RESUMO
STUDY OBJECTIVES: To compare the demographic, behavioural, and biological correlates of use of hormone replacement therapy (HRT) in women with an intact uterus and women who have undergone hysterectomy. DESIGN: Cross sectional analysis of data from the Busselton Health Study and the 1994 Healthway-National Heart Foundation Risk Factor Survey. SETTING: Busselton and Perth, Western Australia, 1994. PARTICIPANTS: 2540 women aged 35-79 years. MAIN OUTCOME MEASURES: Demographic, behavioural, and biological correlates of use of HRT by hysterectomy status. RESULTS: In women with an intact uterus, after adjustment for age and place of residence, current use of HRT was significantly associated with having a professional level of occupation, ever use of alcohol, having a history of smoking, and a lower body mass index. Current users of HRT had significantly lower levels of total cholesterol and higher levels of triglycerides than non-users. In women who had undergone hysterectomy, the only non-biological characteristic associated with use of HRT was having a history of smoking. Current users of HRT had lower levels of systolic blood pressure, lower levels of LDL cholesterol, higher levels of HDL cholesterol, and higher levels of triglycerides. The association between use of HRT and participation in exercise, level of systolic blood pressure, level of HDL cholesterol, and total/HDL cholesterol ratio varied significantly by hysterectomy status. After adjustment for age and place of residence, the mean levels of systolic and diastolic blood pressure, body mass index, waist/hip ratio, LDL cholesterol, and total/HDL cholesterol ratio were highest in women who had undergone hysterectomy and were not using HRT. CONCLUSIONS: Demographic/behavioural and biological correlates of use of HRT varied depending on hysterectomy status. Demographic and behavioural characteristics were more important as selection factors for use of HRT in women with an intact uterus than in women who had undergone hysterectomy. Women who had undergone hysterectomy and were not using HRT had a significantly worse profile for CHD than did women with an intact uterus. These results indicate that any bias in estimates of the protective effect of HRT on risk of CHD in observational studies is likely to depend on the prevalence of hysterectomy within the study population. Hysterectomy status needs to be taken into account in any studies that investigate the effect of HRT on risk of CHD.
Assuntos
Terapia de Reposição de Estrogênios/estatística & dados numéricos , Nível de Saúde , Histerectomia/efeitos adversos , Adulto , Distribuição por Idade , Idoso , Colesterol/sangue , Fatores de Confusão Epidemiológicos , Doença das Coronárias/etiologia , Estudos Transversais , Feminino , Inquéritos Epidemiológicos , Humanos , Pessoa de Meia-Idade , Razão de Chances , Fatores de Risco , Triglicerídeos/sangue , Austrália OcidentalRESUMO
PURPOSE: To explore the prevalence of dysmenorrhea among senior high school girls in Perth, Western Australia, its impact on school, sporting, and social activities, students' management strategies, and their knowledge of available treatment. METHODS: A total of 388 female students in Grades 11 and 12 at three metropolitan secondary schools completed an anonymous questionnaire administered during class time. The following definition of dysmenorrhoea was used: any type of pain or discomfort associated with menstrual periods including cramps, nausea, and headaches. RESULTS: The reported prevalence of dysmenorrhea among these girls was 80%; 53% of those girls with dysmenorrhea reported that it limited their activities. In particular, 37% said that dysmenorrhea affected their school activities. The most common medication used by those reporting dysmenorrhea was simple analgesics (53%), followed by nonsteroidal anti-inflammatory drugs (NSAIDs), used by 42%. More than a quarter of respondents (27%) were unaware that NSAIDs were a possible treatment option for dysmenorrhea. CONCLUSION: The prevalence and impact of dysmenorrhea on Grade 11 and 12 girls is high, and they lack knowledge of and experience with effective treatment. Health education measures are needed in this area to prevent unnecessary suffering and interruption to school routine.
