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1.
Neurotoxicology ; 81: 259-265, 2020 12.
Artigo em Inglês | MEDLINE | ID: mdl-33741111

RESUMO

To examine the prevalence and trends in excess weight among children in the Seychelles. Serial surveys of weight and height were conducted each year between 1998-2002 in all students attending four school grades (crèche, 4th, 7th and 10th years of compulsory school). Overweight and obesity were defined using age-specific body mass index (BMI) criteria of the International Obesity Task Force. Two questions explored physical activity at leisure time and daily walking time. From an eligible total of 32 077 observations between 1998-2002, data were available in 22 694 (71%), which corresponded to 17 627 separate children. Median age in the four grades was respectively 5.5, 9.2, 12.6, and 15.8 years. The overall prevalence of excess weight ('overweight' and 'obese' categories combined) was 10.5% in boys and 16.4% in girls. From 1998 to 2002, the prevalence of excess weight increased from 8.4% to 11.8% in boys and from 11.9% to 18.4% in girls. The increase of excess weight over calendar years was particularly marked among the younger children. Only a quarter of children reported walking at least 30minutes per day. Leisure physical activity was inversely associated with excess body weight. The prevalence of excess body weight was high among school children of Seychelles and increased substantially over a five-year period. This calls for prompt and energetic policies and programs to promote physical activity and healthy nutrition among children.


Assuntos
Obesidade Infantil/epidemiologia , Comportamento Sedentário , Adolescente , Fatores Etários , Índice de Massa Corporal , Criança , Pré-Escolar , Dieta/efeitos adversos , Exercício Físico , Feminino , Inquéritos Epidemiológicos , Humanos , Masculino , Valor Nutritivo , Obesidade Infantil/diagnóstico , Prevalência , Medição de Risco , Fatores de Risco , Seicheles/epidemiologia , Fatores de Tempo
2.
J Public Health (Oxf) ; 41(2): 338-345, 2019 06 01.
Artigo em Inglês | MEDLINE | ID: mdl-29659918

RESUMO

BACKGROUND: The role of dairy products in obesity treatment for adolescents is unclear. The study purpose was to assess the association between dairy intake and changes in BMI z-score (zBMI) during adolescent obesity treatment. METHODS: Observational study nested within a randomized control trial. Linear mixed-effects regression models were adjusted for important non-lifestyle factors then further adjusted for dietary and physical activity variables. In total, 91 adolescents were studied. RESULTS: Each serving of total dairy (ß = -0.0054, P < 0.01), unflavored milk (ß = -0.012, P < 0.01), reduced fat (ß = -0.0078, P < 0.05), and low fat/fat-free products (ß = -0.0149, P < 0.01) was associated with a decrease in zBMI over 12 months. These associations were no longer significant after adjustment for other dietary and physical activity factors. Sugar-sweetened beverage intake was inversely associated with intake of total dairy (ß = -0.186, P = 0.001), unflavored milk (ß = -0.115, P = 0.003) and low fat/fat-free dairy (ß = -0.125, P = 0.001). CONCLUSIONS: Intakes of total dairy, unflavored milk, reduced fat dairy and low fat/fat-free dairy products are associated with improved obesity treatment outcomes among adolescents. This could be due to co-occurring healthy lifestyle behaviors or to replacement of other food and beverages associated with obesity, such as sugar-sweetened beverages, by dairy products.


Assuntos
Laticínios , Obesidade Infantil/dietoterapia , Adolescente , Criança , Dieta Redutora/métodos , Dieta Redutora/estatística & dados numéricos , Ingestão de Energia , Exercício Físico , Feminino , Humanos , Modelos Lineares , Masculino , Obesidade Infantil/terapia
3.
Ann Hum Biol ; 44(2): 108-120, 2017 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-27121656

