RESUMO
Rhabdomyolysis is a clinical syndrome in which skeletal muscle damage and necrosis leads to the release of intracellular muscle contents, which can ultimately lead to electrolyte disturbances, renal failure and even death. Chemotherapy is an extremely rare cause of rhabdomyolysis. Herein, we describe a fatal case of rhabdomyolysis in a patient with metastatic sarcoma after receiving the chemotherapeutic agent Ecteinascidin-743 (ET-743, trabectedin) as palliative chemotherapy treatment.
Assuntos
Antineoplásicos Alquilantes/efeitos adversos , Dioxóis/efeitos adversos , Rabdomiólise/induzido quimicamente , Sarcoma/tratamento farmacológico , Tetra-Hidroisoquinolinas/efeitos adversos , Evolução Fatal , Humanos , Masculino , Pessoa de Meia-Idade , TrabectedinaRESUMO
Cold agglutinin induced autoimmune hemolytic anemia is uncommonly associated with leukemia and lymphomas. We present a case of a young Mexican female presenting with a cold agglutinin hemolytic anemia with expression of a rare Pr antigen specificity and an aggressive NK-cell leukemia. Our patient had a rapid fatal course. To our knowledge this is the first reported case of such an association.