Assuntos
Dismenorreia/epidemiologia , Dismenorreia/terapia , Conhecimentos, Atitudes e Prática em Saúde , Adolescente , Atitude Frente a Saúde , Austrália/epidemiologia , Distribuição de Qui-Quadrado , Criança , Dismenorreia/diagnóstico , Feminino , Inquéritos Epidemiológicos , Humanos , Prevalência , Índice de Gravidade de Doença , Inquéritos e QuestionáriosRESUMO
A culturally appropriate women's health service was established at an Aboriginal community-controlled health service in Darwin in 1994. An initial file audit found that 48% of included women had ever been screened with a Pap smear and 37% of women were considered to have been adequately screened. The enhancement of opportunistic screening by file tagging had a modest effect on screening coverage over a 12-month period for women who attended the health service. The proportion of these women who were adequately screened increased from 43% to 48% and of those ever screened increased from 54% to 62%. A randomised trial of recruitment interventions including personal approach, letter and control groups was subsequently performed for women for whom Pap smears were overdue or not recorded. The impact of both interventions on the number of Pap smears performed was low, with 7% of women in the personal approach group, 2% of women in the letter group and no women in the control group having Pap smears during the three-month follow-up period. Low rates of abnormalities were observed for women having Pap smears over a two-year period. The minimal effect of a formal reminder system and letters at this urban Aboriginal health service has resulted in a re-orientation of activities towards strengthening opportunistic screening and the continued promotion of Pap smears in a range of clinic and community settings. It is important to place Pap smear screening in the context of other social, economic and health priorities for Aboriginal women and health workers.
Assuntos
Serviços de Saúde do Indígena/organização & administração , Programas de Rastreamento/métodos , Havaiano Nativo ou Outro Ilhéu do Pacífico , Teste de Papanicolaou , Aceitação pelo Paciente de Cuidados de Saúde/etnologia , Educação de Pacientes como Assunto/métodos , Serviços Urbanos de Saúde/organização & administração , Neoplasias do Colo do Útero/prevenção & controle , Esfregaço Vaginal , Serviços de Saúde da Mulher/organização & administração , Adolescente , Adulto , Idoso , Feminino , Seguimentos , Humanos , Auditoria Médica , Pessoa de Meia-Idade , Northern Territory , Sistemas de AlertaRESUMO
We assessed the effects of an organised cervical screening program, using a population-based cervical cytology register, for Aboriginal women in the Fitzroy Valley, a remote part of the Kimberley region of Western Australia. Comparison of age-specific screening rates in the area during 1987-88, 1990-92 and 1993-94 showed that establishing the program in late 1989 was accompanied by dramatic increases in cervical screening rates, ranging from two- to over fourfold, with the largest increases in women aged 50 years and over. Following the departure of the coordinator in early 1993, screening rates decreased to between 76 per cent and 29 per cent of their 1990-92 levels, with the largest decreases occurring in the 40-49 and 60-69 years age groups. Rates were still above 1987-88 levels for most age groups. Of 545 women screened during 1991-92, 65 per cent had undergone a second Pap smear within the follow-up period of two to four years. Among women recommended for a repeat smear in two years, the probability of having a second smear was negatively associated with age (log-rank statistic = 35.58, 4 df, P < 0.0001). Follow-up of smears recommended for repeat in 12 months or earlier was less adequate in 1993-94 (46 per cent) than in 1991-92 (75 per cent). The program was successful in recruiting a large proportion of eligible women within a relatively short time, but coverage, especially of older women, was not sustained after a decline in the functioning of the recall system owing to staffing and organisational changes.
Assuntos
Programas de Rastreamento/tendências , Havaiano Nativo ou Outro Ilhéu do Pacífico , Teste de Papanicolaou , Esfregaço Vaginal , Adolescente , Adulto , Idoso , Austrália , Estudos de Coortes , Feminino , Seguimentos , Humanos , Programas de Rastreamento/estatística & dados numéricos , Pessoa de Meia-Idade , População RuralRESUMO
A cost-effectiveness study of three different interventions to promote the uptake of screening for cervical cancer in general practice was carried out in Perth in 1991. Women eligible for a Pap smear were randomly allocated to one of four groups: one receiving letters with specific appointments to attend a screening clinic staffed by female doctors, one receiving letters informing them of the availability of the clinic and suggesting they make an appointment, one whose files were tagged to remind a doctor to offer a smear during a consultation, and a comparison control group that received opportunistic screening only. Variable and fixed costs for each group were itemised and summarised to give an average cost per smear taken. The cost and effectiveness of each intervention were then compared with those of the control group. Sensitivity analysis was performed on the major component of the costs, the doctor's time. Opportunistic screening cost $14.60 per smear and attained 16 per cent recruitment. Tagging files was the cheapest intervention ($14.75 per smear) although it was the least effective in recruiting women (20 per cent). This result held true for different scenarios of doctor's time allocated. Intervention by invitation letter with no appointment cost $45.35 per smear and attained 26 per cent recruitment, and intervention with a specific appointment cost $48.21 per smear and attained 30 per cent recruitment. Compared with the control group, the incremental cost-effectiveness for the tagged group was $15.40, for the letter-without-appointment group $97.75 and for the letter-with-appointment group $86.50.