RESUMO

BACKGROUND: Body composition prediction equations using skinfolds are useful alternatives to advanced techniques, but their utility across diverse paediatric populations is unknown. AIM: To evaluate published and new prediction equations across diverse samples of children with health conditions affecting growth and body composition. SUBJECTS AND METHODS: Anthropometric and dual-energy X-ray absorptiometry (DXA) body composition measures were obtained in children with Down syndrome (n = 59), Crohn disease (n = 128), steroid-sensitive nephrotic syndrome (n = 67) and a healthy reference group (n = 835). Published body composition equations were evaluated. New equations were developed for ages 3-21 years using the healthy reference sample and validated in other groups and national survey data. RESULTS: Fat mass (FM), fat-free mass (FFM) and percentage body fat (%BF) from published equations were highly correlated with DXA-derived measures (r = 0.71-0.98), but with poor agreement (mean difference = 2.4 kg, -1.9 kg and 6.3% for FM, FFM and %BF). New equations produced similar correlations (r = 0.85-1.0) with improved agreement for the reference group (0.2 kg, 0.4 kg and 0.0% for FM, FFM and %BF, respectively) and in sub-groups. CONCLUSIONS: New body composition prediction equations show excellent agreement with DXA and improve body composition estimation in healthy children and those with selected conditions affecting growth.


Assuntos
Absorciometria de Fóton/métodos , Antropometria/métodos , Composição Corporal , Doença de Crohn/fisiopatologia , Síndrome de Down/fisiopatologia , Síndrome Nefrótica/fisiopatologia , Adolescente , Criança , Pré-Escolar , Feminino , Humanos , Masculino , Modelos Teóricos , Inquéritos Nutricionais , Philadelphia , Dobras Cutâneas , Estados Unidos , Adulto Jovem
6.
J Rheumatol ; 42(1): 126-33, 2015 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-25362652

RESUMO

OBJECTIVE: In adults, osteoarthritis (OA) is associated with obesity and knee alignment. Whether knee alignment differences develop during childhood and are associated with obesity is unknown. We assessed the distribution of knee alignment in children and adolescents, and determined how knee alignment differs between obese and nonobese children. METHODS: This cross-sectional study examined knee alignment in 155 healthy weight and 165 obese subjects. Knee alignment [metaphyseal-diaphyseal angle (MDA) and anterior tibiofemoral angle (ATFA)] and fat mass were measured using whole body dual-energy X-ray absorptiometry (DEXA). National reference data were used to generate age- and sex-specific body mass index (BMI, kg/m(2)) Z-scores. Multivariable linear regression was used to identify independent factors associated with ATFA and MDA. RESULTS: The mean MDA and ATFA were similar between obese and nonobese subjects. In stratified analyses, females had greater variability in MDA and ATFA values (p < 0.001 and p = 0.04, respectively) at higher BMI Z-scores. Compared with healthy weight controls, obese subjects had less valgus of the MDA prior to the onset of puberty (+ 2.0°, p = 0.001), but had greater valgus at later pubertal stages (-1.9°, p = 0.01). CONCLUSION: We found significantly greater variability in knee alignment among females at higher BMI Z-scores, and greater valgus alignment in obese adolescents in late puberty. The major limitation is the use of DEXA for assessment of alignment, which needs validation against longstanding radiographs. Longitudinal studies are needed to determine whether childhood obesity is a risk factor for progressive malalignment that may predispose to pain and risk of early osteoarthritis.


Assuntos
Índice de Massa Corporal , Articulação do Joelho/diagnóstico por imagem , Obesidade/diagnóstico por imagem , Osteoartrite do Joelho/diagnóstico por imagem , Adolescente , Composição Corporal , Criança , Pré-Escolar , Estudos Transversais , Feminino , Humanos , Masculino , Obesidade/complicações , Osteoartrite do Joelho/complicações , Radiografia , Fatores de Risco , Adulto Jovem
7.
Bone ; 73: 69-76, 2015 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-25497572

