Assuntos
Inibidores da Angiogênese/uso terapêutico , Anticorpos Monoclonais Humanizados/uso terapêutico , Coriorretinopatia Serosa Central/tratamento farmacológico , Hemorragia Retiniana/tratamento farmacológico , Idoso , Idoso de 80 Anos ou mais , Bevacizumab , Coriorretinopatia Serosa Central/complicações , Exsudatos e Transudatos , Feminino , Humanos , Masculino , Hemorragia Retiniana/complicações , Resultado do TratamentoAssuntos
Inibidores dos Fatores de Coagulação Sanguínea/sangue , Extração de Catarata , Circuncisão Masculina , Fator VIIa/uso terapêutico , Hemofilia A/complicações , Adolescente , Coagulantes/uso terapêutico , Fator VIII/antagonistas & inibidores , Fator VIII/imunologia , Hemostasia Cirúrgica/métodos , Humanos , Isoanticorpos/sangue , Masculino , Proteínas Recombinantes/uso terapêuticoRESUMO
We measured interleukin-1 beta (IL-1beta) and tumour necrosis factor-alpha (TNF-alpha) in the vitreous humour and serum of patients with proliferative diabetic retinopathy (PDR), in order to determine the role of these cytokines in the pathogenesis of the disease. Vitreous and serum samples were collected from 21 patients with PDR who were undergoing pars plana vitrectomy. Control vitreous samples were obtained from cadavers and control serum samples from healthy subjects. The cytokines were measured by enzyme-linked immunosorbent assay. Vitreous IL-1beta and TNF-alpha concentrations in patients with PDR exceeded those of controls (P<0.05), as did serum IL-1beta and TNF-alpha. We suggest that increased vitreous IL-1beta and TNF-alpha levels may play a significant role in the pathogenesis of PDR, which features abnormal cell proliferation and neovascularisation.
Assuntos
Retinopatia Diabética/imunologia , Interleucina-1beta/análise , Neovascularização Retiniana/imunologia , Fator de Necrose Tumoral alfa/análise , Adulto , Idoso , Estudos de Casos e Controles , Retinopatia Diabética/sangue , Retinopatia Diabética/cirurgia , Feminino , Humanos , Interleucina-1beta/sangue , Masculino , Pessoa de Meia-Idade , Neovascularização Retiniana/sangue , Neovascularização Retiniana/cirurgia , Estatísticas não Paramétricas , Vitrectomia , Corpo Vítreo/imunologiaRESUMO
Chronic endophthalmitis, due to Corynebacterium minutissimum, developed in a patient following uncomplicated extracapsular cataract extraction and posterior chamber intraocular lens (PC-IOL) implantation. In this case, which to our knowledge is the first reported case of Corynebacterium minutissimum endophthalmitis, chronic inflammation persisted for 8 months with fluctuations in the inflammation. The specimens from the capsular bag yielded positive culture, but the vitreous culture was negative. The case was successfully treated by a capsular bag irrigation with vancomycin.