On the history of neuroscience research in the Max Planck Society, 1948-2002-German, European, and transatlantic perspectives: Introduction.

To further our understanding of the transformations of the modern, globalized world, historical research concerning the twentieth century must acknowledge the tremendous impact that science and technology exerted and continue to exert on political, economic, military, and social developments. To better comprehend a global history of science, it is also crucial to include Germany's most prominent research organization: The Max Planck Society for the Advancement of Science (MPG). Despite the existence of numerous institute chronicles and selected anniversary editions, the overall development of the MPG-historically situated in more than 80 institutes with more than 250 research service departments (of which approximately 50 have reached into the wider field of neuroscience, behavioral science, and cognitive science)-it remains largely terra incognita from a scholarly perspective. From June 2014 to December 2022, the Research Program on the History of the Max Planck Society (GMPG) opened previously neglected vistas on contemporary history, academic politics, and economic developments of the Federal Republic of Germany and its international relations by raising questions such as these: Who were the key scientific actors? In what networks did they work? In what fields had the MPG paved the way for cutting-edge innovations? What were its successes and where did it fail? In what ways were its institutional structures connected to its scientific achievements and its historical legacies? What is specific about the MPG in comparison to other national institutions in and outside of Germany? These questions relate to the emerging interdisciplinary field of the neurosciences. They refer in part to the MPG's founding years-from the late 1940s to the mid-1960s-which faced significant challenges for a "normalization process" in biomedical research and the burgeoning field of neuroscience. This special issue of the Journal of the History of the Neurosciences is composed of an introduction, five articles, and two neuroscience history interviews. It reflects on the multifold dimensions of behavioral psychology, brain research, and cognitive science developments at the MPG since its beginning through the reopening of several former Kaiser Wilhelm Institutes. After World War II, the extra-university research society-named in honor of physicist Max Planck (1858-1947)-was eventually established in the British Occupation Zone in 1946, in the American Zone in 1948, and in 1949 in the French Zone, unifying the MPG as the successor umbrella organization of the Kaiser Wilhelm Institutes (KWIs), now transformed into Max Planck Institutes. Chronologically, the research period covered in this special issue ranges from 1948 to 2002.

Neuroscience research in the Max Planck Society and a broken relationship to the past: Some legacies of the Kaiser Wilhelm Society after 1948.

The development of the brain sciences (Hirnforschung) in the Max Planck Society (MPG) during the early decades of the Federal Republic of Germany (FRG) was influenced by the legacy of its precursor institution, the Kaiser Wilhelm Society for the Advancement of Science (KWG). The KWG's brain science institutes, along with their intramural psychiatry and neurology research programs, were of considerable interest to the Western Allies and former administrators of the German science and education systems in their plans to rebuild the extra-university research society-first in the British Occupation Zone and later in the American and French Occupation Zones. This formation process occurred under the physicist Max Planck (1858-1947) as acting president, and the MPG was named in his honor when it was formally established in 1948. In comparison to other international developments in the brain sciences, it was neuropathology as well as neurohistology that initially dominated postwar brain research activities in West Germany. In regard to its KWG past, at least four historical factors can be identified that explain the dislocated structural and social features of the MPG during the postwar period: first, the disruption of previously existing interactions between German brain scientists and international colleagues; second, the German educational structures that countered interdisciplinary developments through their structural focus on medical research disciplines during the postwar period; third, the moral misconduct of earlier KWG scientists and scholars during the National Socialism period; and, fourth, the deep rupture that appeared through the forced migration of many Jewish and oppositional neuroscientists who sought to find exile after 1933 in countries where they had already held active collaborations since the 1910s and 1920s. This article examines several trends in the MPG's disrupted relational processes as it sought to grapple with its broken past, beginning with the period of reinauguration of relevant Max Planck Institutes in brain science and culminating with the establishment of the Presidential Research Program on the History of the Kaiser Wilhelm Society in National Socialism in 1997.

