RESUMO
Children with high body mass index (BMI) are at risk of iron deficiency. In present study, 71 children with overweight or obesity were screened for iron deficiency. Mean BMI, ferritin and plasma soluble transferrin receptor (sTrfR) levels were 26.1 kg/m2, 41.9 µg/L and 0.375 mg/L, respectively. Twenty (28%) children had anemia, and 44 (62%) had an underlying hypoferraemic state.
Assuntos
Anemia Ferropriva , Sobrepeso , Obesidade Infantil , Adolescente , Anemia Ferropriva/complicações , Anemia Ferropriva/epidemiologia , Biomarcadores/sangue , Índice de Massa Corporal , Criança , Pré-Escolar , Estudos Transversais , Feminino , Ferritinas/sangue , Humanos , Índia/epidemiologia , Masculino , Sobrepeso/complicações , Sobrepeso/epidemiologia , Obesidade Infantil/complicações , Obesidade Infantil/epidemiologiaRESUMO
Soluble serum transferrin receptor is derived from erythroid transferrin receptor expressed on surface of developing erythroid cells. It can be detected in blood using sensitive ELISA methodology and blood levels reflect physiological iron dependent erythropoiesis state in bone marrow. Normal adult levels vary from 2 to 5 mg/l. However, pediatric studies are few and describe normal ranges to the tune of 1.0-3.0 mg/l, which are relatively lower than that of adults. In present study 40 healthy children (2-12 years) were evaluated to establish normal soluble transferrin receptor range. The mean transferrin receptor levels were 0.39 mg/l with a range of 0.17-2.1 mg/l. The levels were low as compared to mean levels described in other studies from West and our country (4.39 and 2.0 mg/l respectively). Since, no internationally standard method for reporting and testing for transferrin receptor levels are yet available, hence it is imperative to establish normal control ranges in different population cohorts, especially in pediatric age group, to better interpret their levels in diagnostic context.