RESUMO

Childhood obesity is associated with biologic and behavioral characteristics that may impact bone mineral density (BMD) and structure. The objective was to determine the association between obesity and bone outcomes, independent of sexual and skeletal maturity, muscle area and strength, physical activity, calcium intake, biomarkers of inflammation, and vitamin D status. Tibia and radius peripheral quantitative CT scans were obtained in 91 obese (BMI>97th percentile) and 51 non-obese adolescents (BMI>5th and <85th percentiles). Results were converted to sex- and race-specific Z-scores relative to age. Cortical structure, muscle area and muscle strength (by dynamometry) Z-scores were further adjusted for bone length. Obese participants had greater height Z-scores (p<0.001), and advanced skeletal maturity (p<0.0001), compared with non-obese participants. Tibia cortical section modulus and calf muscle area Z-scores were greater in obese participants (1.07 and 1.63, respectively, both p<0.0001). Tibia and radius trabecular and cortical volumetric BMD did not differ significantly between groups. Calf muscle area and strength Z-scores, advanced skeletal maturity, and physical activity (by accelerometry) were positively associated with tibia cortical section modulus Z-scores (all p<0.01). Adjustment for muscle area Z-score attenuated differences in tibia section modulus Z-scores between obese and non-obese participants from 1.07 to 0.28. After multivariate adjustment for greater calf muscle area and strength Z-scores, advanced maturity, and less moderate to vigorous physical activity, tibia section modulus Z-scores were 0.32 (95% CI -0.18, 0.43, p=0.06) greater in obese, vs. non-obese participants. Radius cortical section modulus Z-scores were 0.45 greater (p=0.08) in obese vs. non-obese participants; this difference was attenuated to 0.14 with adjustment for advanced maturity. These findings suggest that greater tibia cortical section modulus in obese adolescents is attributable to advanced skeletal maturation and greater muscle area and strength, while less moderate to vigorous physical activities offset the positive effects of these covariates. The impact of obesity on cortical structure was greater at weight bearing sites.


Assuntos
Obesidade/patologia , Tíbia/anatomia & histologia , Tíbia/patologia , Adolescente , Estudos de Casos e Controles , Estudos Transversais , Feminino , Humanos , Masculino
8.
Int J Womens Health ; 6: 899-912, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-25349482

RESUMO

Maternal nutrition is recognized as one of the determinants of fetal growth. Consumption of fruits and vegetables is promoted as part of a healthful diet; however, intakes are typically lower than recommended levels. The purpose of this study was to systematically review results from studies examining the relationship between maternal consumption of fruits and vegetables during pregnancy with infant birth weight or risk for delivering a small for gestational age baby. A comprehensive search of PubMed and EMBASE was conducted and abstracts were screened using predefined criteria. Eleven relevant studies were identified and systematically reviewed, including six prospective cohort studies, three retrospective cohort studies, and two case-control studies. Seven studies were conducted in cohorts from highly developed countries. One prospective study from a highly developed area reported increased risk for small for gestational age birth by women with low vegetable intakes (odds ratio 3.1; 95% confidence interval 1.4-6.9; P=0.01); another large prospective study reported a 10.4 g increase in birth weight per quintile increase in fruit intake (95% confidence interval 6.9-3.9; P<0.0001) and increases of 8.4 or 7.7 g per quintile intake of fruits and vegetables (combined) or fruits, vegetables, and juice (combined), respectively. One retrospective study reported an association between low fruit intake and birth weight. In less developed countries, increased vegetable or fruit intake was associated with increased birth weight in two prospective studies. Overall, limited inconclusive evidence of a protective effect of increased consumption of vegetables and risk for small for gestational age birth, and increased consumption of fruits and vegetables and increased birth weight among women from highly developed countries was identified. Among women in less developed countries, limited inconclusive evidence suggests that increased consumption of vegetables or fruits may be associated with higher infant birth weight. The available evidence supports maternal consumption of a variety of fruits and vegetables as part of a balanced diet throughout pregnancy.

9.
Pediatr Rheumatol Online J ; 12: 11, 2014 Mar 29.
Artigo em Inglês | MEDLINE | ID: mdl-24678578

RESUMO

BACKGROUND: Obesity associated with joint pain of the lower extremities is likely due to excessive mechanical load on weight bearing joints. Additional mechanical factors may explain the association between obesity and joint pain. FINDINGS: We characterized the association between obesity and non-traumatic lower extremity (LE) joint pain in adolescents and examined the modifying effect of hypermobility on this association.We performed a cross-sectional analysis of data from subjects enrolled in a clinical trial examining the impact of weight loss on bone health in adolescents. Anthropometric data were collected and body mass index (BMI = kg/m2) was calculated. Subjects were categorized as obese or healthy weight controls based on CDC 2000 growth curves for age and gender. We assessed any musculoskeletal pain and LE pain by the PEDS™ Pediatric Pain Questionnaire™. Hypermobility was assessed with the modified Beighton scoring system. Multivariate logistic regression models adjusted for covariates were performed to examine the association between weight status and joint pain.Out of 142 subjects, 91 were obese and 51 were healthy weight. Obesity was not associated with any musculoskeletal pain (OR 0.86, CI 0.49-1.50), LE pain (OR 1.02, CI 0.49-2.15) or hypermobility (OR 1.23, CI 0.72-2.14, p = 0.3). There was no effect modification on the association between obesity and any musculoskeletal pain (OR 0.80, CI 0.45 -1.42) or LE pain (OR 0.98, CI 0.46 - 2.08) by hypermobility status. CONCLUSIONS: We found no association between LE pain and obesity, and hypermobility did not modify this association.


