RESUMO
The prevalence of papillary thyroid cancer (PTC) has been rising in recent years. Despite its relatively low mortality, PTC frequently metastasizes to lymph nodes and often recurs, posing significant health and economic burdens. The role of iodine in the pathogenesis and advancement of thyroid cancer remains poorly understood. Circular RNAs (circRNAs) are recognized to function as competing endogenous RNAs (ceRNAs) that modulate gene expression and play a role in various cancer stages. Consequently, this research aimed to elucidate the mechanism by which circRNA influences the impact of iodine on PTC. Our research indicates that high iodine levels can exacerbate the malignancy of PTC via the circ_0004851/miR-296-3p/FGF11 axis. These insights into iodine's biological role in PTC and the association of circRNA with the disease could pave the way for novel biomarkers and potentially effective therapeutic strategies to mitigate PTC progression.
Assuntos
Regulação Neoplásica da Expressão Gênica , Iodo , MicroRNAs , RNA Circular , Câncer Papilífero da Tireoide , MicroRNAs/genética , MicroRNAs/metabolismo , RNA Circular/genética , RNA Circular/metabolismo , Humanos , Câncer Papilífero da Tireoide/genética , Câncer Papilífero da Tireoide/patologia , Iodo/metabolismo , Linhagem Celular Tumoral , Neoplasias da Glândula Tireoide/genética , Neoplasias da Glândula Tireoide/patologia , Sequência de BasesRESUMO
We report a novel strategy for the enhancement of photocatalytic H2 evolution by doping La into the depletion layer of Cd0.6Zn0.4S (CZS: x% La). The apparent quantum yield of the CZS: 2% La photocatalyst at 350 nm is up to 93.3%, which is extremely high for solar water splitting even compared with the noble metal cocatalyst systems. This work may contribute to the design and construction of materials with outstanding capability for charge separation and hence improve the properties of the materials for various applications.
RESUMO
BiOCl/BiOI composites with a visible light response were prepared by a simple hydrothermal method. Even though both single BiOCl and BiOI show low photocatalytic activity, BiOCl/BiOI composites provide enhanced efficiency in decomposing organic compounds including Methyl Orange (MO) and Rhodamine B (RhB). Furthermore, the 20%BiOCl/BiOI composite shows the highest efficiency for decomposing MO, while the highest performance is observed for the degradation of RhB over 70%BiOCl/BiOI composite. A possible photocatalytic mechanism has been proposed based on the relative experiments and the band positions of BiOCl and BiOI.