1.
Org Lett
; 14(1): 214-7, 2012 Jan 06.
Artigo
em Inglês
| MEDLINE
| ID: mdl-22148911
RESUMO
In the presence of AlMe(3), amines can be directly coupled with acids through dimethylaluminum amide intermediates to form the corresponding amides. A wide range of amines and acids including less nucleophilic amines, bulky amines, unprotected secondary amino acids, and acids with poor solubility were coupled smoothly to give the desired products in 55-98% yields.