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1.
J Am Acad Child Adolesc Psychiatry ; 61(5): 599-600, 2022 05.
Artigo em Inglês | MEDLINE | ID: mdl-34416292

RESUMO

The first paper indicating that a central nervous system stimulant (amphetamine) could be beneficial for children with attention-deficit/hyperactivity disorder (ADHD)-like behavioral symptoms appeared in 1937.1 Over the subsequent 80 years, a range of additional stimulant (methylphenidate) and nonstimulant (atomoxetine, clonidine, guanfacine, and, most recently, viloxazine) drugs have been approved to treat children and adolescents with ADHD. These drug treatments have been the subject of a large number of randomized controlled trails (RCTs). A network meta-analysis found that using clinician ratings, amphetamine, methylphenidate, and atomoxetine were all significantly superior to a placebo.2 These findings suggest that in the short-term at least, these treatments are effective-data are sparse on the efficacy of longer-term drug treatment. However, there are longstanding worries about the use of such drug treatments with children. In particular there are concerns over possible adverse impact on growth. There are also less tangible, but important, concerns of parents as the whether it is appropriate to subject their children to the modification of behavior by drugs.3 For these reasons, there is an urgent need to develop nonpharmacological treatments for children and adolescents with ADHD. One such nonpharmacological treatment is dietary supplementation with micronutrients. In this issue of the Journal, Johnstone et al.4 present a study of micronutrients showing that, under the stringent conditions of an RCT, micronutrients substantially benefit the well-being of young people with ADHD and irritability (risk ratio [RR] = 2.97; 97.5% CI = 1.50-5.90).


Assuntos
Transtorno do Deficit de Atenção com Hiperatividade , Micronutrientes , Adolescente , Anfetaminas/uso terapêutico , Cloridrato de Atomoxetina/farmacologia , Cloridrato de Atomoxetina/uso terapêutico , Transtorno do Deficit de Atenção com Hiperatividade/tratamento farmacológico , Estimulantes do Sistema Nervoso Central/uso terapêutico , Criança , Humanos , Metilfenidato/farmacologia , Metilfenidato/uso terapêutico , Micronutrientes/uso terapêutico
2.
J Child Psychol Psychiatry ; 63(1): 4-6, 2022 01.
Artigo em Inglês | MEDLINE | ID: mdl-34931700

RESUMO

Professor Sir Michael Rutter died on 23 October 2021. He had made an unparalleled and profound contribution to the science underpinning our understanding of the origins and development of psychopathology in children and young people. The unique combination of reforming motivations, intellectual curiosity and commitment to hypothesis-driven science that made this possible are discussed in the editorial for this issue (Sonuga-Barke, Fearon & Scott, 2022). I have recently compiled a systematic and comprehensive Digest of his life's work - 546 journal papers and 52 books published [https://doi.org/10.13056/acamh.13072]. This Editorial Perspective will summarise some highlights of the main areas of his many scientific achievements.


Assuntos
Desenvolvimento Humano , Psicopatologia , Adolescente , Criança , História do Século XX , História do Século XXI , Humanos , Psicopatologia/história
3.
J Atten Disord ; 24(13): 1847-1856, 2020 11.
Artigo em Inglês | MEDLINE | ID: mdl-28800718

RESUMO

Objective: To test explanations for the underrecognition of female ADHD by examining differences in adult ratings of boys and girls matched for levels of directly observed ADHD behaviors. Method: In a secondary analysis of a population-based sample, 3- to 4-year-olds (n = 153, 79 male) and 8- to 9-year-olds (n = 144, 75 male) were grouped according to levels of directly observed ADHD behaviors (low/moderate/high). Groups were then compared with parent/teacher ADHD ratings. Results: There were no sex differences in levels of directly observed ADHD behaviors within groups. For preschoolers, parents' ratings of males, but not females, significantly increased across groups-mirroring levels of observed behaviors. For older children, both parent and teacher mean ratings were significantly higher for males than females across groups. Conclusion: Identified differences in adult ratings of males and females matched for directly observed behaviors may contribute to understanding the substantial ADHD underrecognition in females.


