[Reproductive health disorders in night shift workers (review of literature)].

The review considers problems of reproductive health disorders in night shift workers. In materials of national and foreign authors, ambiguous opinions are presented on the influence, such as on reproductive sphere malignancies development in shift workers. Data of experimental and clnical laboratory studies are presented, that support reproductive pathologies connected with night shift work. The authors tackle a problem on role of epiphysis and circadian rhythms, that influence physiologic biologic rhythms.

[THE RISK OF DEVELOPING DISEASE IN FEMALE WORKERS INVOLVED IN MODERN SECTOR EMPLOYMENT AND THE HEALTH OF THEIR CHILDREN].

There was studied the state of health of females in modern sector employment: office workers (group 1) and managers (group 2), and the health of their newborns. There was established the increase of the risk for the development of extragenital disorders in groups 1 and 2 compared with the control. For adreno-genital syndrome OR = 3.83; (CI: 1.15-12.74) in group 1 and OR = 4,50 (CI: 1.24-16.28) Group 2; for respiratory diseases OR = 2.77-2.98 (CI: 1.82- 4.85) in groups 1 and 2; for digestive diseases OR = 2.45 (CI: 1.39-4.32) in group 1 and 2.77 (CI: 1.46-5.26)--in Group 2. The risk of infertility in the history of the group 2 was OR = 2.56 (CI: 1.33-4.92). The frequency of reproductive loss in the history is signficantly higher in group 1 (12,9 ? 1.28), is increasing in group 2 (20.19 ± 2.75) with 9.74 ± 2.12 in 100 females in the control. In complications of pregnancy the frequency of the threat of its interruption increases from 16.99 ± 2.31 cases per 100 females in the group 1 to 21.60 ± 2.82 in Group 2, with 11.79 ± 2.31 in the control (p < 0.01). In newborn of these female workers there was revealed an increase in the frequency of the congenital defects of development (CDD) of the circulatory system in group 1 by 1.5 times in the group 2-2.5 times if compared to the control (16.38 ± 1.41 and 24.88 ± 2.96, with 9.74 ± 2.12 cases per 100 infants (p < 0.01; p < 0.001), respectively, the frequency of congenital malformations of the urinary system in groups 1 and 2 (10.00 ± 1.14 and 10.80 ± 2.13), was significantly higher than in control--3.08 ± 1.24 per 100 births (p < 0.01); CDD of genitalia was significantly higher in group 1 (11.01 ± 1.19) with 5.13 ± 1.58 per 100 infants in the control (p < 0.01). Thus, disorders of reproductive health in females involved in modern sector employment depend on the degree of occupational hazard factors; can lead to congenital disease in their newborn, which requires the development of preventive measures.

[Information hygiene and regulation of information for vulnerable groups of the population].

Development of information society engenders the problem of hygienic regulation of information load for the population, first of all for vulnerable groups. There are presented international and Russian normative legal documents and experience in this area, there are described the negative effects of information (such as stress, depression, suicidal ideations). There are considered social-psychological characteristics of vulnerable groups that requires their best protection from loads of information, doing harm, particularly in terms of reproductive health, family relationships, children, etc. There was noted the desirability of improvement of sanitary, legislation on the regulation of the information load on the population, especially in vulnerable groups, in terms of optimization of parameters of the signal-carriers on volume, brightness and the adequacy of the volume and content of information in radio and television broadcasting, in an urban environment and at the plant to preserve the health and well-being of the population.

[Prevention and protection of workers' reproductive health].

The article mentiones issues of preserving and strengthening the reproductive health of women workers, dealed by researchers of the laboratory, established in 1974. It describes the developed concept of the reproductive health problems and scientific research areas, developed documents, including legislative fields, formulates main prospects of the laboratory to meet the requirements of the present moment. Noted the role of the Problem Commission "Scientific basis for the reproductive health of workers", in the work of the Scientific Council on medical and environmental issues of workers' health.

[Association of polymorph variants of CYP1A2 and CYP1A1 genes with reproductive and thyroid diseases in female workers of petrochemical industry].

The article presents results obtained in study of relationship between polymorph variants of CYP1A1 and CYP1A2 genes with reproductive and thyroid diseases risk in female workers of petrochemical industry, when compared with reference group females. Variants TD and DD of CYP1A2 gene appeared to be associated with nodes formation in uterus and breast in female workers and reference group females. Following liability markers are obtained: homozygous in rare allele genotype CC of CYP1A1 gene for reproductive and thyroid diseaes (fibrous cystic mastopathy and nodular goitre), heterozygous genotype AG of CYP1A1 gene in uterine myoma and fibrous cystic mastopathy, homozygous in deleted T genotype of CYP1A2 gene in autoimmune thyroiditis. Occupational hazards and long length of service at hazardous industries increase effects of rare alleles of the genes studied.

[The issues of workers reproductive health protection from harmful occupational and enviromenral exposures].