Assuntos
Suporte de Carga/fisiologia , Adolescente , Artralgia/etiologia , Artralgia/fisiopatologia , Índice de Massa Corporal , Criança , Estudos Transversais , Feminino , Humanos , Instabilidade Articular/etiologia , Instabilidade Articular/fisiopatologia , Extremidade Inferior/fisiopatologia , Masculino , Dor Musculoesquelética/etiologia , Dor Musculoesquelética/fisiopatologia , Obesidade Infantil/complicações , Obesidade Infantil/diagnóstico , Obesidade Infantil/epidemiologia , Estatística como Assunto , Estados Unidos/epidemiologia
11.
J Clin Sleep Med ; 9(12): 1303-13, 2013 Dec 15.
Artigo em Inglês | MEDLINE | ID: mdl-24340293

RESUMO

STUDY OBJECTIVES: Adolescents with obstructive sleep apnea syndrome (OSAS) represent an important but understudied subgroup of long-term continuous positive airway pressure (CPAP) users. The purpose of this qualitative study was to identify factors related to adherence from the perspective of adolescents and their caregivers. METHODS: Individual open-ended, semi-structured interviews were conducted with adolescents (n = 21) and caregivers (n = 20). Objective adherence data from the adolescents' CPAP machines during the previous month was obtained. Adolescents with different adherence levels and their caregivers were asked their views on CPAP. Using a modified grounded theory approach, we identified themes and developed theories that explained the adolescents' adherence patterns. RESULTS: Adolescent participants (n = 21) were aged 12-18 years, predominantly male (n = 15), African American (n = 16), users of CPAP for at least one month. Caregivers were mainly mothers (n = 17). Seven adolescents had high use (mean use 381 ± 80 min per night), 7 had low use (mean use 30 ± 24 min per night), and 7 had no use during the month prior to being interviewed. Degree of structure in the home, social reactions, mode of communication among family members, and perception of benefits were issues that played a role in CPAP adherence. CONCLUSIONS: Understanding the adolescent and family experience of using CPAP may be key to increasing adolescent CPAP adherence. As a result of our findings, we speculate that health education, peer support groups, and developmentally appropriate individualized support strategies may be important in promoting adherence. Future studies should examine these theories of CPAP adherence.


Assuntos
Comportamento do Adolescente/psicologia , Pressão Positiva Contínua nas Vias Aéreas/estatística & dados numéricos , Conhecimentos, Atitudes e Prática em Saúde , Cooperação do Paciente/psicologia , Cooperação do Paciente/estatística & dados numéricos , Apneia Obstrutiva do Sono/terapia , Adolescente , Comportamento do Adolescente/fisiologia , Criança , Pressão Positiva Contínua nas Vias Aéreas/métodos , Pressão Positiva Contínua nas Vias Aéreas/psicologia , Família/psicologia , Feminino , Humanos , Entrevistas como Assunto/métodos , Masculino , Apneia Obstrutiva do Sono/psicologia
12.
Diabetes Metab Syndr Obes ; 6: 347-57, 2013 Sep 25.
Artigo em Inglês | MEDLINE | ID: mdl-24106428

