Study on the substituents' effects of a series of synthetic chalcones against the yeast Candida albicans.

A large series of chalcones were synthesized and studied for activity against Candida albicans. The SAR analysis showed that the antifungal activity was highly dependent on the substitution pattern of the aryl rings and correlated to a large extent with the ability of compounds to interact with sulfhydryl groups. The most active were the hydroxylated chalcones as their activity related to the location of the phenolic group in the aryl ring B as follows: o-OH>p-OH approximately 3,4-di-OH>m-OH. These and other correlations obtained strongly contribute to the knowledge for design of anticandidal chalcones.

[Chronic stress and the degree of anxiety in girls with menstrual cycle disorders]. / Khronichen stres i stepen na trevozhnost pri momicheta s narusheniia na menstrualniia tsikul.

The present study was made with the aim to clarify the role of personality attitude as well as of stress actions found in three elements of the environment-family, school and social encirclement in wider aspect in the occurrence of menstrual disturbances. Anxiety as a personality characteristic was examined by a clinical inquiry as well as by the test for anxiety of Taylor and acute and chronic stress actions were search for. 228 girls at the age of 15 and 18 years were investigated. Diagnosis "psychogenic amenorrhea" was established in 34 out of 228 girls. In regard to physical and sexual development there was not significant difference with the girls of the control group. There was direct connection between stress event and the disturbance in the menstrual cycle in 41.2% of the examined girls. The fourth (elevated anxiety) and fifth degree (highly elevated anxiety) according to Taylor was established altogether in 70% of the cases. Polymorphous anxiety was found in structural respect. Third degree according to Taylor-mean manifested anxiety was established in 26% of the girls of the control group. Inferences are made in connection with the therapy.