Therapeutic Effects of Ribunucleinate (Ribonucleotides) in Immuno-Inflammatory and Arthritic Diseases.

Ribonucleic acids from different organs and from yeast have been used for the treatment of chronic and degenerative diseases in the context of naturopathic medicine in the last 60 years. This chapter provides general information about ribonucleinates as therapeutic agents. Past and present pharmacological and clinical investigations are discussed in the field of the central nervous system, sensory organs, cancer and degenerative diseases of joints and vertebra.

The light-stimulated cytosolic calcium transient in Limulus ventral nerve photoreceptors: two components in the rising phase.

1. Light-evoked electrical responses were measured in Limulus ventral nerve photoreceptors simultaneously with changes in the cytosolic free calcium concentration, by means of arsenazo III. 2. It has been shown here for the first time that the rise of the arsenazo signal consists of two phases. Only the slow phase in the rise of the signal depends on the membrane voltage. The reversal potential of the amplitude of this slow rising phase was about +196 mV. After removal of external calcium the reversal potential was about +20 mV. 3. When Na+ in the superfusate was replaced by Li+, the amplitude of the fast rising phase was reduced on the average to 50%, while the slow rising phase was not affected. 4. We conclude that the fast rising phase is caused by release of calcium from internal stores while the slow increase in [Ca2+]i is due to influx across the plasma membrane, possibly through light-activated ion channels.