Making Medical History Relevant to Medical Students: The First Fifty Years of the Calgary History of Medicine Program and History of Medicine Days Conferences.

Medical historians and educators have long lamented that the integration of the study of the history of medicine into the educational curricula of medical schools and clinic-based teaching has been protractedly troubled. Employing the development of the history of medicine program at the University of Calgary as a case study, this article emphasizes the importance of integrating medical history with teaching schedules to further students' insights into changing health care settings, the social contingency of disease concepts, and socio-economic dependences of medical decision-making. History of medicine programs can furnish plentiful opportunities for research training through summer projects, insight courses, and field practica. This article explores the first fifty years of the History of Medicine and Health Care Program in Calgary and considers the impact of interdisciplinary cooperation as well as the role of interprofessional undergraduate and clinical medical education. Through this exploration, I argue that medical history should be a central part of study curricula, that a historical understanding can provide a robust background for physicians in a fast-changing world in the clinic, and that through their disciplinary expertise, medical historians play a fruitful role in scholarly and teaching exchanges with medical students and clinicians in the modern medical humanities.

Neuroscience history interview with Professor Bert Sakmann, Nobel Laureate in Physiology or Medicine (1991), Max Planck Society, Germany.

Dr. Bert Sakmann (b. 1942) studied at the Universities of Tuebingen, Freiburg, Berlin, Paris, and Munich, graduating in 1967. Much of his professional life has been spent in various institutes of the Max Planck Society. In 1971, a British Council Fellowship took him to the Department of Biophysics of University College London to work with Bernard Katz (1911-2003). In 1974, he obtained his Ph.D. from the University of Goettingen and, with Erwin Neher (b. 1944) at the Max Planck Institute for Biophysical Chemistry, began work that would transform cellular biology and neuroscience, resulting in the 1991 Nobel Prize for Physiology or Medicine. In 2008, Dr. Sakmann returned to Munich, where he headed the research group "Cortical Columns in Silico" at the Max Planck Institute of Neurobiology in Martinsried. Here, their group discovered the cell-type specific sensory activation patterns in different layers of a column in the vibrissal area of rodents' somatosensory cortices.

Contextualizing ovarian pain in the late 19th century-Part 1: Women with "hysteria" and "hystero-epilepsy".

"Hysteria" and "hystero-epilepsy" were common medical diagnoses among physicians during the nineteenth century. In Paris, L'Hôpital de la Salpêtrière-originally a hospice for the poor and a prison for prostitutes and other female inmates-became a center of great interest for the possible role of neurological diseases in these conditions. At the same time in the Americas and Europe, gynecologists were removing women's ovaries in cases with the same clinical conditions, which emphasized the role of the ovaries in contemporary hysteria studies in France, Great Britain, and the United States. The objective of this article is to explore nineteenth-century conceptualizations of ovarian pain as an organ-pathological substrate for a portion of these diagnoses. The theoretical role of the pelvic organs in these diagnoses has waxed and waned over the centuries, but there have not been many detailed explorations of the associated clinical phenomena. Suggesting an organic basis (le substratum organique) for the diagnoses remains a precarious notion, given the universally repudiated role of the uterus and decreasing interest in the ovary. In contemporary literature, the potential role of the ovary has not been addressed from a detailed medical perspective, however.

Contextualizing ovarian pain in the late 19th century - Part 2: Ovarian-based treatments of "hysteria".