The problem of workers reproductive health protection from harmful occupational and environmental exposures is amongst the national priorities due to demographic situation in Russia and decrease of the manpower. Some issues of women's reproductive health disorders are considered from occupational health standpoint. The demographic and epidemiological data on pregnancy course and outcome, birth defects, children's morbidity etc. are presented and discussed. Some proposal as to risk management and medical surveillance of reproductive health, including legal instruments are put forward.

[Clinical and genetic criteria of reproductive health disorders in female workers engaged into organic synthesis production].

Chemicals in the air of workplace within organic synthesis enterprises could induce reproductive disorders in the female workers. Analysis of polymorphous variants of P450 cytochrome gens and antioxidant defence system helped to reveal genetic markers for risk of reproductive disorders in the female examinees.

[Methodology to reveal and prevent diseases associated to work].

Based on legislation of RF, Occupational Health Ministry and WHO, the authors specified methodology to reveal diseases associated to work, in addition to present system of occupational diseases diagnosis. The article also covers terminology, premises and causation (determining relationships with work) principles. The authors presented models and criteria for causation in consensus and evidence based medicine with computerized and Internet technologies, described contemporary approaches to prophylaxis.

[Molecular markers of ejaculate fertility in officers of Internal Affairs Ministry Special Forces, if under battle stress].

The article presents results of studies in males participated in anti-terrorist military operations in local conflict areas. Findings are intact general spermogram parameters with lower serum and/or ejaculate levels of glycodeline and inhibin B--that is a precondition for high risk reproductive disorders under battle stress.

[Reproductive disorders unders exposure to hazards].

The article covers problem of occupational and environmental hazards' influence on reproductive health. The authors present topics on preservation of reproductive health in international systems of chemical safety.

[Work conditions and health state of female medical staffers].

The authors studied work conditions of medical personnel and health state including reproductivity, according to periodic medical examinations data, transitory disablement morbidity, occupational morbidity, questioning, clinical, laboratory and instrumental investigations. Reproductive health was assessed through gynecologic observations, course of pregnancy and delivery, the authors evaluated their relationships with work and identified risk groups for target prophylaxis.

[Immune state of workers exposed to nickel aerosols in galvanic production].

Galvanic production workers appeared to have mainly humoral immunity activated--sensitization to nickel, reliable prevalence of immune disorders in males over females, significant influence of immune overstrain on frequency of acute respiratory infections and allergic conditions. The authors justified approaches to safe immune prophylaxis of diseases in workers.

[Occupational medicine documentation as a basis for improving approaches to risk assessment and to workers' social welfare]. / Sovershenstvovanie podkhodov k otsenke riska i sotsial'noi zashchite rabotnikov na osnove dokumentov MOT po meditsine truda.

The article covers materials on medical and social problems associated with up-to-date improving the occupational medical service.

[Occupational accidents and female workers' reproductive health]. / Proizvodstvennyi travmatizm i sostoianie reproduktivnogo zdorov'ia zhenshchin-rabotnits.

The article covers analysis and summary of data on occupational traumatism among female workers engaged into various economic branches of RF. The authors analysed distribution of victims according to occupational accident types, causes of traumatism, studied dependence on the victims' age and length of service, followed the relationships with possible reproductive disorders.

[Ecological and ethical issues related to the protection of population reproductive health]. / Ekologicheskie i éticheskie problemy okhrany reproduktivnogo zdorov'ia naseleniia.

The legal and ethical issues related with the protection of population reproductive health, under the conditions of anthropogenic contamination of the environment, including the labor environment, are discussed in the article. A concept of pregnancy planning to ensure a healthy posterity under the mentioned conditioned was formulated. Documents of WHO, ILO and the EU experience in dealing with the issues in question are illustrated. An increasing role of social labor measurement as well as the evolution of law, i.e. civil, labor, and social law, as well as the right to unified medical-and-social insurance, are in the focus of attention. The prospects for a new WHO-ICF classification, as a social UNO classification, are pointed out. The sensitivity--susceptibility--vulnerability chain was analyzed, and a growing social context was underlined in it. The individual and team risks were considered, and the Code of professional ethics of hygienists was paid attention to.

[Psycho-emotional profile of personality among teenage girls living in the Volgograd industrial region]. / Prikhoémotsional'nyi profil' lichnosti devushek-podrostkov, zhitel'nits Volgogradskogo promyshlennogo regiona.

Social, economic and other factors appeared to form psychoemotional personal profile of teenager girls living in significant industrial region subjected to pollution with chemicals varying in jeopardy. The studies proved that ecologic factors may play an important role in formation of psychoemotional personal profile. All this could be a pathogenetic basis for endocrine disorders among teenagers and subsequent reproductive disturbances and birth of diseased children.

[Medical and ecologic aspects of problems associated with protection of workers' reproductive health in Russia]. / Mediko-ékologicheskie aspekty problemy okhrany reproduktivnogo zdorov'ia rabotaiushchikh Rossii.

The article deals with various aspects of workers' reproductive health care during economic crisis in Russia. Deterioration of health state in children and adults threatens deeper negative demographic trends. The authors discuss basic principles of "Reproductive health as a problem in occupational medicine". Concept and suggest measures aimed to preserve and improve health of Russian population.