RESUMO

Globally, both the incidence of type 2 diabetes and the consumption of meat, in particular pork meat, have increased, concurrently. Processed meats have been associated with an increased risk for diabetes in observational studies. Therefore, it is important to understand the possible mechanisms of this association and the impact of meats from different species. The goal of this systematic review was to assess experimental human studies of the impact of pork intake compared with other protein sources on early markers for the development of diabetes, ie, insulin resistance, glucose intolerance, and the components of the metabolic syndrome. A systematic review was conducted searching PubMed and EMBASE and using the Cochrane and PRISMA guidelines. Eight studies were eligible and critically reviewed. Five studies were based on a single meal or single day exposure to pork, as compared with other sources of protein. The glucose-insulin response following the pork meals did not differ compared with beef, shrimp, or mixed sources of proteins. However, compared with eggs, ham (processed meat) led to a larger insulin response in nonobese subjects. Compared with whey, ham led to a smaller insulin response and a larger glucose response. These findings suggest possible mechanisms for the association between processed meat and the development of diabetes. Nonprocessed pork meats were not compared with eggs or whey. The three longer interventions (11 days to 6 months) did not show a significant impact of pork on the components of the metabolic syndrome, with the exception of a possible benefit on waist circumference and high-density lipoprotein cholesterol (one study each with significant limitations). Most of the findings are weak and there is a lack of solid evidence. The literature on the topic is limited and important research gaps are identified. Considering recent trends and projections for diabetes and pork intake, this is an important global public health question that requires more attention in order to provide improved evidence-based dietary recommendations.

13.
Nutr J ; 12: 53, 2013 Apr 30.
Artigo em Inglês | MEDLINE | ID: mdl-23631725

RESUMO

BACKGROUND: Limited information is available regarding the impact of candy consumption on health. The purpose of this study was to investigate associations between typical frequency of candy consumption and body weight status and select cardiovascular risk factors among adults in the United States. METHODS: Using data collected in the 2003-2006 National Health and Nutrition Examination Surveys (NHANES), adults were categorized as infrequent (≤ 3 eating occasions [EO]/month), moderate (> 3 EO/month and ≤ 3.5 EO/week), or frequent (> 3.5 EO/week) candy consumers based on the combined frequency of chocolate and other candy consumption over the previous 12 months. Weight and adiposity status were analyzed using logistic regression models, and blood pressure, lipids, and insulin sensitivity were analyzed using linear regression models. Models were adjusted for age, sex and race/ethnicity, and also for additional covariates with potential associations with the outcomes. Appropriate statistical weights were used to yield results generalizable to the US population. RESULTS: Frequency of candy consumption was not associated with the risk of obesity, overweight/obesity, elevated waist circumference, elevated skinfold thickness, blood pressure, low density lipoprotein (LDL) or high density lipoprotein (HDL) cholesterol, triglycerides, or insulin resistance. Increased frequency of candy consumption was associated with higher energy intakes and higher energy adjusted intakes of carbohydrates, total sugars and added sugars, total fat, saturated fatty acids and monounsaturated fatty acids (p < 0.05), and lower adjusted intakes of protein and cholesterol (p < 0.001). CONCLUSIONS: Increased frequency of candy consumption among adults in the United States was not associated with objective measures of adiposity or select cardiovascular risk factors, despite associated dietary differences. Given the cross-sectional study design, however, it cannot be concluded that candy consumption does not cause obesity or untoward levels of cardiovascular risk markers. The lack of an association between frequency of candy consumption and cardiovascular risk factors could be due to reduced intake of candy among the overweight due to dieting or a health professional's recommendations. Additionally, it is important to note that the analysis was based on frequency of candy consumption and not amount of candy consumed. Longitudinal studies are needed to confirm the lack of associations between frequency of candy consumption and cardiovascular risk factors.


Assuntos
Peso Corporal , Doces/efeitos adversos , Doenças Cardiovasculares/epidemiologia , Obesidade/epidemiologia , Sobrepeso/epidemiologia , Biomarcadores/sangue , Pressão Sanguínea , HDL-Colesterol/sangue , LDL-Colesterol/sangue , Estudos Transversais , Ingestão de Energia , Feminino , Humanos , Resistência à Insulina , Modelos Logísticos , Masculino , Pessoa de Meia-Idade , Avaliação Nutricional , Inquéritos Nutricionais , Fatores de Risco , Inquéritos e Questionários , Triglicerídeos/sangue , Estados Unidos/epidemiologia , Circunferência da Cintura
14.
Pediatrics ; 130(5): e1096-104, 2012 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-23090343

