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1.
PLoS One ; 18(3): e0283259, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-36947531

RESUMO

This paper focuses on a chemical analysis of human scent samples that were obtained from cartridge cases after being fired and their comparison with scent samples collected under laboratory conditions. Scent samples were analyzed by comprehensive two-dimensional gas chromatography coupled with the time-of-flight mass spectrometer. The results obtained from the chemical analyzes confirmed the desired stability of the human scent evidence and outlined the possible application for forensic purposes. The qualitative results of the study converge with the findings of previous studies on the composition of human scent and the chemical composition of human fingerprints. Furthermore, statistical analyzes were performed employing similarity algorithms such as Pearson's and Spearman's correlations, or Kendall's tau. The resulting comparison of the scent samples secured on fired cartridge cases compared with those samples collected under laboratory conditions yielded ten out of ten correct identifications of the scent inflictor.


Assuntos
Medicina Legal , Odorantes , Humanos , Odorantes/análise , Medicina Legal/métodos , Cromatografia Gasosa , Feromônios
2.
J Fungi (Basel) ; 6(4)2020 Oct 10.
Artigo em Inglês | MEDLINE | ID: mdl-33050542

RESUMO

Onychomycosis is one of the most common nail disorders. Its current treatment is not satisfactorily effective and often causes adverse side effects. This study aims to determine the optimal conditions for non-thermal plasma (NTP) inactivation of the most common dermatophytes in vitro and to apply it in patient`s therapy. The in vitro exposure to NTP produced by negative DC corona discharge caused full inactivation of Trichophyton spp. if applied during the early growth phases. This effect decreased to negligible inactivation with the exposure applied six days after inoculation. In a group of 40 patients with onychomycosis, NTP therapy was combined with nail plate abrasion and refreshment (NPAR) or treatment with antimycotics. The cohort included 17 patients treated with NPAR combined with NTP, 11 patients treated with antimycotics and NTP, and 12 patients treated with NPAR alone. The combination of NPAR and NTP resulted in clinical cure in more than 70% of patients. The synergistic effect of NPAR and NTP caused 85.7% improvement of mycological cure confirmed by negative microscopy and culture of the affected nail plate. We conclude that NTP can significantly improve the treatment of onychomycosis.

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