and anti-bioadhesion coating material as well.

A self-healable and antifouling hydrogel based on PDMS centered ABA tri-block copolymer polymersomes: a potential material for therapeutic contact lenses.

Herein we have prepared an antifouling and self-healable poly(dimethyl siloxane) (PDMS) based hydrogel which consists of a mixture of curcumin loaded zwitterionic PDMS polymersomes and amine functionalized PDMS polymersomes prepared via Reversible Addition-Fragmentation Chain Transfer (RAFT) polymerization and a Schiff-base reaction. The curcumin loaded polymersome consists of a PDMS and poly([dimethyl-[3-(2-methyl-acryloylamino)-propyl]-(3-sulfopropyl)ammonium)] (poly(sulfobetaine)) based tri-block copolymer (BCP) and it was characterized by dynamic light scattering (DLS), high resolution transmission electron microscopy (HRTEM), field emission scanning electron microscopy (FESEM) and atomic force microscopy (AFM) analyses. To prepare the hydrogel, amine functionalized PDMS polymersomes were crosslinked with polyethylene glycol dialdehyde (PEG-DA) in pH 7.4 buffer solution via a Schiff-base reaction. This hydrogel was able to show sustained delivery of the entrapped curcumin drug for more than 72 h. The self-healing characteristic of the prepared hydrogel in the presence of saline water was elucidated by the "scratch and heal" method and subsequently analyzed through tensile study. Due to the presence of the poly(zwitterionic) moiety in the hydrogel system, it was observed that the hydrogel can efficiently reduce protein deposition, where Bovine Serum Albumin (BSA) was taken as a model protein. It was observed that the curcumin loaded hydrogel was detrimental towards both Gram-negative (Escherichia coli) and Gram-positive (Staphylococcus aureus) bacteria. This type of smart soft hydrogel system can be a potential material for therapeutic applications for several eye diseases.

Smart Polyacrylate Emulsion Based on a New ABC-Type Triblock Copolymer via RAFT-Mediated Surfactant-Free Miniemulsion Polymerization: Its Multifunctional Properties.

The present investigation deals with the development of an acrylic-based polymeric emulsion that offers multifunctional properties such as superhydrophobic, antimicrobial, anti-icing, and self-cleaning. The said multifunctional waterborne emulsion was prepared via a surfactant-free reversible addition-fragmentation chain transfer (RAFT) polymerization technique. To accomplish this, a new class of ABC-type triblock copolymer (PMTAC-b-PBA-b-PIBA) based on 2-(methacryloyloxy) ethyl ammonium chloride (MTAC), n-butyl acrylate, and isobornyl acrylate (IBA) was synthesized via a polymerization-induced self-assembly technique in a surfactant-free miniemulsion process. The cationic polymer PMTAC was used as a macro-RAFT agent to prepare the rest of the blocks in the presence of nanosize monodisperse colloidal silica particles, leading to a raspberry-like morphology via ionic interaction between anionic silica particles and the cationic block copolymer (BCP). A water contact angle of more than 150° was achieved for the emulsion coating after the fluorosilane treatment which delineates its superhydrophobic nature. The prepared emulsion showed antimicrobial property both in Gram-positive  (Staphylococcus aureus) and Gram-negative (Escherichia coli) bacteria. The resultant BCP emulsion was coated over different substrates like glass, paper, and cotton, and the coating material showed anti-icing and self-cleaning properties.

A muscle mimetic polyelectrolyte-nanoclay organic-inorganic hybrid hydrogel: its self-healing, shape-memory and actuation properties.

In this investigation, we report a non-covalent (ionic interlocking and hydrogen bonding) strategy of self-healing in a covalently crosslinked organic-inorganic hybrid nanocomposite hydrogel, with specific emphasis on tuning its properties fitting into a muscle mimetic material. The hydrogel was prepared via an in situ free radical polymerization of sodium acrylate (SA) and successive crosslinking in the presence of starch grafted with poly(2-(methacryloyloxy)ethyl trimethyl ammonium chloride) (PMTAC) and montmorillonite modified with cetyl ammonium bromide (OMMT). This hydrogel shows stimuli triggered self-healing following damage in both neutral and acidic solutions (pH = 7.4 and pH = 1.2). This behavior was reported using stress-strain experiments and rheological analyses of the hydrogel segments joined at their fracture points. The hydrogel was also able to display shape memory properties in the presence of water as well as stimuli (salt, acid and electric impulse) driven actuation behavior. It was observed that the ultimate tensile strength (UTS) of the self-healed hydrogel at pH = 7.4 was comparable to the extensor digitorum longus (EDL) muscle of a New Zealand white rabbit and the as synthesized self-healable hydrogel was found to be non-cytotoxic against NIH 3T3 fibroblast cells.

REDOX Responsive Fluorescence Active Glycopolymer Based Nanogel: A Potential Material for Targeted Anticancer Drug Delivery.

A well-defined glycopolymer based fluorescence active nanogel has been prepared via the combination of reversible addition-fragmentation chain transfer (RAFT) polymerization and Diels-Alder (DA) "click" chemistry. To prepare the nanogel, initially, a functional AB block copolymer (BCP) poly(pentafluorophenyl acrylate)-b-poly(furfuryl methacrylate) (PPFPA-b-PFMA), having activated pentafluorophenyl ester group, was synthesized via RAFT polymerization. The activated pentafluorophenyl functionality was replaced by the amine functionality of glucosamine to introduce the amphiphilic BCP poly[2-(acrylamido) glucopyranose]-b-poly(furfuryl methacrylate) (PAG-b-PFMA). Furthermore, the terminal acid (-COOH) functionality of the RAFT agent was modified by gelatin QDs (GQDs) to generate fluorescence active glycopolymer. An anticancer drug, Doxorubicin, was loaded in the micelle via the successive addition of the drug molecule and cross-linking using dithio-bismaleimidoethane (DTME), a REDOX responsive cross-linker. The anticancer activity of the drug loaded nanogel was observed over MBA-MD-231, human breast cancer cell line, and monitored via fluorescence spectroscopy and flow cytometric analyses (FACS). The cytotoxicity of the prepared glycopolymer based nanogel over the MBA-MD-231 cell line was assessed via MTT assay test, and it was observed that the synthesized nanogel was noncytotoxic in nature.