Do adults born preterm deliver preterm babies? A record linkage study from Western Australia.

BACKGROUND: Infants born preterm at <37 + 0 weeks of gestation experience systemic complications later in adulthood. However, the risk of adults born preterm delivering preterm babies themselves is not well investigated. METHODS: Midwives Notifications of births for the Western Australian population from 1980 to 2010 were obtained. A retrospective cohort study of 958,729 live-born singletons infants was conducted. Logistic regression was used to estimate odds ratios of preterm birth for preterm born parents compared to term born parents. Adjustment was made for socioeconomic status (quintiles of an area level disadvantage score), parity, maternal age, and ethnicity. RESULTS: A total of 876,755 term and 81,974 preterm babies were born during the study period. Information on the preterm birth status of the mother or father was available for 138,123 children. Of these, 1555 (12.08%) children were born preterm to parents born preterm (either of the two parents were preterm), 11,504 (9.22%) preterm children were born to parents born at term, 11,319 term children were born to parents born preterm and 113,254 term children were born to parents born at term. 68,915 (8.39%) preterm children were born where parents' whose gestational age was unknown. The unadjusted and adjusted odds ratios with and 95% confidence intervals (CI) for the odds of preterm born adults delivering preterm child were 1.35 (1.29-1.42, p < .0001) and 1.25 (1.18-1.32, p < .0001) respectively. The adjusted odds ratio (with 95% CI) for Aboriginal vs Caucasian adults was 1.96 (1.91-2.01, p < .0001). CONCLUSION:  In Western Australia delivering a preterm child is 25% greater when the parent was born preterm than when the parent was born at term in Western Australia. The effect appears to be transgenerational.

Biracial couples and adverse birth outcomes: a systematic review and meta-analyses.

BACKGROUND: Differences in birth outcomes such as low birthweight (LBW), preterm births (PTB), stillbirth, differences in birthweight in Black vs. White race are well known. Infants born to biracial parents (mother and father from either Black or White races) also experience higher adverse birth outcomes. OBJECTIVE: To systematically review and meta-analyze birth outcomes among parents of mixed racial background compared to parents of same race. SEARCH STRATEGY: Medline, Embase, CINAHL and bibliographies of identified articles were searched for English language studies. SELECTION CRITERIA: Studies reporting association between parental mixed racial status and LBW, PTB, or small-for-gestational age (SGA) outcomes were included. DATA COLLECTION AND ANALYSES: After exclusion of duplicate cohorts in different publications, data from White mother-Black father (WMBF), Black mother-White father (BMWF) and Black mother-Black father (BMBF) groups were compared with the White mother-White father (WMWF) group. RESULTS: Eight English language studies from of 26 335 596 singleton births were included and reviewed. Compared to the WMWF group, the adjusted odds ratio (95% confidence intervals) were: (a) low birthweight; 1.21 (1.10-1.33) for WMBF, 1.75(1.64-1.87) for BMWF, and 2.08 (1.81-2.38) for BMBF; (b) preterm births; 1.17 (1.05-1.31) for WMBF, 1.37 (1.18-1.59) for BMWF, and 1.78 (1.59-2.00) for BMBF; and (c) stillbirths; 1.43 (0.92-2.21) for WMBF, 1.51 (1.09-2.08) for BMWF, and 1.85 (1.47-2.32) for BMBF. CONCLUSION: Biracial status of parents was associated with higher risk for adverse pregnancy outcomes than both White parents but lower than both Black parents, with maternal race having a greater influence than paternal race on pregnancy outcomes.

Congenital Mycoplasma pneumoniae pneumonia in a neonate.

A fatal case of vertical transmission of Mycoplasma pneumoniae manifesting as congenital pneumonia in a neonate is presented. The diagnosis was based on the detection of DNA by polymerase chain reaction on the neonatal nasopharyngeal aspirates and placenta and rising titers of maternal anti Mycoplasma antibodies by complement fixation test.

Cytomegalovirus-associated ileal stricture in a preterm neonate.

Gastrointestinal (GI) manifestations of post-natally acquired cytomegalovirus (CMV) in preterm neonates can vary from mild diarrhoea to severe necrotising enterocolitis. However, the suspicion of CMV-related GI disease remains low. Mild CMV disease localised to the GI tract may go undiagnosed initially until a more obvious complication such as strictures manifest. A case of CMV-associated enteritis in an extremely preterm neonate is presented. The diagnosis was established after the histopathology of the surgical specimen showed the presence of CMV inclusion bodies. Testing the stool specimen for CMV to establish the diagnosis when the pathology is limited to the GI tract is also discussed.