RESUMO

OBJECTIVE: To assess associations of the number of parent stressors and parent-perceived stress with obesity and related behaviors in their children. METHODS: This cross-sectional analysis used data from the 2006 Southeastern Pennsylvania Household Health Survey in which 2119 parents/caregivers answered questions about themselves and their children (ages 3-17 years). Survey data were used to assess the main exposure variables: the number of stressors (measured using a stressor index) and parent-perceived stress (the response to a general stress question); child covariates (age, race/ethnicity, health quality, and gender); adult covariates (education, BMI, gender, poor sleep quality) and study outcomes (child obesity, fast-food consumption, fruit and vegetable consumption, and physical activity). To account for developmental differences, analyses were also stratified by age group (3-5, 6-8, 9-12, and 13-17 years). Analyses used multiple logistic regression, with results expressed as odds ratios and 95% confidence intervals. RESULTS: The number of parent stressors was related to child obesity in unadjusted (1.12, 1.03-1.22, P = .007) and adjusted models (1.12, 1.03-1.23, P = .010). Parent-perceived stress was related to fast-food consumption in unadjusted (1.07, 1.03-1.10, P < .001) and adjusted (1.06, 1.02-1.10, P < .001) models. CONCLUSIONS: The number of parent stressors was directly related to child obesity. Parent-perceived stress was directly related to child fast-food consumption, an important behavioral indicator of obesity risk. Clinical care models and future research that address child obesity should explore the potential benefits of addressing parent stressors and parent-perceived stress.


Assuntos
Saúde da Família , Obesidade/epidemiologia , Pais/psicologia , Estresse Psicológico/epidemiologia , Adolescente , Criança , Pré-Escolar , Estudos Transversais , Feminino , Humanos , Masculino
15.
J Pediatr ; 161(5): 881-6, 2012 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-22622051

RESUMO

OBJECTIVE: To compare lipoprotein profiles of prediabetic to normoglycemic obese adolescents. STUDY DESIGN: Cross-sectional study of 95 obese, pubertal adolescents (12-17 years), who underwent oral glucose tolerance test, lipid panel, and lipoprotein subclass particle analysis (nuclear magnetic resonance spectroscopy). Univariate and linear regression analyses compared prediabetic and normoglycemic groups. RESULTS: Of 95 obese adolescents enrolled in the study, 22.1% (n = 21) had prediabetes. They were similar to normoglycemic adolescents (n = 74) in age, race, body mass index, standard lipids, total low-density lipoprotein particles (LDL-P), and total high-density lipoprotein particles (HDL-P). However, prediabetics had higher concentrations of small LDL-P (714.0 ± 288.0 vs 537.7 ± 266.5 nmol/L, P = .01) and smaller LDL-P size (20.73 ± 0.41 vs 21.18 ± 0.65 nm, P = .003), than normoglycemic youth. Prediabetics had higher small HDL-P (18.5 ± 3.8 vs 16.6 ± 3.9 umol/L, P = .046), lower large HDL-P (4.49 ± 2.0 vs 6.32 ± 2.6 umol/L, P = .004), and smaller HDL-P size (8.73 ± 0.31 vs 9.01 ± 0.39 nm, P = .003). After adjusting for demographics, Tanner stage, and body mass index using multiple linear regression, all differences remained significant except for small HDL-P. After additional adjustment for Homeostasis Model Assessment-Insulin Resistance Index, only LDL-P size difference remained significant. CONCLUSION: Obese prediabetic adolescents have a significantly more atherogenic lipoprotein profile compared with obese normoglycemic peers. Prediabetic adolescents may benefit from more aggressive interventions to decrease future cardiovascular risk.


Assuntos
Obesidade/sangue , Estado Pré-Diabético/sangue , Adolescente , Aterosclerose , Criança , Estudos Transversais , Feminino , Teste de Tolerância a Glucose , Humanos , Resistência à Insulina , Lipoproteínas/sangue , Lipoproteínas HDL/sangue , Lipoproteínas LDL/sangue , Masculino , Obesidade/complicações , Obesidade/diagnóstico , Estado Pré-Diabético/complicações , Estado Pré-Diabético/diagnóstico , Análise de Regressão
16.
Pediatrics ; 129(6): e1382-7, 2012 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-22585768