Assuntos
Transtorno do Deficit de Atenção com Hiperatividade , Caracteres Sexuais , Adolescente , Transtorno do Deficit de Atenção com Hiperatividade/diagnóstico , Transtorno do Deficit de Atenção com Hiperatividade/epidemiologia , Criança , Docentes , Feminino , Humanos , Masculino , Pais
4.
Res Dev Disabil ; 77: 49-59, 2018 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-29660589

RESUMO

BACKGROUND: Deaf and hard of hearing (D/HH) children and young people are known to show group-level deficits in spoken language and reading abilities relative to their hearing peers. However, there is little evidence on the longitudinal predictive relationships between language and reading in this population. AIMS: To determine the extent to which differences in spoken language ability in childhood predict reading ability in D/HH adolescents. METHODS: and procedures: Participants were drawn from a population-based cohort study and comprised 53 D/HH teenagers, who used spoken language, and a comparison group of 38 normally hearing teenagers. All had completed standardised measures of spoken language (expression and comprehension) and reading (accuracy and comprehension) at 6-10 and 13-19 years of age. OUTCOMES: and results: Forced entry stepwise regression showed that, after taking reading ability at age 8 years into account, language scores at age 8 years did not add significantly to the prediction of Reading Accuracy z-scores at age 17 years (change in R2 = 0.01, p = .459) but did make a significant contribution to the prediction of Reading Comprehension z-scores at age 17 years (change in R2  = 0.17, p < .001). CONCLUSIONS: and implications: In D/HH individuals who are spoken language users, expressive and receptive language skills in middle childhood predict reading comprehension ability in adolescence. Continued intervention to support language development beyond primary school has the potential to benefit reading comprehension and hence educational access for D/HH adolescents.


Assuntos
Compreensão , Surdez , Desenvolvimento da Linguagem , Leitura , Fala , Adolescente , Estudos de Casos e Controles , Criança , Estudos de Coortes , Feminino , Perda Auditiva , Humanos , Estudos Longitudinais , Masculino , Prognóstico , Adulto Jovem
5.
J Child Psychol Psychiatry ; 59(2): 180-190, 2018 02.
Artigo em Inglês | MEDLINE | ID: mdl-28872675

RESUMO

BACKGROUND: Permanent childhood hearing loss (PCHL) is associated with an elevated level of emotional and behaviour difficulties (EBD). In children and adolescents with PCHL, EBD has been found to be linked to language ability in children with PCHL. The present study was designed to test whether childhood language and/or reading comprehension abilities of children with PCHL predict subsequent EBD in adolescence. METHODS: Language comprehension (LC) and reading comprehension (RC) were measured at ages 6-10 years (Time 1) and 13-20 years (Time 2) in participants with PCHL who preferred to communicate using spoken language (n = 57) and a hearing comparison group (n = 38). EBD was measured at both time points by parent and by teacher ratings on the Strengths and Difficulties Questionnaire. RESULTS: Within the PCHL group there were negative correlations between EBD scores and concurrent LC and RC scores at Time 1 and at Time 2. Cross-lagged latent variable models fitted to the longitudinal data indicated that the associations between LC, RC and teacher-rated EBD were more likely to arise from the impact of LC and RC on behaviour rather than the other way around. CONCLUSIONS: In those with PCHL, poor language and reading comprehension in middle childhood increased the risk of emotional and behaviour difficulties at school in the teenage years. The results suggest that effective language and literacy interventions for children with hearing loss may also bring benefits to their mental health.


Assuntos
Desenvolvimento do Adolescente/fisiologia , Sintomas Comportamentais/fisiopatologia , Desenvolvimento Infantil/fisiologia , Compreensão/fisiologia , Perda Auditiva/fisiopatologia , Idioma , Leitura , Adolescente , Adulto , Sintomas Afetivos/fisiopatologia , Criança , Feminino , Humanos , Estudos Longitudinais , Masculino , Adulto Jovem
7.
Int J Pediatr Otorhinolaryngol ; 101: 186-195, 2017 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-28964293