The peculiar therapeutic practice of "ovarian compression"-paradoxically, both in initiating and in terminating hysterical activity-remains largely unexplained territory from both historical and medical perspectives. The gynecological indications of "hysteria" and "hystero-epilepsy" are now considered to be among similar questionable indications as contemporaneous "nymphomania" and "epilepsy." This article analyzes historical clinical observations, as well as surgical experiences of the time, to determine if there has been a uniform understanding of the ovarian contribution to "hystero-epilepsy." The respective findings are interpreted in light of the physiology of "chronic pelvic pain." Evidence for pain as a source of hystero-epileptic attacks is further represented through a series of clinical photographs suggesting a link to current problems, such as severe left-lower-quadrant pain. The emerging insights link more clearly to the functional role (le rôle fonctionnel) of the ovaries in relation to the "fits" of hystero-epileptic patients, while validating women's pain experiences during the latter part of the nineteenth century. Differences in the interpretation of disease concepts between Robert Battey (1828-1895) and Octave Terrillon (1844-1895) thereby permit an understanding of variations in the use of the removal of women's ovaries for pain.

A Century of Brain Regeneration Phenomena and Neuromorphological Research Advances, 1890s-1990s-Examining the Practical Implications of Theory Dynamics in Modern Biomedicine.

The modern thesis regarding the "structural plastic" properties of the brain, as reactions to injuries, to tissue damage, and to degenerative cell apoptosis, can hardly be seen as expendable in clinical neurology and its allied disciplines (including internal medicine, psychiatry, neurosurgery, radiology, etc.). It extends for instance to wider research areas of clinical physiology and neuropsychology which almost one hundred years ago had been described as a critically important area for the brain sciences and psychology alike. Yet the mounting evidence concerning the range of structural neuroplastic phenomena beyond the significant early 3 years of childhood has shown that there is a progressive building up and refining of neural circuits in adaptation to the surrounding environment. This review essay explores the history behind multiple biological phenomena that were studied and became theoretically connected with the thesis of brain regeneration from Santiago Ramón y Cajal's pioneering work since the 1890s to the beginning of the American "Decade of the Brain" in the 1990s. It particularly analyzes the neuroanatomical perspectives on the adaptive capacities of the Central Nervous System (CNS) as well as model-like phenomena in the Peripheral Nervous System (PNS), which were seen as displaying major central regenerative processes. Structural plastic phenomena have assumed large implications for the burgeoning field of regenerative or restorative medicine, while they also pose significant epistemological challenges for related experimental and theoretical research endeavors. Hereafter, early historical research precursors are examined, which investigated brain regeneration phenomena in non-vertebrates at the beginning of the 20th century, such as in light microscopic studies and later in electron microscopic findings that substantiated the presence of structural neuroplastic phenomena in higher cortical substrates. Furthermore, Experimental physiological research in hippocampal in vivo models of regeneration further confirmed and corroborated clinical physiological views, according to which "structural plasticity" could be interpreted as a positive regenerative CNS response to brain damage and degeneration. Yet the underlying neuroanatomical mechanisms remained to be established and the respective pathway effects were only conveyed through the discovery of neural stem cells in in adult mammalian brains in the early 1990s. Experimental results have since emphasized the genuine existence of adult neurogenesis phenomena in the CNS. The focus in this essay will be laid here on questions of the structure and function of scientific concepts, the development of research schools among biomedical investigators, as well as the impact of new data and phenomena through innovative methodologies and laboratory instruments in the neuroscientific endeavors of the 20th century.

The Gray Degeneration of the Brain and Spinal Cord: A Story of the Once Favored Diagnosis With Subsequent Vessel-Based Etiopathological Studies in Multiple Sclerosis.

In 1857, French-Austrian psychiatrist Bénédict Augustin Morel (1809-1873) published his infamous though highly successful Traité des dégénérescences physiques, intellectuelles et morales de l'espèce humaine, which was fully dedicated to the social problem of "degeneration" and its psychiatric and neurological underpinnings. European psychiatrists, neurologists, and pathologists integrated Morel's approach into their neuropsychiatric theories and searched for the somatic and morphological alterations in the human brain, as did the versatile pupil of Rudolph Virchow (1821-1902), Georg Eduard von Rindfleisch (1836-1908), in his Lehrbuch der pathologischen Gewebelehre (1867). This can be seen as a starting point of research into the vascular genesis of "multiple sclerosis" by observing that the changes of blood vessels and nerve elements could be the result of inflammation and increased blood flow. We examine the waxing and waning of a 19th century diagnostic condition, which fell out of favor and resurfaced during the 20th century.