Assuntos
Promoção da Saúde/economia , Teste de Papanicolaou , Esfregaço Vaginal/economia , Adulto , Idoso , Análise Custo-Benefício , Medicina de Família e Comunidade/economia , Feminino , Humanos , Programas de Rastreamento/economia , Pessoa de Meia-IdadeRESUMO
A pilot study of a cervical cancer screening service was carried out at a major teaching hospital in Perth. The service, for women inpatients aged 20 to 69 years, was staffed by a women's health nurse. The effect of providing the service (service) was compared with giving a leaflet on Pap smears to eligible women (education) and with no intervention (control). Of 517 women in the service group, 184 (36 per cent) needed a Pap smear and were well enough to be offered screening; only 29 of 184 (16 per cent) refused and 132 of 184 (72 per cent) were screened. Of those screened, 29 per cent had never had a Pap smear. Information on women in the education and control groups was obtained by mailed questionnaire. Of the eligible women in the service group, 72 per cent accepted screening in hospital, but only 24 per cent of eligible women in the education group and 20 per cent in the control group reported having a Pap smear in the four months since leaving hospital. The service group showed a very large effect relative to the control group (odds ratio (OR) 17.71, 95 per cent confidence interval (CI) 10.05 to 31.22), but there was no significant difference between the education and control groups. Other significant variables in the logistic regression model were age, marital status, and sex of the woman's general practitioner. The effect of offering the service was greater for women over 50 (OR 51.51, CI 19.01 to 139.60) A hospital-based cervical screening service provides an important opportunity for screening women who are not being reached by other services.
Assuntos
Educação em Saúde , Teste de Papanicolaou , Neoplasias do Colo do Útero/prevenção & controle , Esfregaço Vaginal , Adulto , Idoso , Recursos Audiovisuais , Intervalos de Confiança , Demografia , Feminino , Humanos , Pessoa de Meia-Idade , Razão de Chances , Avaliação de Resultados em Cuidados de Saúde , Projetos Piloto , Austrália OcidentalRESUMO
This study examined the effect of three interventions for encouraging women to have a Pap smear in a general practice: tagging the medical record to remind the doctor to offer a Pap smear, sending an invitation to make an appointment for a Pap smear, and sending an invitation with an appointment to attend for a Pap smear at a special screening clinic staffed by women. The study took place in a university general practice at Lockridge, near Perth. A computerised practice age-sex register provided 2139 women in the age range 36 to 69 inclusive. Of these, 757 were eligible for inclusion in the study and were allocated randomly to one of three intervention groups or a control group. In total, 177 women had a Pap smear during the study. Significantly more Pap smears were taken for the appointment-letter and letter-only groups than the control group (odds ratio (OR) 2.13, 95% confidence interval (CI) 1.34 to 3.57, and OR 1.67, CI 1.01 to 2.77 respectively), but there was no significant difference between the tagged-notes and the control groups. Women who attended the screening clinic rated the experience positively. Attendance, however, was inadequate for the clinic's viability in a private practice.