RESUMO

OBJECTIVES: It is known that during the middle childhood years those with permanent childhood hearing loss (PCHL) are at increased risk of showing emotional and behaviour difficulties (EBD). It has yet to be established whether this risk continues into the late teenage years. There is a paucity of longitudinal studies on the association between PCHL and EBD. METHODS: The Strengths and Difficulties Questionnaire (SDQ) was used to measure EBD based on parent, teacher and self-ratings in 76 teenagers with PCHL and 38 in a hearing comparison group (HCG) from a population sample of children that was followed up from birth to adolescence. RESULTS: On parent-rated SDQ, the PCHL group had significantly higher Total Difficulties score than the HCG (Standardised mean difference (SMD) = +0.39, 95%CI 0.00 to 0.79). Amongst the PCHL group the presence of disabilities other than hearing loss had a substantial impact on the level of parent-rated EBD (SMD = +1.68, 1.04 to 2.33). There was a relationship between receptive language ability and EBD in both the HCG (r = -0.33, 95%CI -0.59 to -0.01) and the PCHI group (r = -0.33, 95%CI -0.53 to -0.02). The effect of PCHL on EBD became non-significant when receptive language was included as a covariate (F = 0.12, df = 1,95, p = 0.729). Early confirmation of hearing loss (i.e. before 9 months of age) did not have a significant effect on EBD scores (SMD = +0.31, 95%CI -0.15 to 0.77). CONCLUSIONS: PCHL continues to be associated with elevated EBD scores as measured by parent rated SDQ into the late teenage years but the degree of this elevation is less than in childhood and is not apparent on teacher or self-ratings. Poor receptive language ability appeared to account for these elevated EBD scores in the group with PCHL. Particular attention needs to be paid to the mental health of children and adolescents with PCHL that is accompanied by other disabilities and to those with poor receptive language ability. However, the majority of teenagers with PCHL do not show clinically significant elevated levels of EBD.


Assuntos
Perda Auditiva/psicologia , Transtornos Mentais/epidemiologia , Adolescente , Criança , Pré-Escolar , Emoções , Feminino , Seguimentos , Audição , Perda Auditiva/epidemiologia , Testes Auditivos , Humanos , Idioma , Estudos Longitudinais , Masculino , Transtornos Mentais/etiologia , Saúde Mental , Pais , Inquéritos e Questionários
8.
Ear Hear ; 38(5): 598-610, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-28399063

RESUMO

OBJECTIVES: This study aimed to examine whether (a) exposure to universal newborn hearing screening (UNHS) and b) early confirmation of hearing loss were associated with benefits to expressive and receptive language outcomes in the teenage years for a cohort of spoken language users. It also aimed to determine whether either of these two variables was associated with benefits to relative language gain from middle childhood to adolescence within this cohort. DESIGN: The participants were drawn from a prospective cohort study of a population sample of children with bilateral permanent childhood hearing loss, who varied in their exposure to UNHS and who had previously had their language skills assessed at 6-10 years. Sixty deaf or hard of hearing teenagers who were spoken language users and a comparison group of 38 teenagers with normal hearing completed standardized measures of their receptive and expressive language ability at 13-19 years. RESULTS: Teenagers exposed to UNHS did not show significantly better expressive (adjusted mean difference, 0.40; 95% confidence interval [CI], -0.26 to 1.05; d = 0.32) or receptive (adjusted mean difference, 0.68; 95% CI, -0.56 to 1.93; d = 0.28) language skills than those who were not. Those who had their hearing loss confirmed by 9 months of age did not show significantly better expressive (adjusted mean difference, 0.43; 95% CI, -0.20 to 1.05; d = 0.35) or receptive (adjusted mean difference, 0.95; 95% CI, -0.22 to 2.11; d = 0.42) language skills than those who had it confirmed later. In all cases, effect sizes were of small size and in favor of those exposed to UNHS or confirmed by 9 months. Subgroup analysis indicated larger beneficial effects of early confirmation for those deaf or hard of hearing teenagers without cochlear implants (N = 48; 80% of the sample), and these benefits were significant in the case of receptive language outcomes (adjusted mean difference, 1.55; 95% CI, 0.38 to 2.71; d = 0.78). Exposure to UNHS did not account for significant unique variance in any of the three language scores at 13-19 years beyond that accounted for by existing language scores at 6-10 years. Early confirmation accounted for significant unique variance in the expressive language information score at 13-19 years after adjusting for the corresponding score at 6-10 years (R change = 0.08, p = 0.03). CONCLUSIONS: This study found that while adolescent language scores were higher for deaf or hard of hearing teenagers exposed to UNHS and those who had their hearing loss confirmed by 9 months, these group differences were not significant within the whole sample. There was some evidence of a beneficial effect of early confirmation of hearing loss on relative expressive language gain from childhood to adolescence. Further examination of the effect of these variables on adolescent language outcomes in other cohorts would be valuable.