Catalyzing Neurophysiology: Jacques Loeb, the Stazione Zoologica di Napoli, and a Growing Network of Brain Scientists, 1900s-1930s.

Even before the completion of his medical studies at the universities of Berlin, Munich, and Strasburg, as well as his M.D.-graduation - in 1884 - under Friedrich Goltz (1834-1902), experimental biologist Jacques Loeb (1859-1924) became interested in degenerative and regenerative problems of brain anatomy and general problems of neurophysiology. It can be supposed that he addressed these questions out of a growing dissatisfaction with leading perceptions about cerebral localization, as they had been advocated by the Berlin experimental neurophysiologists at the time. Instead, he followed Goltz and later Gustav Theodor Fechner (1801-1887) in elaborating a dynamic model of brain functioning vis-à-vis human perception and coordinated motion. To further pursue his scientific aims, Loeb moved to the Naples Zoological Station between 1889 and 1890, where he conducted a row of experimental series on regenerative phenomena in sea animals. He deeply admired the Italian marine research station for its overwhelming scientific liberalism along with the provision of considerable technical and intellectual support. In Naples, Loeb hoped to advance his research investigations on 'tropisms' further to develop a reliable basis not only regarding the behavior of lower animals, but also concerning perception and general neural capacities. He thought that he could demonstrate the existence of center interdependence in the cerebral cortex of higher animals and humans, and was convinced that regenerative phenomena existed as plastic mechanisms influencing animal as well as human behavioral qualities. This new perspective on the organization of brain functioning and Loeb's astonishing successes in experimental research with hydrozoa and echinoidea brought him in close contact with many biologists working on the nervous system during the early twentieth century. Yet, it is impossible to conceive of Loeb's ground-breaking experiments without also taking his contemporary scientific network of teachers, colleagues, and local research milieus into account. All of these exerted a strong influence on a growing network of physiology, anatomy, and neurology peers and research trainees, who went on to interact in early brain research centers in Central Europe and North America. This article explores some intellectual and organizational influences that developed out of Loeb's early experiences at the Naples Zoological Station in Italy. The main focus is laid here on questions of the structure and organization of scientific institutions, the development of research networks among biologists of the nervous system, as well as the emergence of an interdisciplinary research style during the early decades of the twentieth century. This innovative style of laboratory investigations later influenced the make-up of a number of research units, for example at the Kaiser Wilhelm Society in Germany and the Rockefeller Institute for Medical Research in the United States.

Reflections on the Life and Career of Émigré German-Canadian Psychiatrist Sebastian Klaus Littmann (1931-1986).

OBJECTIVE: This article explores the life and career of Sebastian K. Littmann. He was a foundational figure of the University of Calgary's Department of Psychiatry in his role as its second chair and, before this, as an influential administrator at Toronto's Queen Street Mental Health Centre and Clarke Institute during a transitional period in the 1970s-1980s. According to McGill University's Heinz Lehmann, this transitional period was when the field of psychiatry underwent an identity crisis that threatened to dissolve the discipline and see its functions increasingly filled by counsellors, neurologists, and primary physicians. Littmann's professional background and training in Edinburgh was followed by periods of community work in New York, which-by the time he immigrated to Canada-predisposed him to favour a humane and community-based approach to psychiatric work; this approach encompassed the cultural variations that were increasingly characterizing North America's urban social landscape. His compassionate and progressive approach to treatment was remarkable in light of his troubled and deprived upbringing in Nazi-era Germany. CONCLUSIONS: The present sketch of Littmann's personal and professional biography serves to highlight the ways that major historical events and large-scale migration movements, which affected Central Europe, impacted the development of Canadian psychiatry and, by extension, individual Canadians in the twentieth century.