RESUMO

OBJECTIVES: Our objective was to compare serum lipid profiles, total cholesterol (TC), low-density lipoprotein (LDL), triglycerides (TG), and high-density lipoprotein (HDL) between children with Down syndrome (DS) and their non-DS siblings. We hypothesized that the children with DS would have higher TC, LDL, and TG and lower HDL. The secondary aim was to explore if the difference in lipid profiles could be explained by differences in weight status. METHODS: This was a cross-sectional study. Fasting lipid profile was obtained from 27 children with DS and 31 siblings between 4 and 10 years of age with no severe comorbidities (heart disease, cancer, hypothyroidism, diabetes, or obesity). BMI was calculated and BMI z scores were used to account for differences in BMI throughout childhood. RESULTS: Children with DS had higher TC (difference, 11.2 mg/dL; 95% confidence interval: 2.5-19.9; P = .01), LDL (12.8 mg/dL; 7.2-18.4; P < .001), TG (33.6 mg/dL; 11.1-56.1; P = .003), and lower HDL (-7.6 mg/dL; -12.1 to -3.0; P = .001) after adjustment for race, gender, age, and ethnicity. Results remained significant after additional adjustment for BMI z score: TC (14.9 mg/dL; 4.9-24.9; P = .003), LDL (16.6 mg/dL; 10.1-23.2; P < .001), TG (32.7 mg/dL; 7.7-57.7; P = .01), and lower HDL (-6.4 mg/dL; -12.2 to -0.7; P = .03). CONCLUSIONS: Children with DS have less favorable lipid profiles than their siblings independent of weight status. These findings may have important implications for the screening and treatment of this large population at increased risk for ischemic heart disease.


Assuntos
HDL-Colesterol/sangue , LDL-Colesterol/sangue , Síndrome de Down/sangue , Irmãos , Triglicerídeos/sangue , Criança , Pré-Escolar , Estudos de Coortes , Estudos Transversais , Síndrome de Down/genética , Feminino , Humanos , Lipídeos , Masculino , Estudos Prospectivos
17.
Appetite ; 58(3): 922-7, 2012 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-22343192

RESUMO

This study compared child-feeding and related practices with child weight status between Chinese-American and non-Hispanic white caregivers who attended three community health centers. Study participants were caregivers of 50 Chinese-American and 108 non-Hispanic white children aged 2-12 years who completed a short version of the child feeding questionnaire in English or Chinese. The feeding behaviors assessed were concern, pressure, restriction, and monitoring. Child body mass index (BMI) z-scores were calculated from child weight and height measured in clinic by clinicians trained in anthropometrics. The sample was stratified into 2-5 and 6-12 years age groups to account for developmental differences. Internal consistency (Cronbach's alpha) was moderate to high and similar by ethnicity for all four behaviors for Chinese-Americans and non-Hispanic whites. In models adjusted for confounding variables, Chinese-American caregivers had higher mean scores than non-Hispanic white caregivers for concern and restriction in all age groups and monitoring in 2-5 year-olds. No feeding practices were associated with child BMI in Chinese-Americans; concern and restriction were associated with child BMI in non-Hispanic whites in 2-5 year-olds. These results suggest that differences in child-feeding practices exist between Chinese-American and non-Hispanic white caregivers.


Assuntos
Asiático , Índice de Massa Corporal , Cuidadores , Educação Infantil/etnologia , Etnicidade , Comportamento Alimentar/etnologia , Obesidade/etnologia , Controle Comportamental , Peso Corporal/etnologia , Criança , Pré-Escolar , Dieta/etnologia , Inquéritos sobre Dietas , Feminino , Hispânico ou Latino , Humanos , Idioma , Masculino , Inquéritos e Questionários , População Branca
18.
Paediatr Perinat Epidemiol ; 26(1): 19-26, 2012 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-22150704