Assuntos
Surdez/diagnóstico , Perda Auditiva/diagnóstico , Testes Auditivos , Desenvolvimento da Linguagem , Triagem Neonatal , Adolescente , Feminino , Humanos , Recém-Nascido , Idioma , Masculino , Pessoas com Deficiência Auditiva , Estudos Prospectivos
9.
J Am Acad Child Adolesc Psychiatry ; 55(6): 444-55, 2016 06.
Artigo em Inglês | MEDLINE | ID: mdl-27238063

RESUMO

OBJECTIVE: We performed meta-analyses of randomized controlled trials to examine the effects of neurofeedback on attention-deficit/hyperactivity disorder (ADHD) symptoms and neuropsychological deficits in children and adolescents with ADHD. METHOD: We searched PubMed, Ovid, Web of Science, ERIC, and CINAHAL through August 30, 2015. Random-effects models were employed. Studies were evaluated with the Cochrane Risk of Bias tool. RESULTS: We included 13 trials (520 participants with ADHD). Significant effects were found on ADHD symptoms rated by assessors most proximal to the treatment setting, that is, the least blinded outcome measure (standardized mean difference [SMD]: ADHD total symptoms = 0.35, 95% CI = 0.11-0.59; inattention = 0.36, 95% CI = 0.09-0.63; hyperactivity/impulsivity = 0.26, 95% CI = 0.08-0.43). Effects were not significant when probably blinded ratings were the outcome or in trials with active/sham controls. Results were similar when only frequency band training trials, the most common neurofeedback approach, were analyzed separately. Effects on laboratory measures of inhibition (SMD = 0.30, 95% CI = -0.10 to 0.70) and attention (SMD = 0.13, 95% CI = -0.09 to 0.36) were not significant. Only 4 studies directly assessed whether learning occurred after neurofeedback training. The risk of bias was unclear for many Cochrane Risk of Bias domains in most studies. CONCLUSION: Evidence from well-controlled trials with probably blinded outcomes currently fails to support neurofeedback as an effective treatment for ADHD. Future efforts should focus on implementing standard neurofeedback protocols, ensuring learning, and optimizing clinically relevant transfer.


Assuntos
Transtorno do Deficit de Atenção com Hiperatividade/terapia , Neurorretroalimentação/métodos , Avaliação de Resultados em Cuidados de Saúde/estatística & dados numéricos , Ensaios Clínicos Controlados Aleatórios como Assunto/estatística & dados numéricos , Humanos
10.
Arch Dis Child ; 101(1): 9-15, 2016 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-25425604

RESUMO

OBJECTIVE: To determine whether the benefits of universal newborn hearing screening (UNHS) seen at age 8 years persist through the second decade. DESIGN: Prospective cohort study of a population sample of children with permanent childhood hearing impairment (PCHI) followed up for 17 years since birth in periods with (or without) UNHS. SETTING: Birth cohort of 100 000 in southern England. PARTICIPANTS: 114 teenagers aged 13-19 years, 76 with PCHI and 38 with normal hearing. All had previously their reading assessed aged 6-10 years. INTERVENTIONS: Birth in periods with and without UNHS; confirmation of PCHI before and after age 9 months. MAIN OUTCOME MEASURE: Reading comprehension ability. Regression modelling took account of severity of hearing loss, non-verbal ability, maternal education and main language. RESULTS: Confirmation of PCHI by age 9 months was associated with significantly higher mean z-scores for reading comprehension (adjusted mean difference 1.17, 95% CI 0.36 to 1.97) although birth during periods with UNHS was not (adjusted mean difference 0.15, 95% CI -0.75 to 1.06). The gap between the reading comprehension z-scores of teenagers with early compared with late confirmed PCHI had widened at an adjusted mean rate of 0.06 per year (95% CI -0.02 to 0.13) during the 9.2-year mean interval since the previous assessment. CONCLUSIONS: The benefit to reading comprehension of confirmation of PCHI by age 9 months increases during the teenage years. This strengthens the case for UNHS programmes that lead to early confirmation of permanent hearing loss. TRIAL REGISTRATION NUMBER: ISRCTN03307358.


