RESUMO
Seven-week old female rats fed restricted foods including the fish oils Docosahesaenoic Acid (DHA) and Eicosapentaenoic Acid (EPA) and perilla oil with food intake decreased by 50%, had increases of fracture force and bone mineral density (BMD) and decreases in levels of Deoxypiridinoline (Dpd) and Calcium (Ca) in the urine, compared with those of rats with osteoporosis due to restricted soy bean oil food intake. Therefore, the fish oils DHA and EPA and perilla oil depressed excretion of urinary Ca and inhibited osteoporosis due to restricted food intake.
Assuntos
Óleos de Peixe/farmacologia , Osteoporose/prevenção & controle , Óleos de Plantas/farmacologia , Ácido alfa-Linolênico/farmacologia , Aminoácidos/urina , Animais , Fenômenos Biomecânicos , Densidade Óssea/efeitos dos fármacos , Cálcio/urina , Dieta , Ácidos Docosa-Hexaenoicos/administração & dosagem , Ácidos Docosa-Hexaenoicos/farmacologia , Ácido Eicosapentaenoico/administração & dosagem , Ácido Eicosapentaenoico/farmacologia , Feminino , Fêmur , Óleos de Peixe/administração & dosagem , Óleos de Peixe/química , Fraturas Ósseas/prevenção & controle , Óleos de Plantas/administração & dosagem , Óleos de Plantas/química , Ratos , Ratos Wistar , Óleo de Soja/administração & dosagem , Óleo de Soja/farmacologia , Ácido alfa-Linolênico/administração & dosagem , Ácido alfa-Linolênico/químicaRESUMO
Running at 0.7 km/h for 10 min every day inhibited development of osteoporosis caused by protein deficient (PD) food intake. Urine alkaline phosphatase (ALP), a marker of bone formation osteoporosis, was not elevated in rats fed PD, when the osteoporosis was inhibited by running. Estrogen supplementation increased bone-breaking energy (BBE), but did not increase bone mineral density (BMD), and did not decrease urinary ALP levels.
Assuntos
Osteoporose/prevenção & controle , Deficiência de Proteína/complicações , Corrida/fisiologia , Fosfatase Alcalina/urina , Animais , Peso Corporal/fisiologia , Densidade Óssea/fisiologia , Feminino , Tamanho do Órgão/fisiologia , Osteoporose/etiologia , Osteoporose/metabolismo , Ratos , Ratos WistarRESUMO
Independent use of K(2) and D(3) and simultaneous application of K(2) and D(3) inhibited the development of osteoporosis caused by PD food intake. The ALP activity of urine as a marker of bone formation osteoporosis did not rise in rats fed PD foods containing D(3), K(2) or both together. Body and womb weights fell in rats fed PD foods with D(3) K(2) and both D(3), K(2). Osteoporosis caused by PD food intake found to be very similar to type II osteoporosis in respects of inhibition by D(3) and K(2) and rising urinary ALP activity.