Assuntos
Teste de Papanicolaou , Sistemas de Alerta , Neoplasias do Colo do Útero/diagnóstico , Esfregaço Vaginal , Adulto , Idoso , Medicina de Família e Comunidade , Feminino , Humanos , Pessoa de Meia-Idade , Cooperação do PacienteRESUMO
OBJECTIVES: To estimate the rate of cervical cancer screening in Western Australia in 1992, and any variation by age, place of residence, and socio-economic status; and to determine the proportion of smears taken by different service providers. DESIGN: Descriptive study; collection of data from Papanicolaou (Pap) smear request forms during one calendar month. SETTING: All 13 cytology laboratories in Western Australia. PARTICIPANTS: 15,767 women in Western Australia aged 15 years and over having a cervical smear in March 1992. MAIN OUTCOME MEASURES: Rates by age of cervical cancer screening per 1000 woman-years; age-standardised rate ratios for socioeconomic status and place of residence; proportion of smears taken by male and female service providers. RESULTS: The estimated rate of Pap smears at ages 15 years and over was 303 smears per 1000 woman-years, an increase of 44% over a similar survey in 1983. The greatest increases were among women aged 50 years and over, but their rates were still well below that equivalent to three-yearly smears. Differences in the rate of screening by socioeconomic status (defined by residential postcode) were not statistically significant. The age-standardised rate ratio comparing country women with women in the Perth metropolitan area was 0.91 (95% confidence interval 0.87-0.94). General practitioners took 78% of the smears, and at least 46% of all smears were taken by female service providers. Almost all the increase in the screening rate since 1983 could be attributed to an increase in the rate of smears per 1000 woman-years taken by female general practitioners. CONCLUSION: While there have been marked improvements in the rates of cervical screening in Western Australia over the past nine years, there are still major deficiencies in the screening coverage of women aged 50 years and over.
Assuntos
Programas de Rastreamento/tendências , Teste de Papanicolaou , Neoplasias do Colo do Útero/prevenção & controle , Esfregaço Vaginal/tendências , Adolescente , Adulto , Idoso , Medicina de Família e Comunidade , Feminino , Humanos , Masculino , Programas de Rastreamento/estatística & dados numéricos , Pessoa de Meia-Idade , Médicas , Características de Residência , Fatores Sexuais , Fatores Socioeconômicos , Esfregaço Vaginal/estatística & dados numéricos , Austrália Ocidental/epidemiologiaRESUMO
OBJECTIVE: To describe the operation of the Fitzroy Valley Pap Smear Register, a population-based call and recall system for cervical screening for Aboriginal women, and the prevalence of cervical abnormalities in the women screened. DESIGN: Descriptive study. SETTING: An Aboriginal community in the far north-west of Western Australia. PARTICIPANTS: Aboriginal women aged 15 to 69 years, living in the Fitzroy Valley, Kimberley region. MAIN OUTCOME MEASURES: Proportion of eligible women on the Register; age distribution of women screened; prevalence of squamous cell abnormalities. RESULTS: In December 1990, there were 507 Aboriginal women on the Register, being 86.9% of the Aboriginal women in the Fitzroy Valley aged 15-69 years. During 1990, 53.6% of the target population were screened; 369 Pap smears were taken from 312 Aboriginal women. Seventy-six (24.3%) had never previously been screened. Considering only the first smear for each woman in the study period, 10.6% showed minor abnormalities, and 1.6% (95% confidence interval [CI], 0.2%-3.0%) had cervical intraepithelial neoplasia (CIN I, II or III); 2.6% has smears showing definite evidence of human papillomavirus (HPV) infection. For 15-19 year olds the prevalence of CIN was 4.7% (95% CI, 1.0%-13.3%). CONCLUSIONS: The study shows how an inexpensive call and recall system can ensure good coverage of cervical screening in a group of women who would otherwise be under-screened. The overall prevalence of CIN in Aboriginal women in the Fitzroy Valley was lower than the figure for all Victorian women (3.6%--data from the Victorian Cytology Service). Although the numbers are small, the relatively high prevalence of CIN in young women is of some concern, and emphasises the importance of regular screening in this group.