Assuntos
Perda Auditiva/diagnóstico , Alfabetização , Triagem Neonatal/métodos , Adolescente , Estudos de Coortes , Inglaterra/epidemiologia , Feminino , Seguimentos , Perda Auditiva/congênito , Perda Auditiva/epidemiologia , Perda Auditiva/psicologia , Testes Auditivos/métodos , Humanos , Recém-Nascido , Masculino , Avaliação de Resultados em Cuidados de Saúde , Estudos Prospectivos , Leitura , Adulto Jovem
11.
Eur Child Adolesc Psychiatry ; 24(5): 477-96, 2015 May.
Artigo em Inglês | MEDLINE | ID: mdl-25758233

RESUMO

The aim of this study is to estimate the extent to which children and adolescents with hearing impairment (HI) show higher rates of emotional and behavioural difficulties compared to normally hearing children. Studies of emotional and behavioural difficulties in children and adolescents were traced from computerized systematic searches supplemented, where appropriate, by studies referenced in previous narrative reviews. Effect sizes (Hedges' g) were calculated for all studies. Meta-analyses were conducted on the weighted effect sizes obtained for studies adopting the Strength and Difficulties Questionnaire (SDQ) and on the unweighted effect sizes for non-SDQ studies. 33 non-SDQ studies were identified in which emotional and behavioural difficulties in children with HI could be compared to normally hearing children. The unweighted average g for these studies was 0.36. The meta-analysis of the 12 SDQ studies gave estimated effect sizes of 0.23 (95% CI 0.07, 0.40), 0.34 (95% CI 0.19, 0.49) and -0.01 (95% CI -0.32, 0.13) for Parent, Teacher and Self-ratings of Total Difficulties, respectively. The SDQ sub-scale showing consistent differences across raters between groups with HI and those with normal hearing was Peer Problems. Children and adolescents with HI have scores on emotional and behavioural difficulties measures about a quarter to a third of a standard deviation higher than hearing children. Children and adolescents with HI are in need of support to help their social relationships particularly with their peers.


Assuntos
Emoções , Perda Auditiva/psicologia , Agitação Psicomotora/etiologia , Transtornos do Comportamento Social/etiologia , Comportamento Social , Adolescente , Criança , Pré-Escolar , Docentes , Feminino , Humanos , Masculino , Computação Matemática , Pais , Grupo Associado , Relatório de Pesquisa/normas , Fatores de Risco , Autorrelato , Inquéritos e Questionários
12.
J Am Acad Child Adolesc Psychiatry ; 54(3): 164-74, 2015 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-25721181

RESUMO

OBJECTIVE: The authors performed meta-analyses of randomized controlled trials to examine the effects of cognitive training on attention-deficit/hyperactivity disorder (ADHD) symptoms, neuropsychological deficits, and academic skills in children/adolescents with ADHD. METHOD: The authors searched Pubmed, Ovid, Web of Science, ERIC, and CINAHAL databases through May 18, 2014. Data were aggregated using random-effects models. Studies were evaluated with the Cochrane risk of bias tool. RESULTS: Sixteen of 695 nonduplicate records were analyzed (759 children with ADHD). When all types of training were considered together, there were significant effects on total ADHD (standardized mean difference [SMD] = 0.37, 95% CI = 0.09-0.66) and inattentive symptoms (SMD = 0.47, 95% CI = 0.14-0.80) for reports by raters most proximal to the treatment setting (i.e., typically unblinded). These figures decreased substantially when the outcomes were provided by probably blinded raters (ADHD total: SMD = 0.20, 95% CI = 0.01-0.40; inattention: SMD = 0.32, 95% CI = -0.01 to 0.66). Effects on hyperactivity/impulsivity symptoms were not significant. There were significant effects on laboratory tests of working memory (verbal: SMD = 0.52, 95% CI = 0.24-0.80; visual: SMD = 0.47, 95% CI = 0.23-0.70) and parent ratings of executive function (SMD = 0.35, 95% CI = 0.08-0.61). Effects on academic performance were not statistically significant. There were no effects of working memory training, specifically on ADHD symptoms. Interventions targeting multiple neuropsychological deficits had large effects on ADHD symptoms rated by most proximal assessors (SMD = 0.79, 95% CI = 0.46-1.12). CONCLUSION: Despite improving working memory performance, cognitive training had limited effects on ADHD symptoms according to assessments based on blinded measures. Approaches targeting multiple neuropsychological processes may optimize the transfer of effects from cognitive deficits to clinical symptoms.