RESUMO

To assess the predictive ability of infant weight gain on subsequent obesity we performed a meta-analysis of individual-level data on 47,661 participants from 10 cohort studies from the UK, France, Finland, Sweden, the US and Seychelles. For each individual, weight SD scores at birth and age 1 year were calculated using the same external reference (British 1990). Childhood obesity was defined by International Obesity Task Force criteria. Each +1 unit increase in weight SD scores between 0 and 1 year conferred a twofold higher risk of childhood obesity (odds ratio = 1.97 [95% confidence interval (CI) 1.83, 2.12]), and a 23% higher risk of adult obesity (odds ratio = 1.23 [1.16, 1.30]), adjusted for sex, age and birthweight. There was little heterogeneity between studies. A risk score for childhood obesity comprising weight gain 0-1 year, mother's body mass index, birthweight and sex was generated in a random 50% selection of individuals from general population cohorts with available information (n = 8236); this score showed moderate predictive ability in the remaining 50% sample (area under receiving operating curve = 77% [95% CI 74, 80%]). A separate risk score for childhood overweight showed similar predictive ability (area under receiving operating curve = 76% [73, 79%]). In conclusion, infant weight gain showed a consistent positive association with subsequent obesity. A risk score combining birthweight and infant weight gain (or simply infant weight), together with mother's body mass index and sex may allow early stratification of infants at risk of childhood obesity.


Assuntos
Obesidade/epidemiologia , Aumento de Peso/fisiologia , Fatores Etários , Peso ao Nascer , Índice de Massa Corporal , Criança , Estudos de Coortes , Humanos , Lactente , Valor Preditivo dos Testes , Análise de Regressão , Medição de Risco , Fatores de Risco
19.
World J Pediatr ; 8(1): 76-9, 2012 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-21874618

RESUMO

BACKGROUND: This study explored the association between maternal obesity during pregnancy and the inflammatory markers, tumor necrosis factor-α, interleukin-6 and high sensitivity C-reactive protein (hs-CRP), and the cytokine, adiponectin, in the offspring. METHODS: Weight, height, Tanner stage and biomarkers were measured in thirty-four 12-year-old children, from the Infant Growth Study, who were divided into high risk (HR) and low risk (LR) groups based on maternal pre-pregnancy body mass index (BMI). RESULTS: The two groups differed markedly in their hs-CRP levels, but no group difference was found for the other three biomarkers. The odds ratio (OR) of HR children having detectable hs-CRP levels was 16 times greater than that of LR children after adjusting for confounding variables, including BMI z-score, Tanner stages and gender (OR: 16; 95% CI: 2-123). CONCLUSIONS: These results suggest that maternal obesity during pregnancy is associated with later development of elevated hs-CRP in the offspring, even after controlling for weight.


Assuntos
Adiponectina/sangue , Proteína C-Reativa/metabolismo , Citocinas/sangue , Inflamação/sangue , Obesidade/sangue , Complicações na Gravidez/sangue , Adulto , Biomarcadores/sangue , Estatura , Índice de Massa Corporal , Peso Corporal , Criança , Estudos Transversais , Feminino , Humanos , Inflamação/imunologia , Masculino , Obesidade/imunologia , Obesidade/patologia , Razão de Chances , Valor Preditivo dos Testes , Gravidez , Complicações na Gravidez/imunologia , Complicações na Gravidez/patologia , Sensibilidade e Especificidade
20.
J Sch Nurs ; 28(3): 220-9, 2012 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-22114299

RESUMO

The study's objectives were to gain school personnel's (1) perceptions on diet, physical activity, body size, and obesity, (2) description of school food and physical activity practices, and (3) recommendations for programs to prevent adolescent obesity. The study took place in six junior secondary schools of varying socioeconomic status in Gaborone, Botswana. Using a qualitative descriptive design, semistructured interviews were conducted with key school personnel. Directed content analysis was used to summarize the findings. School personnel believed that obesity was an important problem. They felt that school food was unhealthy and that physical activity was provided insufficiently. Participants shared enthusiasm for a school-based health-promoting intervention that must be fun and include active engagement and education on healthy lifestyles for all students. Participants supported on-site food shop inventory changes and physical activity programs. Potential barriers listed were schools' financial resources, interest of students, and time limitations of all involved.


Assuntos
Pessoal Administrativo/psicologia , Guias como Assunto , Conhecimentos, Atitudes e Prática em Saúde , Promoção da Saúde/métodos , Obesidade/prevenção & controle , Instituições Acadêmicas , Percepção Social , Adolescente , Adulto , Botsuana , Características Culturais , Feminino , Serviços de Alimentação/normas , Serviços de Alimentação/estatística & dados numéricos , Humanos , Entrevistas como Assunto , Masculino , Inquéritos Nutricionais , Pais/psicologia , Psicometria , Distribuição por Sexo , Classe Social , Estudantes/psicologia , Inquéritos e Questionários , Recursos Humanos
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