Assuntos
Programas de Rastreamento/organização & administração , Havaiano Nativo ou Outro Ilhéu do Pacífico , Teste de Papanicolaou , Sistema de Registros , Neoplasias do Colo do Útero/prevenção & controle , Esfregaço Vaginal , Adolescente , Adulto , Idoso , Candidíase Vulvovaginal/epidemiologia , Infecções por Chlamydia/epidemiologia , Feminino , Seguimentos , Doenças dos Genitais Femininos/epidemiologia , Gonorreia/epidemiologia , Humanos , Programas de Rastreamento/estatística & dados numéricos , Pessoa de Meia-Idade , Sistemas de Alerta , Tricomoníase/epidemiologia , Displasia do Colo do Útero/epidemiologia , Neoplasias do Colo do Útero/epidemiologia , Austrália Ocidental/epidemiologiaAssuntos
Teste de Papanicolaou , Esfregaço Vaginal , Adulto , Idoso , Feminino , Humanos , Prontuários Médicos , Pessoa de Meia-IdadeRESUMO
OBJECTIVE: To investigate the association between genital and urinary tract infections in pregnant Aboriginal women and low birth weight. DESIGN: Retrospective case-control study controlling for potential confounding variables. SETTING: Western Australia from 1985 to 1987. SUBJECTS: All Aboriginal women (n = 269) who had given birth to singleton infants weighing 2250 g or less (cases), and 269 randomly selected Aboriginal women who had given birth to singleton infants weighing 3000 g or more (controls). MAIN OUTCOME MEASURES: Proportions of women in case and control groups who had had genital and urinary tract infections; odds ratios for low birth weight when genitourinary tract infection was present; population attributable fraction of low birth weight to genitourinary tract infection. RESULTS: At the time of delivery 51% of women in the case group (109/215) had genitourinary tract infections compared with 13% of controls (35/266). After controlling for potential confounding variables the odds ratio for giving birth to infants weighing 2250 g or less when genitourinary tract infection was present was 4.0 (95% confidence interval 2.3 to 7.0). The proportion of infants with low birth weight attributable to genitourinary tract infection in the whole population of Aboriginal women was 32% (95% confidence interval 17% to 49%). CONCLUSIONS: There was a strong association between low birth weight and the presence of genitourinary tract infections in Aboriginal women both during pregnancy and at the time of delivery. A community intervention trial of screening and treatment of genitourinary infections in this population is recommended.
Assuntos
Doenças Urogenitais Femininas/etnologia , Recém-Nascido de Baixo Peso , Havaiano Nativo ou Outro Ilhéu do Pacífico , Complicações Infecciosas na Gravidez/etnologia , Infecções Urinárias/etnologia , Estudos de Casos e Controles , Feminino , Doenças Urogenitais Femininas/complicações , Humanos , Recém-Nascido , Razão de Chances , Paridade , Gravidez , Prevalência , Distribuição Aleatória , Estudos Retrospectivos , Fatores de Risco , Infecções Urinárias/complicações , Austrália OcidentalRESUMO
The results of a study to assess the level of consumer information about the action and uses of Ipecacuanha Syrup (Emetic) Australian Pharmaceutical Formulary (APF) are reported. Of 40 community pharmacies selected at random from the 321 pharmacies in the Perth metropolitan area, four were unable to supply the syrup. Dosage information provided on the labels of branded products was, for the most part, comprehensive and in line with APF recommendations. Syrup samples dispensed under pharmacy labels provided much less detailed dose information and no information on contraindications on the labels. Counselling by pharmacists was mostly adequate, but information provided by pharmacy assistants was much less detailed. The active alkaloid content of about 77% of the samples of ipecacuanha syrup was within +/- 12% of the target concentration; the remainder had only 56%-58% of the required alkaloid concentration, which indicates a need for more stringent quality control.
Assuntos
Serviços de Informação sobre Medicamentos/normas , Rotulagem de Medicamentos/normas , Ipeca/administração & dosagem , Adulto , Alcaloides/análise , Austrália , Pré-Escolar , Aconselhamento , Armazenamento de Medicamentos , Humanos , Lactente , Ipeca/análise , Ipeca/farmacologia , Ipeca/provisão & distribuição , Farmácias , Farmacêuticos , Técnicos em FarmáciaRESUMO
The relationship between circumcision and sexually transmissible disease was studied in 1350 men who attended the Public Health Department Special Treatment Clinic in Perth, Western Australia. Evidence of circumcision was obtained by examination. More than 98% of the men studied gave a verbal report of their circumcision status which was consistent with the examination findings. Eight hundred and forty-eight men had STD; 471 men, who presented to the clinic for diagnosis and treatment but who were found not to have STD, constituted the control group. The results of the study show significant associations between the state of being uncircumcised and four major sexually transmissible diseases--herpes genitalis, candidiasis, gonorrhoea and syphilis. Estimates of the relative risk suggest that uncircumcised men are twice as likely as circumcised men to develop herpes genitalis or gonorrhoea, and five times as likely to develop candidiasis or syphilis. However, the data for syphilis should be interpreted with caution because of the small number of cases. No significant increase in risk was found for any of the other sexually transmissible diseases diagnosed at the clinic.