Assuntos
Transtorno do Deficit de Atenção com Hiperatividade/terapia , Terapia Cognitivo-Comportamental/métodos , Função Executiva , Memória de Curto Prazo , Adolescente , Criança , Cognição , Prática Clínica Baseada em Evidências , Humanos , Viés de Publicação , Ensaios Clínicos Controlados Aleatórios como Assunto , Resultado do Tratamento
13.
J Child Psychol Psychiatry ; 55(5): 416-27, 2014 May.
Artigo em Inglês | MEDLINE | ID: mdl-24552603

RESUMO

BACKGROUND: The efficacy of three dietary treatments for ADHD has been repeatedly tested in randomized controlled trials (RCTs). These interventions are restricted elimination diets (RED), artificial food colour elimination (AFCE) and supplementation with free fatty acids (SFFA). There have been three systematic reviews and associated meta-analyses of the RCTs for each of these treatments. SCOPE: The aim of this review is to critically appraise the studies on the dietary treatments of ADHD, to compare the various meta-analyses of their efficacy that have been published and to identify where the design of such RCTs could be improved and where further investigations are needed. FINDINGS: The meta-analyses differ in the inclusion and exclusion criteria applied to potentially eligible studies. The range of average effect sizes in standard deviation units is RED (0.29-1.2), AFCE (0.18-0.42) and SFFA (0.17-0.31). The methodology of many of the trials on which the meta-analyses are based is weak. CONCLUSIONS: Nevertheless, there is evidence from well-conducted studies for a small effect of SFFA. Restricted elimination diets may be beneficial, but large-scale studies are needed on unselected children, using blind assessment and including assessment of long-term outcome. Artificial food colour elimination is a potentially valuable treatment but its effect size remains uncertain, as does the type of child for whom it is likely to be efficacious. There are additional dietary supplements that have been used with children with ADHD. A systematic search identified 11 RCTs that investigated the effects of these food supplements. Despite positive results for some individual trials, more studies are required before conclusions can be reached on the value in reducing ADHD symptoms of any of these additional supplements.


Assuntos
Transtorno do Deficit de Atenção com Hiperatividade/dietoterapia , Criança , Suplementos Nutricionais , Ácidos Graxos não Esterificados/administração & dosagem , Humanos , Projetos de Pesquisa , Resultado do Tratamento
14.
Br J Psychol ; 105(1): 92-101, 2014 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-24387098

RESUMO

Cognitive interference theories (e.g. attentional control theory, processing efficiency theory) suggest that high levels of trait anxiety predict adverse effects on the performance of cognitive tasks, particularly those that make high demands on cognitive resources. We tested an interaction hypothesis to determine whether a combination of high anxiety and low working memory capacity (WMC) would predict variance in demanding cognitive test scores. Ninety six adolescents (12- to 14-years-old) participated in the study, which measured self-report levels of trait anxiety, working memory, and cognitive test performance. As hypothesized, we found that the anxiety-WMC interaction explained a significant amount of variance in cognitive test performance (ΔR(2) .07, p < .01). Trait anxiety was unrelated to cognitive test performance for those adolescents with average WMC scores (ß = .13, p > .10). In contrast, trait anxiety was negatively related to test performance in adolescents with low WMC (ß = -.35, p < .05) and positively related to test performance in those with high WMC (ß = .49, p < .01). The results of this study suggest that WMC moderates the relationship between anxiety and cognitive test performance and may be a determinant factor in explaining some discrepancies found in the literature. Further research is needed to fully understand the mechanisms involved.


