1.
Nucl Med Biol
; 27(6): 565-9, 2000 Aug.
Artigo
em Inglês
| MEDLINE
| ID: mdl-11056370
RESUMO
This paper describes the radiosynthesis of [(11)C]CGP62349, a potential ligand to assess GABA(B) receptors in vivo. (11)C was introduced by O-methylation of the corresponding des-methyl precursor, namely CGP67780. The final product was obtained with a reliable method in good yield. The radioligand was tested in monkey, revealing negligible blood-brain barrier penetration and brain uptake, thus prompting us to search for a new target structure with a better lipophilicity.