Assuntos
Circuncisão Masculina , Infecções Sexualmente Transmissíveis/transmissão , Adulto , Austrália , Candidíase/diagnóstico , Candidíase/transmissão , Feminino , Gonorreia/diagnóstico , Gonorreia/transmissão , Herpes Genital/diagnóstico , Herpes Genital/transmissão , Humanos , Masculino , Exame Físico , Risco , Sífilis/diagnóstico , Sífilis/transmissãoRESUMO
PIP: This article reviews the literature of the medical risks associated with teenage pregnancy. Data from South Australia indicate that in 1979 approximately 1/3 of abortions were performed on teenagers. Consideration of the risks of teenage pregnancy must include the risks of abortion. The physical risks of the options of unwanted pregnancy are as important as the psychosocial and the teenager's knowledge of these will help her make the best decision. West Australia data have shown that since 1973 the birthrate for older teenagers (16-19) declined but for younger teenagers has remained steady. The decline in birthrate among older teenagers is likely to be due to increased use of contraception and abortion rather than a decline in sexual activity. The main risk to the teenage mother's health is an increased likelihood of preeclampsia. At highest risk are those under age 16. Other studies have shown that if teenagers have adequate antenatal care they are not at high risk of obstetric complications than older women of similar race and socioeconomic background. The greatest medical risks to teenage childbearing are to the child. West Australian data have confirmed the findings of other studies that the infants of young teenagers in particular are at higher risk of a low birthweight or perinatal death than those of women in their 20s. The higher perinatal mortality in the infants of young teenagers is due in part to the higher percentage of infants of low birth weight. Early medical complications of abortion are those at the time of the procedure or within a few weeks and include a reaction to anesthesia, injury to the cervix or uterus, hemorrhage, pelvic infection, and secondary hemorrhage. When abortions are performed by skilled operators under proper conditions, complications are relatively uncommon. The risk of death from abortion depends on the technique and the stage of pregnancy. Longterm complications include infertility or ectopic pregnancy because of pelvic infection, cervical incompetence leading to spontaneous abortion, and increased risk of premature and low birth weight infants. Currently, there is no agreement in the literature about the magnitude of the longterm risks.^ieng
Assuntos
Aborto Induzido/efeitos adversos , Gravidez na Adolescência , Adolescente , Adulto , Feminino , Humanos , Gravidez , Complicações na Gravidez/etiologia , RiscoRESUMO
Examination of fertility rates among teenagers in Western Australia from 1968 to 1978 revealed a steady decline n the birth rate among older teenagers (16-19); a similar decline did not occur among girls under 16. an increasing proportion of teenage births is occurring to these young teenagers. Information obtained from a linked file of birth and perinatal death registrations in Western Australia over the same period indicates that the infants of young teenage mothers have a substantially higher risk of low birthweight and perinatal death than infants of older mothers. The presence of this high-risk group of very young teenagers needs to be emphasized, as it is usually masked by presentation of data on all teenagers as a group. The authors recommended the involvement of special adolescent units in the prevention and management of teenage pregnancy.
PIP: Trends in the frequency of births in teenagers in Western Australia and the associated low birthweight and perinatal mortality rates were analyzed using data provided by the Registrar General for Western Austrlia for the period 1968-78. The results show that fertility among older teenagers (aged 16-19) has declined steadily since 1973, but not among girls under 16 years of age. Thus, although there are relatively few births to 14- and 15-year olds compared with older teenagers, an increasing proportion of all teenage births is occurring in young teenagers. The falling birth rate in older teenagers may be due to increased contraceptive use and increased availability of abortion, rather than to a decline in sexual activity. Infants of young teenagers are also found to be at increased risk of low birthweight and perinatal death compared to infants of older women. In 1976-78, young teenagers had perinatal death rates 3 times higher than the age groups with the lowest rate (36.3 deaths/1000 total births compared with 11.8 deaths/1000 total births in the 25-29 age group). Rates of low birthweight of the young teenagers were almost double those in the 25-29 year age group (8.3% vs. 4.7%). The Australian Bureau of Statistics usually calculates perinatal mortality rates as a single group for all mothers under 20, thus masking the higher perinatal mortality rates in the infants of young teenagers. Adolescent pregnancy programs should provide support and counseling to pregnant and nonpregnant teenagers. Activiites which prevent teenage pregnancy should be especially encouraged.