Assuntos
Ansiedade/fisiopatologia , Memória de Curto Prazo/fisiologia , Desempenho Psicomotor/fisiologia , Adolescente , Adulto , Ansiedade/psicologia , Criança , Cognição/fisiologia , Análise Fatorial , Feminino , Humanos , Masculino , Testes Neuropsicológicos/estatística & dados numéricos , Teoria Psicológica , Análise de Regressão , Autorrelato
16.
Am J Psychiatry ; 170(3): 275-89, 2013 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-23360949

RESUMO

OBJECTIVE: Nonpharmacological treatments are available for attention deficit hyperactivity disorder (ADHD), although their efficacy remains uncertain. The authors undertook meta-analyses of the efficacy of dietary (restricted elimination diets, artificial food color exclusions, and free fatty acid supplementation) and psychological (cognitive training, neurofeedback, and behavioral interventions) ADHD treatments. METHOD: Using a common systematic search and a rigorous coding and data extraction strategy across domains, the authors searched electronic databases to identify published randomized controlled trials that involved individuals who were diagnosed with ADHD (or who met a validated cutoff on a recognized rating scale) and that included an ADHD outcome. RESULTS: Fifty-four of the 2,904 nonduplicate screened records were included in the analyses. Two different analyses were performed. When the outcome measure was based on ADHD assessments by raters closest to the therapeutic setting, all dietary (standardized mean differences=0.21-0.48) and psychological (standardized mean differences=0.40-0.64) treatments produced statistically significant effects. However, when the best probably blinded assessment was employed, effects remained significant for free fatty acid supplementation (standardized mean difference=0.16) and artificial food color exclusion (standardized mean difference=0.42) but were substantially attenuated to nonsignificant levels for other treatments. CONCLUSIONS: Free fatty acid supplementation produced small but significant reductions in ADHD symptoms even with probably blinded assessments, although the clinical significance of these effects remains to be determined. Artificial food color exclusion produced larger effects but often in individuals selected for food sensitivities. Better evidence for efficacy from blinded assessments is required for behavioral interventions, neurofeedback, cognitive training, and restricted elimination diets before they can be supported as treatments for core ADHD symptoms.


Assuntos
Transtorno do Deficit de Atenção com Hiperatividade/terapia , Estimulantes do Sistema Nervoso Central/uso terapêutico , Dietoterapia , Psicoterapia , Adolescente , Transtorno do Deficit de Atenção com Hiperatividade/diagnóstico , Transtorno do Deficit de Atenção com Hiperatividade/psicologia , Terapia Comportamental , Criança , Pré-Escolar , Transtornos Cognitivos/diagnóstico , Transtornos Cognitivos/psicologia , Transtornos Cognitivos/terapia , Terapia Cognitivo-Comportamental , Terapia Combinada , Ácidos Graxos não Esterificados/administração & dosagem , Corantes de Alimentos/administração & dosagem , Corantes de Alimentos/efeitos adversos , Hipersensibilidade Alimentar/complicações , Hipersensibilidade Alimentar/terapia , Humanos , Neurorretroalimentação , Ensaios Clínicos Controlados Aleatórios como Assunto
18.
Dev Med Child Neurol ; 53(3): 269-74, 2011 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-21121905

RESUMO

AIM: To determine if the benefit of early confirmation of permanent childhood hearing impairment (PCHI) on children's receptive language development is associated with fewer behavioural problems. METHOD: Follow-up of a total population cohort of 120 children with PCHI of moderate or greater severity (≥ 40 decibels relative to hearing threshold level) (67 males, 53 females; mean age 7 y 11 mo, range 5 y 5 mo-11 y 8 mo) and 63 hearing children (37 males, 26 females; mean age 8 y 1 mo, range 6 y 4 mo-9 y 10 mo). The main outcome measures were the Strengths and Difficulties Questionnaire (SDQ) completed by teachers and parents and the Vineland Adaptive Behaviour Scales (VABS) which are completed on the basis of a parental interview. RESULTS: Children with PCHI had lower standard scores than hearing children on the Daily Living Skills (p=0.001) and the Socialisation (p=0.001) scales of the VABS. They had significantly higher Total Behaviour Problem scores on the parent-rated (p=0.002) and teacher-rated SDQ (p=0.03). Children for whom PCHI was confirmed by 9 months did not have significantly fewer problems on the behavioural measures than those confirmed after that age (p=0.635 and p=0.196). INTERPRETATION: Early confirmation has a beneficial effect on receptive language development but no significant impact in reducing behavioural problems in children with PCHI.


