Addressing clozapine under-prescribing and barriers to initiation: a psychiatrist, advanced practice provider, and trainee survey.

Clozapine use has declined, despite its superior antipsychotic efficacy in treatment-resistant schizophrenia. Implications for clozapine underutilization include suboptimal treatment outcomes and increased hospitalizations. Many barriers preventing the use of clozapine have been described in the literature, including suboptimal knowledge and poor perceptions. The aim of this study was to assess psychiatry prescribers' perception and knowledge of clozapine. A survey was distributed to advanced practice providers, psychiatrists, and trainees (i.e. residents and fellows) at 10 medical centers within the US and Canada. The survey asked respondents about their perception of clozapine use and assessed their pharmacotherapeutic knowledge of clozapine. Two hundred eleven individual submitted completed surveys of a possible 1152; a response rate of 18.3%. There were no statistically significant differences between the advanced practice provider plus psychiatrist groups and the trainee group for most perception (eight of nine) and knowledge (eight of nine) questions. The knowledge questions with the lowest scores pertained to clozapine reinitiation and myocarditis. The majority of all respondents (144, 68.2%) felt that clozapine prescribing was a burden. Findings of this study support the need for continued clozapine education regardless of a prescriber's age/experience. Future studies to assess barriers to clozapine prescribing should extend beyond academic centers.

Psychosocial Difficulties in Adolescent Idiopathic Scoliosis: Body Image, Eating Behaviors, and Mood Disorders.

OBJECTIVE: To examine the recent literature on psychologic comorbidities prevalent in youth living with adolescent idiopathic scoliosis (AIS)-including body image, eating behaviors, and mood disorders-to improve patient outcomes. METHODS: A comprehensive literature review was performed using the PubMed database. Eligible studies were extracted based on defined inclusion criteria, and the effects of AIS on psychologic comorbidities were evaluated. Studies were categorized and analyzed based on 3 recurrent themes: body image, eating behaviors, and mood. RESULTS: Body image presents the most important link between psychosocial difficulties and AIS. Self-reported body image is a significant factor for successful treatment outcomes in AIS. As such, specific patient-reported outcome measures have recently been developed and validated to aid in the treatment of AIS. Although patients with AIS consistently demonstrate altered anthropometry compared with their healthy counterparts, links between these factors and pathologic behaviors, such as abnormal fear of gaining weight or disordered eating, are not clear. Equally unclear is the association between AIS and altered moods, notably depression and anxiety, because of the wide variety of disparate instruments used to measure mood disorders in patients with AIS. CONCLUSIONS: Patients with AIS undergoing treatment often face psychosocial difficulties. Together, the current literature points to a growing understanding and appreciation of the psychosocial aspects of AIS, but a clear need for more study is needed to optimize treatment of these patients.

Clinical Case Vignettes: A Promising Tool to Assess Competence in the Management of Agitation.

OBJECTIVE: While standardized patients (SPs) remain the gold standard for assessing clinical competence in a standardized setting, clinical case vignettes that allow free-text, open-ended written responses are more resource- and time-efficient assessment tools. It remains unknown, however, whether this is a valid method for assessing competence in the management of agitation. METHODS: Twenty-six psychiatry residents partook in a randomized controlled study evaluating a simulation-based teaching intervention on the management of agitated patients. Competence in the management of agitation was assessed using three separate modalities: simulation with SPs, open-ended clinical vignettes, and self-report questionnaires. RESULTS: Performance on clinical vignettes correlated significantly with SP-based assessments (r = 0.59, p = 0.002); self-report questionnaires that assessed one's own ability to manage agitation did not correlate with SP-based assessments (r = -0.06, p = 0.77). CONCLUSIONS: Standardized clinical vignettes may be a simple, time-efficient, and valid tool for assessing residents' competence in the management of agitation.

Psychiatric aspects of comorbid HIV/AIDS and pain, Part 2.

The high prevalence, underassessment, and undertreatment of pain throughout the course of HIV disease make understanding the barriers and inequalities in HIV/AIDS-related pain care essential. There is a tremendous need for integrated implementation of pharmacological and psychosocial interventions. Part 2 of this review aims to discuss mood, anxiety, and substance abuse assessments; barriers to care; and psychiatric treatments in the context of HIV-AIDS-related pain. Recommendations are made from the gathered data that highlight the need for an interdisciplinary comprehensive approach to managing pain in HIV disease. Further research is needed to examine the relationship of pain and psychiatric issues in order to formulate effective treatment strategies.

Psychiatric aspects of comorbid HIV/AIDS and pain, Part 1.

HIV/AIDS-related pain remains a clinically challenging condition despite recent advances in treatment modalities. The existing data on pain in HIV-positive persons demonstrate a high prevalence, wide variability in clinical presentation, significant negative impact on health-related quality of life, and alarmingly inadequate assessment and management. Patients with HIV/AIDS have clearly identified physician attention to pain control as extremely important. This article discusses the psychiatric components and considerable impact of pain in the HIV population. Special attention is given to psychological assessment issues, psychosocial barriers to treatment, and psychotherapeutic approaches. An integrated, flexible, and interdisciplinary team approach model for treating HIV/AIDS-related pain is presented with specific recommendations.

Self-triggered functional electrical stimulation during swallowing.

Hyolaryngeal elevation is essential for airway protection during swallowing and is mainly a reflexive response to oropharyngeal sensory stimulation. Targeted intramuscular electrical stimulation can elevate the resting larynx and, if applied during swallowing, may improve airway protection in dysphagic patients with inadequate hyolaryngeal motion. To be beneficial, patients must synchronize functional electrical stimulation (FES) with their reflexive swallowing and not adapt to FES by reducing the amplitude or duration of their own muscle activity. We evaluated the ability of nine healthy adults to manually synchronize FES with hyolaryngeal muscle activity during discrete swallows, and tested for motor adaptation. Hooked-wire electrodes were placed into the mylo- and thyrohyoid muscles to record electromyographic activity from one side of the neck and deliver monopolar FES for hyolaryngeal elevation to the other side. After performing baseline swallows, volunteers were instructed to trigger FES with a thumb switch in synchrony with their swallows for a series of trials. An experimenter surreptitiously disabled the thumb switch during the final attempt, creating a foil. From the outset, volunteers synchronized FES with the onset of swallow-related thyrohyoid activity (approximately 225 ms after mylohyoid activity onset), preserving the normal sequence of muscle activation. A comparison between average baseline and foil swallows failed to show significant adaptive changes in the amplitude, duration, or relative timing of activity for either muscle, indicating that the central pattern generator for hyolaryngeal elevation is immutable with short term stimulation that augments laryngeal elevation during the reflexive, pharyngeal phase of swallowing.