Assuntos
Comportamento Infantil , Perda Auditiva Bilateral/diagnóstico , Perda Auditiva Bilateral/psicologia , Transtornos do Desenvolvimento da Linguagem/etiologia , Desenvolvimento da Linguagem , Fatores Etários , Criança , Pré-Escolar , Diagnóstico Precoce , Feminino , Perda Auditiva Bilateral/fisiopatologia , Humanos , Masculino , Índice de Gravidade de Doença , Inquéritos e Questionários
19.
Am J Psychiatry ; 167(9): 1108-15, 2010 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-20551163

RESUMO

OBJECTIVE: Food additives can exacerbate ADHD symptoms and cause non-immunoglobulin E-dependent histamine release from circulating basophils. However, children vary in the extent to which their ADHD symptoms are exacerbated by the ingestion of food additives. The authors hypothesized that genetic polymorphisms affecting histamine degradation would explain the diversity of responses to additives. METHOD: In a double-blind, placebo-controlled crossover trial, challenges involving two food color additive and sodium benzoate (preservative) mixtures in a fruit drink were administered to a general community sample of 3-year-old children (N = 153) and 8/9-year-old children (N = 144). An aggregate ADHD symptom measure (based on teacher and parent blind ratings of behavior, blind direct observation of behavior in the classroom, and--for 8/9-year-old children only--a computerized measure of attention) was the main outcome variable. RESULTS: The adverse effect of food additives on ADHD symptoms was moderated by histamine degradation gene polymorphisms HNMT T939C and HNMT Thr105Ile in 3- and 8/9-year-old children and by a DAT1 polymorphism (short versus long) in 8/9-year-old children only. There was no evidence that polymorphisms in catecholamine genes COMT Val108Met, ADRA2A C1291G, and DRD4-rs7403703 moderated the effect on ADHD symptoms. CONCLUSIONS: Histamine may mediate the effects of food additives on ADHD symptoms, and variations in genes influencing the action of histamine may explain the inconsistency between previous studies. Genes influencing a range of neurotransmitter systems and their interplay with environmental factors, such as diet, need to be examined to understand genetic influences on ADHD symptoms.


Assuntos
Transtorno do Deficit de Atenção com Hiperatividade/induzido quimicamente , Transtorno do Deficit de Atenção com Hiperatividade/genética , Aditivos Alimentares/efeitos adversos , Histamina/genética , Polimorfismo de Nucleotídeo Único/genética , Adolescente , Transtorno do Deficit de Atenção com Hiperatividade/diagnóstico , Criança , Dieta/efeitos adversos , Dopamina/metabolismo , Proteínas da Membrana Plasmática de Transporte de Dopamina/genética , Feminino , Aditivos Alimentares/farmacologia , Corantes de Alimentos/efeitos adversos , Corantes de Alimentos/farmacologia , Histamina/metabolismo , Histamina N-Metiltransferase/genética , Liberação de Histamina/efeitos dos fármacos , Liberação de Histamina/genética , Humanos , Desequilíbrio de Ligação , Masculino , Receptores de Dopamina D4/efeitos dos fármacos , Receptores de Dopamina D4/genética
20.
Behav Sleep Med ; 8(1): 16-27, 2010.
Artigo em Inglês | MEDLINE | ID: mdl-20043246

RESUMO

There are limited published data comparing the information provided by parental reports of sleep habits with actigraphic information. This study compares parental report of sleep habits using the Children's Sleep Habits Questionnaire with actigraphic data in 91 typically developing children aged 6 to 11 years. The study found that sleep duration (as measured using actigraphy [ACT]) was longer in children whose parents rated their child as having enough sleep. Parental reports of night wakings did not correspond with ACT measures of night wakings. The findings show that ACT and parental reports provide differing, but complimentary, information about a child's sleep habits.


Assuntos
Actigrafia , Pais , Sono , Criança , Feminino , Humanos , Masculino , Reprodutibilidade dos Testes , Fatores Sexuais , Inquéritos e Questionários , Fatores de Tempo , Vigília
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